Small Fiber Neuropathy and Related Syndromes: Pain and Neurodegeneration

Small Fiber Neuropathy and Related Syndromes: Pain and Neurodegeneration PDF Author: Sung-Tsang Hsieh
Publisher: Springer
ISBN: 981133546X
Category : Medical
Languages : en
Pages : 193

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Book Description
This book provides comprehensive coverage of small fiber neuropathy (SFN), from diagnosis to therapy. It focuses on nerve degeneration and neuropathic pain, and their underlying pathology, physiology, psychophysics, genetics and imaging. In particular, this book describes and discusses the major advances in diagnostic techniques for assessing SFN. These include skin biopsy, evoked potentials, quantitative sensory testing and functional studies, as biomarkers of SFN. SFN is a common peripheral nerve disorder, but was often overlooked due to a lack of objective and specific diagnostic tests for the assessment of small nerve fibers. These fibers mediate thermal sensation, pain detection (nociception), and autonomic regulation. Major symptoms of SFN include neuropathic pain, impaired sensation and autonomic dysfunction. Neuropathic pain poses a diagnostic challenge to clinicians, an essential step for selecting appropriate treatment to relieve suffering. SFN frequently develops in systemic diseases such as diabetes mellitus, following chemotherapy, infections etc., or presents as a major feature of various genetic neuropathies (e.g. channelopathy and familial amyloidosis). In addition to describing these conditions which lead to SFN, this book also describes related syndromes of neurodegeneration and pain, including fibromyalgia, visceral pain and hypersensitivity. This definitive book covers both clinical aspects and research progress, which provides in-depth and up-to-date information on SFN. It would be immensely useful for clinicians, neurologists, neuroscientists, diabetologists, and pain specialists. Dr. Sung-Tsang Hsieh is a professor at Department of Neurology and Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taiwan. He is also the associate dean of College of Medicine, National Taiwan University, Taiwan. Dr. Praveen Anand is a professor at Department of Clinical Neurology and head of Centre for Clinical Translation, Hammersmith Hospital, UK. Dr. Christopher Gibbons is an associate professor of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, USA. Dr. Claudia Sommer is a professor of Neurology at the Department of Neurology, Würzburg University Hospital, Germany.

Small Fiber Neuropathy and Related Syndromes: Pain and Neurodegeneration

Small Fiber Neuropathy and Related Syndromes: Pain and Neurodegeneration PDF Author: Sung-Tsang Hsieh
Publisher: Springer
ISBN: 981133546X
Category : Medical
Languages : en
Pages : 193

Get Book Here

Book Description
This book provides comprehensive coverage of small fiber neuropathy (SFN), from diagnosis to therapy. It focuses on nerve degeneration and neuropathic pain, and their underlying pathology, physiology, psychophysics, genetics and imaging. In particular, this book describes and discusses the major advances in diagnostic techniques for assessing SFN. These include skin biopsy, evoked potentials, quantitative sensory testing and functional studies, as biomarkers of SFN. SFN is a common peripheral nerve disorder, but was often overlooked due to a lack of objective and specific diagnostic tests for the assessment of small nerve fibers. These fibers mediate thermal sensation, pain detection (nociception), and autonomic regulation. Major symptoms of SFN include neuropathic pain, impaired sensation and autonomic dysfunction. Neuropathic pain poses a diagnostic challenge to clinicians, an essential step for selecting appropriate treatment to relieve suffering. SFN frequently develops in systemic diseases such as diabetes mellitus, following chemotherapy, infections etc., or presents as a major feature of various genetic neuropathies (e.g. channelopathy and familial amyloidosis). In addition to describing these conditions which lead to SFN, this book also describes related syndromes of neurodegeneration and pain, including fibromyalgia, visceral pain and hypersensitivity. This definitive book covers both clinical aspects and research progress, which provides in-depth and up-to-date information on SFN. It would be immensely useful for clinicians, neurologists, neuroscientists, diabetologists, and pain specialists. Dr. Sung-Tsang Hsieh is a professor at Department of Neurology and Institute of Anatomy and Cell Biology, College of Medicine, National Taiwan University, Taiwan. He is also the associate dean of College of Medicine, National Taiwan University, Taiwan. Dr. Praveen Anand is a professor at Department of Clinical Neurology and head of Centre for Clinical Translation, Hammersmith Hospital, UK. Dr. Christopher Gibbons is an associate professor of Neurology, Harvard Medical School, Beth Israel Deaconess Medical Center, USA. Dr. Claudia Sommer is a professor of Neurology at the Department of Neurology, Würzburg University Hospital, Germany.

