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Author: Julian M L Budd
Publisher: Frontiers Media SA
ISBN: 2889197964
Category : Computational neuroscience
Languages : en
Pages : 246
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Book Description
The true revolution in the age of digital neuroanatomy is the ability to extensively quantify anatomical structures and thus investigate structure-function relationships in great detail. Large-scale projects were recently launched with the aim of providing infrastructure for brain simulations. These projects will increase the need for a precise understanding of brain structure, e.g., through statistical analysis and models. From articles in this Research Topic, we identify three main themes that clearly illustrate how new quantitative approaches are helping advance our understanding of neural structure and function. First, new approaches to reconstruct neurons and circuits from empirical data are aiding neuroanatomical mapping. Second, methods are introduced to improve understanding of the underlying principles of organization. Third, by combining existing knowledge from lower levels of organization, models can be used to make testable predictions about a higher-level organization where knowledge is absent or poor. This latter approach is useful for examining statistical properties of specific network connectivity when current experimental methods have not yet been able to fully reconstruct whole circuits of more than a few hundred neurons.
Author: Julian M L Budd
Publisher: Frontiers Media SA
ISBN: 2889197964
Category : Computational neuroscience
Languages : en
Pages : 246
Get Book Here
Book Description
The true revolution in the age of digital neuroanatomy is the ability to extensively quantify anatomical structures and thus investigate structure-function relationships in great detail. Large-scale projects were recently launched with the aim of providing infrastructure for brain simulations. These projects will increase the need for a precise understanding of brain structure, e.g., through statistical analysis and models. From articles in this Research Topic, we identify three main themes that clearly illustrate how new quantitative approaches are helping advance our understanding of neural structure and function. First, new approaches to reconstruct neurons and circuits from empirical data are aiding neuroanatomical mapping. Second, methods are introduced to improve understanding of the underlying principles of organization. Third, by combining existing knowledge from lower levels of organization, models can be used to make testable predictions about a higher-level organization where knowledge is absent or poor. This latter approach is useful for examining statistical properties of specific network connectivity when current experimental methods have not yet been able to fully reconstruct whole circuits of more than a few hundred neurons.
Author: Stephen M. Evans
Publisher: Oxford University Press, USA
ISBN: 0198505280
Category : Medical
Languages : en
Pages : 349
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Book Description
Stereology is a valuable tool for scientists, allowing them to make 3-D reconstructions of the brain from 2-D data. This is a 'cookbook' of stereological methods written especially for neuroscientists, with clear advice about when and when not to use stereology
Author: Michael G. Stewart
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 380
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Book Description
A comprehensive and up-to-date reference that deals with methods of evaluation of structure and function of the nervous system, both in vitro and in vivo. Part I considers in vitro and ex vivo applications, beginning with the fundamentals of the autoradiographic technique followed by autoradiography and image analysis. Part II discusses several of the latest methods used in evaluating cerebral structure and function in vivo and recent advances in PET, magnetic resonance imaging and biomagnetism. Part III examines applications for quantification of the components of neurons and synapses and considers two- and three-dimensional methods of neuronal reconstruction. Also features the latest advances in stereology.
Author: Luigi F. Agnati
Publisher: Springer Science & Business Media
ISBN: 1461321395
Category : Medical
Languages : en
Pages : 416
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Book Description
Author: 3Island Press
Publisher:
ISBN: 9781461321408
Category :
Languages : en
Pages : 436
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Book Description
Author: Heidi Johansen-Berg
Publisher: Academic Press
ISBN: 0124055095
Category : Medical
Languages : en
Pages : 627
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Book Description
Diffusion MRI remains the most comprehensive reference for understanding this rapidly evolving and powerful technology and is an essential handbook for designing, analyzing, and interpreting diffusion MR experiments. Diffusion imaging provides a unique window on human brain anatomy. This non-invasive technique continues to grow in popularity as a way to study brain pathways that could never before be investigated in vivo. This book covers the fundamental theory of diffusion imaging, discusses its most promising applications to basic and clinical neuroscience, and introduces cutting-edge methodological developments that will shape the field in coming years. Written by leading experts in the field, it places the exciting new results emerging from diffusion imaging in the context of classical anatomical techniques to show where diffusion studies might offer unique insights and where potential limitations lie. Fully revised and updated edition of the first comprehensive reference on a powerful technique in brain imaging Covers all aspects of a diffusion MRI study from acquisition through analysis to interpretation, and from fundamental theory to cutting-edge developments New chapters covering connectomics, advanced diffusion acquisition, artifact removal, and applications to the neonatal brain Provides practical advice on running an experiment Includes discussion of applications in psychiatry, neurology, neurosurgery, and basic neuroscience Full color throughout
Author: Giorgio A. Ascoli
Publisher: Springer Science & Business Media
ISBN: 1592592759
Category : Medical
Languages : en
Pages : 466
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Book Description
In Computational Neuroanatomy: Principles and Methods, the path-breaking investigators who founded the field review the principles and key techniques available to begin the creation of anatomically accurate and complete models of the brain. Combining the vast, data-rich field of anatomy with the computational power of novel hardware, software, and computer graphics, these pioneering investigators lead the reader from the subcellular details of dendritic branching and firing to system-level assemblies and models.
Author: Nir Kalisman
Publisher:
ISBN:
Category :
Languages : en
Pages : 27
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Book Description
Author: Richard T. Robertson
Publisher: Academic Press
ISBN: 1483266400
Category : Science
Languages : en
Pages : 462
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Book Description
Neuroanatomical Research Techniques discusses developments in major neuroanatomical research techniques. The book is organized into four parts. Part I deals generally with the preparation and study of brain tissue. It includes a chapter on the microscope, discussing optical magnification, limitations of microscopy, and optical contrasting methods. Other chapters summarize basic techniques for tissue preparation and sectioning; present guidelines for a number of standard, but essential, staining procedures; and present sophisticated and contemporary computer techniques that are proving to be invaluable as neuroanatomy evolves from a qualitative to a quantitative discipline. Part II deals with techniques often used for the study of normal tissue. These include the Golgi method, fluorescence histochemistry, techniques for staining single neurons, and the use of the electron microscope. Part III presents techniques for studying intrinsic connections of the nervous system. These include techniques for silver impregnation of degenerating fibers; autoradiographic technique for studying axonal projections; and somatopetal movement of horseradish peroxidase as a tool for studying connections and neuron morphology. Part IV discusses the interpretation of results from neuroanatomical research techniques and presents examples of the applications of neuroanatomical methods to major problems in physiological psychology.
Author: Society for Neuroscience
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
