Handbook of Grignard Reagents

Handbook of Grignard Reagents PDF Author: Gary S. Silverman
Publisher: CRC Press
ISBN: 9780824795450
Category : Science
Languages : en
Pages : 740

Get Book

Book Description
This handbook provides the theoretical and practical information necessary to explore new applications for Grignard reagents on a day-to-day basis, presenting a comprehensive overview of current research activities in Grignard chemistry. This book surveys specific reactions and applications of Grignard reagents, organized by type of substrate and the general category of reaction. It also summarizes the spectrum of reactions exhibited by Grignard reagents.

Handbook of Grignard Reagents, Second Edition

Handbook of Grignard Reagents, Second Edition PDF Author: Larry J. Westrum
Publisher: CRC Press
ISBN: 9781574446678
Category : Science
Languages : en
Pages : 600

Get Book

Book Description


Organic Mechanisms

Organic Mechanisms PDF Author: Reinhard Bruckner
Publisher: Springer Science & Business Media
ISBN: 3642036503
Category : Science
Languages : en
Pages : 873

Get Book

Book Description
This English edition of a best-selling and award-winning German textbook Reaction Mechanisms: Organic Reactions · Stereochemistry · Modern Synthetic Methods is aimed at those who desire to learn organic chemistry through an approach that is facile to understand and easily committed to memory. Michael Harmata, Norman Rabjohn Distinguished Professor of Organic Chemistry (University of Missouri) surveyed the accuracy of the translation, made certain contributions, and above all adapted its rationalizations to those prevalent in the organic chemistry community in the English-speaking world. Throughout the book fundamental and advanced reaction mechanisms are presented with meticulous precision. The systematic use of red "electron-pushing arrows" allows students to follow each transformation elementary step by elementary step. Mechanisms are not only presented in the traditional contexts of rate laws and substituent effects but, whenever possible, are illustrated using practical, useful and state-of-the-art reactions. The abundance of stereoselective reactions included in the treatise makes the reader familiar with key concepts of stereochemistry. The fundamental topics of the book address the needs of upper-level undergraduate students, while its advanced sections are intended for graduate-level audiences. Accordingly, this book is an essential learning tool for students and a unique addition to the reference desk of practicing organic chemists, who as life-long learners desire to keep abreast of both fundamental and applied aspects of our science. In addition, it will well serve ambitious students in chemistry-related fields such as biochemistry, medicinal chemistry and pharmaceutical chemistry. From the reviews: "Professor Bruckner has further refined his already masterful synthetic organic chemistry classic; the additions are seamless and the text retains the magnificent clarity, rigour and precision which were the hallmark of previous editions. The strength of the book stems from Professor Bruckner’s ability to provide lucid explanations based on a deep understanding of physical organic chemistry and to limit discussion to very carefully selected reaction classes illuminated by exquisitely pertinent examples, often from the recent literature. The panoply of organic synthesis is analysed and dissected according to fundamental structural, orbital, kinetic and thermodynamic principles with an effortless coherence that yields great insight and never over-simplifies. The perfect source text for advanced Undergraduate and Masters/PhD students who want to understand, in depth, the art of synthesis ." Alan C. Spivey, Imperial College London "Bruckner’s ‘Organic Mechanisms’ accurately reflects the way practicing organic chemists think and speak about organic reactions. The figures are beautifully drawn and show the way organic chemists graphically depict reactions. It uses a combination of basic valence bond pictures with more sophisticated molecular orbital treatments. It handles mechanisms both from the "electron pushing perspective" and from a kinetic and energetic view. The book will be very useful to new US graduate students and will help bring them to the level of sophistication needed to be serious researchers in organic chemistry." Charles P. Casey, University of Wisconsin-Madison "This is an excellent advanced organic chemistry textbook that provides a key resource for students and teachers alike." Mark Rizzacasa, University of Melbourne, Australia.

Grignard Reagents

Grignard Reagents PDF Author: H. G. Richey
Publisher: John Wiley & Sons
ISBN:
Category : Science
Languages : en
Pages : 450

Get Book

Book Description
The Grignard reagent is one of the most useful and versatile reagents known to the organic chemist and 100 years after its discovery, this book presents authoritative perspectives on the significant developments taking place using Grignard Reagents and related organomagnesium compounds. This volume focuses on a dozen areas of organomagnesium chemistry, including: * New reactions of Grignard Reagents * Stereoselective Reactions of Organomagnesium Compounds * Mechanistic Features of Organomagnesium Compounds * Industrial Applications and Strategy * Unusual Organomagnesium Compounds * Structures of Organomagnesium Solids and Solutions The book will prove of great interest to academic and industrial chemists active in organometallic chemistry of main group metals, organic syntheses, reaction mechanisms and structural organic chemistry.

