Concise Guide to Drug Interaction Principles for Medical Practice PDF Download
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Author: Kelly L. Cozza
Publisher: American Psychiatric Publishing
ISBN:
Category : Medical
Languages : en
Pages : 564
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Book Description
An understanding of drug interactions has become essential to the practice of medicine. Since publication of the first edition of this Concise Guide in 2001, our increasing pharmacopoeia—coupled with prolonged human life spans—has made polypharmacy commonplace. Like the first edition of this unique pocket reference, the Second Edition is written expressly for clinicians. With four new contributors, this bestseller includes expanded sections on both phase I and phase II metabolism, updates of existing chapters and tables, new graphics, and extensive Web site references. Brand-new chapters discuss P-glycoproteins, "minor" cytochrome P450 enzymes, pain management with narcotic and nonnarcotic analgesics, prescribing guidelines, and medicolegal issues. This exceptionally practical guide is divided into four parts: 1. An easy-to-read, succinct review of pharmacology, written with clinicians in mind, explaining the importance of understanding our metabolic system and pharmacokinetics and P-glycoprotein drug interactions. 2. Thorough, carefully referenced reviews of the most clinically relevant phase I and phase II metabolic enzymes highlighted with newly expanded tables and study cases. 3. A section unique to this book on drug interactions by medical specialty, with drug tables arranged by how they are used in specialties such as gynecology, infectious diseases, internal medicine, neurology, oncology, psychiatry, and pain medicine. 4. Chapters on practical matters: prescribing guidelines, how to identify drug interaction patterns, strategies for reviewing the current literature, and medicolegal concerns. Enhanced by detailed descriptions and clinically based explanations, and complemented by a unique pocket guide to the most common and potent inhibitors and inducers of drug metabolism, this updated concise "how-to" guide will prove indispensable for busy students, teachers, and practitioners in all medically specialties.
Author: Kelly L. Cozza
Publisher: American Psychiatric Publishing
ISBN:
Category : Medical
Languages : en
Pages : 564
Get Book Here
Book Description
An understanding of drug interactions has become essential to the practice of medicine. Since publication of the first edition of this Concise Guide in 2001, our increasing pharmacopoeia—coupled with prolonged human life spans—has made polypharmacy commonplace. Like the first edition of this unique pocket reference, the Second Edition is written expressly for clinicians. With four new contributors, this bestseller includes expanded sections on both phase I and phase II metabolism, updates of existing chapters and tables, new graphics, and extensive Web site references. Brand-new chapters discuss P-glycoproteins, "minor" cytochrome P450 enzymes, pain management with narcotic and nonnarcotic analgesics, prescribing guidelines, and medicolegal issues. This exceptionally practical guide is divided into four parts: 1. An easy-to-read, succinct review of pharmacology, written with clinicians in mind, explaining the importance of understanding our metabolic system and pharmacokinetics and P-glycoprotein drug interactions. 2. Thorough, carefully referenced reviews of the most clinically relevant phase I and phase II metabolic enzymes highlighted with newly expanded tables and study cases. 3. A section unique to this book on drug interactions by medical specialty, with drug tables arranged by how they are used in specialties such as gynecology, infectious diseases, internal medicine, neurology, oncology, psychiatry, and pain medicine. 4. Chapters on practical matters: prescribing guidelines, how to identify drug interaction patterns, strategies for reviewing the current literature, and medicolegal concerns. Enhanced by detailed descriptions and clinically based explanations, and complemented by a unique pocket guide to the most common and potent inhibitors and inducers of drug metabolism, this updated concise "how-to" guide will prove indispensable for busy students, teachers, and practitioners in all medically specialties.
