Author: Chaim Putterman
Publisher: Academic Press
ISBN: 0128033703
Category : Medical
Languages : en
Pages : 192
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Book Description
Structural Biology in Immunology, Structure/Function of Novel Molecules of Immunologic Importance delivers important information on the structure and functional relationships in novel molecules of immunologic interest. Due to an increasingly sophisticated understanding of the immune system, the approach to the treatment of many immune-mediated diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease has been dramatically altered. Furthermore, there is an increasing awareness of the critical role of the immune system in cancer biology. The improved central structure function relationships presented in this book will further enhance our ability to understand what defects in normal individuals can lead to disease. - Describes novel/recently discovered immunomodulatory proteins, including antibodies and co-stimulatory or co-inhibitory molecules - Emphasizes new biologic and small molecule drug design through the exploration of structure-function relationship - Features a collaborative editorial effort, involving clinical immunologists and structural biologists - Provides useful and practical insights on developing the necessary links between basic science and clinical therapy in immunology - Gives interested parties a bridge to learn about computer modeling and structure based design principles
Author: Anders Liljas
Publisher: World Scientific
ISBN: 9813142499
Category : Science
Languages : en
Pages : 610
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Book Description
This book provides a comprehensive coverage of the basic principles of structural biology, as well as an up-to-date summary of some main directions of research in the field. The relationship between structure and function is described in detail for soluble proteins, membrane proteins, membranes, and nucleic acids.There are several books covering protein structure and function, but none that give a complete picture, including nucleic acids, lipids, membranes and carbohydrates, all being of central importance in structural biology.The book covers state-of-the-art research in various areas. It is unique for its breadth of coverage by experts in the fields. The book is richly illustrated with more than 400 color figures to highlight the wide range of structures.
Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0
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Book Description
Author: Tasuku Honjo
Publisher: Elsevier
ISBN: 0123984904
Category : Medical
Languages : en
Pages : 587
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Book Description
Molecular Biology of B Cells, Second Edition is a comprehensive reference to how B cells are generated, selected, activated and engaged in antibody production. All of these developmental and stimulatory processes are described in molecular, immunological, and genetic terms to give a clear understanding of complex phenotypes. Molecular Biology of B Cells, Second Edition offers an integrated view of all aspects of B cells to produce a normal immune response as a constant, and the molecular basis of numerous diseases due to B cell abnormality. The new edition continues its success with updated research on microRNAs in B cell development and immunity, new developments in understanding lymphoma biology, and therapeutic targeting of B cells for clinical application. With updated research and continued comprehensive coverage of all aspects of B cell biology, Molecular Biology of B Cells, Second Edition is the definitive resource, vital for researchers across molecular biology, immunology and genetics. - Covers signaling mechanisms regulating B cell differentiation - Provides information on the development of therapeutics using monoclonal antibodies and clinical application of Ab - Contains studies on B cell tumors from various stages of B lymphocytes - Offers an integrated view of all aspects of B cells to produce a normal immune response
Author: Abul K. Abbas
Publisher: W B Saunders Company
ISBN: 9781416023890
Category : Medical
Languages : en
Pages : 564
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Book Description
The 5th Edition of this comprehensive title continues the tradition of delivering an accessible, engaging, and current introduction to this essential subject. The authors describe the principles of basic and applied immunology in a concise, straightforward manner, while incorporating the most up-to-date information. Over 400 illustrations help readers quickly and easily grasp key concepts. The entire text has been revised and includes new information about the organization of lymphoid organs and the mechanisms of innate immunity. (Midwest).
