Bacterial Cellular Metabolic Systems PDF Download
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Author: K. Shimizu
Publisher: Elsevier
ISBN: 1908818204
Category : Science
Languages : en
Pages : 497
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Book Description
The metabolic regulation of a cell system is of critical importance in systems biology, and a robust model of these mechanisms is essential in predicting the effects on the metabolism of both the culture environment and the knockout of specific genes. Bacterial cellular metabolic systems focuses on this highly topical subject in relation to culture environment and provides a detailed analysis from gene level to metabolic level regulation, as well as offering a discussion of the most recent modelling approaches. The book begins with an introduction to metabolic mechanisms and to the metabolic regulation of a cell, before moving on to discussing the action of global regulators in response to a specific culture environment. The second half of the book examines conventional flux balance analysis and its applications, 13C-metabolic flux analysis, and the effect of a specific gene knockout on the metabolism. Comprehensive account of metabolic regulation via global regulators in response to changes in the culture environment Basic formulation of 13C-metabolic flux analysis based on 13C-labelling experiments Systems biology approach for the modelling and computer simulation of the main metabolic pathways of a cell system
Author: K. Shimizu
Publisher: Elsevier
ISBN: 1908818204
Category : Science
Languages : en
Pages : 497
Get Book Here
Book Description
The metabolic regulation of a cell system is of critical importance in systems biology, and a robust model of these mechanisms is essential in predicting the effects on the metabolism of both the culture environment and the knockout of specific genes. Bacterial cellular metabolic systems focuses on this highly topical subject in relation to culture environment and provides a detailed analysis from gene level to metabolic level regulation, as well as offering a discussion of the most recent modelling approaches. The book begins with an introduction to metabolic mechanisms and to the metabolic regulation of a cell, before moving on to discussing the action of global regulators in response to a specific culture environment. The second half of the book examines conventional flux balance analysis and its applications, 13C-metabolic flux analysis, and the effect of a specific gene knockout on the metabolism. Comprehensive account of metabolic regulation via global regulators in response to changes in the culture environment Basic formulation of 13C-metabolic flux analysis based on 13C-labelling experiments Systems biology approach for the modelling and computer simulation of the main metabolic pathways of a cell system
Author: Rani Gupta
Publisher: Springer Nature
ISBN: 9811607230
Category : Science
Languages : en
Pages : 670
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Book Description
This book provides useful information on microbial physiology and metabolism. The key aspects covered are prokaryotic diversity, growth physiology, basic metabolic pathways and their regulation, metabolic diversity with details of various unique pathways. Another focus area is stress physiology with details on varying environmental stresses, signal transduction, adaptation and survival. For instructional purposes, the book provides case studies, interesting facts, techniques etc. which help in showcasing the inter-disciplinary nature and bridge the gap between various aspects of applied microbiology.
Author: Gerhard Gottschalk
Publisher: Springer Science & Business Media
ISBN: 1461210720
Category : Science
Languages : en
Pages : 371
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Book Description
This concise yet comprehensive text surveys the field of bacterial metabolism in terms useful to students and researchers. Emphasis is on those metabolic reactions occurring only in bacteria. Thus, the book describes in detail the energy metabolism of the various groups of bacteria. In addition, it examines pathways used by bacteria for the degradation of organic compounds, the synthesis of cellular constituents, the regulation of bacterial metabolism and the fixation of molecular nitrogen.
Author: H. W. Doelle
Publisher: Academic Press
ISBN: 1483272745
Category : Nature
Languages : en
Pages : 501
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Book Description
Bacterial Metabolism focuses on metabolic events that occur in microorganisms, as well as photosynthesis, oxidation, polysaccharide formation, and homofermentation. The book first discusses the thermodynamics of biological reactions, photosynthesis and photometabolism, and chemosynthesis. Free energy, photosynthesis, enzymes, and terminology in bacterial metabolism are elaborated. The manuscript then examines acetic acid bacteria and lactic acid bacteria. Discussions focus on lactate, ethanol, glucose, and glycerol metabolism, glycol oxidation, homofermentation, polysaccharide formation, and electron transport systems. The publication takes a look at pseudomonadaceae and nitrogen metabolism as an energy source for anaerobic microorganisms. Topics include metabolism of pairs of amino acids, single amino acid metabolism, oxidation of glycolate and malonate, and oxygenases. The book is a dependable source of information for readers interested in bacterial metabolism.
Author: G. Gottschalk
Publisher: Springer Science & Business Media
ISBN: 1468404652
Category : Science
Languages : en
Pages : 292
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Book Description
This book has been written for students who are taking a course in bacterial metabolism. I hope, however, that scholars will also find it useful either as a help in teaching bacterial metabolism or as a review on the special aspects of metabolism in bacteria. The concept of this book results from my experience in teaching bacterial metabolism. In the first chapters the principal reactions of the energy and biosynthetic metabolism have been discussed using Escherichia coli as a model organism. Then the diversity of aerobic metabolism has been out lined. Following a brief description of the regulation of the level and the activity of enzymes in bacteria the characteristic features of fermentative, chemolithotrophic and phototrophic metabolism have been discussed. Finally, the last chapter has been devoted to nitrogen fixation. Throughout the text I have tried not only to describe metabolic pathways and enzyme reactions but also to elucidate the physiology of the microorganisms which carry out all these metabolic reactions. Two comments regarding the formulas used in this book are necessary.
