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Author: Marie-Claude Potier
Publisher: Frontiers Media SA
ISBN: 2889450457
Category :
Languages : en
Pages : 183
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Book Description
Research on the multiple aspects of cognitive impairment in Down syndrome (DS), from genes to behavior to treatment, has made tremendous progress in the last decade. The study of congenital intellectual disabilities such as DS is challenging since they originate from the earliest stages of development and both the acquisition of cognitive skills and neurodegenerative pathologies are cumulative. Comorbidities such as cardiac malformations, sleep apnea, diabetes and dementia are frequent in the DS population, as well, and their increased risk provides a means of assessing early stages of these pathologies that is relevant to the general population. Notably, persons with DS will develop the histopathology of Alzheimer’s disease (formation of neuritic plaques and tangles) and are at high risk for dementia, something that cannot be predicted in the population at large. Identification of the gene encoding the amyloid precursor protein, its localization to chromosome 21 in the 90’s and realization that all persons with DS develop pathology identified this as an important piece of the amyloid cascade hypothesis in Alzheimer’s disease. Awareness of the potential role of people with DS in understanding progression and treatment as well as identification of genetic risk factors and also protective factors for AD is reawakening. For the first time since DS was recognized, major pharmaceutical companies have entered the search for ameliorative treatments, and phase II clinical trials to improve learning and memory are in progress. Enriched environment, brain stimulation and alternative therapies are being tested while clinical assessment is improving, thus increasing the chances of success for therapeutic interventions. Researchers and clinicians are actively pursuing the possibility of prenatal treatments for many conditions, an area with a huge potential impact for developmental disorders such as DS. Our goal here is to present an overview of recent advances with an emphasis on behavioral and cognitive deficits and how these issues change through life in DS. The relevance of comorbidities to the end phenotypes described and relevance of pharmacological targets and possible treatments will be considerations throughout.
Author: Marie-Claude Potier
Publisher: Frontiers Media SA
ISBN: 2889450457
Category :
Languages : en
Pages : 183
Get Book Here
Book Description
Research on the multiple aspects of cognitive impairment in Down syndrome (DS), from genes to behavior to treatment, has made tremendous progress in the last decade. The study of congenital intellectual disabilities such as DS is challenging since they originate from the earliest stages of development and both the acquisition of cognitive skills and neurodegenerative pathologies are cumulative. Comorbidities such as cardiac malformations, sleep apnea, diabetes and dementia are frequent in the DS population, as well, and their increased risk provides a means of assessing early stages of these pathologies that is relevant to the general population. Notably, persons with DS will develop the histopathology of Alzheimer’s disease (formation of neuritic plaques and tangles) and are at high risk for dementia, something that cannot be predicted in the population at large. Identification of the gene encoding the amyloid precursor protein, its localization to chromosome 21 in the 90’s and realization that all persons with DS develop pathology identified this as an important piece of the amyloid cascade hypothesis in Alzheimer’s disease. Awareness of the potential role of people with DS in understanding progression and treatment as well as identification of genetic risk factors and also protective factors for AD is reawakening. For the first time since DS was recognized, major pharmaceutical companies have entered the search for ameliorative treatments, and phase II clinical trials to improve learning and memory are in progress. Enriched environment, brain stimulation and alternative therapies are being tested while clinical assessment is improving, thus increasing the chances of success for therapeutic interventions. Researchers and clinicians are actively pursuing the possibility of prenatal treatments for many conditions, an area with a huge potential impact for developmental disorders such as DS. Our goal here is to present an overview of recent advances with an emphasis on behavioral and cognitive deficits and how these issues change through life in DS. The relevance of comorbidities to the end phenotypes described and relevance of pharmacological targets and possible treatments will be considerations throughout.
Author: Susan E. Gathercole
Publisher: Psychology Press
ISBN: 1317775287
Category : Psychology
Languages : en
Pages : 281
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Book Description
This book evaluates the involvement of working memory in five central aspects of language processing: vocabulary acquisition, speech production, reading development, skilled reading, and comprehension. The authors draw upon experimental, neuropsychological and developmental evidence in a wide-ranging evaluation of the contribution of two components of working memory to each aspect of language. The two components are the phonological loop, which is specialised for the processing and maintenance of verbal material, and the general-purpose processing system of the central executive. A full introduction to the application of the working memory model to normal adults, neuropsychological patients and children is provided in the two opening chapters. Non-experts within this area will find these chapters particularly useful in providing a clear statement of the current theoretical and empirical status of the working memory model. Each of the following chapters examines the involvement of working memory in one specialised aspect of language processing, in each case integrating the available experimental, neuropsychological and developmental evidence. The book will therefore be of direct relevance to researchers interested in both language processing and memory. Working Memory and Language is unique in that it draws together findings from normal adults, brain-damaged patients, and children. For each of these populations, working memory involvement in language processing ranging from the speech production to comprehension are evaluated. Working Memory and Language provides a comprehensive analysis of just what roles working memory does play in the processing of language.
