Physiologic and Pathologic Angiogenesis PDF Download
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Author: Dan Simionescu
Publisher: BoD – Books on Demand
ISBN: 9535130234
Category : Medical
Languages : en
Pages : 466
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Book Description
The purpose of this book is to highlight novel advances in the field and to incentivize scientists from a variety of fields to pursue angiogenesis as a research avenue. Blood vessel formation and maturation to capillaries, arteries, or veins is a fascinating area which can appeal to multiple scientists, students, and professors alike. Angiogenesis is relevant to medicine, engineering, pharmacology, and pathology and to the many patients suffering from blood vessel diseases and cancer, among others. We are hoping that this book will become a source of inspiration and novel ideas for all.
Author: Dan Simionescu
Publisher: BoD – Books on Demand
ISBN: 9535130234
Category : Medical
Languages : en
Pages : 466
Get Book Here
Book Description
The purpose of this book is to highlight novel advances in the field and to incentivize scientists from a variety of fields to pursue angiogenesis as a research avenue. Blood vessel formation and maturation to capillaries, arteries, or veins is a fascinating area which can appeal to multiple scientists, students, and professors alike. Angiogenesis is relevant to medicine, engineering, pharmacology, and pathology and to the many patients suffering from blood vessel diseases and cancer, among others. We are hoping that this book will become a source of inspiration and novel ideas for all.
Author: Derek J. Chadwick
Publisher: John Wiley & Sons
ISBN: 0470319429
Category : Science
Languages : en
Pages : 260
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Book Description
The formation of blood vessels is an essential aspect of embryogenesis in vertebrates. It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour formation and certain inflammatory conditions. In recent years, comprehension of the molecular genetics of blood vessel formation has progressed enormously and studies in vertebrate model systems, especially the mouse and the zebrafish, have identified a common set of molecules and processes that are conserved throughout vertebrate embryogenesis while, in addition, highlighting aspects that may differ between different animal groups. The discovery in the past decade of the crucial role of new blood vessel formation for the development of cancers has generated great interest in angiogenesis (the formation of new blood vessels from pre-existing ones), with its major implications for potential cancer-control strategies. In addition, there are numerous situations where therapeutic treatments either require or would be assisted by vasculogenesis (the de novo formation of blood vessels). In particular, post-stroke therapies could include treatments that stimulate neovascularization of the affected tissues. The development of such treatments, however, requires thoroughly understanding the developmental properties of endothelial cells and the basic biology of blood vessel formation. While there are many books on angiogenesis, this unique book focuses on exactly this basic biology and explores blood vessel formation in connection with tissue development in a range of animal models. It includes detailed discussions of relevant cell biology, genetics and embryogenesis of blood vessel formation and presents insights into the cross-talk between developing blood vessels and other tissues. With contributions from vascular biologists, cell biologists and developmental biologists, a comprehensive and highly interdisciplinary volume is the outcome.
Author: Lorna Fiedler
Publisher: Humana Press
ISBN: 9781493943708
Category : Science
Languages : en
Pages : 225
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Book Description
This volume provides a collection of protocols for studying and manipulating VEGF signaling pathways in vitro and in vivo, and in particular, aims to present a range of both firmly established and newly emerging technologies, including those that are amenable to aiding in drug discovery or pre-clinical investigations. Each of the three sections begins with an introductory overview followed by supporting relevant methods. A major advantage of this book is that each chapter not only contains methodological detail rarely seen in other literature, but also contains a section on key notes and troubleshooting advice. Part I focuses on quantification of specific VEGF and VEGF receptor isoforms, beginning with a summary on VEGF splice variants, their function and their regulation. Part II relates to the study of VEGF dependent signaling in vitro, starting with a comprehensive overview of VEGF-mediated signal transduction in the cardiovascular system that highlights recent discoveries in the field. Part III first details genetic mouse models, then discusses techniques for studying physiological angiogenesis in the developing mouse embryo. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and thorough, VEFG Signaling: Methods and Protocols is a useful tool for researching and understanding the basic biology of VEGF signaling and translating it into the clinic.
