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Author: Mario Stefanini
Publisher: Springer Science & Business Media
ISBN: 3662036711
Category : Medical
Languages : en
Pages : 356
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Book Description
This volume contains the text of the plenary lectures given by internationally recognized experts in the field of gametogenesis and endocrinology at the 10th European Workshop on Molecular and Cellular Endocrinology of the Testis. Topics include spermatogonial transplantation, germ stem cell biology, regulation of meiosis and spermiogenesis, growth factors, cell signaling and transduction, steriodogenesis, androgen-regulated genes, sperm activation and sperm factors active at fertilization. The present volume pays particular attention to the use of genetically manipulated animal models in the study of the regulation of spermatogenesis and testicular functions.
Author: Mario Stefanini
Publisher: Springer Science & Business Media
ISBN: 3662036711
Category : Medical
Languages : en
Pages : 356
Get Book Here
Book Description
This volume contains the text of the plenary lectures given by internationally recognized experts in the field of gametogenesis and endocrinology at the 10th European Workshop on Molecular and Cellular Endocrinology of the Testis. Topics include spermatogonial transplantation, germ stem cell biology, regulation of meiosis and spermiogenesis, growth factors, cell signaling and transduction, steriodogenesis, androgen-regulated genes, sperm activation and sperm factors active at fertilization. The present volume pays particular attention to the use of genetically manipulated animal models in the study of the regulation of spermatogenesis and testicular functions.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Testicular cancer (TC) is the most common cancer in males aged 20-40 years, with a worldwide incidence of 7.5 per 100,000, but the rates vary considerably between countries and ethnic groups and there is evidence also for an increasing incidence in last decades. About 95% of all TCs are represented by testicular germ cell tumors (TGCTs), which include seminoma and non-seminoma histological types. It is generally assumed that the development of TGCT is under endocrine control. In particular, unbalanced androgen/estrogen levels and/or activity are believed to represent the key events for TGCT development and progression. Furthermore, recent evidence has suggested genetic association of TGCT with variations in genes involved in hypothalamic-pituitary-testicular axis and steroidogenic enzymes. This recent evidence expands the current knowledge on the role of genetic contribution in testicular cancer susceptibility, and supports the hypothesis that variations in hormone metabolism genes might change the hormonal environment implicated in testicular carcinogenesis. Therefore, hormonal carcinogenesis is an important and controversial area of current research in TGCT, and further attention is given to genetic factors influencing hormone-related cancer risk. The genetic component to TGCT is in general strong. In fact, although environmental factors clearly contribute to TGCT development (and probably to its increasing incidence in some geographical areas), the proportion of TGCT susceptibility accounted for by the genetic effects is estimated at 25%. TGCT has high familial risks compared with most other cancer types that are generally no more than two-fold: brothers of individuals with TGCT have an 8- to 12-fold increased risk of disease, and sons of affected individuals have a 4- to 6-fold increased risk. Despite this strong familial relative risk, early results from linkage studies identified a limited relationship with genetic factors, suggesting that TGCT is a genetically complex trait. However, more recently, four genome-wide association studies (GWAS) from the UK and USA have reported association of TGCTs with six new loci (KITLG, SPRY4, BAK1, DMRT1, TERT, and ATF7IP). The strongest association for TGCT susceptibility was found for SNPs in KITLG (ligand for the membrane-bound receptor tyrosine kinase KIT) gene with a greater than 2.5-fold increased risk of disease per major allele, which is the highest reported for any cancer to date. These studies are being now replicated by other researches and attention is given to the relationship between these genetic variations, TGCT risk and frequently associated anomalies of the reproductive tract, such as cryptorchidism and infertility. Finally, over the past few decades, TCGT research has focused also on external environmental causes acting mainly as endocrine disrupters of androgen and oestrogen pathways, even during the foetal development of the testis. It is well known that the testicular dysgenesis syndrome (TDS) hypothesis, proposed ten years ago, suggests that disturbed testicular development in fetal life may result in one or more of four disorders postnatally, named cryptorchidism, hypospadias, poor semen quality, and TGCT. These four disorders are therefore considered as one clinical entity and are linked together by epidemiological and pathophysiological relations. The relative contribution of genetics and environment in TGCT development, and the interactions between endocrine disruptors and variations in genes involved in hormonal carcinogenesis is therefore another interesting area of research.
Author: National Research Council (U.S.). Subcommittee on Reproductive and Neurodevelopmental Toxicology
Publisher: Routledge
ISBN:
Category : Medical
Languages : en
Pages : 424
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Book Description
Author: Rama S. Singh
Publisher: Oxford University Press
ISBN: 0199642273
Category : Science
Languages : en
Pages : 309
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Book Description
A range of theories on the rates of evolution-from static to gradual to punctuated to quantum-have been developed, mostly by comparing morphological changes over geological timescales as described in the fossil record.