Author: Sue Buckley
Publisher: Frontiers Media SA
ISBN: 2832542859
Category : Science
Languages : en
Pages : 160
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Book Description
Author: Pasquale J. Accardo
Publisher: Brookes Publishing Company
ISBN:
Category : Medical
Languages : en
Pages : 140
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Book Description
Created for use in clinical settings, The Capute Scales are effective both as a screener for general practitioners and as an assessment tool for specialists such as developmental pediatricians, speech-language pathologists, and occupational therapists. With its high correlation with the Bayley Scales of Infant Development, this standardized instrument will assist clinicians in making developmental diagnoses, counseling families, and guiding them to appropriate intervention services. The Capute Scales Manual includes an explanation of the scales' development, guidelines on administration and scoring, an overview of clinical and research use, and information on standardization of the scales and their use in other languages. Available in other languages! Spanish and Russian translations of The Capute Scales are included in the manual, and work on other translations is ongoing. This manual is part of The Capute Scales, a norm-referenced, 100-item screening and assessment tool that helps experienced practitioners identify developmental delays in children from 1-36 months of age. Developed by Arnold J. Capute, the founding father of neurodevelopmental pediatrics, this reliable, easy-to-administer tool was tested and refined at the Kennedy Krieger Institute for more than 30 years. Learn more about The Capute Scales.
Author: Dante Cicchetti
Publisher: Cambridge University Press
ISBN: 9780521386678
Category : Medical
Languages : en
Pages : 492
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Book Description
This volume offers a state-of-art review of what is known about young children with Down syndrome from a developmental perspective. The underlying theme of the book is that children with Down syndrome, despite their constitutional anomalies and their additional medical and biological problems, can be understood from a normative developmental framework. Interventions guided by developmental principles in the biological, educational and psychological realms are more likely to result in informed knowledge about how best to help children with Down syndrome and their families. Children with Down Syndrome will appeal to researchers, theoreticians, educators, and clinicians in a range of disciplines, as well as to parents, social policymakers, and other advocates for the best interests of children with Down syndrome.
Author: Lucy Henry
Publisher: SAGE
ISBN: 1446254194
Category : Psychology
Languages : en
Pages : 393
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Book Description
Using the highly influential working memory framework as a guide, this textbook provides a clear comparison of the memory development of typically developing children with that of atypical children. The emphasis on explaining methodology throughout the book gives students a real understanding about the way experiments are carried out and how to critically evaluate experimental research. The first half of the book describes the working memory model and goes on to consider working memory development in typically developing children. The second half of the book considers working memory development in several different types of atypical populations who have intellectual disabilities and/or developmental disorders. In addition, the book considers how having a developmental disorder and/or intellectual disabilities may have separate or combined effects on the development of working memory. The Development of Working Memory in Children is for undergraduate and postgraduate students taking courses in development/child psychology, cognitive development and developmental disorders.
Author: Sue Buckley
Publisher: DSE Enterprises
ISBN: 190380602X
Category : Children with disabilities
Languages : en
Pages : 46
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Book Description
Offers an introduction to the development of infants with Down syndrome. Drawing on the research, this book examines many aspects of development during the early years, and is a useful reference for families and professionals caring for young children with Down syndrome.
Author: Charles Hulme
Publisher: Psychology Press
ISBN: 1317748425
Category : Psychology
Languages : en
Pages : 148
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Book Description
"Working memory" is a term used to refer to the systems responsible for the temporary storage of information during the performance of cognitive tasks. The efficiency of working memory skills in children may place limitations on the learning and performance of educationally important skills such as reading, language comprehension and arithmetic. Originally published in 1992, this monograph considers the development of working memory skills in children with severe learning difficulties. These children have marked difficulties with a wide range of cognitive tasks. The studies reported show that they also experience profound difficulties in verbal working memory tasks. These memory problems are associated with a failure to rehearse information within an articulatory loop. Training the children to rehearse material is shown to help alleviate these problems. The implications of these studies for understanding normal memory development, and for models of the structure of working memory and its development are discussed. It is argued that the working memory deficits seen in people with severe learning difficulties may contribute to their difficulties on other cognitive tasks.
Author: Barbara A. Wilson
Publisher:
ISBN:
Category : Memory
Languages : en
Pages : 0
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Book Description
Author: Elisabeth M. Dykens
Publisher: Brookes Publishing Company
ISBN:
Category : Education
Languages : en
Pages : 348
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Book Description
This book discusses in detail the genetic causes and implications, prevalence, physical characteristics, cognitive profiles, speech and language, medical complications, and behaviors of four major syndromes (Down, Williams, fragile X, and Prader-Willi) an