Author: Tom T. Chen
Publisher:
ISBN:
Category :
Languages : en
Pages : 524
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Book Description
Author: Christiana Ruhrberg
Publisher: Springer Science & Business Media
ISBN: 0387786325
Category : Science
Languages : en
Pages : 116
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Book Description
This book covers vascular endothelial growth factor A (VEGF or VEGFA), a secreted signaling protein. It highlights the central importance of this growth factor for vertebrate development.
Author: Marcellus L. Parker
Publisher:
ISBN: 9781626186569
Category : Medical
Languages : en
Pages : 239
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Book Description
Vascular endothelial growth factor (VEGF) is one of the most potent and specific angiogenic factors. The physiologic roles of VEGF in humans include neovascularization and endometrium implantation, and in pathological processes VEGF has been involved in the initation, growth, and metastasis of tumors. In this book, the authors discuss the biology, regulation and clinical significance of VEGF. Topics include VEGF signaling and multi-drug resistance transporter (ABCB1); clinical imaging of tumor vascularity as a biomarker during anti-VEGF therapy; VEGF and kidney cancer; the effect of VEGF on oocyte maturation and embryo development of bovine and ovine in vitro and its mechanisms; physiological functions of VEGF in the retina; VEGF in the regulation of gingival venule diameter under physiological and pathological circumstances; regulation of VEGF expression by progesterone and estradiol in normal and cancer cells; ethanol stimulated angiogenesis via VEGF and protection from ischemia and reperfusion injury; and the role of VEGF in major depression.
Author: Ziquan Cao
Publisher: Linköping University Electronic Press
ISBN: 9175190796
Category : Diseases
Languages : en
Pages : 135
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Book Description
Angiogenesis is essential for physiological processes including embryonic development, tissue regeneration, and reproduction. Under various pathological conditions the same angiogenic process contribute to the onset, development, and progression of many human diseases including cancer, diabetic complications, ocular disease, chronic inflammation and cardiovascular disease. Vascular endothelial growth factor (VEGF) is a key angiogenic factor for physiological and pathological angiogenesis. In addition to its strong angiogenic activity, VEGF also potently induces vascular permeability, often causing tissue edema in various pathological tissues. VEGF transduces its vascular signal through two tyrosine kinase receptors-VEGFR1 and VEGFR2, the latter being a functional receptor that mediates both angiogenic and vascular permeability effects. To study physiological and pathological functions of VEGF, we developed novel zebrafish disease models that permit us to study hypoxia-induced retinopathy and cancer metastasis processes. We have also administered anti-VEGF and anti-VEGFR specific antibodies to healthy mice to study the homeostatic role of VEGF in the maintenance of vascular integrity and its functions in various tissues and organs. Finally, using a zebrafish model, we evaluated if VEGF expression is regulated by circadian clock genes. In paper I, we developed protocols that create hypoxia-induced retinopathy in adult zebrafish. Adult fli1:EGFP zebrafish were placed in hypoxic water for 3-10 days with retinal neovascularization being analyzed using confocal microscopy. This model provides a unique opportunity to kinetically study the development of retinopathy in adult animals using non-invasive protocols and to assess the therapeutic efficacy of orally administered anti-angiogenic drugs. In paper II, we developed a zebrafish metastasis model to dissect the complex events of hypoxia-induced tumor cell invasion and metastasis in association with angiogenesis at the single-cell level. In this model, fluorescent DiI-labeled human or mouse tumor cells were implanted into the perivitelline cavity of 48-hour-old zebrafish embryos, which were subsequently placed in hypoxic water for 3 days. Tumor cell invasion, metastasis and pathological angiogenesis were analyzed using fluorescent microscopy in the living fish. The average experimental time for this model is 7 days. Our protocol offers an opportunity to study molecular mechanisms of hypoxia-induced cancer metastasis. In paper III, we show that systemic delivery of an anti-VEGF or an anti-VEGF