Relaxation of Insulin-Like Growth Factor II Imprinting in Prostate Cancer Development PDF Download
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Author:
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ISBN:
Category :
Languages : en
Pages : 30
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Book Description
A marked propensity for prostate cancer to arises in the peripheral prostate with aging. The Insulin-like Growth Factor-II (IGF-II) gene is an auto-paracrine growth stimulator that is an important positive modulator of cancer development. lGF-II typically demonstrates monoallelic, or imprinted, expression in adult tissues and indeed this pattern is maintained in the periurethral zone, a region where cancer development is rare. In addition, IGF-II loss of imprinting (LOl), as well as increased lGF-II expression, are common attributes of prostate cancer. It is our hypothesis to be tested that an age-dependent loss of lGF-II imprinting, resulting from age-dependent changes in DNA methylation, occurs specifically in the peripheral zone of the prostate and contributes to the increased risk for cancer development. To examine temporally when this loss of IGF-II imprinting occurs and the mechanisms underlying it we propose 3 Specific Aims: (1) To determine if IGF-II LOl in the peripheral prostate derives from stromal and/or epithelial cells; (2) To determine whether lGF-II LOl occurs as an age-dependent process in human prostate tissues that are uninvolved with cancer; and (3) To examine DNA methylation as a mechanism for any observed changes in the imprint status in prostate tissues. This proposal is significant and unique in testing whether regional epigenetic changes occur in histologically normal prostate tissues that are destined to become neoplastic. We expect to determine whether specific age-related, peripheral zone changes in methylation and imprinting occur in the general population and whether these changes are linked to prostate cancer development.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 30
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Book Description
A marked propensity for prostate cancer to arises in the peripheral prostate with aging. The Insulin-like Growth Factor-II (IGF-II) gene is an auto-paracrine growth stimulator that is an important positive modulator of cancer development. lGF-II typically demonstrates monoallelic, or imprinted, expression in adult tissues and indeed this pattern is maintained in the periurethral zone, a region where cancer development is rare. In addition, IGF-II loss of imprinting (LOl), as well as increased lGF-II expression, are common attributes of prostate cancer. It is our hypothesis to be tested that an age-dependent loss of lGF-II imprinting, resulting from age-dependent changes in DNA methylation, occurs specifically in the peripheral zone of the prostate and contributes to the increased risk for cancer development. To examine temporally when this loss of IGF-II imprinting occurs and the mechanisms underlying it we propose 3 Specific Aims: (1) To determine if IGF-II LOl in the peripheral prostate derives from stromal and/or epithelial cells; (2) To determine whether lGF-II LOl occurs as an age-dependent process in human prostate tissues that are uninvolved with cancer; and (3) To examine DNA methylation as a mechanism for any observed changes in the imprint status in prostate tissues. This proposal is significant and unique in testing whether regional epigenetic changes occur in histologically normal prostate tissues that are destined to become neoplastic. We expect to determine whether specific age-related, peripheral zone changes in methylation and imprinting occur in the general population and whether these changes are linked to prostate cancer development.
Author: Derek Leroith
Publisher: Springer Science & Business Media
ISBN: 9780306478468
Category : Medical
Languages : en
Pages : 524
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Book Description
Insulin-like growth factors are ubiquitously expressed and are crucial for growth and function of almost all cells. Together with their binding proteins and receptors, they form a widely studied biological system involving many proteins and characterized by complex interactions. In addition to its significance in growth and development, the insulin-like growth factor system also has important roles in a wide variety of pathological states. This has led to interest in the therapeutic potential of insulin-like growth factors and their binding proteins as candidate drug targets. This comprehensive book contains current information on both basic science and clinical aspects of IGFs and their regulatory proteins, with emphasis on their relevance to cancer.
