Chemistry and Biology of [beta]-lactam Antibiotics PDF Download
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![Chemistry and Biology of [beta]-lactam Antibiotics PDF](https://books.google.com/books/content/images/frontcover/_LBFAQAAMAAJ?fife=w150-h200)
Author: Robert B. Morin
Publisher:
ISBN:
Category : Antibiotics
Languages : en
Pages : 464
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Book Description
![Chemistry and Biology of [beta]-lactam Antibiotics PDF](https://books.google.com/books/content/images/frontcover/_LBFAQAAMAAJ?fife=w80-h100)
Author: Robert B. Morin
Publisher:
ISBN:
Category : Antibiotics
Languages : en
Pages : 464
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Book Description
Author: M.I. Page
Publisher: Springer Science & Business Media
ISBN: 9401129282
Category : Science
Languages : en
Pages : 368
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Book Description
It is over sixty years since Alexander Fleming observed antibiosis between a Penicillium mould and bacterial cultures and gave the name penicillin to the active principle. Although it was proposed in 1943 that penicillin (1) contained a tJ-Iactam ring, this was not generally accepted until an X-ray crystallographic determination of the structure had been completed. RCONH )=r)
Author: Robert B. Morin
Publisher:
ISBN:
Category : Antibiotics
Languages : en
Pages :
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Author: Alle Bruggink
Publisher: Springer Science & Business Media
ISBN: 9401008507
Category : Science
Languages : en
Pages : 328
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Book Description
Penicillins and cephalosporins have a long history in combating bacterial infections. Despite new infectious diseases and occurring resistance, beta-lactam antibiotics will for many years to come continue to play a prominent role in our therapeutic arsenal. This book covers the industrial development of the chemical and biochemical processes used to manufacture these products, as well as looking ahead to possible future processes. The interplay between synthetic organic chemistry with the understanding and application of enzymes, modeling of fermentation processes and integration through (bio-) chemical process engineering is illustrated. In-depth scientific approaches to biocatalysis and biocatalyst development including enzyme kinetics, enzyme crystal studies and semi-rational enzyme mutations are also presented. Metabolic pathway analysis and modeling of fermentation process are treated as well as molecular precision in synthetic approaches to beta-lactams, their precursors and derivatives. Process technology studies including new reactor concepts, possible short-cut routes and improved down-stream-processing methods complete a broad view on the scope and limitations of the presently developed industrial processes including an intriguing insight into future process possibilities. This book represents an excellent case study on the transformation of traditional, stoïchiometric, organic synthesis and classical fermentations into modern (bio-) catalysis and biosynthesis based on insights in metabolic pathways and enzyme actions.
Author: Robert B. Morin
Publisher:
ISBN:
Category : Antibiotics
Languages : en
Pages : 608
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Book Description
Author: Daniel Zerong Wang
Publisher:
ISBN: 9781774911723
Category : Beta lactamases
Languages : en
Pages : 0
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Book Description
"This new volume, The Chemistry and Biology of Beta-Lactams, provides the most updated information about beta-lactams relating to both the pharmaceutical industry and synthetic chemistry. It provides valuable information regarding antibiotic activities as well as chemical reactivities of beta-lactams, which are important because they are commonly applied as antibiotics in the treatment of bacterial infections. Presenting the most up-to-date literature information on beta-lactams, the volume provides comprehensive coverage of most of the known beta-lactam antibiotics with both structural and biological information, antibiotic mechanisms, self-defense mechanisms of bacteria, nearly all known synthetic methods for the preparation of beta-lactams, and possible reactions in which beta-lactams can participate. Key features: • Provides the most comprehensive collection of beta-lactam antibiotics (up to 269 molecules) with chemical structures, CAS number, IUPAC names and associated biological activities • Offers a comprehensive collection of beta-lactamase databases, where the features of each database have been described • Explains the self-defense mechanisms of bacteria for surviving, including the formation of biofilm and conversion into L-form, as well as secretion of beta-lactamase to deactivate the beta-lactam antibiotics • Provides a comprehensive survey on the synthetic methods to make beta-lactams • Gives all of the possible reactions involving beta-lactams as the starting materials • Surveys over 1000 research works and includes all available DOI information The important information provided here will be a valuable resource on the antibiotic activities as well as chemical reactivities of beta-lactams for researchers and scientists, faculty, and advanced students, as well as for industry professionals working in medicinal and pharmaceutical chemistry, organic chemistry, organic synthesis, heterocycles, proteins and peptides."--
Author: Robert B. Morin
Publisher:
ISBN:
Category : Antibiotics
Languages : en
Pages : 0
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Book Description
Author: Robert B. Morin
Publisher:
ISBN:
Category : Antibiotics
Languages : en
Pages : 456
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Book Description
Author: Zerong Wang
Publisher: CRC Press
ISBN: 1000755215
Category : Science
Languages : en
Pages : 502
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Book Description
Provides the most comprehensive collection of beta-lactam antibiotics (up to 269 molecules) with chemical structures, CAS number, IUPAC names and associated biological activities Offers a comprehensive collection of beta-lactamase databases, where the features of each database have been described Explains the self-defense mechanisms of bacteria for surviving, including the formation of biofilm and conversion into L-form, as well as secretion of beta-lactamase to deactivate the beta-lactam antibiotics Provides a comprehensive survey on the synthetic methods to make beta-lactams Gives all of the possible reactions involving beta-lactams as the starting materials Surveys over 1000 research works and includes all available DOI information
Author: Robert B. Morin
Publisher:
ISBN:
Category : Antibiotics
Languages : en
Pages : 0
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Book Description
