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Author: Nurcan Buduneli
Publisher: Springer
ISBN: 9783030373153
Category : Medical
Languages : en
Pages : 0
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Book Description
This book examines all aspects of the progress being made towards the development of highly specific and sensitive biomarkers that will overcome the shortcomings of clinical assessments in periodontics. The opening chapters present the basic anatomic features of periodontal tissues, outline the nature and pathogenic mechanisms of periodontal diseases, and discuss both conventional and novel methods of diagnosis with reference to their specificity and sensitivity. The potential role of biomarkers in periodontal diagnosis is then presented in the light of the published data. The biological samples in which potential biomarkers are sought are evaluated comparatively, drawing attention to their strengths and weaknesses, and the available technologies for biomarker studies are reviewed. The potential benefits of biomarkers are also discussed with regard to the possible bidirectional interactions between periodontal diseases and systemic health. Finally, the past, present, and future of periodontics are examined from a broader perspective. Readers will find the book to be an ideal summary of the state of the art in the field as biomarkers emerge that promise to facilitate periodontal diagnostics and permit timely, personally tailored interventions.
Author: Nurcan Buduneli
Publisher: Springer
ISBN: 9783030373153
Category : Medical
Languages : en
Pages : 0
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Book Description
This book examines all aspects of the progress being made towards the development of highly specific and sensitive biomarkers that will overcome the shortcomings of clinical assessments in periodontics. The opening chapters present the basic anatomic features of periodontal tissues, outline the nature and pathogenic mechanisms of periodontal diseases, and discuss both conventional and novel methods of diagnosis with reference to their specificity and sensitivity. The potential role of biomarkers in periodontal diagnosis is then presented in the light of the published data. The biological samples in which potential biomarkers are sought are evaluated comparatively, drawing attention to their strengths and weaknesses, and the available technologies for biomarker studies are reviewed. The potential benefits of biomarkers are also discussed with regard to the possible bidirectional interactions between periodontal diseases and systemic health. Finally, the past, present, and future of periodontics are examined from a broader perspective. Readers will find the book to be an ideal summary of the state of the art in the field as biomarkers emerge that promise to facilitate periodontal diagnostics and permit timely, personally tailored interventions.
Author: Ulvi Kahraman Gürsoy
Publisher: Frontiers Media SA
ISBN: 2889451240
Category :
Languages : en
Pages : 107
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Book Description
Periodontitis is an infection-induced inflammatory disease of the tooth supporting tissues. Treatment of periodontal diseases and regeneration of the effected tissues can be possible only in the early diagnosis of the disease. If left undiagnosed or untreated, periodontitis leads to irreversible soft and hard tissue destruction and finally to tooth loss. Saliva is known to contain inflammatory mediators, host tissue and cell degradation products as well as microbial metabolites and enzymes, reflecting the health status of the oral cavity. In this topic, in collaboration with the well-known scientists working on the field of salivary diagnostics, we demonstrate evidence on monitoring periodontitis by salivary analysis.
Author: Afaf Zia
Publisher: LAP Lambert Academic Publishing
ISBN: 9783848480678
Category :
Languages : de
Pages : 132
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Book Description
Periodontitis is a disease characterized by loss of connective tissue attachment and bone around the teeth in conjunction with the formation of periodontal pockets due to the apical migration of the junctional epithelium.Early diagnosis and treatment of progressive periodontitis is important because of the irreversible nature of this disease. Traditional clinical measurements used for periodontal diagnosis are often of limited usefulness in that they are indicators of previous periodontal disease rather than present disease activity. There is a need for development of new diagnostic tests that can detect the presence of active disease, predict future disease progression and evaluate the response to periodontal therapy, thereby improving the clinical management of periodontal patients. This book discusses the role of oral bio-markers in the diagnosis and progression of periodontal disease and describes the role of GCF -Glucuronidase levels as a diagnostic tool and measure of treatment outcome in patients with chronic periodontitis."
Author: Nurcan Buduneli
Publisher: Springer Nature
ISBN: 3030373177
Category : Medical
Languages : en
Pages : 90
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Book Description
This book examines all aspects of the progress being made towards the development of highly specific and sensitive biomarkers that will overcome the shortcomings of clinical assessments in periodontics. The opening chapters present the basic anatomic features of periodontal tissues, outline the nature and pathogenic mechanisms of periodontal diseases, and discuss both conventional and novel methods of diagnosis with reference to their specificity and sensitivity. The potential role of biomarkers in periodontal diagnosis is then presented in the light of the published data. The biological samples in which potential biomarkers are sought are evaluated comparatively, drawing attention to their strengths and weaknesses, and the available technologies for biomarker studies are reviewed. The potential benefits of biomarkers are also discussed with regard to the possible bidirectional interactions between periodontal diseases and systemic health. Finally, the past, present, and future of periodontics are examined from a broader perspective. Readers will find the book to be an ideal summary of the state of the art in the field as biomarkers emerge that promise to facilitate periodontal diagnostics and permit timely, personally tailored interventions.
