Fifty Years of Genetic Load

Fifty Years of Genetic Load PDF Author: Bruce Wallace
Publisher:
ISBN:
Category : Biography & Autobiography
Languages : en
Pages : 202

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Book Description
In this personal history, one of the pioneers in population genetics recounts the evolution of his ideas about the effects of genetic variability on a population. Tracing the results of successive experiments over the years, it is, like the author's career, highly original.

Fifty Years of Genetic Load

Fifty Years of Genetic Load PDF Author: Bruce Wallace
Publisher:
ISBN:
Category : Biography & Autobiography
Languages : en
Pages : 202

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Book Description
In this personal history, one of the pioneers in population genetics recounts the evolution of his ideas about the effects of genetic variability on a population. Tracing the results of successive experiments over the years, it is, like the author's career, highly original.

The Society of Genes

The Society of Genes PDF Author: Itai Yanai
Publisher: Harvard University Press
ISBN: 0674425022
Category : Science
Languages : en
Pages : 295

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Book Description
Nearly four decades ago Richard Dawkins published The Selfish Gene, famously reducing humans to “survival machines” whose sole purpose was to preserve “the selfish molecules known as genes.” How these selfish genes work together to construct the organism, however, remained a mystery. Standing atop a wealth of new research, The Society of Genes now provides a vision of how genes cooperate and compete in the struggle for life. Pioneers in the nascent field of systems biology, Itai Yanai and Martin Lercher present a compelling new framework to understand how the human genome evolved and why understanding the interactions among our genes shifts the basic paradigm of modern biology. Contrary to what Dawkins’s popular metaphor seems to imply, the genome is not made of individual genes that focus solely on their own survival. Instead, our genomes comprise a society of genes which, like human societies, is composed of members that form alliances and rivalries. In language accessible to lay readers, The Society of Genes uncovers genetic strategies of cooperation and competition at biological scales ranging from individual cells to entire species. It captures the way the genome works in cancer cells and Neanderthals, in sexual reproduction and the origin of life, always underscoring one critical point: that only by putting the interactions among genes at center stage can we appreciate the logic of life.

Current Catalog

Current Catalog PDF Author: National Library of Medicine (U.S.)
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 690

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Book Description
First multi-year cumulation covers six years: 1965-70.

Perspectives on Genetics

Perspectives on Genetics PDF Author: James Franklin Crow
Publisher: Univ of Wisconsin Press
ISBN: 9780299166045
Category : Medical
Languages : en
Pages : 748

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Book Description
For more than ten years, the distinguished geneticists James F. Crow and William F. Dove have edited the popular "Perspectives" column in Genetics, the journal of the Genetics Society of America. This book, Perspectives on Genetics, collects more than 100 of these essays, which cumulatively are a history of modern genetics research and its continuing evolution.

Population Genetics

Population Genetics PDF Author: Matthew B. Hamilton
Publisher: John Wiley & Sons
ISBN: 1444362453
Category : Science
Languages : en
Pages : 658

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Book Description
This book aims to make population genetics approachable, logical and easily understood. To achieve these goals, the book’s design emphasizes well explained introductions to key principles and predictions. These are augmented with case studies as well as illustrations along with introductions to classical hypotheses and debates. Pedagogical features in the text include: Interact boxes that guide readers step-by-step through computer simulations using public domain software. Math boxes that fully explain mathematical derivations. Methods boxes that give insight into the use of actual genetic data. Numerous Problem boxes are integrated into the text to reinforce concepts as they are encountered. Dedicated website at www.wiley.com/go/hamiltongenetics This text also offers a highly accessible introduction to coalescent theory, the major conceptual advance in population genetics of the last two decades.

The Neurobiological Basis of Suicide

The Neurobiological Basis of Suicide PDF Author: Yogesh Dwivedi
Publisher: CRC Press
ISBN: 143983881X
Category : Medical
Languages : en
Pages : 485

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Book Description
With recent studies using genetic, epigenetic, and other molecular and neurochemical approaches, a new era has begun in understanding pathophysiology of suicide. Emerging evidence suggests that neurobiological factors are not only critical in providing potential risk factors but also provide a promising approach to develop more effective treatment and prevention strategies. The Neurobiological Basis of Suicide discusses the most recent findings in suicide neurobiology. Psychological, psychosocial, and cultural factors are important in determining the risk factors for suicide; however, they offer weak prediction and can be of little clinical use. Interestingly, cognitive characteristics are different among depressed suicidal and depressed nonsuicidal subjects, and could be involved in the development of suicidal behavior. The characterization of the neurobiological basis of suicide is in delineating the risk factors associated with suicide. The Neurobiological Basis of Suicide focuses on how and why these neurobiological factors are crucial in the pathogenic mechanisms of suicidal behavior and how these findings can be transformed into potential therapeutic applications.

