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Author: Alexander V. Karasev
Publisher: Springer Science & Business Media
ISBN: 3540708685
Category : Medical
Languages : en
Pages : 126
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Book Description
In recent years, plants have been increasingly explored for production of biomedicines and vaccine components. The two main advantages of plant systems are low cost and a greater potential for scalability as compared to microbial or animal systems. An additional advantage from the public health point of view is high safety compared to animal systems, which is important for vaccine production: there are no known plant pathogens capable of replicating in animals, and in humans in particular. A particular antigen or a protein has to be expressed in a plant using one of many available platforms; this antigen/protein subsequently needs to be purified or processed, and later formulated into a vaccine or a therapeutic; these need to be delivered to a human or animal body via an appropriate route. Naturally, all these vaccines and therapeutics must be subjected to regulatory approvals prior to their use. Thus, the challenge is to adapt plant-based platforms for production of cost-efficient biomedicals that can be approved by FDA for use as vaccine components or therapeutics which will be competitive against existing vaccines and drugs. This volume attempts to address the entire spectrum of challenges facing the nascent field of plant-based biomedicals, from the selection of an appropriate production platform to specific methods of downstream processing and regulatory approval issues.
Author: Alexander V. Karasev
Publisher: Springer Science & Business Media
ISBN: 3540708685
Category : Medical
Languages : en
Pages : 126
Get Book Here
Book Description
In recent years, plants have been increasingly explored for production of biomedicines and vaccine components. The two main advantages of plant systems are low cost and a greater potential for scalability as compared to microbial or animal systems. An additional advantage from the public health point of view is high safety compared to animal systems, which is important for vaccine production: there are no known plant pathogens capable of replicating in animals, and in humans in particular. A particular antigen or a protein has to be expressed in a plant using one of many available platforms; this antigen/protein subsequently needs to be purified or processed, and later formulated into a vaccine or a therapeutic; these need to be delivered to a human or animal body via an appropriate route. Naturally, all these vaccines and therapeutics must be subjected to regulatory approvals prior to their use. Thus, the challenge is to adapt plant-based platforms for production of cost-efficient biomedicals that can be approved by FDA for use as vaccine components or therapeutics which will be competitive against existing vaccines and drugs. This volume attempts to address the entire spectrum of challenges facing the nascent field of plant-based biomedicals, from the selection of an appropriate production platform to specific methods of downstream processing and regulatory approval issues.
Author:
Publisher:
ISBN: 9781780841465
Category : Electronic books
Languages : en
Pages : 143
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Book Description
The enormous progress made in plant genomics is opening the possibility of using plants as bioreactors for the production of pharmaceutical products, ranging from immunogens (single peptides to complex structures such as virus-like particles) to adjuvants, microbicides and monoclonal antibodies. This book includes 11 chapters spanning most of the issues involved in plant-based vaccine production, including intellectual property considerations and veterinary applications. In addition to the detailed description of antigen expression in different plant systems, adjuvant production and plant glyc.
Author: Virgil Schijns
Publisher: Elsevier
ISBN: 0080457215
Category : Medical
Languages : en
Pages : 396
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Book Description
Immunopotentiators in Modern Vaccines provides an in-depth insight and overview of a number of most promising immunopotentiators in modern vaccines. In contrast to existing books on the subject it provides recent data on the critical mechanisms governing the activity of vaccine adjuvants and delivery systems. Knowledge of immunological pathways and scenarios of the cells and molecules involved is described and depicted in comprehensive illustrations. Contributions from leading international authorities in the field Well-illustrated, informative figures present the interactions between immunopotentiators and the host immune system Each chapter lists advantages and potential hurdles for achieving a practical application for the specific immunopentiator
Author: Malik Zainul Abdin
Publisher: Springer
ISBN: 981102961X
Category : Science
Languages : en
Pages : 405
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Book Description
The book traces the roots of plant biotechnology from the basic sciences to current applications in the biological and agricultural sciences, industry, and medicine. Providing intriguing opportunities to manipulate plant genetic and metabolic systems, plant biotechnology has now become an exciting area of research. The book vividly describes the processes and methods used to genetically engineer plants for agricultural, environmental and industrial purposes, while also discussing related bioethical and biosafety issues. It also highlights important factors that are often overlooked by methodologies used to develop plants’ tolerance against biotic and abiotic stresses and in the development of special foods, bio-chemicals, and pharmaceuticals. The topics discussed will be of considerable interest to both graduate and postgraduate students. Further, the book offers an ideal reference guide for teachers and researcher alike, bridging the gap between fundamental and advanced approaches.
