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Author: Ilse Zolle
Publisher: Springer Science & Business Media
ISBN: 3540339906
Category : Medical
Languages : en
Pages : 354
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Book Description
Radioactive drug development is a multi-disciplinary task. Therefore, dedicated scientists and experts from different fields of specialisation have contributed to this book. The text reviews forty years of advances in radiopharmaceutical development based on Technetium. The first section reviews basic principles and analytic methods, and information on chemical makeup of radiopharmaceuticals. Part 2 reviews 99mTc-radiopharmaceuticals used in nuclear medicine, thoroughly outlining their chemistry, formulation, pharmacokinetics and clinical applications.
Author: Ilse Zolle
Publisher: Springer Science & Business Media
ISBN: 3540339906
Category : Medical
Languages : en
Pages : 354
Get Book Here
Book Description
Radioactive drug development is a multi-disciplinary task. Therefore, dedicated scientists and experts from different fields of specialisation have contributed to this book. The text reviews forty years of advances in radiopharmaceutical development based on Technetium. The first section reviews basic principles and analytic methods, and information on chemical makeup of radiopharmaceuticals. Part 2 reviews 99mTc-radiopharmaceuticals used in nuclear medicine, thoroughly outlining their chemistry, formulation, pharmacokinetics and clinical applications.
Author: Ilse Zolle
Publisher: Springer
ISBN: 9783642070501
Category : Medical
Languages : en
Pages : 0
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Book Description
Radioactive drug development is a multi-disciplinary task. Therefore, dedicated scientists and experts from different fields of specialisation have contributed to this book. The text reviews forty years of advances in radiopharmaceutical development based on Technetium. The first section reviews basic principles and analytic methods, and information on chemical makeup of radiopharmaceuticals. Part 2 reviews 99mTc-radiopharmaceuticals used in nuclear medicine, thoroughly outlining their chemistry, formulation, pharmacokinetics and clinical applications.
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 0309445310
Category : Medical
Languages : en
Pages : 264
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Book Description
The decay product of the medical isotope molybdenum-99 (Mo-99), technetium-99m (Tc-99m), and associated medical isotopes iodine-131 (I-131) and xenon-133 (Xe-133) are used worldwide for medical diagnostic imaging or therapy. The United States consumes about half of the world's supply of Mo-99, but there has been no domestic (i.e., U.S.-based) production of this isotope since the late 1980s. The United States imports Mo-99 for domestic use from Australia, Canada, Europe, and South Africa. Mo-99 and Tc-99m cannot be stockpiled for use because of their short half-lives. Consequently, they must be routinely produced and delivered to medical imaging centers. Almost all Mo-99 for medical use is produced by irradiating highly enriched uranium (HEU) targets in research reactors, several of which are over 50 years old and are approaching the end of their operating lives. Unanticipated and extended shutdowns of some of these old reactors have resulted in severe Mo-99 supply shortages in the United States and other countries. Some of these shortages have disrupted the delivery of medical care. Molybdenum-99 for Medical Imaging examines the production and utilization of Mo-99 and associated medical isotopes, and provides recommendations for medical use.
Author: International Atomic Energy Agency
Publisher: IAEA
ISBN: 9789201035097
Category : Reference
Languages : en
Pages : 360
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Book Description
Technetium-99m radiopharmaceuticals will continue to have a significant impact in several areas of nuclear medicine. This publication is intended to provide a broad overview of the current status of technetium-99m radiopharmaceuticals. It includes chapters on the most advanced chemical techniques for labelling biomolecules and synthesizing suitable multifunctional ligands that will help in the development of specific radiotracers. Of special interest for the reader are details of recent research to develop technetium-99m tracers for monitoring different biological processes enabling the development of new radiopharmaceuticals with greatly improved clinical potential.
