Author: Neil B. Sandson
Publisher: American Psychiatric Pub
ISBN: 1585626775
Category : Medical
Languages : en
Pages : 408
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Book Description
This user-friendly resource offers complete and comprehensive coverage of the difficult challenges posed by drug-drug interactions. Over 170 case vignettes illustrate a variety of interactions (DDIs) to provide an unintimidating -- even entertaining -- approach to understanding these issues. Drug-Drug Interaction Primer builds on the author's earlier work, Drug Interactions Casebook: The Cytochrome P450 System and Beyond, and features updated references throughout and 29 new cases that provide such clinical examples as: a patient diagnosed with schizoaffective disorder transitions from haloperidol to aripiprazole with disastrous results; an AIDS patient's trimethoprim-sulfamethoxazole is replaced with warfarin following atrial fibrillation, resulting in ischemic stroke; and a delusional patient on risperidone is placed on phenytoin following seizures, and delusions return. Previous cases have been revised to enhance clarity. An introduction to core concepts, which includes brief reviews of each enzyme system, brings the reader up to speed on how to think about DDIs and begin to grapple with what might seem like an imposing subject. The vignettes that follow each include a case presentation and an explanation of the mechanism by which the interaction(s) occurred, and each derives from sound clinical evidence -- not merely extrapolations from drug characteristics -- to offer a more realistic understanding of DDIs. Most of the interactions described involve the cytochrome P450 enzyme system; others involve alterations in phase II metabolism and P-glycoprotein functioning, as well as plasma protein displacement effects. The appendices detail most drug-drug interactions between psychotropic agents and contain metabolic pathways and inhibitory and inductive profiles for antidepressants, antipsychotics, and mood stabilizing agents -- as well as tables that detail all known and clinically significant DDIs between pairings of any two agents from these drug classes. An extensive index allows quick reference. Among the book's other features: Reorganization by medical subspecialty -- psychiatry, internal medicine, neurology, surgery/anesthesia, and gynecology, oncology, and dermatology -- better facilitates clinical application. Comprehensive tables detail substrates, inhibitors, and inducers for P450, phase II, and P-glycoprotein. DDIs involving select nonpsychotropic agents such as tobacco, ethinylestradiol, and statins. Exploration of the paradigm of plasma protein binding mediated DDIs in detail, with cases conveniently indexed. These cases bring DDIs alive in a way that drier descriptions cannot, and this volume introduces more original material than will be found in other sources. Drug-Drug Interaction Primer is brimming with material that can be put to immediate use, offering insights that will improve any practitioner's skills.
Author: P. J. Bentley
Publisher: Cambridge University Press
ISBN: 9780521280747
Category : Medical
Languages : en
Pages : 170
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Book Description
Written primarily for students of medicine, pharmacy, and pharmacology, this introductory book provides a concise summary of the principles that underlie the science of pharmacology. It presents the basic concepts required for understanding the use, mechanisms of action, toxicity and side effects, and therapeutic application of drugs in man. Thus the book may also be of interest to medical practitioners and to biological and medical scientists. Among topics covered are the sources of drugs, the way they are administered and dealt with in the body, as well as concepts about the nature of their actions. The last include their chemical interactions with components of cells and the manner in which these lead to therapeutically desirable as well as undesirable and even toxic effects. In addition, clinically related subjects, such as drug interactions, teratogenic and carcinogenic effects are discussed. The development and testing of new drugs are also described. For easy reference, at the back of the book there is a glossary of drugs named in the text.
