Clinic-oriented Multifunctional Biomaterials: From Rational Design to Applications

Clinic-oriented Multifunctional Biomaterials: From Rational Design to Applications PDF Author: Meng Tian
Publisher: Frontiers Media SA
ISBN: 2832540678
Category : Science
Languages : en
Pages : 156

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Book Description

Clinic-oriented Multifunctional Biomaterials: From Rational Design to Applications

Clinic-oriented Multifunctional Biomaterials: From Rational Design to Applications PDF Author: Meng Tian
Publisher: Frontiers Media SA
ISBN: 2832540678
Category : Science
Languages : en
Pages : 156

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Book Description


Rational Design and Characterization of Innovative Multifunctional Biomimetic Materials

Rational Design and Characterization of Innovative Multifunctional Biomimetic Materials PDF Author: Lia Rimondini
Publisher: Frontiers Media SA
ISBN: 2889666875
Category : Technology & Engineering
Languages : en
Pages : 176

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Book Description


Immunomodulatory Biomaterials

Immunomodulatory Biomaterials PDF Author: Stephen F. Badylak
Publisher: Woodhead Publishing
ISBN: 0128214562
Category : Technology & Engineering
Languages : en
Pages : 296

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Book Description
Biomaterials have existed for millennia as mechanical replacement structures following disease or injury. Biomaterial design has changed markedly from structural support with an "inert immune profile as the primary objective to designs that elicit an integrative local tissue response and a pro-repair immune cell phenotype. Immunomodulatory Biomaterials: Regulating the Immune Response with Biomaterials to Affect Clinical Outcome offers a single, comprehensive reference on biomaterials for modulation of the host response, for materials scientists, tissue engineers and those working in regenerative medicine. This book details methods, materials and strategies designed to regulate the host immune response following surgical implantation and thus facilitate specific local cell infiltration and tissue deposition. There has been a dramatic transformation in our understanding of the role of the immune system, both innate and adaptive; these changes include recognition of the plasticity of immune cells, especially macrophages, cross-talk between the immune system and stem cells, and the necessity for in situ transition between inflammatory and regulatory immune cell phenotypes. The exploitation of these findings and the design and manufacture of new biomaterials is occurring at an astounding pace. There is currently no book directed at the interdisciplinary principles guiding the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response. The challenge for academia, industry, and regulatory agencies to encourage innovation while assuring safety and maximizing efficacy has never been greater. Given the highly interdisciplinary requirements for the design, manufacture and use of immunomodulatory biomaterials, this book will prove a useful single resource across disciplines. - Holistically covers the design, manufacture, testing, and clinical translation of biomaterials that proactively regulate the host tissue immune response - Provides a single reference for understanding and utilizing the host response in biomaterials design - An international collaboration of leading researchers in the field offering a novel insight into this fast-growing area

Engineering Biomaterials for Regenerative Medicine

Engineering Biomaterials for Regenerative Medicine PDF Author: Sujata K. Bhatia
Publisher: Springer Science & Business Media
ISBN: 1461410800
Category : Technology & Engineering
Languages : en
Pages : 350

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Book Description
Regeneration of tissues and organs remains one of the great challenges of clinical medicine, and physicians are constantly seeking better methods for tissue repair and replacement. Tissue engineering and regenerative medicine have been investigated for virtually every organ system in the human body, and progress is made possible by advances in materials science, polymer chemistry, and molecular biology. This book reviews the current status of biomaterials for regenerative medicine, and highlights advances in both basic science and clinical practice. The latest methods for regulating the biological and chemical composition of biomaterials are described, together with techniques for modulating mechanical properties of engineered constructs. Contributors delineate methods for guiding the host response to implantable materials, and explain the use of biologically-inspired materials for optimal biological functionality and compatibility. The book culminates in a discussion of the clinical applications of regenerative medicine. By integrating engineering and clinical medicine, Engineering Biomaterials for Regenerative Medicine examines how tissue engineering and regenerative medicine can be translated into successful therapies to bridge the gap between laboratory and clinic. The book will aid materials scientists and engineers in identifying research priorities to fulfill clinical needs, and will also enable physicians to understand novel biomaterials that are emerging in the clinic. This integrated approach also gives engineering students a sense of the excitement and relevance of materials science in the development of novel therapeutic strategies.

Functional Biomaterials

Functional Biomaterials PDF Author: Sougata Jana
Publisher: Springer Nature
ISBN: 9811671524
Category : Science
Languages : en
Pages : 524

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Book Description
This book explores in depth a wide range of functional biomaterials-based systems for drug, gene delivery, and biomedical aspects. The chapters cover newer technologies such as polymeric micelle, pH-responsive biomaterials, stimuli-responsive hydrogels, silk fibroin, inorganic biomaterials, synthetic biomaterials, 3D printed biomaterials, metallic biomaterials, ceramic and hybrid biomaterials. It also describes the theranostic approaches for cancer therapy, the biomaterials-based nanofibers scaffolds in tissue engineering, as well as the strategies applications of metallic biomaterials for the medical and dental prosthetic field. This newer and updated approach will be attractive for biomedical engineering students working on materials science in the development of novel drug delivery strategies. The book will be an important reference for researchers and professionals working on biomaterial research in the pharmaceutical and medical fields.

