The Regulation and Function of Progesterone Receptor Isoforms A and B in the Normal Mouse Mammary Gland PDF Download
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Author: Mark Douglas Aupperlee
Publisher:
ISBN:
Category : Breast
Languages : en
Pages : 396
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Book Description
Author: Mark Douglas Aupperlee
Publisher:
ISBN:
Category : Breast
Languages : en
Pages : 396
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Book Description
Author: Emily Elizabeth Flynn
Publisher:
ISBN: 9781124510972
Category : Electronic dissertations
Languages : en
Pages : 299
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Book Description
Author: Yuqian Zhou
Publisher:
ISBN:
Category :
Languages : en
Pages : 456
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Book Description
Author: Sharianne G. Louie
Publisher:
ISBN:
Category :
Languages : en
Pages : 178
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Book Description
Author: Margaret C. Neville
Publisher: Springer
ISBN:
Category : Medical
Languages : en
Pages : 656
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Book Description
Author: Sarah Jane Santos
Publisher:
ISBN:
Category : Cellular signal transduction
Languages : en
Pages : 282
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Book Description
Author: Orla M. Conneely
Publisher: Springer Science & Business Media
ISBN: 3540734937
Category : Science
Languages : en
Pages : 211
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Book Description
Progestins play a key role in reproductive endocrinology and as pharmaceutical drugs for contraception and in combined hormone therapy. To further our understanding of progestin action in the mammary gland, an international symposium, attended by leading researchers from academia and industry, was held in Berlin, 21–23 March 2007. Genetic mouse models helped to elucidate the role of progestins, both in normal breast development and in disease. Mechanistic molecular studies inspired the design of new progestins with improved tissue selectivity. In addition, the clinical impact of progesterone receptor agonists and antagonists for the prevention and treatment of breast cancer was discussed.
Author: Benjamin S. Leung
Publisher: Springer London
ISBN:
Category : Breast
Languages : en
Pages : 330
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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Both the growth and the development of the mammary gland are controlled by the female hormones estrogen, prolactin and progesterone, and by interactions between the epithelial and stromal compartments of the breast. Changes in the regulation of any of these processes may lead to breast cancer. We have investigated the role of progesterone in the process of sidebranching and alveologenesis in the mammary gland using mice lacking the progesterone receptor which are defective in these processes. By reconstituting murine mammary glands in vivo, we have shown that the progesterone receptor is required only in epithelial cells for proper sidebranching and alveologenesis to occur. Our studies indicate that progesterone acts in a paracrine manner and suggest that Wnt-4 is a mediator of the paracrine signals released from progesterone receptor-positive cells. In addition, we have characterized the role of the estrogen receptor (ER) in regulating the proliferation of breast cancer cells. We postulate that the ability of ER to control cyclin Dl expression and proliferation of breast cancer cells may be acquired during breast cancer progression. This is indicated by the fact that ectopic expression of the estrogen receptor in human epithelial cells does not, on its own, enable signaling between the ER and the cyclin D1 gene. Moreover, others have demonstrated that the ER-positive cells in the mammary epithelium are distinguishable from those that are actively mitotic. Finally, our work indicates that the effects of deletion of the prolactin receptor (PrlR) from mammary epithelial cells closely phenocopy the consequences of deleting cyclin Dl from these cells. We suggest that activation of the PrlR by its ligand results in the production of insulin-like growth factor-2 which in turn induces cyclin D1 synthesis in these cells.
Author: Benjamin S. Leung
Publisher: Springer Science & Business Media
ISBN: 9401180458
Category : Medical
Languages : en
Pages : 296
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Book Description
The concept that hormones influence tumor growth originated in 1889 with the proposal of Albert Schinzinger who suggested that breast cancer is related to the ovaries. Several years later, Sir George Beatson observed that remission of disseminated breast cancer could be achieved in premenopausal patients by performing bilateral oophorectomy. As a result of the contri butions of Hedley Atkins, Charles Huggins and others, additive and ablative hormonal therapies have been widely used for the treatment of advanced breast cancers for several decades. Model systems to study the effects of hormones on growth and regression of breast tumors have been available for many years; however, the complexities of the hormonal environment have rendered in vivo studies difficult in man and experimental animals. Recently, the availability of long-term cultures of breast cancer cells has stimulated many investigators to use these cell lines to unravel the mechanisms of hormone action. Because of the extreme diversity and complexity of advances regarding the endocrinology of the breast and breast cancers, a multi-authored review was deemed necessary. It has been gratifying to receive contributions from many noted scholars. In Volume I of this monograph, the influence of steroid hormones and their antagonists upon normal and neoplastic tissues of the mammary gland are presented. In Volume II, the effects of peptide and other hormones are reviewed.
