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Author: Manuel Menéndez-González
Publisher: Frontiers Media SA
ISBN: 2889194000
Category : Biochemical markers
Languages : en
Pages : 123
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Book Description
The prevalence of neurodegenerative disorders is increasing dramatically and one of the major challenges today is the need of early and accurate diagnosis, the other is the need of more effective therapies -in turn the development of such therapies also requires early and accurate diagnosis-. The main hope for an earlier and more accurate diagnosis comes from the use of biomarkers. Much research is being done trying to solve the many interrogates related to the role of biomarkers in clinical practice, including the early diagnosis, differential diagnosis and follow-up of neurodegenerative disorders. This is a field where translational research is intense enough to make this topic interesting for basic researchers and clinicians. Indeed, the amount and quality of articles received in response to the call for contributions was very good. This eBook contains a good amount of high quality articles devoted to diverse techniques across several neurodegenerative disorders from different perspectives, including original reports, reviews, methods reports and opinion letters on biochemical biomarkers in biological fluids, neuroimaging techniques and multidimensional approaches linking clinical findings with biomarkers. The disorders covered are also diverse: Alzheimer’s disease, Frontotemporal Dementia, Dementia with Lewy Bodies, Huntington’s disease, Parkinson’s disease among others. As we can learn from articles in this Research Topic, biomarkers are allowing us to expand the knowledge on the biological and anatomical basis of neurodegenerative diseases and to implement diagnostic techniques in clinical practice and clinical trials.
Author: Manuel Menéndez-González
Publisher: Frontiers Media SA
ISBN: 2889194000
Category : Biochemical markers
Languages : en
Pages : 123
Get Book Here
Book Description
The prevalence of neurodegenerative disorders is increasing dramatically and one of the major challenges today is the need of early and accurate diagnosis, the other is the need of more effective therapies -in turn the development of such therapies also requires early and accurate diagnosis-. The main hope for an earlier and more accurate diagnosis comes from the use of biomarkers. Much research is being done trying to solve the many interrogates related to the role of biomarkers in clinical practice, including the early diagnosis, differential diagnosis and follow-up of neurodegenerative disorders. This is a field where translational research is intense enough to make this topic interesting for basic researchers and clinicians. Indeed, the amount and quality of articles received in response to the call for contributions was very good. This eBook contains a good amount of high quality articles devoted to diverse techniques across several neurodegenerative disorders from different perspectives, including original reports, reviews, methods reports and opinion letters on biochemical biomarkers in biological fluids, neuroimaging techniques and multidimensional approaches linking clinical findings with biomarkers. The disorders covered are also diverse: Alzheimer’s disease, Frontotemporal Dementia, Dementia with Lewy Bodies, Huntington’s disease, Parkinson’s disease among others. As we can learn from articles in this Research Topic, biomarkers are allowing us to expand the knowledge on the biological and anatomical basis of neurodegenerative diseases and to implement diagnostic techniques in clinical practice and clinical trials.
Author: Philip V. Peplow
Publisher:
ISBN: 9781071617120
Category : Biochemical markers
Languages : en
Pages : 565
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Book Description
This volume presents recent data on the latest achievements in new and emerging technologies for biomarkers and for innovations in their assessment. The chapters cover topics such as activation of microglia and macrophages in neurodegenerative diseases; oxidative stress and cellular dysfunction in neurodegenerative diseases; TSPO PET imaging as a biomarker of neuroinflammation in neurodegenerative disorders; and imaging biomarkers in Huntington's disease and amyotrophic lateral sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Neurodegenerative Diseases Biomarkers: Towards Translating Research to Clinical Practice is a valuable resource for both experimental and clinical experts in the field of neurodegenerative diseases who are looking to expand their knowledge of novel biomarkers in different types of neurodegenerative diseases.
