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Author: Aoife McLysaght
Publisher: Springer
ISBN: 3540318143
Category : Science
Languages : en
Pages : 175
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Book Description
This volume contains the papers presented at the 3rd RECOMB Comparative Genomics meeting, which was held in Dublin, Ireland, on September 18–20, 2005.
Author: Aoife McLysaght
Publisher: Springer
ISBN: 3540318143
Category : Science
Languages : en
Pages : 175
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Book Description
This volume contains the papers presented at the 3rd RECOMB Comparative Genomics meeting, which was held in Dublin, Ireland, on September 18–20, 2005.
Author: Konstantinos Papadimitriou
Publisher: Frontiers Media SA
ISBN: 2889637174
Category : Medical
Languages : en
Pages : 309
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Book Description
The economic importance of lactic acid bacteria (LAB) for the food industry and their implication in health and disease has rendered them attractive models for research in many laboratories around the world. Over the past three decades, molecular and genetic analysis of LAB species provided important insights into the biology and application of starter and probiotic LAB and in the virulence of LAB pathogens. The knowledge obtained prepared LAB researchers for the forthcoming opportunities provided by the advent of microbial genomics. Today, developments in next-generation sequencing technologies have rocketed LAB genome research and the sequences of several hundreds of strains are available. This flood of information has revolutionized our view of LAB. First of all, a detailed picture has emerged about the evolutionary mechanisms allowing LAB to inhabit the very diverge ecological niches in which they can be found. Adaptation of LAB to nutrient-rich environments has led to degenerative evolution processes that resulted in shortening of chromosomes and simplified metabolic potential. Gene acquisition through horizontal transfer, on the other hand, is also important in shaping LAB gene pools. Horizontally acquired genes have been shown to be essential in technological properties of starters and in probiosis or virulence of commensals. Progress in bioinformatics tools has allowed rapid annotation of LAB genomes and the direct assignment of genetic traits among species/strains through comparative genomics. In this way, the molecular basis of many important traits of LAB has been elucidated, including aspects of sugar fermentation, flavor and odor formation, production of textural substances, stress responses, colonization of and survival in the host, cell-tocell interactions and pathogenicity. Functional genomics and proteomics have been employed in a number of instances to support in silico predictions. Given that the costs of advanced next-generation methodologies like RNA-seq are dropping fast, bottlenecks in the in silico characterization of LAB genomes will be rapidly overcome. Another crucial advancement in LAB research is the application of systems biology approaches, by which the properties and interactions of components or parts of a biological system are investigated to accurately understand or predict LAB behavior. Practically, systems biology involves the mathematical modeling of complex biological systems that can be refined iteratively with wet-lab experiments. High-throughput experimentation generating huge amounts of data on the properties and quantities of many components such as transcripts, enzymes and metabolites has resulted in several systems models of LAB. Novel techniques allow modelling of additional levels of complexity including the function of small RNAs, structural features of RNA molecules and post-translational modifications. In addition, researchers have started to apply systems approaches in the framework of LAB multispecies ecosystems in which each species or strain is considered as a part of the system. Metatransciptomics, metaproteomics and metametabolomics offer the means to combine cellular behavior with population dynamics in microbial consortia.
Author: Rajeev K. Azad
Publisher: Springer Nature
ISBN: 1071638866
Category :
Languages : en
Pages : 392
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Book Description
Author: Mohammad "Sufian" Badar
Publisher: Springer Nature
ISBN: 3031222067
Category : Science
Languages : en
Pages : 273
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Book Description
This textbook is an introductory guide to applied machine learning, specifically for biology students. It familiarizes biology students with the basics of modern computer science and mathematics and emphasizes the real-world applications of these subjects. The chapters give an overview of computer systems and programming languages to establish a basic understanding of the important concepts in computer systems. Readers are introduced to machine learning and artificial intelligence in the field of bioinformatics, connecting these applications to systems biology, biological data analysis and predictions, and healthcare diagnosis and treatment. This book offers a necessary foundation for more advanced computer-based technologies used in biology, employing case studies, real-world issues, and various examples to guide the reader from the basic prerequisites to machine learning and its applications.
Author: Hervé Tettelin
Publisher: Springer Nature
ISBN: 3030382818
Category : Science
Languages : en
Pages : 311
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Book Description
This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The book’s respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.
Author: Abhishek Kumar
Publisher: CRC Press
ISBN: 1000539970
Category : Computers
Languages : en
Pages : 241
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Book Description
In the last two decades, machine learning has developed dramatically and is still experiencing a fast and everlasting change in paradigms, methodology, applications and other aspects. This book offers a compendium of current and emerging machine learning paradigms in healthcare informatics and reflects on their diversity and complexity. Machine Learning Approaches and Applications in Applied Intelligence for Healthcare Data Analytics presents a variety of techniques designed to enhance and empower multi-disciplinary and multi-institutional machine learning research. It provides many case studies and a panoramic view of data and machine learning techniques, providing the opportunity for novel insights and discoveries. The book explores the theory and practical applications in healthcare and includes a guided tour of machine learning algorithms, architecture design and interdisciplinary challenges. This book is useful for research scholars and students involved in critical condition analysis and computation models.
Author: Laxmi Parida
Publisher: CRC Press
ISBN: 1420010735
Category : Computers
Languages : en
Pages : 512
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Book Description
The computational methods of bioinformatics are being used more and more to process the large volume of current biological data. Promoting an understanding of the underlying biology that produces this data, Pattern Discovery in Bioinformatics: Theory and Algorithms provides the tools to study regularities in biological data. Taking a systema
Author: Kenneth M. Weiss
Publisher: Cambridge University Press
ISBN: 9780521336604
Category : Medical
Languages : en
Pages : 384
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Book Description
Recent developments in molecular and computational methods have made it possible to identify the genetic basis of any biological trait, and have led to spectacular advances in the study of human disease. This book provides an overview of the concepts and methods needed to understand the genetic basis of biological traits, including disease, in humans. Using examples of qualitative and quantitative phenotypes, Professor Weiss shows how genetic variation may be quantified, and how relationships between genotype and phenotype may be inferred. This book will appeal to many biologists and biological anthropologists interested in the genetic basis of biological traits, as well as to epidemiologists, biomedical scientists, human geneticists and molecular biologists.
Author: Marzena Kryszkiewicz
Publisher: Springer
ISBN: 3319087290
Category : Computers
Languages : en
Pages : 408
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Book Description
This book constitutes the refereed proceedings of the 23rd Australasian Joint Conference on Rough Sets and Intelligent Systems Paradigms, RSEISP 2014, held in Granada and Madrid, Spain, in July 2014. RSEISP 2014 was held along with the 9th International Conference on Rough Sets and Current Trends in Computing, RSCTC 2014, as a major part of the 2014 Joint Rough Set Symposium, JRS 2014. JRS 2014 received 40 revised full papers and 37 revised short papers which were carefully reviewed and selected from 120 submissions and presented in two volumes. This volume contains the papers accepted for the conference RSEISP 2014, as well as the three invited papers presented at the conference. The papers are organized in topical sections on plenary lecture and tutorial papers; foundations of rough set theory; granular computing and covering-based rough sets; applications of rough sets; induction of decision rules - theory and practice; knowledge discovery; spatial data analysis and spatial databases; information extraction from images.
Author: Chao Xu
Publisher: Frontiers Media SA
ISBN: 2889714365
Category : Science
Languages : en
Pages : 136
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Book Description
