Fifty Years of Genetic Load

Fifty Years of Genetic Load PDF Author: Bruce Wallace
Publisher:
ISBN:
Category : Biography & Autobiography
Languages : en
Pages : 202

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Book Description
In this personal history, one of the pioneers in population genetics recounts the evolution of his ideas about the effects of genetic variability on a population. Tracing the results of successive experiments over the years, it is, like the author's career, highly original.

Fifty Years of Genetic Load

Fifty Years of Genetic Load PDF Author: Bruce Wallace
Publisher:
ISBN:
Category : Biography & Autobiography
Languages : en
Pages : 202

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Book Description
In this personal history, one of the pioneers in population genetics recounts the evolution of his ideas about the effects of genetic variability on a population. Tracing the results of successive experiments over the years, it is, like the author's career, highly original.

Genome Chaos

Genome Chaos PDF Author: Henry H. Heng
Publisher: Academic Press
ISBN: 0128136367
Category : Medical
Languages : en
Pages : 564

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Book Description
Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine transports readers from Mendelian Genetics to 4D-genomics, building a case for genes and genomes as distinct biological entities, and positing that the genome, rather than individual genes, defines system inheritance and represents a clear unit of selection for macro-evolution. In authoring this thought-provoking text, Dr. Heng invigorates fresh discussions in genome theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine. - Bridges basic research and clinical application and provides a foundation for re-examining the results of large-scale omics studies and advancing molecular medicine - Gathers the most pressing questions in genomic and cytogenomic research - Offers alternative explanations to timely puzzles in the field - Contains eight evidence-based chapters that discuss 4d-genomics, genes and genomes as distinct biological entities, genome chaos and macro-cellular evolution, evolutionary cytogenetics and cancer, chromosomal coding and fuzzy inheritance, and more

Selected Genetic Papers of J. B. S. Haldane (Routledge Revivals)

Selected Genetic Papers of J. B. S. Haldane (Routledge Revivals) PDF Author: John Burdon Sanderson Haldane
Publisher:
ISBN: 9781138783379
Category : Evolution
Languages : en
Pages : 0

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Book Description
First published in 1990, this is a compilation of several important papers that have contributed to the foundation of population genetics, evolutionary biology and human genetics. The collection includes Haldane's first paper in genetics, which was published in 1915, reporting the first case of linkage in a mammal, and - fifty years later, in 1965 - his last paper in genetics on selection for a single pair of allelomorphs with complete replacement. Haldane's Rule, the only idea named after him, was published in 1922 and is still valid today. Other papers, which include many Haldane firsts, such as the first estimation of a human mutation rate, first human gene map, first papers in population genetics, first estimate of the probability of fixation of a new mutation, and first measurement of mutation impact on a population, leading to the "genetic load" concept, are included. The volume also includes a paper presenting an ancient logical system for interpreting scientific results.

Current Catalog

Current Catalog PDF Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 690

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Book Description
First multi-year cumulation covers six years: 1965-70.

Population Genetics

Population Genetics PDF Author: John H. Gillespie
Publisher: JHU Press
ISBN: 0801880084
Category : Medical
Languages : en
Pages : 270

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Book Description
Publisher Description

Variation and Evolution in Plants and Microorganisms

Variation and Evolution in Plants and Microorganisms PDF Author: National Academy of Sciences
Publisher: National Academies Press
ISBN: 0309172268
Category : Science
Languages : en
Pages : 353

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Book Description
"The present book is intended as a progress report on [the] synthetic approach to evolution as it applies to the plant kingdom." With this simple statement, G. Ledyard Stebbins formulated the objectives of Variation and Evolution in Plants, published in 1950, setting forth for plants what became known as the "synthetic theory of evolution" or "the modern synthesis." The pervading conceit of the book was the molding of Darwin's evolution by natural selection within the framework of rapidly advancing genetic knowledge. At the time, Variation and Evolution in Plants significantly extended the scope of the science of plants. Plants, with their unique genetic, physiological, and evolutionary features, had all but been left completely out of the synthesis until that point. Fifty years later, the National Academy of Sciences convened a colloquium to update the advances made by Stebbins. This collection of 17 papers marks the 50th anniversary of the publication of Stebbins' classic. Organized into five sections, the book covers: early evolution and the origin of cells, virus and bacterial models, protoctist models, population variation, and trends and patterns in plant evolution.

Who We Are and How We Got Here

Who We Are and How We Got Here PDF Author: David Reich
Publisher: Oxford University Press
ISBN: 0192554387
Category : Science
Languages : en
Pages : 400

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Book Description
The past few years have seen a revolution in our ability to map whole genome DNA from ancient humans. With the ancient DNA revolution, combined with rapid genome mapping of present human populations, has come remarkable insights into our past. This important new data has clarified and added to our knowledge from archaeology and anthropology, helped resolve long-existing controversies, challenged long-held views, and thrown up some remarkable surprises. The emerging picture is one of many waves of ancient human migrations, so that all populations existing today are mixes of ancient ones, as well as in many cases carrying a genetic component from Neanderthals, and, in some populations, Denisovans. David Reich, whose team has been at the forefront of these discoveries, explains what the genetics is telling us about ourselves and our complex and often surprising ancestry. Gone are old ideas of any kind of racial 'purity', or even deep and ancient divides between peoples. Instead, we are finding a rich variety of mixtures. Reich describes the cutting-edge findings from the past few years, and also considers the sensitivities involved in tracing ancestry, with science sometimes jostling with politics and tradition. He brings an important wider message: that we should celebrate our rich diversity, and recognize that every one of us is the result of a long history of migration and intermixing of ancient peoples, which we carry as ghosts in our DNA. What will we discover next?

Perspectives on Genetics

Perspectives on Genetics PDF Author: James Franklin Crow
Publisher: Univ of Wisconsin Press
ISBN: 9780299166045
Category : Medical
Languages : en
Pages : 748

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Book Description
For more than ten years, the distinguished geneticists James F. Crow and William F. Dove have edited the popular "Perspectives" column in Genetics, the journal of the Genetics Society of America. This book, Perspectives on Genetics, collects more than 100 of these essays, which cumulatively are a history of modern genetics research and its continuing evolution.

Population Genetics

Population Genetics PDF Author: Matthew B. Hamilton
Publisher: John Wiley & Sons
ISBN: 1444362453
Category : Science
Languages : en
Pages : 658

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Book Description
This book aims to make population genetics approachable, logical and easily understood. To achieve these goals, the book’s design emphasizes well explained introductions to key principles and predictions. These are augmented with case studies as well as illustrations along with introductions to classical hypotheses and debates. Pedagogical features in the text include: Interact boxes that guide readers step-by-step through computer simulations using public domain software. Math boxes that fully explain mathematical derivations. Methods boxes that give insight into the use of actual genetic data. Numerous Problem boxes are integrated into the text to reinforce concepts as they are encountered. Dedicated website at www.wiley.com/go/hamiltongenetics This text also offers a highly accessible introduction to coalescent theory, the major conceptual advance in population genetics of the last two decades.

The Search for the Gene

The Search for the Gene PDF Author: Bruce Wallace
Publisher: Cornell University Press
ISBN: 1501717340
Category : Science
Languages : en
Pages : 237

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Book Description
From Gregor Mendel's experiments on garden peas to the mammoth Human Genome Project of today—how did we get where we are in the science of genetics? In this intriguing book, Bruce Wallace examines the concept of the gene and recounts the history of genetic research, providing a concise transition from genetics to modern molecular biology.