OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 476: In Vitro Mammalian Cell Gene Mutation Tests using the Hprt and xprt genes PDF Download
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Author: OECD
Publisher: OECD Publishing
ISBN: 9264264809
Category :
Languages : en
Pages : 18
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Book Description
The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In this test, the used genetic endpoints measure mutation at hypoxanthine-guanine phosphoribosyl transferase (HPRT), and at a transgene of xanthineguanine phosphoribosyl transferase...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264264809
Category :
Languages : en
Pages : 18
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Book Description
The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In this test, the used genetic endpoints measure mutation at hypoxanthine-guanine phosphoribosyl transferase (HPRT), and at a transgene of xanthineguanine phosphoribosyl transferase...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264071326
Category :
Languages : en
Pages : 10
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Book Description
The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In the cell lines the most commonly-used genetic endpoints measure mutation at thymidine kinase (TK) and hypoxanthine-guanine ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264243089
Category :
Languages : en
Pages : 18
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Book Description
The in vitro mammalian cell gene mutation test can be used to detect gene mutations induced by chemical substances. In this test, the used genetic endpoints measure mutation at hypoxanthine-guanine phosphoribosyl transferase (HPRT), and at a transgene of xanthineguanine phosphoribosyl ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264274766
Category :
Languages : en
Pages : 60
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Book Description
Following a general update of the Genetic Toxicology TGs in 2015, the present Document was written to provide succinct and useful information to individuals unfamiliar with genetic toxicology testing, as well as experienced individuals wishing to obtain an overview of the recent changes that ...
Author: Wanda M. Haschek
Publisher: Academic Press
ISBN: 0128218290
Category : Medical
Languages : en
Pages : 1154
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Book Description
Haschek and Rousseaux's Handbook of Toxicologic Pathology, recognized by many as the most authoritative single source of information in the field of toxicologic pathology, has been extensively updated to continue its comprehensive and timely coverage. The fourth edition has been expanded to four separate volumes due to an explosion of information in this field requiring new and updated chapters. Completely revised with a number of new chapters, Volume 1, "Principles and the Practice of Toxicologic Pathology," covers the practice of toxicologic pathology in three parts: Principles of Toxicologic Pathology, Methods in Toxicologic Pathology, and the Practice of Toxicologic Pathology. Other volumes in this work round out the depth and breadth of coverage.Volume 2 encompasses "Toxicologic Pathology in Safety Assessment" and "Environmental Toxicologic Pathology". These two sections cover the application of toxicologic pathology in developing specific product classes, principles of data interpretation for safety assessment, and toxicologic pathology of major classes of environmental toxicants. Volumes 3 and 4 provide deep and broad treatment of "Target Organ Toxicity", emphasizing the comparative and correlative aspects of normal biology and toxicant-induced dysfunction, principal methods for toxicologic pathology evaluation, and major mechanisms of toxicity. These volumes comprise the most authoritative reference on toxicologic pathology for pathologists, toxicologists, research scientists, and regulators studying and making decisions on drugs, biologics, medical devices, and other chemicals, including agrochemicals and environmental contaminants. Each volume is being published separately. - Provides new chapters on digital pathology, juvenile pathology, in vitro/in vivo correlation, big data technologies and in-depth discussion of timely topics in the area of toxicologic pathology - Offers high-quality and trusted content in a multi-contributed work written by leading international authorities in all areas of toxicologic pathology - Features hundreds of full-color images in both the print and electronic versions of the book to highlight difficult concepts with clear illustrations
Author: World Health Organization
Publisher: World Health Organization
ISBN: 9240098887
Category : Medical
Languages : en
Pages : 302
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Book Description
The Ninety-seventh meeting of the Joint FAO/WHO Executive Committee on Food Additives (JECFA) was held in Rome from 31 October to 9 November 2023. The purpose of the meeting was to evaluate the safety of certain food additives and flavourings. The Committee evaluated the safety of the food additive titanium dioxide and the safety and dietary exposure to three groups of flavouring agents (aliphatic primary alcohols, aldehydes, carboxylic acids, acetals and esters containing additional oxygenated functional groups; linear and branched-chain aliphatic, unsaturated and unconjugated alcohols, aldehydes, acids and related esters; and saturated aliphatic acyclic linear primary alcohols, aldehydes and acids). These monographs summarize the data on specific food additives reviewed by the Committee.