receptor (VEGFR)-2 neutralizing antibody cause global vascular regression in mice. Among all examined tissues, the vasculature in endocrine glands, intestinal villi, and the uterus are most affected in response to VEGF or VEGFR-2 blockades. Pro-longed anti-VEGF treatment resulted in a significant decrease in the circulating levels of the predominant thyroid hormone, free thyroxine, but not the minimal isoform of triiodothyronine, suggesting that chronic anti-VEGF treatment impairs thyroid function. These findings provide structural and functional bases of anti-VEGF-specific druginduced side effects in relation to vascular changes in healthy tissues. In paper IV, we show that disruption of the circadian clock by constant exposure to light coupled with genetic manipulation of key genes in the zebrafish led to impaired developmental angiogenesis. A bmal1-specific morpholino inhibited developmental angiogenesis in zebrafish embryos without causing obvious nonvascular phenotypes. Conversely, a period2 morpholino accelerated angiogenic vessel growth, suggesting that Bmal1 and Period2 display opposing angiogenic effects. These results offer mechanistic insights into the role of the circadian clock in regulation of developmental angiogenesis, and our findings may be reasonably extended to other types of physiological or pathological angiogenesis. Overall, the results in this thesis provide further insight to angiogenic mechanistic properties in tissues and suggest possible novel therapeutic targets for the treatment of various angiogenesis-dependent diseases.
Author: Marcellus L. Parker
Publisher: Nova Science Publishers
ISBN: 9781626186552
Category : Medical
Languages : en
Pages : 0
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Book Description
Vascular endothelial growth factor (VEGF) is one of the most potent and specific angiogenic factors. The physiologic roles of VEGF in humans include neovascularisation and endometrium implantation, and in pathological processes VEGF has been involved in the initiation, growth, and metastasis of tumors. In this book, the authors discuss the biology, regulation and clinical significance of VEGF. Topics include VEGF signalling and multi-drug resistance transporter (ABCB1); clinical imaging of tumour vascularity as a biomarker during anti-VEGF therapy; VEGF and kidney cancer; the effect of VEGF on oocyte maturation and embryo development of bovine and ovine in vitro and its mechanisms; physiological functions of VEGF in the retina; VEGF in the regulation of gingival venule diameter under physiological and pathological circumstances; regulation of VEGF expression by progesterone and estradiol in normal and cancer cells; ethanol stimulated angiogenesis via VEGF and protection from ischemia and reperfusion injury; and the role of VEGF in major depression.
Author: Gera Neufeld
Publisher: Springer
ISBN: 3319488244
Category : Medical
Languages : en
Pages : 236
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Book Description
This book covers basic research topics such as the structure-function relationships of neuropilins and mechanisms of neuropilin-mediated signal transduction, details the most important roles of the neuropilins in developmental biology, and addresses their roles in various conditions such as cancer and various eye diseases. The two neuropilin genes encode scaffold receptors that can bind several different ligands, and also associate with many other receptors and modify their activity. Further, it has been confirmed that they play important roles in the shaping of major organs and tissues such as the nervous system and the vascular system, and that they can modulate immune responses. The book offers a helpful guide for biomedical researchers and all scientists active in the neurosciences, vascular and molecular biology, as well as developmental biology and immunology.
Author: Yuping Wang
Publisher: Biota Publishing
ISBN: 1615047514
Category : Medical
Languages : en
Pages : 126
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Book Description
The placenta is an organ that connects the developing fetus to the uterine wall, thereby allowing nutrient uptake, waste elimination, and gas exchange via the mother's blood supply. Proper vascular development in the placenta is fundamental to ensuring a healthy fetus and successful pregnancy. This book provides an up-to-date summary and synthesis of knowledge regarding placental vascular biology and discusses the relevance of this vascular bed to the functions of the human placenta.
