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Author: Organisation for Economic Co-operation and Development
Publisher:
ISBN:
Category :
Languages : en
Pages : 16
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Book Description
This Test Guideline describes a laboratory test method to assess abiotic hydrolytic transformations of chemicals in aquatic systems at pH values normally found in the environment (pH 4 - 9). This Guideline is designed as a tiered approach; each tier is triggered by the results of the previous tier. Sterile aqueous buffer solutions of different pH values (pH 4, 7 and 9) are treated with the non-labelled or labelled test substance (only one concentration, which should not exceed 0.01 M or half of the saturation concentration). They are incubated in the dark under controlled laboratory conditions (at constant temperatures). After appropriate time intervals, buffer solutions are analysed for the test substance and for hydrolysis products. The preliminary test should be carried out for 5 days at 50 ± 0.5°C and pH 4.0, 7.0 and 9.0. The second tier consists of the hydrolysis of unstable substances, and the third tier is the identification of hydrolysis products. The higher Tier tests should be conducted until 90 % hydrolysis of the test substance is observed or for 30 days whichever comes first.
Author: Organisation for Economic Co-operation and Development
Publisher:
ISBN:
Category :
Languages : en
Pages : 16
Get Book Here
Book Description
This Test Guideline describes a laboratory test method to assess abiotic hydrolytic transformations of chemicals in aquatic systems at pH values normally found in the environment (pH 4 - 9). This Guideline is designed as a tiered approach; each tier is triggered by the results of the previous tier. Sterile aqueous buffer solutions of different pH values (pH 4, 7 and 9) are treated with the non-labelled or labelled test substance (only one concentration, which should not exceed 0.01 M or half of the saturation concentration). They are incubated in the dark under controlled laboratory conditions (at constant temperatures). After appropriate time intervals, buffer solutions are analysed for the test substance and for hydrolysis products. The preliminary test should be carried out for 5 days at 50 ± 0.5°C and pH 4.0, 7.0 and 9.0. The second tier consists of the hydrolysis of unstable substances, and the third tier is the identification of hydrolysis products. The higher Tier tests should be conducted until 90 % hydrolysis of the test substance is observed or for 30 days whichever comes first.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264069704
Category :
Languages : en
Pages : 16
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Book Description
This Test Guideline describes a laboratory test method to assess abiotic hydrolytic transformations of chemicals in aquatic systems at pH values normally found in the environment (pH 4 – 9). This Guideline is designed as a tiered approach; each tier ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264466185
Category :
Languages : en
Pages : 30
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Book Description
This Test Guideline describes a standardised method to examine the transformation of chemicals in pig and cattle liquid manure under anaerobic conditions.
Author: OECD
Publisher: OECD Publishing
ISBN: 9264303235
Category :
Languages : en
Pages : 36
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Book Description
The Test Guideline (TG) describes the use of liver S9 sub-cellular fraction (RT-S9) of rainbow trout (Oncorhynchus mykiss) as a metabolising system to determine the clearance (CL, IN VITRO, INT ) of a test chemical using a substrate depletion approach. Introduction of the test chemical to the ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264303219
Category :
Languages : en
Pages : 41
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Book Description
The Test Guideline (TG) describes the use of cryopreserved rainbow trout (Oncorhynchus mykiss) hepatocytes (RT-HEP) as a metabolising system to determine the clearance (CL, IN VITRO, INT) of a test chemical using a substrate depletion approach. Introduction of the test chemical to the RT-HEP ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264185291
Category :
Languages : en
Pages : 72
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Book Description
This Test Guideline describes a procedure for characterising the bioconcentration potential of substances in fish, using an aqueous (standard and minimised tests) or dietary exposure, under flow-through conditions (but semi-static regimes are ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264284141
Category :
Languages : en
Pages : 32
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Book Description
This test guideline describes a test procedure to gain information on dispersion stability of manufactured nanomaterials in simulated environmental media. The main purpose of this guideline is to assess the ability of a nanomaterial to attain a colloidal dispersion and to conserve this ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264015841
Category :
Languages : en
Pages : 17
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Book Description
This Test Guideline describes the slow-stirring method, which permits the determination of the 1-octanol/water partition coefficient (POW) values up to a log POW of 8.2. The partition coefficient between water and 1-octanol (POW) is defined as the ...
Author: OECD
Publisher: OECD Publishing
ISBN: 9264067493
Category :
Languages : en
Pages : 51
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Book Description
This Test Guideline describes a method to assess the extent and kinetics of primary and ultimate biodegradation of organic chemicals whose route of entry into the environment begins with their discharge to wastewater. It consists of five simulation ...
Author: Adam D. K. Abelkop
Publisher: CRC Press
ISBN: 1482298783
Category : Science
Languages : en
Pages : 303
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Book Description
Developed from the efforts of a multiyear, international project examining how persistent, bioaccumulative, and toxic (PBT) chemicals are evaluated and managed, Persistent, Bioaccumulative, and Toxic (PBT) Chemicals: Technical Aspects, Policies, and Practices focuses on improving the processes that govern PBTs. Incorporating science and policy literature—as well as interviews and panel discussions featuring experts from around the world—this book provides you with an international perspective of PBT policies (centering on Europe, Asia, and North America), and reveals major findings and recommendations for improving PBT science, laws, and policies. It includes case studies of specific chemicals, provides an introduction to the overall subject of toxic chemicals, and weighs in on science and policy expansion for PBTs. It also provides summary tables of important PBTs, and discussions on the number of PBTs in commerce, weight of evidence approaches, market deselection, and international management. The text: Assesses the history, current practice, and future of PBT management Considers the roles scientific data, modeling, and conventions play in identifying and regulating PBTs Explores the number of PBTs in commerce and the growing role of weight of evidence (WOE) in the making of PBT determinations Identifies issues that are likely to come up in WOE judgments Examines international, national, subnational, and regional PBT policies Includes a comprehensive and easy-to-understand analysis of PBT science and policy This book reviews the current science, policies, and practices surrounding the regulation of PBTs. It also provides relevant research, recommendations, and suggestions for improving the management and oversight of PBTs.
