Author: Xianrui Zhao
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Design, Synthesis and Biological Evaluation of Novel Taxane-based Anticancer Agents and Their Applications to Tumor-targeting Drug Delivery Systems
Author: Xianrui Zhao
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Design, Synthesis and Biological Evaluation of Novel Taxane-based Anticancer Agents and Their Tumor Targeting Delivery
Author: Larisa Kuznetsova
Publisher:
ISBN:
Category : Antineoplastic agents
Languages : en
Pages : 584
Book Description
Publisher:
ISBN:
Category : Antineoplastic agents
Languages : en
Pages : 584
Book Description
Design, Synthesis and Biological Evaluation of Novel Tumor-targeting Taxane-based Anticancer Agents
Author: Jin Chen
Publisher:
ISBN: 9781109967388
Category : Antineoplastic agents
Languages : en
Pages : 373
Book Description
A novel series of the second-generation taxoid conjugates with o-3 polyunsaturated fatty acids (PUFA) such as docosahexanoic acid (DHA), linolenic acid (LNA) and linoleic acid (LA) has been successfully developed. The new conjugates, tested in vivo, exhibited strong activity against both resistant and sensitive colon and ovarian cancer xenografts. Two of the new conjugates (DHA-SB-T-1214 and DHA-SB-T-1213) caused the total regression of resistant and sensitive type cancers, respectively, with reduced side toxicity.
Publisher:
ISBN: 9781109967388
Category : Antineoplastic agents
Languages : en
Pages : 373
Book Description
A novel series of the second-generation taxoid conjugates with o-3 polyunsaturated fatty acids (PUFA) such as docosahexanoic acid (DHA), linolenic acid (LNA) and linoleic acid (LA) has been successfully developed. The new conjugates, tested in vivo, exhibited strong activity against both resistant and sensitive colon and ovarian cancer xenografts. Two of the new conjugates (DHA-SB-T-1214 and DHA-SB-T-1213) caused the total regression of resistant and sensitive type cancers, respectively, with reduced side toxicity.
Design, Synthesis and Biological Evaluation of Tumor-targeting Taxane-based Anticancer Agents and MDR Modulators
Author: Xinyuan Wu
Publisher:
ISBN:
Category : Antineoplastic agents
Languages : en
Pages : 754
Book Description
Publisher:
ISBN:
Category : Antineoplastic agents
Languages : en
Pages : 754
Book Description
Design, Synthesis, and Biological Evaluations of Novel Taxane-based and Taxane-free Anticancer Agents
Author: Xudong Geng
Publisher:
ISBN:
Category : Antineoplastic agents
Languages : en
Pages : 1608
Book Description
Publisher:
ISBN:
Category : Antineoplastic agents
Languages : en
Pages : 1608
Book Description
Anticancer Agents
Author: Qiao-Hong Chen
Publisher: MDPI
ISBN: 3036501401
Category : Business & Economics
Languages : en
Pages : 606
Book Description
This book is a printed edition of the Special Issue entitled “Anticancer Agents: Design, Synthesis and Evaluation” that was published in Molecules. Two review articles and thirty research papers are included in the Special Issue. Three second-generation androgen receptor antagonists that have been approved by the U.S. FDA for the treatment of prostate cancer have been reviewed. Identification of mimics of protein partners as protein-protein interaction inhibitors via virtual screening has been summarized and discussed. Anticancer agents targeting various protein targets, including IGF-1R, Src, protein kinase, aromatase, HDAC, PARP, Toll-Like receptor, c-Met, PI3Kdelta, topoisomerase II, p53, and indoleamine 2,3-dioxygenase, have been explored. The analogs of three well-known tubulin-interacting natural products, paclitaxel, zampanolide, and colchicine, have been designed, synthesized, and evaluated. Several anticancer agents representing diverse chemical scaffolds were assessed in different kinds of cancer cell models. The capability of some anticancer agents to overcome the resistance to currently available drugs was also studied. In addition to looking into the in vitro ability of the anticancer agents to inhibit cancer cell proliferation, apoptosis, and cell cycle, in vivo antitumor efficacy in animal models and DFT were also investigated in some papers.