Author: Gary H. Wynn
Publisher: American Psychiatric Pub
ISBN: 1585628921
Category : Medical
Languages : en
Pages : 608
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Book Description
Drug interactions have become a significant iatrogenic complication, with as many as 5% of hospitalizations and 7,000 deaths annually attributable to drug-drug interactions in the United States. There are several reasons these numbers have increased. First, many new medications have been brought to market in recent years. Second, advances in medical care have resulted in increased longevity and more elderly patients than ever before -- patients who are more likely to be following polypharmacy regimens. Population patterns in the U.S. have amplified this trend, with aging baby boomers swelling the patient pool and demanding treatment with medications advertised on television and in print. Fortunately, drug interactions can be prevented with access to current, comprehensive, reliable information, and the Clinical Manual of Drug Interaction Principles for Medical Practice provides just that in a user-friendly format psychiatry clinicians (including residents and nurses) and forensics experts will find indispensable. With this new edition, the book has evolved from "Concise Guide" to "Clinical Manual" and offers the expanded coverage and features healthcare providers need to keep up with this critical field. The book is well organized, with major sections on metabolism; cytochrome P450 enzymes; drug interactions by medical specialty; and practical matters, such as the medicolegal implications of drug-drug interactions and how to retrieve and review the literature. In the section on P450 enzymes, each chapter addresses what the individual enzyme does and where, its polymorphisms, and drugs that inhibit or induce activity. Each chapter also includes extensive references and study cases to help the reader understand and contextualize the information. A number of additional features enhance the book's scope and utility: The book boasts the very latest information in the area of drug metabolism, transport, and interaction. The chapter on P-glycoprotein (a drug transporter) was expanded from the last edition to include a broader array of transport mechanisms. The highest ethical standard was adhered to in the development of this volume, which was not supported in any way by pharmaceutical makers or distributors. All eight contributors to this excellent resource are experts in the fields they have addressed, and clinicians can trust that the information contained in the Manual reflects the very latest research. This exceptionally practical manual is essential to maintaining the highest standard of care.
Author: Neil B. Sandson
Publisher: American Psychiatric Pub
ISBN: 1585626775
Category : Medical
Languages : en
Pages : 409
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Book Description
This user-friendly resource offers complete and comprehensive coverage of the difficult challenges posed by drug-drug interactions. Over 170 case vignettes illustrate a variety of interactions (DDIs) to provide an unintimidating -- even entertaining -- approach to understanding these issues. Drug-Drug Interaction Primer builds on the author's earlier work, Drug Interactions Casebook: The Cytochrome P450 System and Beyond, and features updated references throughout and 29 new cases that provide such clinical examples as: a patient diagnosed with schizoaffective disorder transitions from haloperidol to aripiprazole with disastrous results; an AIDS patient's trimethoprim-sulfamethoxazole is replaced with warfarin following atrial fibrillation, resulting in ischemic stroke; and a delusional patient on risperidone is placed on phenytoin following seizures, and delusions return. Previous cases have been revised to enhance clarity. An introduction to core concepts, which includes brief reviews of each enzyme system, brings the reader up to speed on how to think about DDIs and begin to grapple with what might seem like an imposing subject. The vignettes that follow each include a case presentation and an explanation of the mechanism by which the interaction(s) occurred, and each derives from sound clinical evidence -- not merely extrapolations from drug characteristics -- to offer a more realistic understanding of DDIs. Most of the interactions described involve the cytochrome P450 enzyme system; others involve alterations in phase II metabolism and P-glycoprotein functioning, as well as plasma protein displacement effects. The appendices detail most drug-drug interactions between psychotropic agents and contain metabolic pathways and inhibitory and inductive profiles for antidepressants, antipsychotics, and mood stabilizing agents -- as well as tables that detail all known and clinically significant DDIs between pairings of any two agents from these drug classes. An extensive index allows quick reference. Among the book's other features: Reorganization by medical subspecialty -- psychiatry, internal medicine, neurology, surgery/anesthesia, and gynecology, oncology, and dermatology -- better facilitates clinical application. Comprehensive tables detail substrates, inhibitors, and inducers for P450, phase II, and P-glycoprotein. DDIs involving select nonpsychotropic agents such as tobacco, ethinylestradiol, and statins. Exploration of the paradigm of plasma protein binding mediated DDIs in detail, with cases conveniently indexed. These cases bring DDIs alive in a way that drier descriptions cannot, and this volume introduces more original material than will be found in other sources. Drug-Drug Interaction Primer is brimming with material that can be put to immediate use, offering insights that will improve any practitioner's skills.
Author: Theodore A. Stern
Publisher: Elsevier Health Sciences
ISBN: 0323076912
Category : Medical
Languages : en
Pages : 2883
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Book Description
The Massachusetts General Hospital is widely respected as one of the world's premier psychiatric institutions. Now, preeminent authorities from MGH present a reference that is carefully designed to simplify your access to the current clinical knowledge you need! A remarkably user-friendly organization - with abundant boxed summaries, bullet points, case histories, and algorithms - speeds you to the answers you need. In short, this brand-new reference delivers all the authoritative answers you need to overcome any clinical challenge, in a format that's easier to consult than any other source! Peerless, hands-on advice from members of the esteemed MGH Department of Psychiatry helps you put today's best approaches to work for your patients. The book's highly templated format - with abundant boxed overviews, bulleted points, case histories, algorithms, references, and suggested readings - enables you to locate essential information quickly.
