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Author: Flavia Marinelli
Publisher: Springer Science & Business Media
ISBN: 3642399681
Category : Medical
Languages : en
Pages : 363
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Book Description
Reports on the emergence and prevalence of resistant bacterial infections in hospitals and communities raise concerns that we may soon no longer be able to rely on antibiotics as a way to control infectious diseases. Effective medical care would require the constant introduction of novel antibiotics to keep up in the “arms race” with resistant pathogens. This book closely examines the latest developments in the field of antibacterial research and development. It starts with an overview of the growing prevalence of resistant Gram-positive and Gram-negative pathogens, including their various resistance mechanisms, prevalence, risk factors and therapeutic options. The focus then shifts to a comprehensive description of all major chemical classes with antibacterial properties, their chemistry, mode of action, and the generation of analogs; information that provides the basis for the design of improved molecules to defeat microbial infections and combat the emerging resistances. In closing, recently developed compounds already in clinical use, those in preclinical or first clinical studies, and a number of promising targets to be exploited in the discovery stage are discussed.
Author: Flavia Marinelli
Publisher: Springer Science & Business Media
ISBN: 3642399681
Category : Medical
Languages : en
Pages : 363
Get Book Here
Book Description
Reports on the emergence and prevalence of resistant bacterial infections in hospitals and communities raise concerns that we may soon no longer be able to rely on antibiotics as a way to control infectious diseases. Effective medical care would require the constant introduction of novel antibiotics to keep up in the “arms race” with resistant pathogens. This book closely examines the latest developments in the field of antibacterial research and development. It starts with an overview of the growing prevalence of resistant Gram-positive and Gram-negative pathogens, including their various resistance mechanisms, prevalence, risk factors and therapeutic options. The focus then shifts to a comprehensive description of all major chemical classes with antibacterial properties, their chemistry, mode of action, and the generation of analogs; information that provides the basis for the design of improved molecules to defeat microbial infections and combat the emerging resistances. In closing, recently developed compounds already in clinical use, those in preclinical or first clinical studies, and a number of promising targets to be exploited in the discovery stage are discussed.
Author: Wu-Kuang Yeh
Publisher: John Wiley & Sons
ISBN: 0470627298
Category : Science
Languages : en
Pages : 388
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Book Description
An authoritative review of the latest developments in the chemical biology of enzymes In the first decade of the twenty-first century, enzymes and their multiple applications have played a critical role in the discovery and development of many new therapeutic agents.This book is a coordinated compilation of research expertise and current opinion uniquely focused on enzymes and their properties and applications. Compiled by editors with a combined pharmaceutical experience of over sixty years, the text provides in-depth reviews of recent developments in selective topics on biosynthesis, biocatalysis, and chemical biology of enzymes as it applies to drug discovery, development, and manufacture. The first in a multi-part series on enzymes, this volume features three sections: New Approaches to Find and Modify Enzymes describes the emerging field of metagenomics, presents the practical applications of directed evolution to enzymes and pathways, and explores approaches for the discovery and design of biocatalysts Biocatalytic Applications reviews specific applications of different reactions in producing active pharmaceutical ingredients and surveys recent developments employing enzymes in organic synthesis Biosynthetic Applications goes over successful drug discoveries and developments by combinatorial biosynthesis and reviews the application of combinatorial biosynthesis among multiple compatible hosts These timely discussions, which cover everything from chemical biology of enzymes, to the redesign of binding and catalytic specificities of enzymes, make this volume a valuable tool for keeping up to date. As such, it is an important read for researchers, students, and professors in the study of biotechnology, life sciences, biochemistry, enzymology, medicinal chemistry, and natural products.
Author: Egil Sakshaug
Publisher: Tapir Academic Press
ISBN: 9788251924610
Category : Nature
Languages : en
Pages : 596
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Book Description
This book describes the marine ecosystem of the Barents Sea, located north of Norway and Russia as part of the Arctic Ocean. Basic knowledge is presented about components of the ecosystem from virus and bacteria via plankton and fish to seabirds through to marine mammals and their interactions with the physical environment. Ecosystem dynamics are given a prominent role in the book. Mathematical models of the plankton and important fish stocks are employed to help elucidate the interplay between populations and trophic levels. The situation regarding contaminants is reviewed, as is the newly established Norwegian plan for the management of the Barents Sea. The impact of global warming is also discussed. Ecosystem Barents Sea is written for all those with an interest in marine ecology in the arctic seas, including research institutes, governmental ecosystem management units, and natural resources organizations.