Author: Jason S. Lewis
Publisher: Springer
ISBN: 3319989472
Category : Medical
Languages : en
Pages : 648
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Book Description
This book is a comprehensive guide to radiopharmaceutical chemistry. The stunning clinical successes of nuclear imaging and targeted radiotherapy have resulted in rapid growth in the field of radiopharmaceutical chemistry, an essential component of nuclear medicine and radiology. However, at this point, interest in the field outpaces the academic and educational infrastructure needed to train radiopharmaceutical chemists. For example, the vast majority of texts that address radiopharmaceutical chemistry do so only peripherally, focusing instead on nuclear chemistry (i.e. nuclear reactions in reactors), heavy element radiochemistry (i.e. the decomposition of radioactive waste), or solely on the clinical applications of radiopharmaceuticals (e.g. the use of PET tracers in oncology). This text fills that gap by focusing on the chemistry of radiopharmaceuticals, with key coverage of how that knowledge translates to the development of diagnostic and therapeutic radiopharmaceuticals for the clinic. The text is divided into three overarching sections: First Principles, Radiochemistry, and Special Topics. The first is a general overview covering fundamental and broad issues like “The Production of Radionuclides” and “Basics of Radiochemistry”. The second section is the main focus of the book. In this section, each chapter’s author will delve much deeper into the subject matter, covering both well established and state-of-the-art techniques in radiopharmaceutical chemistry. This section will be divided according to radionuclide and will include chapters on radiolabeling methods using all of the common nuclides employed in radiopharmaceuticals, including four chapters on the ubiquitously used fluorine-18 and a “Best of the Rest” chapter to cover emerging radionuclides. Finally, the third section of the book is dedicated to special topics with important information for radiochemists, including “Bioconjugation Methods,” “Click Chemistry in Radiochemistry”, and “Radiochemical Instrumentation.” This is an ideal educational guide for nuclear medicine physicians, radiologists, and radiopharmaceutical chemists, as well as residents and trainees in all of these areas.
Author: National Academies of Sciences, Engineering, and Medicine
Publisher: National Academies Press
ISBN: 030946627X
Category : Medical
Languages : en
Pages : 87
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Book Description
Participants of the July 17-18, 2017, symposium titled Opportunities and Approaches for Supplying Molybdenum-99 and Associated Medical Isotopes to Global Markets examined current trends in molybdenum-99 production, prospects for new global supplies, and technical, economic, regulatory, and other considerations for supplying molybdenum-99 to global markets. This publication summarizes the presentations and discussions from the symposium.
Author: IAEA.
Publisher:
ISBN:
Category :
Languages : en
Pages : 378
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Book Description
Technetium-99m radiopharmaceuticals will continue to have a significant impact in several areas of nuclear medicine. This publication is intended to provide a broad overview of the current status of technetium-99m radiopharmaceuticals. It includes chapters on the most advanced chemical techniques for labelling biomolecules and synthesizing suitable multifunctional ligands that will help in the development of specific radiotracers. Of special interest for the reader are details of recent research to develop technetium-99m tracers for monitoring different biological processes enabling the develo.