Author: Theodore A. Stern
Publisher: Elsevier Health Sciences
ISBN: 0323496431
Category : Medical
Languages : en
Pages : 791
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Book Description
For generations of practitioners, the Massachusetts General Hospital Handbook of General Hospital Psychiatry has been and is the "gold standard" guide to consultation-liaison psychiatry and psychosomatic medicine. The fully updated 7th Edition, by Drs. Theodore A. Stern, Oliver Freudenreich, Felicia A. Smith, Gregory L. Fricchione, and Jerrold F. Rosenbaum, provides an authoritative, easy-to-understand review of the diagnosis, evaluation, and treatment of psychiatric problems experienced by adults and children with medical and surgical conditions. Covers the psychological impact of chronic medical problems and life-threatening diseases, somatic symptom disorders, organ donors and recipients, pain, substance abuse, and polypharmacy, including a thorough review of drug actions and interactions, metabolism, and elimination. - Features DSM-5 updates throughout, as well as case studies in every chapter. - Contains practical tips on how to implement the most current and effective pharmacological therapies as well as cognitive-behavioral approaches. - Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, videos (including video updates), glossary, and references from the book on a variety of devices.
Author: Siamak Cyrus Khojasteh
Publisher: Springer Science & Business Media
ISBN: 1441956298
Category : Medical
Languages : en
Pages : 222
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Book Description
Drug Metabolism and Pharmacokinetics Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations. It covers key concepts, with useful tables on physiological parameters (eg. blood flow to organs in x-species, expression and localization of enzymes and transporters), chemical structure, nomenclature, and moieties leading to bioactivation (with examples). Overall it includes a number of key topics useful at the drug discovery stage, which would serve as a quick reference with several examples from the literature to illustrate the concept.
Author: Ronald W. Pies
Publisher: American Psychiatric Pub
ISBN: 1585626600
Category : Medical
Languages : en
Pages : 558
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Book Description
Handbook of Essential Psychopharmacology, Second Edition, provides an indispensable guide to vital information in the rapidly expanding field of psychopharmacology. The updated edition of this popular handbook will continue to be a reference that is simply the essential starting point in psychopharmacology for residents and experienced clinicians alike. Busy residents and clinicians will find a quick, current, and accessible guide to basic facts about psychotropic drugs, including dosages, indications, and drug interactions. As in the first edition, its structure is clear and easy to read, including An all-new introductory chapter, designed to equip the reader with a basic understanding of pharmacodynamics and pharmacokinetics Four main chapters covering the four main groups of psychotropic medications: antidepressants, antipsychotics, anxiolytics, and mood stabilizers A consistent format for all four chapters that summarizes critical information about each group of medications, including drug class, indications, mechanisms of action, pharmacokinetics, main side effects, drug-drug interaction, potentiating maneuvers, and use in special populations A wealth of tables and graphs for quick clinical consultation and unique self-instruction sets of questions and answers Fascinating and educational vignettes and puzzlers, extensive references for further reading, and -- new to this edition -- an invaluable appendix of fifty questions and answers, designed to test the reader's knowledge and comprehension of the text Densely informative and packed with practical material and special features, this truly essential guide is a handy clinical reference for experienced clinicians, an ideal teaching tool for educators, and a useful resource for residents, especially those preparing for the psychiatry board examinations.