Cross-Coupling Reactions

Cross-Coupling Reactions PDF Author: Norio Miyaura
Publisher: Springer
ISBN: 354045313X
Category : Science
Languages : en
Pages : 253

Get Book

Book Description
In 1972, a very powerful catalytic cycle for carbon-carbon bond formation was 2 first discovered by the coupling reaction of Grignard reagents at the sp -carbon. Over the past 30 years, the protocol has been substantially improved and expanded to other coupling reactions of Li,B,N,O,Al,Si,P,S,Cu,Mn,Zn,In,Sn, and Hg compounds. These reactions provided an indispensable and simple methodology for preparative organic chemists. Due to the simplicity and rel- bility in the carbon-carbon, carbon-heteroatom, and carbon-metalloid bo- formations,as well as high efficiency of the catalytic process,the reactions have been widely employed by organic chemists in various fields. Application of the protocol ranges from various syntheses of complex natural products to the preparation of biologically relevant molecules including drugs, and of sup- molecules, and to functional materials. The reactions on solid surfaces allow robot synthesis and combinatorial synthesis. Now, many organic chemists do not hesitate to use transition metal complexes for the transformation of org- ic molecules. Indeed, innumerable organic syntheses have been realized by the catalyzed reactions of transition metal complexes that are not achievable by t- ditional synthetic methods. Among these, the metal-catalyzed cross-coupling reactions have undoubtedly contributed greatly to the development of such a new area of “metal-catalyzed organic syntheses”. An excellent monograph for the cross-coupling reactions and other met- catalyzed C-C bond-forming reactions recently appeared in Metal-catalyzed Cross-coupling Reactions (Wiley-VCH,1998).

Handbook of Organopalladium Chemistry for Organic Synthesis

Handbook of Organopalladium Chemistry for Organic Synthesis PDF Author: Ei-ichi Negishi
Publisher: John Wiley & Sons
ISBN: 0471473812
Category : Science
Languages : en
Pages : 1657

Get Book

Book Description
Organized to provide maximum utility to the bench synthetic chemist. The editor is well-known for his work in exploring, developing, and applying organopalladium chemistry. Contributors include over 24 world authorities in the field.

Reagents for Silicon-Mediated Organic Synthesis

Reagents for Silicon-Mediated Organic Synthesis PDF Author: Philip L. Fuchs
Publisher: John Wiley & Sons
ISBN: 1118636139
Category : Technology & Engineering
Languages : en
Pages : 816

Get Book

Book Description
Over the last three decades the importance of organosiliconchemistry has greatly increased because it has opened a number ofnew synthetic strategies. Silicon reagents are usually low-cost,versatile and allow a wide range of reactions. This is the firstHandbook to compile essential Silicon containing reagents and makesuse of the leading reagent database e-EROS. Another hotvolume in the series Handbooks of Reagents for OrganicSynthesis, this is a must-have resource for all syntheticchemists working in drug development and medicinal chemistry. For the selection the Editor focussed on three key syntheticapproaches with the greatest impact: 1. Use of silicon as a 'temporary tether' by unifying a reactivepair of functional groups and taking advantage of theirtemplate-biased intramolecular cyclization. 2. The specific use of the silane functionality as a heterot-butyl group, often colloquially referred to as the use ofsilicon as a 'fat proton'. 3. The use of the Brook rearrangement as an 'anion relaystratagem'. A new feature in this Handbook is the reagent finder, analphabetically organized lookup table arranged by organicfunctionality and specific structure of the silicon atom to whichit is bound.

Grignard Reagents and Transition Metal Catalysts

Grignard Reagents and Transition Metal Catalysts PDF Author: Janine Cossy
Publisher: Walter de Gruyter GmbH & Co KG
ISBN: 3110352729
Category : Science
Languages : en
Pages : 295

Get Book

Book Description
In 1912, the Chemistry Nobel Prize was awarded for the discovery of the so-called Grignard reagents. Nowadays, many transition metal variants are developed to modify reactivity and selectivity of the C–C bond formation reaction. The Grignard reaction is one of the fundamental organometallic reactions, often used in alcohol syntheses. With transition metals like iron, cobalt and nickel or with noble metals like copper, silver and palladium, modern Grignard reagents can be designed in reactivity, selectivity and functional group tolerance. This book, written by international experts, presents an overview on timely Grignard chemistry involving transition metals.

Advanced Organic Chemistry

Advanced Organic Chemistry PDF Author: Francis A. Carey
Publisher: Springer Science & Business Media
ISBN: 038768350X
Category : Medical
Languages : en
Pages : 1344

Get Book

Book Description
The two-part, fifth edition of Advanced Organic Chemistry has been substantially revised and reorganized for greater clarity. The material has been updated to reflect advances in the field since the previous edition, especially in computational chemistry. Part B describes the most general and useful synthetic reactions, organized on the basis of reaction type. It can stand-alone; together, with Part A: Structure and Mechanisms, the two volumes provide a comprehensive foundation for the study in organic chemistry. Companion websites provide digital models for students and exercise solutions for instructors.

The Chemistry of Organomagnesium Compounds, 2 Volume Set

The Chemistry of Organomagnesium Compounds, 2 Volume Set PDF Author: Zvi Rappoport
Publisher: John Wiley & Sons
ISBN: 047075186X
Category : Science
Languages : en
Pages : 920

Get Book

Book Description
Magnesium remains almost unique among the metals in its ability to react directly with a wide variety of compounds. This organic chemistry field has seen steady progress, and a volume on this topic is long overdue. In the tradition of the Patai Series this title treats all aspects of functional groups, containing chapters on the theoretical and computational foundations; on analytical and spectroscopic aspects with dedicated chapters on Mass Spectrometry, NMR, IR/UV, etc.; on reaction mechanisms; on applications in syntheses. Depending on the functional group there are also chapters on industrial use, on effects in biological and/or environmental systems. Since the area of Organomagnesium Chemistry continues to grow far beyond the classical Grignard Reagents, this is an essential resource to help the reader keep abreast of the latest developments.