Author: Mary Luckey
Publisher: Cambridge University Press
ISBN: 1107729335
Category : Science
Languages : en
Pages : 427
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Book Description
This textbook provides a strong foundation and a clear overview for students of membrane biology and an invaluable synthesis of cutting-edge research for working scientists. The text retains its clear and engaging style, providing a solid background in membrane biochemistry, while also incorporating the approaches of biophysics, genetics and cell biology to investigations of membrane structure, function and biogenesis to provide a unique overview of this fast-moving field. A wealth of new high resolution structures of membrane proteins are presented, including the Na/K pump and a receptor-G protein complex, offering exciting insights into how they function. All key tools of current membrane research are described, including detergents and model systems, bioinformatics, protein-folding methodology, crystallography and diffraction, and molecular modeling. This comprehensive and up-to-date text, emphasising the correlations between membrane research and human health, provides a solid foundation for all those working in this field.
Author: Gary Stormo
Publisher:
ISBN: 9781936113491
Category : Science
Languages : en
Pages : 198
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Book Description
One of the foundations of molecular biology is how the interactions of proteins with DNA control many aspects of gene expression. Since the mid-20th century discoveries of the lac repressor and operator and the competition between the cI and cro proteins for the same segment of DNA, we have learned an enormous amount about the interactions of proteins with DNA and their control of fundamental processes in the cell. Introduction to Protein-DNA Interactions: Structure, Thermodynamics, and Bioinformatics describes what we know about protein-DNA interactions from the complementary perspectives of molecular and structural biology and bioinformatics and how each perspective informs the others. A particular emphasis is on how insights from experimental work can be translated into specific computational approaches to create unified view of the field and a fuller understanding of protein-DNA interactions.
Author: Albert M. Wu
Publisher: Springer Science & Business Media
ISBN: 1461316634
Category : Medical
Languages : en
Pages : 866
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Book Description
During the past three decades, the sugar moiety of complex carbohydrates has been found to be involved in important interactions of immunological specificity of antigens and to participate in a variety of cellular functions. The long polysaccharide side chains of the lipopolysaccharides on the outer membrane of Gram negative organisms provide surface antigens for differential serodiagnosis. Bacterial surface lectins are important in mediating the attachment of bacteria to host cells in the of infectious diseases. The carbohydrate pathogenesis moieties of cell surface glycoconjugates (glycoproteins and glycolipids) of mammals are the sites for intercellular recognition and for the regulatory molecular interactions such as interaction of complex carbohydrate with hormones or hepatic lectins. The carbohydrate side chains of many complex carbohydrates play essential roles as antigenic determinants b of human blood group ABH, Lea, Le , I, and i activities, as the Forssman specific determinant, and as tumor associated antigenic determinants. Prompted by these and other advances in the field, a Symposium on Molecular Immunology of Complex Carbohydrates was organized as a satellite meeting of the 8th International Glycoconjugate Conference held on September 8- 13, 1985, in Houston, Texas, U. S . A. Many eminent scientists contributed their knowledge at this meeting. The lecture and poster materials of the symposium are contained in this proceeding book, which is divided into four Sections and one Appendix. Section I is entitled Antibody Specificity, Epitope, and Lectinology. Dr. Elvin A.
Author: Steven A. Frank
Publisher: Princeton University Press
ISBN: 9780691095950
Category : Medical
Languages : en
Pages : 364
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Book Description
Publisher Description
Author: Frederick H. Silver
Publisher: Springer Science & Business Media
ISBN: 1461205573
Category : Science
Languages : en
Pages : 349
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Book Description
Adopting an interdisciplinary approach to the chemistry and physics of materials, their biocompatibility, and the consequences of implantation of such devices into the human body, this text introduces readers to the principles of polymer science and the study of metals, ceramics and composites, and also to the basic biology required to understand the nature of the host-transplant interface. Topics covered include the macromolecular components of cells and tissues, self-assembly processes, biological cascade systems, microscopic structure of cells and tissues, immunology, transplantation biology, and the pathobiology of wound healing. The materials science section includes the structures and properties of polymers, metals, ceramics and composites, and the processes for forming materials as well as the pathobiology of devices. The final two chapters deal with tissue engineering and the relations between the biology of cells and tissue transplantation, and the engineering of tissue replacements using passaged cells.
