Author: Joseph P. Edardes
Publisher: Nova Publishers
ISBN: 9781600219900
Category : Medical
Languages : en
Pages : 176
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Book Description
Warfarin (also known under the brand names of Coumadin, Jantoven, Marevan, and Waran) is an anticoagulant medication that is administered orally or, very rarely, by injection. It is used for the prophylaxis of thrombosis and embolism in many disorders. Its activity has to be monitored by frequent blood testing for the international normalised ratio (INR). It is named for the Wisconsin Alumni Research Foundation. Warfarin is a synthetic derivative of coumarin, a chemical found naturally in many plants, notably woodruff (Galium odoratum, Rubiaceae), and at lower levels in liquorice, lavender and various other species. Warfarin was originally developed as a rat poison; however, more modern poisons are much more potent and toxic (e.g., brodifacoum). Warfarin and contemporary rodenticides belong to the same class of drugs (coumarins) and both decrease blood coagulation by interfering with vitamin K metabolism. For this reason, drugs in this class are also referred to as vitamin K antagonists.
Author: Venketeshwer Rao
Publisher: BoD – Books on Demand
ISBN: 9535121707
Category : Science
Languages : en
Pages : 351
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Book Description
Global dietary recommendations emphasize the consumption of plant-based foods for the prevention and management of chronic diseases. Plants contain many biologically active compounds referred to as phytochemicals or functional ingredients. These compounds play an important role in human health. Prior to establishing the safety and health benefits of these compounds, they must first be isolated, purified, and their physico-chemical properties established. Once identified, their mechanisms of actions are studied. The chapters are arranged in the order from isolation, purification and identification to in vivo and clinical studies, there by covering not only the analytical procedures used but also their nutraceutical and therapeutic properties.
Author: Maria João Matos
Publisher: Mdpi AG
ISBN: 9783036527758
Category : Science
Languages : en
Pages : 416
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Book Description
Coumarins are widely distributed in nature and can be found in a large number of naturally occurring and synthetic bioactive molecules. The unique and versatile oxygen-containing heterocyclic structure makes them a privileged scaffold in Medicinal Chemistry. Many coumarin derivatives have been extracted from natural sources, designed, synthetized, and evaluated on different pharmacological targets. In addition, coumarin-based ion receptors, fluorescent probes, and biological stains are growing quickly and have extensive applications to monitor timely enzyme activity, complex biological events, as well as accurate pharmacological and pharmacokinetic properties in living cells. The extraction, synthesis, and biological evaluation of coumarins have become extremely attractive and rapidly developing topics. A large number of research and review papers have compiled information on this important family of compounds in 2020. Research articles, reviews, communications, and concept papers focused on the multidisciplinary profile of coumarins, highlighting natural sources, most recent synthetic pathways, along with the main biological applications and theoretical studies, were the main focus of this book. The huge and growing range of applications of coumarins described in this book is a demonstration of the potential of this family of compounds in Organic Chemistry, Medicinal Chemistry, and different sciences related to the study of natural products. This book includes 23 articles: 17 original papers and six review papers.
Author: United States. Surgeon-General's Office. Research and Development Division
Publisher:
ISBN:
Category : Medical research
Languages : en
Pages : 728
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Book Description
Author: Venketeshwer Rao
Publisher: BoD – Books on Demand
ISBN: 178985587X
Category : Science
Languages : en
Pages : 300
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Book Description
Naturally present bioactive compounds in plants are referred to as "Phytochemicals" and are being studied extensively for their role in human health. Studies have shown that they can have an important role to play in the prevention and management of several human diseases. Recognizing the increasing interest in this area, this book is being published in response to the need for more current information globally about phytochemicals and their role in human health. Chapters of the book are authored by internationally recognized authors who are experts in their respective field of expertise. The chapters represent both original research as well as up-to-date and comprehensive reviews. We are sure that the book will be an important reference source meeting the needs of a wide range of interest groups.
Author: Mojca Božič-Mijovski
Publisher: BoD – Books on Demand
ISBN: 1789236223
Category : Medical
Languages : en
Pages : 122
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Book Description
Anticoagulant drugs are among the most frequently prescribed drugs in everyday clinical practice. In the past decades, several new direct oral anticoagulants were developed that changed the anticoagulant therapy landscape considerably. This book provides an extensive overview of all the known anticoagulants that can be useful for studying different aspects of the haemostatic system or as a starting point for new drug development. It is also a valuable tool for clinicians providing a description of the mode of action and management of therapy for anticoagulant drugs used in everyday clinical practice in different clinical settings, including direct oral anticoagulants dabigatran, rivaroxaban, apixaban and edoxaban.
Author: Alok A. Khorana
Publisher: CRC Press
ISBN: 1420048007
Category : Medical
Languages : en
Pages : 290
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Book Description
Showcasing the expertise of top-tier specialists who contributed to the newly released guidelines for the care of thrombosis in cancer patients, this exciting guide was written and edited by members of the American Society of Clinical Oncology panel, (ASCO), on the prevention and treatment of cancer-associated thrombosis, among others, and provides
Author: Hyman J. Zimmerman
Publisher: Lippincott Williams & Wilkins
ISBN: 9780781719520
Category : Medical
Languages : en
Pages : 850
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Book Description
Written by the foremost authority in the field, this volume is a comprehensive review of the multifaceted phenomenon of hepatotoxicity. Dr. Zimmerman examines the interface between chemicals and the liver; the latest research in experimental hepatotoxicology; the hepatotoxic risks of household, industrial, and environmental chemicals; and the adverse effects of drugs on the liver. This thoroughly revised, updated Second Edition features a greatly expanded section on the wide variety of drugs that can cause liver injury. For quick reference, an appendix lists these medications and their associated hepatic injuries. Also included are in-depth discussions of drug metabolism and factors affecting susceptibility to liver injury.
Author:
Publisher: Elsevier
ISBN: 0080862586
Category : Medical
Languages : en
Pages : 307
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Book Description
Progress in Medicinal Chemistry
Author: Theodore Warkentin
Publisher: CRC Press
ISBN: 0824758846
Category : Medical
Languages : en
Pages : 660
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Book Description
Taking stock of advances in clinical recognition, laboratory testing, and pharmacologic therapy as well as basic aspects of pathogenesis, the Third Edition of Heparin-Induced Thrombocytopenia reinforces its standing as the leading guide to accurate diagnosis and effective management of this complex condition. Featuring added chapters on bivalirudin
