Integrating Liquid Chromatography and Surface-enhanced Raman Scattering in a Microfluidic Platform PDF Download
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Author: 王怡穎
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: 王怡穎
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 131
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Book Description
The arena of microfluidics ([micro]fluidics) has grown over the past decade to encompass myriad separation techniques and exploit copious detection modes. The direct integration of a vibrational spectroscopic detection technique, rich with structural information, onto a platform that is portable and potentially highly controllable such as [micro]fluidics, could offer redress for some of the problems inherent in many of the electrophoretically driven separations carried out on said devices. Herein, this direct integration is explored, and methods of device fabrication, spectroscopic data collection conditions, analytical figures of merit of the detection technique, and separations method development results are discussed. The creation of surface enhanced Raman scattering/spectroscopy (SERS) substrates within the architecture of miniaturized separation devices made of glass, polymer, silicon, and combinations thereof represents not only a novel and useful detection tool for [micro]fluidics but also a facile means of interrogating new, optimized SERS substrates for increased enhancement activity with low-volume fluidic delivery. Finally, the contemporary, ʺreal-worldʺ relevance of the development of [micro]fluidic-SERS comes to light with preliminary studies of aflatoxins, a fungal byproduct contaminating foodstuffs and a threat from both an agribusiness and a Homeland Security standpoint, and, even more important, endocrine disrupting chemicals, a wide class of ubiquitous pollutants that act both as acute teratogens and, in the long term, as potent carcinogens.
Author: Zhong-Qun Tian
Publisher: John Wiley & Sons Incorporated
ISBN: 9780470068083
Category : Science
Languages : en
Pages : 400
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Book Description
Surface-Enhanced Raman Spectroscopy: Principles, Experiments, and Applications is a comprehensive, up to date, and balanced treatment of the theoretical and practical aspects of Surface-Enhanced Raman Scattering (SERS), a useful branch of spectroscopy for several areas of science. This book describes the basic principles of SERS, including SERS mechanisms, performing SERS measurements, and interpreting data. Also emphasized are applications in electrochemistry; catalysis; surface processing and corrosion; Self-Assemble-Layer and L-B Films; polymer science; biology; medicine and drug analysis; sensors; fuel cells; forensics; and archaeology. It is an essential guide for student and professional analytical chemists.
Author: Betsy Jean Yakes
Publisher:
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Category :
Languages : en
Pages :
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Author:
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Category :
Languages : en
Pages : 44
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Author: 林上竣
Publisher:
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Category :
Languages : en
Pages :
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Author: Yu-Han Ho
Publisher:
ISBN:
Category :
Languages : en
Pages : 45
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Book Description
Surface-enhanced Raman spectroscopy (SERS) has immerged as a power analytical and sensing technique for many applications in biomedical diagnosis, life sciences, food safety, and environment monitoring because of its molecular specificity and high sensitivity. The inactive Raman scattering of water molecule makes SERS a suitable tool for studying biological systems. Microfluidic devices have also attracted a tremendous interest for the aforementioned applications. By integrating SERS-active substrates with microfluidic devices, it offers a new capability for in situ investigation of biological systems, their dynamic behaviors, and response to drugs or microenvironment changes. In this work, we designed and fabricated a microfluidic device with SERS-active substrates surrounding by cell traps in microfluidic channels for in situ study of live cells using SERS. The SERS-active substrates are quasi-3D plasmonic nanostructure array (Q3D-PNA) made in h-PDMS/PMDS with physically separated gold film with nanoholes op top and gold nanodisks at the bottom of nanowells. The Q3D-PNAs with the strongest local electric fields (hot spots) at the top and bottom water/Au interfaces, designed by 3D finite-difference time-domain (3D-FDTD) electromagnetic simulations, were placed at the up and down stream of the microfluidic channel for sensitive analysis of cells and small components, respectively. The microfluidic device was fabricated via soft lithography. We demonstrated that normal (COS-7) and cancer (HpeG2) cells were captured on the Q3D-PNAs and investigated in situ using SERS.
Author: Anh H. Nguyen
Publisher:
ISBN:
Category :
Languages : en
Pages : 185
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Author: Xingyu Jiang
Publisher: John Wiley & Sons
ISBN: 3527345337
Category : Technology & Engineering
Languages : en
Pages : 444
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Book Description
The book focuses on microfluidics with applications in nanotechnology. The first part summarizes the recent advances and achievements in the field of microfluidic technology, with emphasize on the the influence of nanotechnology. The second part introduces various applications of microfluidics in nanotechnology, such as drug delivery, tissue engineering and biomedical diagnosis.
Author: Jing Ni
Publisher:
ISBN:
Category :
Languages : en
Pages : 322
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Book Description
The second direction explores the surface enhanced Raman spectroscopy (SERS) as a signal transduction method for immunoassay analysis. It takes advantage of the improved detection sensitivity as a result of surface enhancement on colloidal gold, the narrow width of Raman band, and the stability of Raman scattering signals to distinguish several different species simultaneously without exploiting spatially-separated addresses on a biochip. By labeling gold nanoparticles with different Raman reporters in conjunction with different detection antibodies, a simultaneous detection of a dual-analyte immunoassay was demonstrated. Using this scheme for quantitative analysis was also studied and preliminary dose-response curves from an immunoassay of a model antigen were obtained. Simultaneous detection of several analytes at the same address can potentially increase the analysis speed, and can further expand the analysis capability of a microarray chip.