Rational and Combinatorial Design of Biomaterials for Tissue Engineering Applications

Rational and Combinatorial Design of Biomaterials for Tissue Engineering Applications PDF Author: Sriram Ramamoorthy
Publisher:
ISBN:
Category :
Languages : en
Pages : 242

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Book Description


Biomedical Nanostructures

Biomedical Nanostructures PDF Author: Kenneth Gonsalves
Publisher: John Wiley & Sons
ISBN: 0470185821
Category : Science
Languages : en
Pages : 543

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Book Description
Learn to Use Nanoscale Materials to Design Novel Biomedical Devices and Applications Discover how to take full advantage of nanoscale materials in the design and fabrication of leading-edge biomedical devices. The authors introduce you to a variety of possible clinical applications such as drug delivery, diagnostics, and cancer therapy. In addition, the authors explore the interface between micron and nanoscale materials for the development of applications such as tissue engineering. Finally, they examine the mechanisms of cell interactions with material surfaces through the use of nanotechnology-based material processing and characterization methods. The text's three sections highlight its interdisciplinary approach: * Part One: Nanostructure Fabrication * Part Two: Bio-Nano Interfaces * Part Three: Clinical Applications of Nanostructures Among the key topics covered are nanotechnology in tissue regeneration; biomolecular engineering; receptor-ligand interactions; cell-biomaterial interactions; nanomaterials in diagnostics, drug delivery, and cancer therapy; and nano- and micron-level engineering and fabrication. Throughout the text, clear examples guide you through the chemistry and the processing involved in designing and developing nanoscale materials for biomedical devices. Each chapter begins with an introduction and ends with a conclusion highlighting the key points. In addition, references at the end of the chapter help you expand your research on any individual topic. In summary, this book helps biomedical researchers and engineers understand the physical phenomena that occur at the nanoscale in order to design novel cell-based constructs for a wide range of applications.

Multi-Functional Collagen-Based Biomaterials for Biomedical Applications

Multi-Functional Collagen-Based Biomaterials for Biomedical Applications PDF Author: Nunzia Gallo
Publisher: Mdpi AG
ISBN: 9783036570730
Category : Science
Languages : en
Pages : 0

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Book Description
Polymeric biomaterials represent an essential tool in the biomedical field. Their high biocompatibility and ability to provide adequate regenerative support are fundamental for the development of new therapeutic devices. In particular, biomaterials derived from living organisms can exhibit not only structural roles but also several non-structural functions implicated in cellular growth, migration, and differentiation. Among them, type I collagen, a ubiquitous structural protein present in the mammalian body, plays a dominant role in maintaining the biological and structural integrity of various tissues. In recent years, with the goal of developing multi-functional collagen-based devices able to better promote the functional recovery of damaged tissues, numerous studies have focused on novel techniques and methods for the development and characterization of innovative and advanced high-performance formulations. The ability to control, modify, and tune collagen-based biomaterials performance by optimizing their architecture, besides modifying their chemistry, blending with other materials/therapeutics, or developing stimuli-responsive formulations, is an extremely important knowledge to acquire when specific multi-functionalities are sought. The present Special Issue collected 12 peer-reviewed interdisciplinary contributions on the broad topic of multi-functional collagen-based biomaterials.

Self-assembling Biomaterials

Self-assembling Biomaterials PDF Author: Helena S. Azevedo
Publisher: Woodhead Publishing
ISBN: 0081020120
Category : Technology & Engineering
Languages : en
Pages : 614

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Book Description
Self-assembling biomaterials: molecular design, characterization and application in biology and medicine provides a comprehensive coverage on an emerging area of biomaterials science, spanning from conceptual designs to advanced characterization tools and applications of self-assembling biomaterials, and compiling the recent developments in the field. Molecular self-assembly, the autonomous organization of molecules, is ubiquitous in living organisms and intrinsic to biological structures and function. Not surprisingly, the exciting field of engineering artificial self-assembling biomaterials often finds inspiration in Biology. More important, materials that self-assemble speak the language of life and can be designed to seamlessly integrate with the biological environment, offering unique engineering opportunities in bionanotechnology. The book is divided in five parts, comprising design of molecular building blocks for self-assembly; exclusive features of self-assembling biomaterials; specific methods and techniques to predict, investigate and characterize self-assembly and formed assemblies; different approaches for controlling self-assembly across multiple length scales and the nano/micro/macroscopic properties of biomaterials; diverse range of applications in biomedicine, including drug delivery, theranostics, cell culture and tissue regeneration. Written by researchers working in self-assembling biomaterials, it addresses a specific need within the Biomaterials scientific community. - Explores both theoretical and practical aspects of self-assembly in biomaterials - Includes a dedicated section on characterization techniques, specific for self-assembling biomaterials - Examines the use of dynamic self-assembling biomaterials

Nanostructured Biomaterials for Overcoming Biological Barriers

Nanostructured Biomaterials for Overcoming Biological Barriers PDF Author: Maria Jose Alonso
Publisher: Royal Society of Chemistry
ISBN: 1849733635
Category : Medical
Languages : en
Pages : 643

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Book Description
This book provides a critical overview of the advances being made toward overcoming biological barriers through the contribution of nanosciences and nanotechnologies to solve the problems of many current drugs and vaccines.