Author: British Library. Document Supply Centre
Publisher:
ISBN:
Category : Conference proceedings
Languages : en
Pages : 890
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Book Description
Author: Jørgen Berge
Publisher: Springer Nature
ISBN: 303033208X
Category : Science
Languages : en
Pages : 380
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Book Description
Until recently, the prevailing view of marine life at high latitudes has been that organisms enter a general resting state during the dark Polar Night and that the system only awakens with the return of the sun. Recent research, however, with coordinated, multidisciplinary field campaigns based on the high Arctic Archipelago of Svalbard, have provided a radical new perspective. Instead of a system in dormancy, a new perspective of a system in full operation and with high levels of activity across all major phyla is emerging. Examples of such activities and processes include: Active marine organisms at sea surface, water column and the sea-floor. At surface we find active foraging in seabirds and fish, in the water column we find a high biodiversity and activity of zooplankton and larvae such as active light induced synchronized diurnal vertical migration, and at seafloor there is a high biodiversity in benthic animals and macroalgae. The Polar Night is a period for reproduction in many benthic and pelagic taxa, mass occurrence of ghost shrimps (Caprellides), high abundance of Ctenophores, physiological evidence of micro- and macroalgal cells that are ready to utilize the first rays of light when they appear, deep water fishes found at water surface in the Polar night, and continuous growth of bivalves throughout the winter. These findings not only begin to shape a new paradigm for marine winter ecology in the high Arctic, but also provide conclusive evidence for a top-down controlled system in which primary production levels are close to zero. In an era of environmental change that is accelerated at high latitudes, we believe that this new insight is likely to strongly impact how the scientific community views the high latitude marine ecosystem. Despite the overwhelming darkness, the main environmental variable affecting marine organisms in the Polar Night is in fact light. The light regime during the Polar Night is unique with respect to light intensity, spectral composition of light and photoperiod.
Author: David Nichols
Publisher:
ISBN:
Category : Science
Languages : en
Pages : 232
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Book Description
Author: Stephanie J. Dancer
Publisher: Anchor Books
ISBN: 9781904392835
Category : Medical
Languages : en
Pages : 0
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Book Description
With challenging infectious diseases facing all doctors, this latest case study guide will prove to be an invaluable resource. Fifty clinical cases are authored by leading experts in the field. The book covers special patient groups, discussing- amongst others- community acquired infection, the immunocompromised patient and those in critical care. Each clinical case includes learning points, provide background information and discuss recent developments for each area. The best strategies for management are presented for each case creating a rich resource of essential information for all physic.
Author: W. Schönfeld
Publisher: Springer Science & Business Media
ISBN: 9783764361860
Category : Medical
Languages : en
Pages : 344
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Book Description
There are only very few chemical classes of antibiotics in medical use, and these have originated over a span of more than 60 years of research. Almost half a century ago, the first member of the macrolides, erythromycin, was introduced as a treatment option for bacterial infections. Erythromycin is a very complex fermentation product obtained from the soil bacterium Saccharopolyspora ery thraea (originally named Streptomyces erythreus). The success of erythromycin, based on its efficacy and tolerability, stimulated researchers throughout the world to undertake intense efforts to understand the biology and chemistry of macrolides and to use this experience to improve the properties of this compound class. The second generation of macrolides, based on chemical modifications of erythromy cin, is currently being in broad use, especially for treatment of respiratory tract infections. We presently foresee the introduction of a new generation of macro lides, i. e. the ketolides, which have the potential to overcome rising resistance problems. This monograph is intended to give the interested reader an overview on "macrolide experience", covering important areas from basic research to clinical use. Starting from a historic overview, the essential basic parameters - efficacy, pharmacokinetics, pharmacodynamics, and pharmacology - are highlighted in order to introduce the reader to the rationale for clinical use of macrolides. The following group of chapters cover the complex chemistry of the macro lactone structures, giving historic background, basic structure-activity relation ships of various derivatization strategies, and perspectives for future discovery of new semisynthetic macrolide antibiotics.
Author: Nicholas Searle
Publisher: HarperCollins
ISBN: 1443444626
Category : Fiction
Languages : en
Pages : 241
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Book Description
Spinning a page-turning story of literary suspense that begins in the present and unwinds over almost a century, this unforgettable debut channels the haunting allure of Atonement as its masterfully woven web of lies, secrets, and betrayals unravels to a shocking conclusion Veteran con artist Roy spots an obvious easy mark when he meets Betty, a wealthy widow, online. In no time at all, he’s moved into Betty’s lovely cottage and is preparing to accompany her on a romantic trip to Europe. Betty’s grandson disapproves of their blossoming relationship, but Roy is sure this scheme will be a success. He knows what he’s doing. As this remarkable feat of storytelling weaves together Roy’s and Betty’s futures, it also unwinds their pasts. Dancing across almost a century, decades that encompass unthinkable cruelty, extraordinary resilience, and remarkable kindness, The Good Liar is an epic narrative of sin, salvation, and survival—and for Roy and Betty, there is a reckoning to be made when the endgame of Roy’s crooked plot plays out.
Author: Derek J. Chadwick
Publisher: John Wiley & Sons
ISBN: 0470514353
Category : Science
Languages : en
Pages : 328
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Book Description
A comprehensive review of current thinking on the biosynthesis, function and evolution of secondary metabolites in animals, plants and microorganisms. Examines the traditional context of secondary metabolites as natural products having no obvious part to play in the producing organism's life cycle. Covers issues related to genetic and antibiotic applications.