Author: Robert E. Hales
Publisher: American Psychiatric Pub
ISBN: 1585622575
Category : Medical
Languages : en
Pages : 1820
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Book Description
Its previous edition hailed as "the best reference for the majority of practicing psychiatrists" (Doody's Book Reviews) and a book that "more than any other, provides an approach to how to think about psychiatry that integrates both the biological and psychological" (JAMA), The American Psychiatric Publishing Textbook of Psychiatry has been meticulously revised to maintain this preeminence as an accessible and authoritative educational reference and clinical compendium. It combines the strengths of its three editors -- Robert Hales in clinical and community psychiatry, Stuart Yudofsky in neuropsychiatry, and new co-editor Glen Gabbard in psychotherapy -- in recruiting outstanding authors to summarize the latest developments in psychiatry and features 101 contributors, 65 of whom are new to this edition. The book boasts a new interior design, with more figures and color throughout to aid comprehension. Each chapter ends with 5-10 key points, 5-10 recommended readings, and helpful Web sites not only for the clinician but also for patients and family members. The book also includes complimentary access to the full text online. Online benefits include powerful searching, electronic bookmarking, and access by username and password from wherever you have Web access -- especially convenient for times when the print copy of your textbook is not where you are. The online version is accompanied by a downloadable PowerPoint presentation, which contains a wealth of material to enhance classroom presentation, study, and clinical use. Among the improvements to this edition's content: • Of the text's 44 chapters, 23 either feature new topics or have new authors, making this the most completely revised edition yet.• New basic-science chapters on cellular and molecular biology of the neuron and on neuroanatomy for the psychiatrist conveniently distill essential information on the biological foundations of psychiatric disorders for clinicians.• A new chapter on human sexuality and sexual dysfunctions, and another new chapter on treatment of gay, lesbian, bisexual, and transgender patients, equips clinicians to address the entire spectrum of sexual issues and their attendant mental health concerns.• New chapters on nonpharmacological somatic treatments, supportive psychotherapy, and combination psychotherapy and pharmacotherapy augment the section on psychiatric treatments.• A new chapter on the assessment of dangerousness -- an individual's propensity to commit violent acts -- presents helpful guidelines for appropriately evaluating and minimizing the risk of violence in both outpatient and inpatient settings. Why The American Psychiatric Publishing Textbook of Psychiatry will be your first choice among comprehensive psychiatry textbooks: • Complimentary Access to the Full Text Online -- Online benefits include powerful searching, electronic bookmarking, and download to PDA.• PowerPoint Presentation -- Online version is accompanied by a downloadable PowerPoint presentation, which contains a wealth of material to help you enhance classroom presentation, study, and in clinical use. • Self-Assessment -- An interactive online Self-Assessment allows you to assess your knowledge of each chapter, with links back to the textbook when more study is needed.• Summary Points -- Each chapter ends with 5-10 key points, 5-10 recommended readings, and helpful web sites not only for the clinician but also for referral to patients and family members. • Co-Editor Glen O. Gabbard, M.D. -- As the third Co-Editor, Dr. Gabbard adds depth and perspective to psychotherapeutic approaches.• Chapter Authors -- Partnership of senior and junior faculty brings fresh insights tempered by wisdom and experience.• Peer-Reviewed -- Rigorously peer reviewed and updated to reflect the rapidly changing profession. • Disclosure of Interest Statements -- Disclosure from each chapter author assures you that potential biases have been removed.• Comprehensive But Concise -- Inclusion of essential information eases information overload.• Better Layout -- Larger type for text makes book easier to read and color figures are provided throughout the text. It's no wonder that this text has established itself as both a leading scholarly reference and an indispensable clinical resource. The American Psychiatric Publishing Textbook of Psychiatry is a proven teaching tool and an essential component of every practitioner's library.
Author: James L. Levenson, M.D.
Publisher: American Psychiatric Pub
ISBN: 1615371362
Category : Medical
Languages : en
Pages : 1596
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Book Description
Preceded by American Psychiatric Publishing textbook of psychosomatic medicine: psychiatric care of the medically ill / edited by James L. Levenson. 2nd ed. 2011.
Author: Miles Hacker
Publisher: Academic Press
ISBN: 0080919227
Category : Medical
Languages : en
Pages : 607
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Book Description
Pharmacology meets the rapidly emerging needs of programs training pharmacologic scientists seeking careers in basic research and drug discovery rather than such applied fields as pharmacy and medicine. While the market is crowded with many clinical and therapeutic pharmacology textbooks, the field of pharmacology is booming with the prospects of discovering new drugs, and virtually no extant textbook meets this need at the student level. The market is so bereft of such approaches that many pharmaceutical companies will adopt Hacker et al. to help train new drug researchers. The boom in pharmacology is driven by the recent decryption of the human genome and enormous progress in controlling genes and synthesizing proteins, making new and even custom drug design possible. This book makes use of these discoveries in presenting its topics, moving logically from drug receptors to the target molecules drug researchers seek, covering such modern topics along the way as side effects, drug resistance, pharmacogenomics, and even nutriceuticals, one in a string of culminating chapters on the drug discovery process. The book is aimed at advanced undergraduates and beginning graduate students in medical, pharmacy, and graduate schools looking for a solid introduction to the basic science of pharmacology and envisioning careers in drug research. - Uses individual drugs to explain molecular actions - Full color art program explains molecular and chemical concepts graphically - Logical structure reflecting the current state of pharmacology and translational research - Covers such intricacies as drug resistance and cell death - Consistent format across chapters and pedagogical strategies make this textbook a superior learning tool