Author: Manuel Menéndez-González
Publisher:
ISBN:
Category : Neurology
Languages : en
Pages : 122
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Book Description
The world has a rapidly ageing population. Neurodegenerative diseases (ND) are strongly linked with age, with older citizens more at risk. Therefore the prevalence of ND is increasing dramatically. The major problem with ND is its difficulty to be diagnosed early. The goal of biomarker characterization is to increase certainty that a person has or does not have underlying pathology. During last decades, many research projects where focused on research on biomarkers for ND and this research has blasted into hundreds of scientific articles. However, few studies assessed their use in real clinical practice conditions. This Frontiers Research Topic is focused in the use of biomarkers for neurodegenerative disorders in the clinical setting. Topics include the use of biomarkers in the differential diagnosis of ND, the use of biomarkers to assess the risk of conversion from preclinical conditions, the use of biomarkers to follow up of clinical conditions and studies comparing biomarkers. We challenge to publish studies not only for the more frequent and more studied ND (Alzheimer's and Parkinson's diseases), but also for other less known ND such as prion diseases, motor neurone diseases, Huntington's disease, spinocerebellar ataxia or spinal muscular atrophy among others. Biomarkers are very different in nature - from neuroimaging techniques to molecular parameters to be determined in the biochemical laboratory-. We welcome manuscripts reporting all kind of biomarkers since we wish to join and show together studies from different domains and thus give a perspective throughout the whole spectrum of research on biomarkers for ND.
Author: Philip V. Peplow
Publisher: Humana
ISBN: 9781071617144
Category : Medical
Languages : en
Pages : 0
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Book Description
This volume presents recent data on the latest achievements in new and emerging technologies for biomarkers and for innovations in their assessment. The chapters cover topics such as activation of microglia and macrophages in neurodegenerative diseases; oxidative stress and cellular dysfunction in neurodegenerative diseases; TSPO PET imaging as a biomarker of neuroinflammation in neurodegenerative disorders; and imaging biomarkers in Huntington's disease and amyotrophic lateral sclerosis. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and comprehensive, Neurodegenerative Diseases Biomarkers: Towards Translating Research to Clinical Practice is a valuable resource for both experimental and clinical experts in the field of neurodegenerative diseases who are looking to expand their knowledge of novel biomarkers in different types of neurodegenerative diseases.
Author: Orla Hardiman
Publisher: Springer
ISBN: 3319233092
Category : Medical
Languages : en
Pages : 336
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Book Description
This new edition provides an accessible guide to the commonest neurodegenerative diseases, outlining the main clinical features, treatment options and outcomes of the conditions most frequently encountered in clinical practice. Beginning with an overview of the general principles that underlie degeneration, and the contribution of established and new diagnostics techniques, the book goes on to describe the most common neurodegenerative conditions and, new for the second edition, also HIV dementia and multiple sclerosis. Final chapters cover important management issues including the use of palliative care strategies, biomarkers and neuropsychology. Written by experts in the field internationally Neurodegenerative Disorders, Second Edition is a practical guide for clinicians that will be indispensable for the management of these conditions.
Author: Charlotte E. Teunissen
Publisher: Humana
ISBN: 9781071613214
Category : Medical
Languages : en
Pages : 236
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Book Description
This volume covers the latest methods used in clinical neurochemistry laboratories for both clinical practice and research. Chapters in this book discuss topics such as techniques for cerebrospinal fluid (CSF) collection, pre-analytical processing, and basic CSF analysis; an examination of biomarkers including ELISA and automated immunochemical assays for amyloid and tau markers for Alzheimer’s disease; the analysis of neurofilaments by digital ELISA; and an example of successful novel immunoassay development. In the Neuromethods series style, chapters include the kind of detail and key advice from the specialists needed to get successful results in your laboratory. Cutting-edge and thorough, Cerebrospinal Fluid Biomarkers is a valuable resource for clinicians and researchers to use in CSF labs and CSF courses.
