Electrical Stimulation Enhances Cellular/Molecular Functions of Osteoblasts Relevant to New Bone Formation in Vitro PDF Download
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Languages : en
Pages : 0
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The static conditions conventionally used in tissue-culture do not represent the biophysical milieu of bone in vivo and, thus, leave cells without stimuli which may affect functions pertinent to new bone formation. Bone in vivo exists in a dynamic environment subject to various, such as mechanical and electrical stimulation, specifically, when applied to osteotomies created in animal models, resulted in accelerating healing of the damaged bone (Bassett et al., 1969; Black et al., 1986). These animal studies provided evidence that electrical stimulation promotes bones regeneration and became the impetus to investigate the effects of electrical stimulation at the cellular/molecular level. It is, therefore, our hypothesis that electrical stimulation enhances in vitro osteoblast functions that are pertinent to new bone formation. In addition, application of electrical stimulation to tissue engineering endeavors is one possible method to overcome the limitations inherent in new bone formation under static cell culture conditions.
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Languages : en
Pages : 0
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Book Description
The static conditions conventionally used in tissue-culture do not represent the biophysical milieu of bone in vivo and, thus, leave cells without stimuli which may affect functions pertinent to new bone formation. Bone in vivo exists in a dynamic environment subject to various, such as mechanical and electrical stimulation, specifically, when applied to osteotomies created in animal models, resulted in accelerating healing of the damaged bone (Bassett et al., 1969; Black et al., 1986). These animal studies provided evidence that electrical stimulation promotes bones regeneration and became the impetus to investigate the effects of electrical stimulation at the cellular/molecular level. It is, therefore, our hypothesis that electrical stimulation enhances in vitro osteoblast functions that are pertinent to new bone formation. In addition, application of electrical stimulation to tissue engineering endeavors is one possible method to overcome the limitations inherent in new bone formation under static cell culture conditions.
Author: Damir Janigro
Publisher: Springer Science & Business Media
ISBN: 1597450219
Category : Medical
Languages : en
Pages : 555
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Book Description
Cell Cycle in the Central Nervous System overviews the changes in cell cycle as they relate to prenatal and post natal brain development, progression to neurological disease or tumor formation.Topics covered range from the cell cycle during the prenatal development of the mammalian central nervous system to future directions in postnatal neurogenesis through gene transfer, electrical stimulation, and stem cell introduction. Additional chapters examine the postnatal development of neurons and glia, the regulation of cell cycle in glia, and how that regulation may fail in pretumor conditions or following a nonneoplastic CNS response to injury. Highlights include treatments of the effects of deep brain stimulation on brain development and repair; the connection between the electrophysiological properties of neuroglia, cell cycle, and tumor progression; and the varied immunological responses and their regulation by cell cycle.
Author: Charles Polk
Publisher: CRC Press
ISBN: 9780849306419
Category : Technology & Engineering
Languages : en
Pages : 636
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Book Description
The first edition of this book has been recognized as the standard reference on biological effects of electric and magnetic fields from DC to microwaves. But much has changed in this science since the book's original publication in 1986. With contributions from eighteen leading researchers, this latest edition includes authoritative discussions of many new developments and will quickly become the new, must-have resource handbook. Dielectric properties of biological tissue are thoroughly examined, followed by chapters on physical mechanisms and biological effects of static and extremely low frequency magnetic fields. New chapters on topics that were treated very briefly in the first edition now receive extensive treatment. These topics include electric and magnetic fields for bone and soft tissue repair, electroporation, and epidemiology of ELF health effects. The chapter on computer methods for predicting field intensity has been substantially revised to describe new numerical techniques developed within the last few years and includes calculations of power absorbed in the human head from cellular telephones. The chapter discussing experimental results on RF interaction with living matter now contains information on effects of very high power, very short duration pulses. A new appendix on safety standards is based on the latest publications of governmental, as well as quasi-governmental organizations (such as the U.S. Council on Radiation Protection) in the United States, Europe, and Australia. With all its revisions, this updated version of the CRC Handbook of Biological Effects of Electromagnetic Fields provides the most comprehensive overview available of this rapidly changing science.