Author: Saravana Babu Chidambaram
Publisher: Springer Nature
ISBN: 9811660921
Category : Medical
Languages : en
Pages : 205
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Book Description
This book focuses on the principles, methods, and interpretation involved in establishing the safety, risk, and hazard assessment of small molecules. It presents the regulatory requirements for risk and hazard identification as per the guidelines of the Organization for Economic Cooperation and Development (OECD), Paris, and the International Council for Harmonisation (ICH) of Technical Requirements for Pharmaceuticals for Human Use ICH and Schedule ‘Y’, India. It serves as reference material for undergraduate and postgraduate pharmacy degree students as well as senior researchers to learn about the principles, methods, and interpretations of systemic dosage (acute and repeated dose) and genotoxicity (in vitro and in vivo), special toxicological investigations such as reproductive and developmental toxicology, carcinogenicity, and toxicokinetics using animal models or in vitro methods, as applicable. This book is the first of its kind in providing information on the principles and methods of implementation of Good Laboratory Practice based on the guidelines of OECD. It includes detailed chapters about the regulatory requirements and guidelines in pharmaceutical products and agrochemicals. It also describes the infrastructure needed for preclinical studies, including in vivo and in vitro facilities.
Author: Laura Robinson
Publisher: John Wiley & Sons
ISBN: 1118881907
Category : Science
Languages : en
Pages : 401
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Book Description
Toxicology – the study of the adverse effects of chemicals on living organisms is the cornerstone to all aspects of chemical safety and knowledge of the subject is needed in a wide spectrum of fields from the chemical industry to medicine, emergency services, forensics, and regulatory science. Toxicology involves the study of symptoms, mechanisms, treatments and detection of poisoning ... especially the poisoning of people. The many problems arising from a poor understanding of toxicology and its applications in hazard communication and chemical safety motivated the author's training courses and webinars, leading to this valuable book. Providing a practical and accessible guide, A Practical Guide to Toxicology and Human Health Risk Assessment enables readers to quickly build up knowledge and understanding of toxicology and its use in hazard identification, which is a fundamental part of chemical risk assessment. The book also covers current toxicological testing strategies and the use of physicochemical test data in hazard identification and exposure assessment. Examples are provided throughout the book to highlight important issues along with a summary of the key points that have been covered in each of the respective chapters. The book concludes with a listing of online resources on toxicology and risk assessment.
Author: Nishikant A. Raut
Publisher: Elsevier
ISBN: 0323910394
Category : Technology & Engineering
Languages : en
Pages : 356
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Book Description
360 Degree Waste Management, Volume Two: Biomedical, Pharmaceutical, and Industrial Waste and Remediation presents an interdisciplinary approach to understanding various types of biomedical, pharmaceutical, and industrial waste, including their origin, management, recycling, disposal, effects on ecosystems, and social and economic impacts. By applying the concepts of sustainable, affordable and integrated approaches for the improvement of waste management, the book confronts social, economic and environmental challenges. Thus, researchers, waste managers and environmental engineers will find critical information to identify long-term answers to problems of waste management that require complex understanding and analysis.Presenting key concepts in the management of biomedical and industrial waste, Volume Two of this two volume series includes aspects on microbiology of waste management, advanced treatment processes, environmental impacts, technological developments, economics of waste management and future implications. - Provides a critical assessment of economic, social and environmental challenges due to solid wastes, highlighting sustainable management approach - Describes various factors to be considered while developing waste management strategies, including techniques for reuse, reduce, recycle or recovery of solid waste and management of other wastes, such as wastes from pharmaceuticals, aluminum industry, heavy metal, and other metallurgical waste - Addresses contemporary issues such as the transformation of waste into value-added products - Presents an interdisciplinary approach to the management of various types of biomedical, pharmaceutical and industrial waste
Author: Amy J. Clippinger
Publisher: Frontiers Media SA
ISBN: 2832508596
Category : Science
Languages : en
Pages : 139
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Book Description