Author: Henry G. Burger
Publisher: Raven Press (ID)
ISBN:
Category : Testicular Diseases
Languages : en
Pages : 616
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Book Description
Author: F.F.G. Rommerts
Publisher: Springer Science & Business Media
ISBN: 3662050668
Category : Medical
Languages : en
Pages : 200
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Book Description
During the past two decades research on the testis has created a vast number of publications. New techniques, such as cell and gene clon ing, germ cell manipulation and transplantation, as well as gene ex pression, have surpassed the classical approaches that involved studies on receptor activation and endocrine, paracrine and autocrine regula tory mechanisms. Due to the expansion of this field of research it has become increasingly difficult to integrate the large number of observa tions and relate them to the physiology and pathophysiology of the tes tis. More emphasis must, therefore, be put on the integration of isolated findings and the construction of the total picture. In order to stimulate this specific mental activity we have named this book Testicular Tan gram. We hope that the chapters in this book will be used as pieces of the testicular puzzle and that the reader enjoys composing new shapes. The chapters of this book are representative of the plenary lectures presented at the I ih European Workshop on Molecular and Cellular Endocrinology of the Testis held in Doorwerth The Netherlands, from April 6 - I 0, 2002. Publication of this book has been made possible by the generous support of the Ernst Schering Research Foundation. We would also like to thank the distinguished scientists, who have pro vided us with their excellent manuscripts well before the start of the Workshop. We acknowledge the help of Dr. U. -F. Habenicht, Dr. M.
Author: Sijo J. Parekattil
Publisher: Springer Nature
ISBN: 3030323005
Category : Health & Fitness
Languages : en
Pages : 895
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Book Description
A groundbreaking contribution to the literature now in its revised and expanded second edition, this textbook offers a comprehensive review of diagnostic and treatment techniques for male infertility. This state-of-the-art, evidence-based textbook incorporates new multidisciplinary and complementary medicine approaches to create a first-of-its-kind guide to treatment strategies for male infertility and beyond. While this new edition is primarily designed as a reference for students and residents in reproductive medicine and andrology, it will be equally useful as well for professionals in urology, reproductive endocrinology, embryology, and research fields who are interested in the role that antioxidants play in male infertility. World-renowned experts in these areas have been selected to participate in this work. Careful selection of the highest quality content will span the whole range of topics in the area of male infertility, providing a complete review of well-established and current diagnostic and treatment techniques for male infertility. The incorporation of 20 new chapters will enhance the book’s appeal by including the most recent advances brought to the male infertility arena. Additionally, this edition incorporates new features, including bulleted key points, review criteria and select video clips demonstrating some of the most fascinating male infertility treatment modalities. A dedicated new section on current guidelines on male infertility will enlighten readers on how to most optimally manage male infertility clinical scenarios. Covering all aspects of diagnosis and management, ART, lifestyle factors and associated conditions for male infertility, Male Infertility: Contemporary Clinical Approaches, Andrology, ART and Antioxidants will be a readily accessible, high quality reference for medical students and residents, and will be of significant value to professionals working in the various fields treating this condition as well.
Author: B. Jegou
Publisher: Springer Science & Business Media
ISBN: 3662040506
Category : Medical
Languages : en
Pages : 296
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Book Description
A number of chapters present the most novel research on testicular and epididymal functions or on more general fields of hormone action and molecular cell biology as it is now a tradition. However, exceptionally, the book also contains several chapters dealing with the "Approaches and Tools in the Third Millenium". The unusual inclusion of technologies as such in the 2000 edition of the workshop was an absolute necessity, as these technologies are revolutionizing the fields of biology and medicine and, in many instances, how to do research. This volume gives the scientific community essential information about the very latest technical developments and their potential for future progress.
Author: Robert E. Sobol
Publisher: Springer Science & Business Media
ISBN: 3662035774
Category : Medical
Languages : en
Pages : 250
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Book Description
This book is a collection of preclinical and clinical reports on the application of gene therapy to human disease. The two methods available for delivering therapeutic genes to diseased cells, viral and non-viral vector systems, are detailed and characterized. Several reports describe both approaches currently used in gene therapy: the introduction of a wild-type gene to restore normal gene function in diseased cells, and the use of antisense molecules to hinder abnormal gene expression. Clinical studies detail several different strategies for the treatment of cancer and cardiovascular diseases, using genetic material as therapeutic agents. The regulatory issues governing the use of gene therapy in Europe and the United States are also presented. This book highlights the range of applications and demonstrates the rapid progress being made in the field of gene therapy.
Author: Lars Björndahl
Publisher: CRC Press
ISBN: 184184747X
Category : Medical
Languages : en
Pages : 445
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Book Description
A major new international reference work on andrology from the EAU Section of Andrological Urology covering such issues as male infertility, erectile dysfunction, late-onset hypogonadism, and reproductive cancers that engages with contemporary concern for evidence based practice, minimizing interventions, and promoting male reproductive heal