The Search for the Gene

The Search for the Gene PDF Author: Bruce Wallace
Publisher: Cornell University Press
ISBN: 1501717340
Category : Science
Languages : en
Pages : 237

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Book Description
From Gregor Mendel's experiments on garden peas to the mammoth Human Genome Project of today—how did we get where we are in the science of genetics? In this intriguing book, Bruce Wallace examines the concept of the gene and recounts the history of genetic research, providing a concise transition from genetics to modern molecular biology.

Conceptual Breakthroughs in Evolutionary Genetics

Conceptual Breakthroughs in Evolutionary Genetics PDF Author: John C. Avise
Publisher: Academic Press
ISBN: 0124202373
Category : Science
Languages : en
Pages : 185

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Book Description
Conceptual Breakthroughs in Evolutionary Genetics is a pithy, lively book occupying a special niche—the conceptual history of evolutionary genetics— not inhabited by any other available treatment. Written by a world-leading authority in evolutionary genetics, this work encapsulates and ranks 70 of the most significant paradigm shifts in evolutionary biology and genetics during the century-and-a-half since Darwin and Mendel. The science of evolutionary genetics is central to all of biology, but many students and other practitioners have little knowledge of its historical roots and conceptual developments. This book fills that knowledge gap in a thought-provoking and readable format. This fascinating chronological journey along the many conceptual pathways to our modern understanding of evolutionary and genetic principles is a wonderful springboard for discussions in undergraduate or graduate seminars in evolutionary biology and genetics. But more than that, anyone interested in the history and philosophy of science will find much of value between its covers. - Provides a relative ranking of 70 seminal breakthroughs and paradigm shifts in the field of evolutionary biology and genetics - Modular format permits ready access to each described subject - Historical overview of a field whose concepts are central to all of biology and relevant to a broad audience of biologists, science historians, and philosophers of science - Extensively cross-referenced with a guide to landmark papers and books for each topic

Evolutionary Biology

Evolutionary Biology PDF Author: Max K. Hecht
Publisher: Springer Science & Business Media
ISBN: 1489917519
Category : Science
Languages : en
Pages : 378

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Book Description
After volume 33, this book series was replaced by the journal "Evolutionary Biology." Please visit www.springer.com/11692 for further information. Volume 30 brings readers up to date on the investigation of eminent evolutionary biologists and paleobiologists. Contributions explore such topics as Adaptation in Drosophila and the role of cytochrome P450s Population genetics and species conservation of the cheetah germ-layer theory assymetry in the mammalian skeleton genetic diversity of marine fish the phenomenon of industrial melanism the variation in lizard cranal kinesis. Other chapters focus on such issues as overdominance and its relation to higher mutation-rate estimates and the use of molecular clocks in determining the rate of nucleotide substitution in higher plants.

A Dominant Character: How J. B. S. Haldane Transformed Genetics, Became a Communist, and Risked His Neck for Science

A Dominant Character: How J. B. S. Haldane Transformed Genetics, Became a Communist, and Risked His Neck for Science PDF Author: Samanth Subramanian
Publisher: W. W. Norton & Company
ISBN: 0393634256
Category : Biography & Autobiography
Languages : en
Pages : 475

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Book Description
One of the Wall Street Journal's 10 Best Books of 2020 One of the New York Times's 100 Notable Books of 2020 A biography of J. B. S. Haldane, the brilliant and eccentric British scientist whose innovative predictions inspired Aldous Huxley’s Brave New World. J. B. S. Haldane’s life was rich and strange, never short on genius or drama—from his boyhood apprenticeship to his scientist father, who first instilled in him a devotion to the scientific method; to his time in the trenches during the First World War, where he wrote his first scientific paper; to his numerous experiments on himself, including inhaling dangerous levels of carbon dioxide and drinking hydrochloric acid; to his clandestine research for the British Admiralty during the Second World War. He is best remembered as a geneticist who revolutionized our understanding of evolution, but his peers hailed him as a polymath. One student called him “the last man who might know all there was to be known.” He foresaw in vitro fertilization, peak oil, and the hydrogen fuel cell, and his contributions ranged over physiology, genetics, evolutionary biology, mathematics, and biostatistics. He was also a staunch Communist, which led him to Spain during the Civil War and sparked suspicions that he was spying for the Soviets. He wrote copiously on science and politics in newspapers and magazines, and he gave speeches in town halls and on the radio—all of which made him, in his day, as famous in Britain as Einstein. It is the duty of scientists to think politically, Haldane believed, and he sought not simply to tell his readers what to think but to show them how to think. Beautifully written and richly detailed, Samanth Subramanian’s A Dominant Character recounts Haldane’s boisterous life and examines the questions he raised about the intersections of genetics and politics—questions that resonate even more urgently today.