Author: Sergey V. Dorozhkin
Publisher: CRC Press
ISBN: 9814364177
Category : Science
Languages : en
Pages : 863
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Book Description
Due to a great chemical similarity with the biological calcified tissues, many calcium orthophosphates possess remarkable biocompatibility and bioactivity. Materials scientists use this property extensively to construct artificial bone grafts that are either entirely made of or only surface-coated with the biologically relevant calcium orthophospha
Author: Gregory H. Hudalla
Publisher: Royal Society of Chemistry
ISBN: 1849738335
Category : Medical
Languages : en
Pages : 422
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Book Description
Mimicking the Extracellular Matrix approaches this topic from both basic science and practical engineering perspectives. Suitable for undergraduates, postgraduates, and academics, this text aims to unify the current knowledge of ECM biology and matrix-mimicking biomaterials.
Author: Jasvir S. Khurana
Publisher: Springer Science & Business Media
ISBN: 1597453471
Category : Medical
Languages : en
Pages : 419
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Book Description
Bone Pathology is the second edition of the book, A Compendium of Skeletal Pathology that published 10 years ago. Similar to the prior edition, this book complements standard pathology texts and blends new but relatively established information on the molecular biology of the bone. Serving as a bench-side companion to the surgical pathologist, this new edition reflects new advances in our understanding of the molecular biology of bone. New chapters on soft-tissue sarcomas and soft-tissue tumors have been added as well as several additional chapters such as Soft-tissue pathology and Biomechanics. The volume is written by experts who are established in the field of musculoskeletal diseases. Bone Pathology is a combined effort from authors of different specialties including surgeons, pathologists, radiologists and basic scientists all of whom have in common an interest in bone diseases. It will be of great value to surgical pathology residents as well as practicing pathologists, skeletal radiologists, orthopedic surgeons and medical students.
Author: Mitsuhiro Ebara
Publisher: Springer
ISBN: 4431544003
Category : Technology & Engineering
Languages : en
Pages : 380
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Book Description
This book provides comprehensive coverage of smart biomaterials and their potential applications, a field that is developing at a very rapid pace. Because smart biomaterials are an emerging class of biomaterials that respond to small changes in external stimuli with large discontinuous changes in their physical properties, they have been designed to act as an “on–off” switch for, among others, bio separation, immunoanalysis, drug delivery technologies, gene therapy, diagnostics, bio sensors and artificial muscles. After an introduction to the topic and the history of smart biomaterials, the author gives the reader an in-depth look at the properties, mechanics, and characterization of smart biomaterials including hydrogels, particles, assemblies, surfaces, fibers and conjugates. Information on the wide range of applications for these materials follows, including drug delivery, tissue engineering, diagnostics, biosensors, bio separation and actuators. In addition, recent advances in shape memory biomaterials as active components of medical devices are also presented.
Author: Jeffrey O. Hollinger
Publisher: CRC Press
ISBN: 1135501912
Category : Medical
Languages : en
Pages : 500
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Book Description
Focusing on bone biology, Bone Tissue Engineering integrates basic sciences with tissue engineering. It includes contributions from world-renowned researchers and clinicians who discuss key topics such as different models and approaches to bone tissue engineering, as well as exciting clinical applications for patients. Divided into four sections, t
Author: Gaetano Gargiulo
Publisher: BoD – Books on Demand
ISBN: 9533072563
Category : Medical
Languages : en
Pages : 516
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Book Description
This book presents a collection of recent and extended academic works in selected topics of biomedical technology, biomedical instrumentations, biomedical signal processing and bio-imaging. This wide range of topics provide a valuable update to researchers in the multidisciplinary area of biomedical engineering and an interesting introduction for engineers new to the area. The techniques covered include modelling, experimentation and discussion with the application areas ranging from bio-sensors development to neurophysiology, telemedicine and biomedical signal classification.
Author: Alexander Mauro
Publisher: Raven Press (ID)
ISBN:
Category : Medical
Languages : en
Pages : 582
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Book Description