Author: Chaur-Jong Hu
Publisher: Frontiers Media SA
ISBN: 2889458024
Category :
Languages : en
Pages : 83
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Book Description
Biomarkers for risk detection and outcome prediction of neurodegenerative diseases become more and more important for the clinical practise and neuroscience research. This eBook presents novel findings in this field, including amyotrophic lateral sclerosis, Alzheimer's disease, Parkinson's disease, Creutzfeldt-Jakob disease and application of neuroimaging, underlying mechanism of oxidative stress. The readers can catch new information about this emerging frontier of neurology with this eBook.
Author: Kevin K. W. Wang
Publisher: CRC Press
ISBN: 1482239825
Category : Medical
Languages : en
Pages : 652
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Book Description
This book explores the recent advances in the techniques and platforms used in biomarker research that have revolutionized the way we study, diagnose, and treat brain injury conditions. The contributors describe different biomarker studies pertaining to brain injury and other neurological disorders and analyze the different models and technologies used to identify these biological markers. The book includes findings from "Omics research" that have been utilized to decipher and identify such biomarkers. It discusses protein, microRNA, and altered gene profiles and reviews neurological disorders such as multiple sclerosis, Charcot-Marie-Tooth disease, and prion and Alzheimer’s disease.
Author: Tabish Qidwai
Publisher: Bentham Science Publishers
ISBN: 9815040928
Category : Medical
Languages : en
Pages : 306
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Book Description
This reference is the definitive guide to common neurodegenerative diseases that affect humans. The book covers mechanisms of some of the most well-known neurodegenerative diseases, their biomarkers, neuropharmacology, and emerging treatment strategies. The book introduces the subject of neurodegeneration by outlining the biochemistry, pathophysiology and multifactorial neurological mechanisms (the role of genetics, environmental factors and mitochondrial damage, for example). Next, it explains some of the most studied diseases, namely, Parkinson’s Disease, Alzheimer’s Disease, Huntington’s Disease, and Multiple Sclerosis. Subsequent chapters delve into current knowledge about diagnostic and immunological biomarkers, followed by a summary of novel therapeutic strategies. Special attention has been given to the role of medicinal plants in attempting to treat neurodegenerative diseases, as well as the public health burden posed by these conditions. Key Features - give readers an overview of multifactorial disease mechanisms in neurodegeneration - covers some major neurodegenerative diseases in detail - covers diagnostic and immunological biomarkers - explores current therapeutic strategies and drug targets in common neurodegenerative diseases - offers a simple presentation with references for advanced readers The book is a suitable reference for all readers, including students, research scholars, and physicians who are interested in the mechanisms and treatment of neurodegenerative diseases.
Author: Elizabeth A. Thomas
Publisher: Springer Nature
ISBN: 3031328159
Category : Medical
Languages : en
Pages : 476
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Book Description
Huntington’s disease (HD) is a fatal, inherited, neurodegenerative disorder, characterized by chorea, motor instabilities, psychiatric manifestations and cognitive decline. Early genetic testing provides an opportunity for clinical interventions aimed at delaying onset and/or slowing progression of disease; however, current treatments for HD are limited, with only two FDA-approved drugs available to manage chorea. Encouragingly, however, several disease-modifying treatment approaches are in the therapeutic pipeline, with more than 200 clinical studies, and many more preclinical studies, in the works. Robust and reliable biomarkers are needed to predict disease onset, monitor disease progression and assess treatment responses. More specifically, biomarkers to stratify patients for clinical trials and biomarkers to track drug efficacy will certainly lead to improved clinical trial design and success. This book represents the first book focused solely on biomarkers for HD and represents a distinct resource that will be informative, not only for clinicians and those involved in clinical trial design, but also for a wide range of neurodegenerative disease researchers. This edited volume is written by top leaders in the field, and takes a cross-disciplinary approach to cover a broad spectrum of biomarker types, in order to provide the latest advances in the development of biochemical, molecular, imaging and digital biomarkers that have been investigated for HD. With the ultimate goal of treating patients, the development of disease-associated biomarkers has never been more important.