Author: David Wong
Publisher: Wiley-Blackwell
ISBN:
Category : Medical
Languages : en
Pages : 330
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Book Description
'Salivary Diagnostics' describes the nature of saliva and the basis for its usefulness as a diagnostic fluid. It then surveys and reviews the field of research, moving on to detail the development of technologies and the deciphering of the human salivary proteome.
Author:
Publisher: BoD – Books on Demand
ISBN: 1789844606
Category : Medical
Languages : en
Pages : 100
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Book Description
This book aims to provide readers with the latest updates and an informative overview of the most successful diagnostic aids for periodontal diseases. This book is divided into three sections. Section 1 discusses the periodontal disease pathogenesis and how the disease develops and the contributing factors in disease development. Section 2 includes three chapters that focus mainly on the most common and recent biomarkers that aid in diagnosis of periodontal diseases. Section 3 includes one chapter and discusses a non-surgical treatment modality that could provide definite improvement in the mild to moderate conditions in periodontal diseases.
Author: Mona Dagar
Publisher: LAP Lambert Academic Publishing
ISBN: 9783659193149
Category :
Languages : en
Pages : 88
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Book Description
Periodontitis is an inflammatory condition of the supporting tissues of the teeth. Intracellular enzymes are increasingly released from the damaged cells of periodontal tissues into the gingival crevicular fluid and saliva. It has been a great challenge to determine biomarkers for screening and predicting the early onset of disease (prognostic tests) or evaluating the disease activity and the efficacy of therapy.Various enzymes evaluated for the early diagnosis of periodontal disease are aspartate and alanine aminotransferases ( AST, ALT ), lactate dehydrogenase ( LDH ), creatine kinase ( CK ), alkaline and acid phosphatase ( ALP, ACP ) and gamma glutamiltransferase ( GGT ), myeloperoxidase ( MPO ). The activities of CK, LDH, AST, ALT, GGT, ALP, ACP, MPO, enzymes are found to be increased in periodontal diseases. Thus, an attempt has been made to review the diagnostic value of salivary enzymes in the diagnosis and progression of periodontal disease.
Author: Rajveer Kaur
Publisher: LAP Lambert Academic Publishing
ISBN: 9783659121982
Category :
Languages : en
Pages : 168
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Book Description
Periodontitis is a disease characterized by loss of connective tissue attachment and bone around the teeth in conjunction with the formation of periodontal pockets due to the apical migration of the junctional epithelium. Early diagnosis and treatment of progressive periodontitis is important because of the irreversible nature of this disease. Clinical measurements used in diagnosis of periodontal diseases are often of limited usefulness in that they are indications of previous periodontal disease rather than the present disease activity. Diagnostic biomarkers in oral fluids like saliva and gingival crevicular fluid (GCF) are highly beneficial in the determination of current periodontal status. These substances known as biomarkers help in determination of inflammatory mediator levels.
Author: Tonnie Kituku Mulli
Publisher:
ISBN:
Category : Biochemical markers
Languages : en
Pages : 544
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Book Description
Introduction: The aim of the study was to investigate novel biomarkers of periodontal disease present in GCF and saliva. -- Methods: The identities of specific putative biomarkers identified by SELDI-TOF MS were confirmed using 1-D PAGE coupled with LC-MS/MS. These biomarkers were then tested using ELISA in the samples that had been initially screened using SELDI-TOF MS as well as in saliva samples in an independent cohort selected according to diabetic status rather than periodontal status. The effect of non-surgical periodontal therapy, diabetes, saliva sample collection method, eating, time of day, day of the week and storage conditions on the salivary concentration of human neutrophil peptide 1-3 (HNP 1-3), cathelicidin LL-37 and protein S100A8 were tested. Copy number variation for HNP 1-3 gene, DEFA1A3 was tested in an independent cohort and the data analysed for association with presence and degree of periodontal disease. -- Results: Antimicrobial peptides, HNP 1-3, LL-37 and S100A8 were identified. GCF and salivary HNP 1-3 and LL-37 concentrations were significantly elevated in periodontitis than in gingivitis or health. LL-37 was significantly elevated in aggressive periodontitis (AgP) compared with chronic periodontitis (CP) and gingivitis/health. Periodontal therapy reduced the salivary levels of HNP 1-3. Diabetes, eating and day of week had no significant effect on AMP levels. Saliva collection using spitting method yielded significantly more AMPs than using Salivettes®. Sample collection at 16:00 hours yielded significantly higher amounts of AMPs than samples collected at other times. Sample storage at room temperature (RT) for up to 48 hours had no significant impact on the salivary HNP 1-3 and LL-37 concentration while a proteinase inhibitor did not did improve the recovery of the AMPs after 72 hours.
Author: Pachiappan Arjunan
Publisher: BoD – Books on Demand
ISBN: 9535136054
Category : Medical
Languages : en
Pages : 200
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Book Description
Periodontitis - A Useful Reference is a comprehensive book compiled by a team of experts with the objective of providing an overview of the basic pathology of "periodontitis" and its implication on oral health and general systemic health. Periodontitis has become a global health burden in recent days. It is noteworthy that oral health is being considered as the mirror of general health and the study of oral-systemic health connections has advanced among scientists, clinicians, and the public as well. We wish the array of chapters that highlights the importance and impact of periodontal health could be a useful guide for the community of public, students, and clinicians.