Small Nerves. Big Problems

Small Nerves. Big Problems PDF Author: David Saperstein Saperstein
Publisher:
ISBN: 9780998328201
Category :
Languages : en
Pages : 64

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Book Description


Sensory Neuropathies

Sensory Neuropathies PDF Author: Arthur K. Asbury
Publisher: Springer Science & Business Media
ISBN: 3709165954
Category : Medical
Languages : en
Pages : 228

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Book Description
While motor neuropathies and neuronopathies and mixed sensory-motor neuropathies have been met with adequate interest by clinical and basic researchers and physicians, pure sensory neuropathies and neuro nopathies have received comparably less attention, despite of the consider able morbidity they may cause in the individual patient. This prompted us to organize an International Symposium on Sensory Neuropathies which was held in Vienna, September 22-24,1990, as satellite to the International Neuromuscular Congress held one week earlier in Munich, Germany. We were fortunate to have a faculty of experienced authorities in the field as participants. This volume is the proceedings of the symposium. Due to factors which were beyond our control, publication of this volume was significantly delayed. Despite the enormous progress of biomedicine in recent years, most prominently in molecular biology, we feel that the contributions of this volume still represent a valuable reference for clinical, physiological, biochemical and pathomorphological studies on the sensory nervous system for which similarly comprehensive data are difficult to locate. November 1994 Arthur K Asbury Herbert Budka ElJriede Sluga Contents Contributors 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 IX 1.

Progressive Brain Disorders in Childhood

Progressive Brain Disorders in Childhood PDF Author: Juan M. Pascual
Publisher: Cambridge University Press
ISBN: 1107042054
Category : Medical
Languages : en
Pages : 507

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Book Description
A review of childhood neurodegenerative and other progressive but non-degenerative disorders to guide their diagnosis and management.

Mechanisms and Mediators of Neuropathic Pain

Mechanisms and Mediators of Neuropathic Pain PDF Author: Annika B. Malmberg
Publisher: Springer
ISBN: 3034881290
Category : Medical
Languages : en
Pages : 278

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Book Description
Numerous improvements in our understanding of the mechanisms that underlie neuropathic pain states have come from the development of animal models, most of which involve partial peripheral nerve injury. The animal models have shown that nerve injury initiates a cascade of events resulting in altered neurochemistry and molecular biology of the peripheral neurons, the dorsal root ganglion cell, and changes in neurotransmitter and receptor expression in the dorsal horn of the spinal cord. Moreover, nerve injury produces anatomical changes with functional consequences. This volume summarises the current understanding of the pathophysiological processes in the peripheral and central nervous system that contribute to the neuropathic pain. It provides a timely review of neuropathic pain mechanisms, written by experts in the field.

Complications of Diabetes Mellitus

Complications of Diabetes Mellitus PDF Author: Jahangir Moini
Publisher: CRC Press
ISBN: 1000554961
Category : Medical
Languages : en
Pages : 407

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Book Description
Diabetes mellitus is a global epidemic with severe complications that can be of great cost. This book focuses on the complications of hypertension, heart attack or heart failure, stroke, blindness, nephropathy, neuropathy, amputations, and death, along with the prevalence and prevention of disease development. It explains distribution of the disease by age and gender, such as the development of type II diabetes in relation to obesity, which is more prevalent in younger age groups. Global mortality and costs of complications are significant, as the disease affects all ages, races, and ethnicities, making this book an invaluable resource for healthcare professionals and students everywhere. Key Features A useful ready reference for students, physicians, and healthcare professionals detailing the latest diagnostic tests and treatments of diabetes and its complications Explains how heart failure and stroke are deadly complications of diabetes along with kidney failure and life-threatening infections Establishes how cancer is linked to diabetes – a fact many people are not aware of – this book details the six types of cancer that may result from the disease, along with an individualized focus on the different "areas" of issues that occur from diabetes Discusses the effect of diabetes on the minds of patients, in relation to depression, anxiety, panic, PTSD, eating disorders, delirium, and dementia