Author: Hiroshi Kiyono
Publisher: Elsevier
ISBN: 0080537057
Category : Medical
Languages : en
Pages : 501
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Book Description
This comprehensive, authoritative treatise covers all aspects of mucosal vaccines including their development, mechanisms of action, molecular/cellular aspects, and practical applications. The contributing authors and editors of this one-of-a-kind book are very well known in their respective fields. Mucosal Vaccines is organized in a unique format in which basic, clinical, and practical aspects of the mucosal immune system for vaccine development are described and discussed. This project is endorsed by the Society for Mucosal Immunology. Provides the latest views on mucosal vaccines Applies basic principles to the development of new vaccines Links basic, clinical, and practical aspects of mucosal vaccines to different infectious diseases Unique and user-friendly organization
Author: Kathleen Laura Hefferon
Publisher: CRC Press
ISBN: 9781439804759
Category : Medical
Languages : en
Pages : 224
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Book Description
Transgenic plants present enormous potential to become one of the most cost-effective and safe systems for large-scale production of proteins for industrial, pharmaceutical, veterinary, and agricultural uses. Over the past decade, much progress has been made with respect to the development of vaccines, antibodies, and other therapeutic proteins. Bi
Author: Charles Arntzen
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Sergio Rosales-Mendoza
Publisher: Springer
ISBN: 1493908502
Category : Science
Languages : en
Pages : 295
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Book Description
Genetically Engineered Plants as a Source of Vaccines Against Wide Spread Diseases: An Integrated View provides an integrated outlook of the disciplines involved in the development of plant-based vaccines as well as an updated compilation of the successful developments in the field. The volume covers immunological aspects of mucosal vaccine design, molecular approaches to attain high levels of the recombinant antigens, the rationale of using bioreactor to expand plant biomass, and pharmaceutical technology approaches that have been applied to the development of plant-based vaccine formulations. Practical figures and tables are presented to facilitate reading and identification of key points. Perspectives for this field are also discussed. Written by authorities in the field, Genetically Engineered Plants as a Source of Vaccines Against Wide Spread Diseases: An Integrated View is a comprehensive resource for researchers and students interested in plant genetics and breeding, immunology, and genetic engineering.
Author: Yuk-Ting Lee
Publisher: Open Dissertation Press
ISBN: 9781374721111
Category : Science
Languages : en
Pages : 150
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Book Description
This dissertation, "Production of Transgenic Plant-derived Vaccines via Plastid Transformation Technology" by Yuk-ting, Lee, 李玉婷, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled PRODUCTION OF TRANSGENIC PLANT-DERIVED VACCINES VIA PLASTID TRANSFORMATION TECHNOLOGY Submitted by Lee Yuk Ting for the degree of Master of Philosophy at The University of Hong Kong in July 2004 With the advent of genetic engineering in higher plants, the need for very large quantities of therapeutic protein at low cost, and the desire to have heat-stable edible vaccines directed at human and animal diseases, transgenic plant-derived vaccines offer a new strategy for the development of safe, inexpensive vaccines against infectious diseases. The first success of plastid transformation in tobacco in 1990 has opened up the opportunities for genetically modifying plastids in higher plants for high level expression of biopharmaceuticals, such as antibodies and vaccines for oral administration. Since each plant cell contains up to 10,000 copies of identical plastid genome, plastid engineering should result in very high levels of transgene expression. In addition, due to the prokaryotic feature of the plastids, engineering the plastid genome bears the advantages of expressing multiple genes as operons without the problem of positional and epigenetic effects affecting transgene activity. Therefore, plastid transformation technology is a promising alternative to the conventional nuclear transformation. The objectives of this research are: 1) to examine if plastids can be used to produce edible vaccines suitable for uses against Epstein-Barr (EBV) and Hepatitis B Virus (HBV), and 2) if such a production can be regulated through a chemically inducible gene expression system. The genes encoding the early antigen of the Epstein-Barr virus and the Hepatitis B surface antigen (HBsAg) are introduced into tobacco plastids via biolistic bombardment techniques. Simultaneously, an alcohol-inducible alc gene expression system is established and integrated into the tobacco nuclear genome for controlling plastid expression of antigen genes. It was found that chloroplast- derived antigen against EBV could be successfully produced in transplastomic tobacco using a constitutive plastid-derived promoter. However, constitutive expression of Hepatitis B surface antigen (HBsAg) apparently results in growth retardation and lethality of the plants. By adapting the ethanol inducible (alc) gene expression system to control engineered plastid operons, it is possible to regulate a marker gene (uidA) expression and the production of antigen (HBsAg) in plastids upon ethanol administration. The technology developed here could contribute to a much more cost-effective system for vaccine production system in the future. DOI: 10.5353/th_b3015943 Subjects: Plastids Transgenic plants Vaccines Viral antigens
Author: L. Erickson
Publisher: Springer Science & Business Media
ISBN: 9401723176
Category : Science
Languages : en
Pages : 381
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Book Description
Molecular farming has been hailed as the "third wave" of genetically-modified organisms produced through biotechnology for the bio-based economy of the future. Unlike products of the first wave, such as herbicide resistant crop plants, which were perceived to benefit only the farmers who used them and the agrochemical companies who developed them, products of molecular farming are designed specifically for the benefit of the consumer. Such products could be purified from food or non-food organisms for a range of applications in industry, as well as animal and human health. Alternatively, the products of this technology could be consumed more directly in some edible format, such as milk, eggs, fruits or vegetables. There is a rapidly-growing interest Qn the part of the public as well as in the medical community in the role food plays in health, especially in the immunophysiological impact of food over and above the role of basic nutrition.