Publisher: MDPI
ISBN: 3036501401
Category : Business & Economics
Languages : en
Pages : 606
Book Description
This book is a printed edition of the Special Issue entitled “Anticancer Agents: Design, Synthesis and Evaluation” that was published in Molecules. Two review articles and thirty research papers are included in the Special Issue. Three second-generation androgen receptor antagonists that have been approved by the U.S. FDA for the treatment of prostate cancer have been reviewed. Identification of mimics of protein partners as protein-protein interaction inhibitors via virtual screening has been summarized and discussed. Anticancer agents targeting various protein targets, including IGF-1R, Src, protein kinase, aromatase, HDAC, PARP, Toll-Like receptor, c-Met, PI3Kdelta, topoisomerase II, p53, and indoleamine 2,3-dioxygenase, have been explored. The analogs of three well-known tubulin-interacting natural products, paclitaxel, zampanolide, and colchicine, have been designed, synthesized, and evaluated. Several anticancer agents representing diverse chemical scaffolds were assessed in different kinds of cancer cell models. The capability of some anticancer agents to overcome the resistance to currently available drugs was also studied. In addition to looking into the in vitro ability of the anticancer agents to inhibit cancer cell proliferation, apoptosis, and cell cycle, in vivo antitumor efficacy in animal models and DFT were also investigated in some papers.
Design, Synthesis, Biological Evaluation and Molecular Modeling of Novel Taxane-based Anticancer Agents and Paclitaxel Mimics
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Design, Synthesis and Biological Evaluation of Taxane-based Anticancer Agents
Author: Qing Huang
Publisher:
ISBN:
Category : Antineoplastic agents
Languages : en
Pages : 722
Book Description
Publisher:
ISBN:
Category : Antineoplastic agents
Languages : en
Pages : 722
Book Description
The Design, Synthesis and Biological Evaluation of Novel Multiple Targeting Anti-cancer Agents
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Tumor-Targeting Taxane-Based Anti-Cancer Agents
Author: Melvin Parasram
Publisher: LAP Lambert Academic Publishing
ISBN: 9783846508046
Category :
Languages : en
Pages : 148
Book Description
Cancer is the leading cause of death of patients below the age of 85. Traditional chemotherapeutics, such as Taxol (r) and Taxotere (r) have had a significant impact in the field of chemotherapy because of their unique mechanism of action of inducing apoptosis by stabilizing microtubules during mitotic cell division. However, studies have indicated that these drugs are not active in multi-drug resistant (MDR) cancer cells. MDR arises from the overexpression of ATP-binding cassette proteins which enable the cancer cell to remove cytotoxic agents from the cell via ATP dependent efflux pumps, resulting in the loss of efficacy of the drug. In addition to the problem of MDR, traditional chemotherapeutics have little or no specificity, which leads to systemic toxicity, causing severe and harmful side effects. Therefore, it is important to develop next generation taxoids with increased potency and activity in MDR expressing cancers, as well as to incorporate these cytotoxic agents to tumor-targeting delivery systems to ensure selective cytotoxicity and reduce systemic toxicity. In general, these delivery systems include a tumor-targeting module and a cytotoxic ag
Publisher: LAP Lambert Academic Publishing
ISBN: 9783846508046
Category :
Languages : en
Pages : 148
Book Description
Cancer is the leading cause of death of patients below the age of 85. Traditional chemotherapeutics, such as Taxol (r) and Taxotere (r) have had a significant impact in the field of chemotherapy because of their unique mechanism of action of inducing apoptosis by stabilizing microtubules during mitotic cell division. However, studies have indicated that these drugs are not active in multi-drug resistant (MDR) cancer cells. MDR arises from the overexpression of ATP-binding cassette proteins which enable the cancer cell to remove cytotoxic agents from the cell via ATP dependent efflux pumps, resulting in the loss of efficacy of the drug. In addition to the problem of MDR, traditional chemotherapeutics have little or no specificity, which leads to systemic toxicity, causing severe and harmful side effects. Therefore, it is important to develop next generation taxoids with increased potency and activity in MDR expressing cancers, as well as to incorporate these cytotoxic agents to tumor-targeting delivery systems to ensure selective cytotoxicity and reduce systemic toxicity. In general, these delivery systems include a tumor-targeting module and a cytotoxic ag