Author: Michael R. Kilbourn
Publisher: John Wiley & Sons
ISBN: 1119500540
Category : Science
Languages : de
Pages : 768
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Book Description
Sorgfältig aktualisierte Neuauflage dieses wegweisenden Referenzwerk der radiopharmazeutischen Wissenschaften Die 2. Auflage des Handbook of Radiopharmaceuticals wirft einen umfassenden analytischen Blick auf das Fachgebiet und bietet aktuelle Informationen zu zentralen Themen, u. a. die Herstellung von Radionukliden, synthetische Methoden, Entwicklungen in der Radiopharmazie, Regelwerke, und zu einer Fülle praktischer Anwendungen. Als wertvolles Nachschlagewerk für Einsteiger und erfahrene Praktiker untersucht diese Publikation die neuesten Konzepte und Fragestellungen unter Berücksichtigung des gezielten Einsatzes diagnostischer und therapeutischer Radiopharmazeutika. Die Beiträge stammen von Experten verschiedenster Unterdisziplinen und lassen den Leser eintauchen in die Radiochemie, Nuklearmedizin, molekulare Bildgebung u.v.m. Die Nuklearmedizin und radiopharmazeutischen Wissenschaften haben sich seit Veröffentlichung der 1. Auflage stark verändert. Neue Radiopharmazeutika für Diagnostik und Therapie wurden von der FDA zugelassen, klinische PET- und SPECT-Scans haben drastisch zugenommen und Fortschritte im Bereich Künstliche Intelligenz haben zu signifikant verbesserten Forschungsverfahren geführt. Diese vollständig überarbeitete Auflage stellt den derzeitigen Erkenntnisstand des Fachgebiets vor, ergänzt um aktualisierte und neue Inhalte. Neue Kapitel beschäftigen sich mit heutigen Good Manufacturing Practice, regulatorischen Entwicklungen und neuen Ansätzen bei der Qualitätskontrolle. Damit wird sichergestellt, dass die Leserschaft über die aufregenden Entwicklungen der letzten Jahre rundum im Bilde ist. Dieses wichtige Referenzwerk - bietet durchgängig neue und überarbeitete Inhalte. - deckt zentrale Anwendungsbereiche in der Diagnostik und Therapie ab, für die Onkologie, Neurologie und Kardiologie. - unterstreicht die multidisziplinäre Ausrichtung der radiopharmazeutischen Wissenschaften. - zeigt, wie Pharmaunternehmen mit modernen Bildgebungsverfahren der Radiopharmazie neue Medikamente entwickeln. - untersucht heutige und neue Anwendungen der Positronen-Emissions-Tomographie (PET) und Single-Photonen-Emissions-Computertomographie (SPECT). Die Herausgeber sind anerkannte Experten der Fachrichtungen Radiochemie und PET-Bildgebung. Die 2. Auflage des Handbook of Radiopharmaceuticals: Radiochemistry and Applications ist ein Muss für Postdoktoranden, Forscher und Fachexperten in der Pharmazeutischen Industrie und richtet sich ebenso an die akademische Forschung und Lehre, an Graduierte und Einsteiger in das Fachgebiet der Radiopharmazeutika.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309134153
Category : Medical
Languages : en
Pages : 173
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Book Description
Nearly 20 million nuclear medicine procedures are carried out each year in the United States alone to diagnose and treat cancers, cardiovascular disease, and certain neurological disorders. Many of the advancements in nuclear medicine have been the result of research investments made during the past 50 years where these procedures are now a routine part of clinical care. Although nuclear medicine plays an important role in biomedical research and disease management, its promise is only beginning to be realized. Advancing Nuclear Medicine Through Innovation highlights the exciting emerging opportunities in nuclear medicine, which include assessing the efficacy of new drugs in development, individualizing treatment to the patient, and understanding the biology of human diseases. Health care and pharmaceutical professionals will be most interested in this book's examination of the challenges the field faces and its recommendations for ways to reduce these impediments.
Author: Magdy M. Khalil
Publisher: Springer Nature
ISBN: 3030652459
Category : Medical
Languages : en
Pages : 571
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Book Description
This book provides comprehensive and detailed information on the scientific bases of nuclear medicine, addressing a wide variety of topics and explaining the concepts that underlie many of the investigations and procedures performed in the field. The book is divided into six sections that cover the physics and chemistry of nuclear medicine besides associated quality assurance/quality control procedures; dosimetry and radiation biology; SPECT and PET imaging instrumentation plus CT imaging technology in hybrid modalities; data analysis including image processing, reconstruction, radiomics, image degrading correction techniques, along with image quantitation and kinetic modeling. Within these sections, particular attention is paid to recent developments and the advances in knowledge that have taken place since release of the first edition in 2011. Several entirely new chapters have been included and the remaining chapters, thoroughly updated. Innovations in the ever-expanding field of nuclear medicine are predominantly due to integration of the basic sciences with complex technological advances. This excellently illustrated book on the subject will be of interest to not only nuclear medicine physicists and physicians but also clinical scientists, radiologists, radiopharmacists, medical students and technologists.