Author: Terry Kenakin
Publisher: Academic Press
ISBN: 0128139587
Category : Medical
Languages : en
Pages : 488
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Book Description
A Pharmacology Primer: Techniques for More Effective and Strategic Drug Discovery, Fifth Edition features the latest ideas and research regarding the application of pharmacology to the process of drug discovery. Written by well-respected pharmacologist, Terry P. Kenakin, this primer is an indispensable resource for all those involved in drug discovery. This updated edition has been thoroughly revised to include material on quantifying drug efficacy through bias and cluster analysis, the impact of molecular dynamics and protein structural analysis, the real time kinetic analysis of drug effect, virtual screening for new drug chemical scaffolds, and much more. With full color illustrations and new examples throughout, this book remains a top reference for all industry and academic scientists that is also ideal for students directly involved in drug discovery or pharmacologic research. Highlights changes surrounding strategies for drug discovery, providing a comprehensive reference and featuring advances in the methods involved Includes multiple new sections, such as development and utilization of models in pharmacology, de-orphanization of new drug targets, predicting impact of disease on drug pharmacokinetics, and the impact of enzyme kinetics on drug-drug interactions Illustrates the application of rapid inexpensive assays to predict activity in the therapeutic setting, showing data outcomes and the limitations inherent in interpreting this data
Author: Domenic A. Ciraulo
Publisher: Lippincott Williams & Wilkins
ISBN: 9780781748179
Category : Medical
Languages : en
Pages : 474
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Book Description
Thoroughly updated for its Third Edition, this handbook provides complete, current, and easily accessible information on how psychotropic drugs interact with one another and with compounds used to treat non-psychiatric medical conditions. The book is organized for rapid reference, includes numerous tables, and offers guidelines for managing adverse effects. The Third Edition includes an adverse drug effects table in the appendix section, tables on receptor binding and dosing, and the latest information on drugs of abuse and chemical dependence. This edition also includes drug-food interactions for each drug category and interactions of psychotropic drugs with HIV medications.
Author: Terrence P. Kenakin
Publisher: Gulf Professional Publishing
ISBN: 9780124041615
Category : Chemicals
Languages : en
Pages : 234
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Book Description
This guide has been designed especially for scientists trained in molecular biology and related fields who now need to know more about the basic theories, principles and practical applications of pharmacology.
Author: Frederic J. Zucchero
Publisher: American Pharmaceutical Association
ISBN: 9780917330933
Category : Medical
Languages : en
Pages : 468
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Book Description
A condensed version of Evaluations of Drug Interactions, designed to facilitate quick access to the information most frequently needed by busy health practitioners. It contains 952 drug interaction monographs organized by drug class. Most monographs contain eight concise pieces of information and the volume is indexed by generic names.
Author: John R Horn
Publisher:
ISBN: 9780981944074
Category :
Languages : en
Pages : 204
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Book Description
This is the 21st edition of Top 100 Drug Interactions, with more than 300,000 copies in print since the first edition was published in 2000. In this book the authors attempt to identify drug interactions that should not be ignored in clinical practice. Management options are given for each interaction to offer the clinician actions that may be taken to reduce the risk of an adverse outcome. The book also contains a clinically useful and comprehensive table of drugs that are substrates, inhibitors or inducers of cytochrome P450 isozymes and ABC transporters.
Author: Robert M. Julien
Publisher:
ISBN: 9780716719632
Category : Pharmacology
Languages : en
Pages : 364
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Book Description
Author: Joe Graedon, MS
Publisher: Macmillan
ISBN: 9780312155100
Category : Health & Fitness
Languages : en
Pages : 472
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Book Description
Did You Know? Eating too much broccoli could be deadly if you also take the popluar blood thinner called Coumadin (warfarin)? Grapefruit juice, when used to wash down certain atihistamines, immune suppressors, or blood pressure drugs, can cause blood levels of these powerful drugs to soar? The result: serious side effects. Birth control pills might be rendered ineffective by the following substances: barbituates, antibiotics, anti-fungal drugs, tuberculosis drugs, certain anticonvulsants? Is Your Life In Danger? Everyone has taken more than one pill simultaneously. Yet every time you combine drugs with prescription medicines, foods, vitamins, minerals, herbs or alcohol you explose yourself to the risk of a potentially dangerous interaction. Deadly Drug Interactions Can Help You. Over 200 easy-to-understand charts with information on medications for pain relief, allergies, asthma, arthritis, heart problems, depression, diabetes, contraception, ulcers and much more. Descriptions of the symptoms of interactions. Specific concerns of women, children and older people. Vital information of Lanoxin, Cardizem, Prozac, Mevacor, Ortho-Novum, Tagamet, Coumadin, Dilatin, Cipro, Synthroid, Procardia, and scores of other commonly prescribed medicines.
Author: Philip D. Hansten
Publisher: Createspace Independent Publishing Platform
ISBN: 9781522757139
Category : Drug interactions
Languages : en
Pages : 0
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Book Description
This is the 17th yearly edition of The Top 100 Drug Interactions, with more than 300,000 copies in print since the first edition was published in 2000. In this book the authors attempt to identify drug interactions that should not be ignored in clinical practice. Management options are given for each interaction to offer the clinician actions that may be taken to reduce the risk of an adverse outcome. The book also contains a clinically useful and comprehensive table of drugs that are substrates, inhibitors or inducers of cytochrome P450 isozymes and ABC transporters.
