The Homologous Recombination Machinery Regulates Increased Chromosomal Mobility After DNA Damage in Saccharomyces Cerevisiae PDF Download
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Author: Michael Joseph Smith
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
I have also studied how the baseline confinement of loci is established, and assessed the contributions of several genes involved in repair to increased mobility. These observations offer novel insight into previously unappreciated regulatory functions performed by the recombination machinery, and demonstrate how the progression of DNA repair pathways influences nuclear organization.
Author: Michael Joseph Smith
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
I have also studied how the baseline confinement of loci is established, and assessed the contributions of several genes involved in repair to increased mobility. These observations offer novel insight into previously unappreciated regulatory functions performed by the recombination machinery, and demonstrate how the progression of DNA repair pathways influences nuclear organization.
Author: Paul James Smith
Publisher: Oxford University Press, USA
ISBN:
Category : Medical
Languages : en
Pages : 260
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Book Description
The processes of DNA recombination and repair are vital to cell integrity - an error can lead to disease such as cancer. It is therefore a large and exciting area of research and is also taught on postgraduate and undergraduate courses. This book is not a comprehensive view of the field, but a selection of the issues currently at the forefront of knowledge.
Author: Andrés Aguilera
Publisher: Springer Science & Business Media
ISBN: 3540710213
Category : Science
Languages : en
Pages : 536
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Book Description
This work offers a fascinating insight into a crucial genetic process. Recombination is, quite simply, one of the most important topics in contemporary biology. This book is a totally comprehensive treatment of the subject, summarizing all existing views on the topic and at the same time putting them into context. It provides in-depth and up-to-date analysis of the chapter topics, and has been written by international experts in the field.
Author: Errol C. Friedberg
Publisher:
ISBN: 9781936113545
Category : Cellular control mechanisms
Languages : en
Pages : 0
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Book Description
Cellular DNA is constantly bombarded with environmental and chemical assaults that damage its molecular structure. In addition, the normal process of DNA replication is prone to error and may introduce mutations that can be passed to daughter cells. If left unrepaired, these DNA lesions can have serious consequences, such as cancer. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology reviews the mechanisms that cells use to recognize and repair various types of DNA damage. Contributors discuss base excision repair, nucleotide excision repair, mismatch repair, homologous recombination, nonhomologous end joining, the SOS response, and other pathways in prokaryotes and eukaryotes, and describe how these processes are linked to DNA replication, transcription, and cell cycle controls. The repair of telomeric and mitochondrial DNA is described, as is the influence of chromatin structure on DNA repair. This volume also includes discussion of human genetic diseases that involve defects in DNA damage repair. It is an essential reference for molecular and cell biologists, medical geneticists, cancer biologists, and all who want to understand how cells maintain genomic integrity.
Author: David C. Amberg
Publisher: CSHL Press
ISBN: 0879697288
Category : Genetics
Languages : en
Pages : 250
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Book Description
"Methods in Yeast Genetics" is a course that has been offered annually at Cold Spring Harbor for the last 30 years. This provides a set of teaching experiments along with the protocols and recipes for the standard techniques and reagents used in the study of yeast biology.
Author: Fumio Hanaoka
Publisher: Springer
ISBN: 443155873X
Category : Science
Languages : en
Pages : 548
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Book Description
This book is a comprehensive review of the detailed molecular mechanisms of and functional crosstalk among the replication, recombination, and repair of DNA (collectively called the "3Rs") and the related processes, with special consciousness of their biological and clinical consequences. The 3Rs are fundamental molecular mechanisms for organisms to maintain and sometimes intentionally alter genetic information. DNA replication, recombination, and repair, individually, have been important subjects of molecular biology since its emergence, but we have recently become aware that the 3Rs are actually much more intimately related to one another than we used to realize. Furthermore, the 3R research fields have been growing even more interdisciplinary, with better understanding of molecular mechanisms underlying other important processes, such as chromosome structures and functions, cell cycle and checkpoints, transcriptional and epigenetic regulation, and so on. This book comprises 7 parts and 21 chapters: Part 1 (Chapters 1–3), DNA Replication; Part 2 (Chapters 4–6), DNA Recombination; Part 3 (Chapters 7–9), DNA Repair; Part 4 (Chapters 10–13), Genome Instability and Mutagenesis; Part 5 (Chapters 14–15), Chromosome Dynamics and Functions; Part 6 (Chapters 16–18), Cell Cycle and Checkpoints; Part 7 (Chapters 19–21), Interplay with Transcription and Epigenetic Regulation. This volume should attract the great interest of graduate students, postdoctoral fellows, and senior scientists in broad research fields of basic molecular biology, not only the core 3Rs, but also the various related fields (chromosome, cell cycle, transcription, epigenetics, and similar areas). Additionally, researchers in neurological sciences, developmental biology, immunology, evolutionary biology, and many other fields will find this book valuable.
Author: Yu Zhang
Publisher: Springer
ISBN: 9811305935
Category : Medical
Languages : en
Pages : 171
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Book Description
This volume discusses various aspects of mechanisms and methodologies of chromosome translocations, ranging from a historical and clinical overview of chromosome translocations to the rapid development of the next-generation sequencing technologies, which has dramatically increased our understanding of the spectrum of chromosome translocations in human diseases. The book also introduces the mechanistic studies on chromosome deletions and their implications in cancer, and discusses the mechanisms of regulating chromothripsis, a unique complex type of chromosome translocation. It is a valuable resource for students and researchers alike, providing insights into chromosome translocations and, potentially, other genomic aberrations involved in understanding and curing human diseases.
Author: Jeffrey N. Strathern
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 776
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Book Description
Author: Clark Chen
Publisher: BoD – Books on Demand
ISBN: 9535111140
Category : Medical
Languages : en
Pages : 676
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Book Description
This book is intended for students and scientists working in the field of DNA repair. Select topics are presented here to illustrate novel concepts in DNA repair, the cross-talks between DNA repair and other fundamental cellular processes, and clinical translational efforts based on paradigms established in DNA repair. The book should serve as a supplementary text in courses and seminars as well as a general reference for biologists with an interest in DNA repair.
Author: Mark O. J. Olson
Publisher: Springer Science & Business Media
ISBN: 1461405149
Category : Science
Languages : en
Pages : 434
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Book Description
Within the past two decades, extraordinary new functions for the nucleolus have begun to appear, giving the field a new vitality and generating renewed excitement and interest. These new discoveries include both newly-discovered functions and aspects of its conventional role. The Nucleolus is divided into three parts: nucleolar structure and organization, the role of the nucleolus in ribosome biogenesis, and novel functions of the nucleolus.