Author: Anna Perri
Publisher: Frontiers Media SA
ISBN: 2832552587
Category : Medical
Languages : en
Pages : 133
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Book Description
Prostate cancer is the second most common cancer in men, and prognosis varies with age, ethnicity, genetic background, and stage of progression. Disease progression that has been observed in a substantial proportion of patients despite androgen ablation, can arise from many factors, such as the presence of cells that are resistant de novo or acquire resistance induced by androgen-deprivation therapy (ADT) or androgen receptor antagonists.
Author:
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 544
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Book Description
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 1796
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Book Description
Author: Thomas Büchner
Publisher: Springer Science & Business Media
ISBN: 3642603777
Category : Medical
Languages : en
Pages : 1005
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Book Description
For 10 years the book series Acute Leukemias has been providing updates on the rapid progress being made internationally concerning this group of diseases. The fifth volume mainly addressed experimental approaches, but the present issue presents both therapeutic and prognostic aspects of the most recent results from major multicenter clinical trials. Additional chapters report new trends in leukemia cell biology,the monitoring of minimal residual disease, and secondary leukemias, as well as new antileukemic drugs, antimicrobial strategies, and the use of cytokines. The combined efforts against acute leukemias described in this book explain the recent improvements in the outcome of patients suffering from acute leukemias.
Author:
Publisher:
ISBN:
Category : Chemistry
Languages : en
Pages : 2800
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Book Description
Author: Richard G. Pestell
Publisher: Springer Science & Business Media
ISBN: 1603270795
Category : Medical
Languages : en
Pages : 462
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Book Description
Award winning authors present a comprehensive review of new perspectives in prostate cancer research and open up new directions in the clinical management of prostate cancer. The authors focus on the biology, genetics, molecular signaling networks in the disease process, and recent advances in the treatment of prostate cancer. This state-of-the-art title provides key insights into cutting edge advances in prostate cancer and into future, novel treatment strategies.
Author: Albert Altchek
Publisher: Elsevier
ISBN: 008049451X
Category : Medical
Languages : en
Pages : 595
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Book Description
This updated second edition of Diagnosis and Management of Ovarian Disorders provides thorough, yet succinct insight into the ever-changing realm of ovarian disorders. It presents a novel multidisciplinary approach to the subject as described by clinicians, surgeons, pathologists, basic scientists and related medical researchers. Topics covered include reproductive technology, early diagnosis of ovarian cancer, and management of menopause among others. The breadth of information provided by this book will appeal to clinicians and researchers involved in the study and treatment of ovarian disorders. KEY FEATURES* Includes updated information on early diagnosis of ovarian cancer* Reviews new diagnostic techniques for ovarian disorders* Discusses latest information on reproductive technology* Presents translational treatment linking laboratory research with clinical medicine
Author: David O. Walterhouse
Publisher: Springer Science & Business Media
ISBN: 9780792399780
Category : Medical
Languages : en
Pages : 404
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Book Description
The purpose of Diagnostic and Therapeutic Advances in Pediatric Oncology for the Cancer Treatment and Research Series is to provide an up-to-date summary of how recent advances in cancer research are being applied to the care of children with solid tumors. The interface of cancer research with clinical practice in pediatric oncology has never been more intimate than today. While researchers are identifying oncogenes and tumor suppressor genes and are studying their specific functions, clinicians are using knowledge of oncogenes and tumor suppressor genes for diagnosing cancer in children, for therapeutic decision-making purposes, and for prognostic purposes. The first three chapters in this book describe models for understanding the causes of childhood cancer that were perhaps initially identified by clinicians and that are now being studied and understood by researchers. These chapters will describe research evidence that supports roles for the involvement of normal developmental regulatory genes in childhood oncogenesis, of abnormal immune regulation in childhood oncogenesis, and of heredity in childhood oncogenesis. The next eight chapters are devoted to descriptions of the appli cation of new research developments to clinical practice with reference to the most common forms of solid tumors of childhood outside the central nervous system. The final chapter will describe late effects of childhood cancer and its therapy and the impact research is having on understanding and perhaps preventing these late effects.