Peripheral Neuropathy

Peripheral Neuropathy PDF Author: Norman Latov
Publisher: Demos Medical Publishing
ISBN: 193260359X
Category : Health & Fitness
Languages : en
Pages : 151

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Book Description
Peripheral neuropathy, the variety of conditions that result when the nerves that connect to the brain and spinal cord are damaged or diseased, is commonly associated with diseases such as diabetes, HIV, alcoholism, and lupus. Although widespread -- it affects 10-20 million people in the United States -- information about the condition has been difficult to obtain. This essential guide explains what is known about peripheral neuropathy, including its causes and manifestations, and what can be done to manage it. Topics include drug therapy for the condition and its symptoms, interventional therapy, alternative medicines, caring for the feet, and much more. This book will enable patients to make informed decisions about their care.

Diabetes and the Nervous System

Diabetes and the Nervous System PDF Author: Douglas W. Zochodne
Publisher: Elsevier
ISBN: 9780444534804
Category : Medical
Languages : en
Pages : 0

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Book Description
This is a unique compilation, by experts worldwide, addressing how diabetes impacts the nervous system. For example, diabetic polyneuropathy, a disorder more common than MS, Parkinson's disease, and ALS combined, is a major source of disability to diabetic persons worldwide. This book addresses diabetic polyneuropathy and how diabetes alters other parts of the nervous system.

Peripheral Neuropathy

Peripheral Neuropathy PDF Author: Janice F. Wiesman
Publisher: Johns Hopkins University Press
ISBN: 1421420856
Category : Health & Fitness
Languages : en
Pages : 132

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Book Description
Healing and symptom relief from an expert in treating this debilitating and dangerous condition. Nearly one in fifteen people—that's 20 million people in the United States—suffers from peripheral neuropathy, or nerve damage. Caused by such conditions as diabetes, cancer, vitamin deficiencies, and kidney disease as well as certain drugs and toxins, neuropathy brings numbness, tingling, and burning in the feet, legs, and fingertips. Neuropathy can be more than uncomfortable—it can be disabling: people whose fingertips are numb may find it hard to button clothing and complete other everyday tasks. Neuropathy is often dangerous, as well: people who cannot feel their feet are more likely to stumble and fall, and they may not notice injuries that need medical attention. Dr. Janice F. Wiesman, a neurologist with twenty years of experience helping people who have neuropathy find relief, shares her special insights into this painful and debilitating condition. With exceptional clarity, Dr. Wiesman begins by outlining the basics of nerve anatomy and function. She explains how peripheral neuropathy is diagnosed and treated, describes neuropathy’s disparate causes, and offers readers lifestyle changes that can help keep nerves healthy. A useful glossary defines terms, patient stories offer real-world experiences, and illustrations provide a visual key to the condition. A detailed resources section points the reader to reliable web sites and organizations that offer more help. Concentrating on the most common types of neuropathy, Dr. Wiesman provides hope, help, and comfort to patients, families, and caregivers.

Cerebellar Disorders

Cerebellar Disorders PDF Author: Mario Ubaldo Manto
Publisher: Cambridge University Press
ISBN: 1139487264
Category : Medical
Languages : en
Pages : 313

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Book Description
During the last three decades, many laboratories worldwide have dedicated their research activities to understanding the roles of the cerebellum in motor control, cognitive processes and the biology of mental processes, behavioral symptoms and emotion. These advances have been associated with discoveries of new clinical disorders, in particular in the field of genetic ataxias, and the growing number of diseases presents a source of difficulty for clinicians during daily practice. This practical guide summarizes and evaluates current knowledge in the field of cerebellar disorders. Encompassing details of both common and uncommon cerebellar ataxias, including vascular, immune, neoplastic, infectious, traumatic, toxic and inherited disorders, this book will assist clinicians in the diagnosis and management of the full spectrum of cerebellar ataxias encountered in daily practice. Essential reading for clinicians, including general practitioners, neurologists, pediatricians, radiologists, psychiatrists and neuropsychologists, this will also prove a valuable tool for students, trainees and researchers.