Environmental and Genetic Influences on the Life Span of Adult Drosophila Melanogaster PDF Download
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Author: Murray Dean Richter
Publisher:
ISBN:
Category : Longevity
Languages : en
Pages : 350
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Book Description
Author: Murray Dean Richter
Publisher:
ISBN:
Category : Longevity
Languages : en
Pages : 350
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Book Description
Author: Patricia Anne-Marie Zeemann
Publisher:
ISBN: 9780494389379
Category :
Languages : en
Pages : 204
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Book Description
Aging is a universal biological process that involves both environmental and genetic factors. Using single gene mutations and/or DNA microarray analyses several genes affecting lifespan have been identified in model organisms. The goal of my thesis was to use a proteomics based approach in Drosophila to identify proteins that were up-regulated during aging. I found that Turandots, a novel family of proteins previously implicated in stress response, were highly up-regulated during aging. To determine if Turandots play a direct role in aging/lifespan I used a combination of RT-PCR and western blot analysis to demonstrate that TurandotA was expressed in the nervous system. I also found that overexpression of TurandotA in the Drosophila nervous system increased lifespan and resistance to oxidative stress. Together, these studies demonstrate that proteomics can be used to identify genes implicated in organismal lifespan and demonstrate an essential role for Turandots in this process.
Author:
Publisher:
ISBN:
Category : Demography
Languages : en
Pages : 312
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Book Description
Author: Josh Dubnau
Publisher: Cambridge University Press
ISBN: 1107009030
Category : Medical
Languages : en
Pages : 309
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Book Description
A comprehensive portrayal of the behaviour genetics of the fruit fly (Drosophila melanogaster) and the methods used in these studies.
Author: Caleb E. Finch
Publisher:
ISBN:
Category : Health & Fitness
Languages : en
Pages : 304
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Book Description
Demographers and public health specialists have been surprised by the rapid increases in life expectancy, especially at the oldest ages, that have occurred since the early 1960s. Some scientists are calling into question the idea of a fixed upper limit for the human life span. There is new evidence about the genetic bases for both humans and other species. There are also new theories and models of the role of mutations accumulating over the life span and the possible evolutionary advantages of survival after the reproductive years. This volume deals with such diverse topics as the role of the elderly in other species and among human societies past and present, the contribution of evolutionary theory to our understanding of human longevity and intergenerational transfers, mathematical models for survival, and the potential for collecting genetic material in household surveys. It will be particularly valuable for promoting communication between the social and life sciences.
Author: Raymond Pearl
Publisher:
ISBN:
Category : Drosophila
Languages : en
Pages : 220
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Book Description
Author: Michael Robertson Rose
Publisher: World Scientific
ISBN: 9812387412
Category : Science
Languages : en
Pages : 495
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Book Description
Methuselah Flies presents a trailblazing project on the biology of aging. It describes research on the first organisms to have their lifespan increased, and their aging slowed, by hereditary manipulation. These organisms are fruit flies from the species Drosophila melanogaster, the great workhorse of genetics. Michael Rose and his colleagues have been able to double the lifespan of these insects, and improved their health in numerous respects as well. The study of these flies with postponed aging is one of the best means we have of understanding, and ultimately achieving, the postponement of aging in humans. As such, the carefully presented detail of this book will be of value to research devoted to the understanding and control of aging.Methuselah Flies: ? is a tightly edited distillation of twenty years of work by many scientists? contains the original publications regarding the longer-lived fruit flies? offers commentaries on each of the topics covered ? new, short essays that put the individual research papers in a wider context? gives full access to the original data ? captures the scientific significance of postponed aging for a wide academic audienc
Author: David E. Harrison
Publisher: CRC Press
ISBN: 9780936923314
Category : Medical
Languages : en
Pages : 612
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Book Description
This volume provides background knowledge useful to those setting out to do genetic studies of aging in mammals, and raises vital questions: How many genes are important in mammalian aging? What are the optimal methods for their study? To what degree are patterns of aging, and patterns of growth and development part of the same process? Do patterns of development predict subsequent patterns of growth and aging? Are there a few fundamental aging processes, or does every biological system age? The rapid rate of progress in this field required a new volume with a new approach, based on the combination of classical genetics and the powerful new tools of molecular genetics. Although mammalian systems are emphasized, representatives of the advanced genetic studies in Drosophila and other model systems are included. The purpose is to enrich and stimulate genetic studies of mammalian aging by suggesting and evaluating future possibilities.
Author: Bo Ebenman
Publisher: Springer Science & Business Media
ISBN: 3642740014
Category : Science
Languages : en
Pages : 288
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Book Description
At last both ecology and evolution are covered in this study on the dynamics of size-structured populations. How does natural selection shape growth patterns and life cycles of individuals, and hence the size-structure of populations? This book will stimulate biologists to look into some important and interesting biological problems from a new angle of approach, concerning: - life history evolution, - intraspecific competition and niche theory, - structure and dynamics of ecological communities.
Author: Anne Charmantier
Publisher: Oxford University Press
ISBN: 019967423X
Category : Medical
Languages : en
Pages : 293
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Book Description
This book gathers the expertise of 30 evolutionary biologists from around the globe to highlight how applying the field of quantitative genetics - the analysis of the genetic basis of complex traits - aids in the study of wild populations.