Author: Byung Hong Kim
Publisher: Cambridge University Press
ISBN: 113946762X
Category : Science
Languages : en
Pages : 934
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Book Description
Recent determination of genome sequences for a wide range of bacteria has made in-depth knowledge of prokaryotic metabolic function essential in order to give biochemical, physiological, and ecological meaning to the genomic information. Clearly describing the important metabolic processes that occur in prokaryotes under different conditions and in different environments, this advanced text provides an overview of the key cellular processes that determine bacterial roles in the environment, biotechnology, and human health. Prokaryotic structure is described as well as the means by which nutrients are transported into cells across membranes. Glucose metabolism through glycolysis and the TCA cycle are discussed, as well as other trophic variations found in prokaryotes, including the use of organic compounds, anaerobic fermentation, anaerobic respiratory processes, and photosynthesis. The regulation of metabolism through control of gene expression and control of the activity of enzymes is also covered, as well as survival mechanisms used under starvation conditions.
Author: I Gunsalus
Publisher: Elsevier
ISBN: 0323145094
Category : Science
Languages : en
Pages : 589
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Book Description
The Bacteria: A Treatise on Structure and Function, Volume II: Metabolism deals with the gross metabolism of microorganisms in energy liberating reactions and pathways. The book investigates energy-yielding metabolism in bacteria; fermentation; terminal oxidation and its cyclic mechanisms; electron transport; and bacterial photosynthesis and luminescence. This volume is organized into 11 chapters and begins with a discussion of problems of energy metabolism that apply to all cells and unicellular organisms. The book also explains the biologically available energy released by glycolysis, oxidation, and light to chemical bond transformation and its quantitative relationships to whole cell requirements. The reader is then introduced to the fermentation of carbohydrates and related compounds, particularly the pathways of carbon and the role of hydrogen acceptors in fermentation, along with the decomposition of nitrogenous compounds such as amino acids, purines, and pyrimidines. The remaining chapters focus on the cyclic mechanisms for the synthesis of cellular components and for the yield of energy by oxidation. The breakdown of high molecular weight substances such as polysaccharides and bacterial cell walls is also explained. The chapters discuss as well the mechanisms of electron transport in microbes. The book concludes by exploring the physiological aspects of bacterial luminescence as well as the taxonomy and evolution of luminous bacteria. This book is a valuable resource for biochemists, microbiologists, bacteriologists, investigators, and students interested in the metabolic processes affecting bacteria.
Author: Tyrrell Conway
Publisher: John Wiley & Sons
ISBN: 1555818889
Category : Science
Languages : en
Pages : 382
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Book Description
Groundbreaking thinking on how bacterial metabolism is foundational to pathogenesis For too long, bacterial metabolism and bacterial pathogenesis have been studied as separate entities. However, the scientific community is beginning to realize that not only are bacterial nutrient acquisition and utilization essential for pathogenesis, but that interfering with the pathogen-specific metabolic pathways used during infection can regulate virulence factor expression and might lead to effective breakthroughs in a variety of treatments. Editors Paul Cohen and Tyrrell Conway, who pioneered the use of metabolic mutants in competitive colonization assays, an approach now widely used to investigate the nutrition of pathogens in vivo, are uniquely qualified to advance our knowledge of this integrative field of research. They convened a group of contributors who are breaking new ground in understanding how bacterial metabolism is foundational to pathogenesis to share their expert perspectives and outlook for the future. Beginning with overviews, Metabolism and Bacterial Pathogenesis covers a wide range of diseases and both Gram-positive and -negative bacteria that serve as model systems for in vitro and in vivo investigations intracellular, respiratory, and enteric pathogens pathogen-specific nutrient acquisition in hosts mechanisms of host-driven metabolic adaptation by pathogens metabolic regulation of virulence gene expression Useful for specialists in bacterial pathogenesis and specialists in metabolism as well as molecular biologists, physicians, veterinarians, dentists, graduate and undergraduate students, and laboratory technicians, Metabolism and Bacterial Pathogenesis is also essential reading for scientists studying the microbiome.
Author: Stephanie M. Amato
Publisher:
ISBN: 9781681179896
Category :
Languages : en
Pages : 377
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Book Description
Metabolism refers to all the biochemical reactions that take place in a cell or organism. The study of bacterial metabolism focuses on the chemical diversity of substrate oxidations and dissimilation reactions, which normally function in bacteria to generate energy. The role of metabolism in the bacterial response to antibiotics has recently garnered interest because of a rapid rise in antibiotic resistance, a clear link between metabolic function and cell viability, and the lack of novel targets for hard-to-treat infections. Also within the scope of bacterial metabolism is the study of the uptake and utilization of the inorganic or organic compounds required for growth and maintenance of a cellular steady state (assimilation reactions). Genome-scale metabolic models bridge the gap between genome-derived biochemical information and metabolic phenotypes in a principled manner, providing a solid interpretative framework for experimental data related to metabolic states, and enabling simple in silico experiments with whole-cell metabolism.This book entitled "Bacterial Metabolism" presents cutting-edge research and reviews on how bacterial and archaeal structure lead to function, how metabolic processes are regulated, how microbes respond to environmental stressors, and how microbes can be manipulated to enhance their growth or the production of desired products. It also summarises the current knowledge of the bacterial isolates capable of anaerobic mineralization of hydrocarbons, and of the biochemistry and molecular biology of enzymes involved in the catabolic pathways of some of these substrates. Several alkylbenzenes, alkanes or alkenes are anaerobically utilized as substrates by several species of denitrifying, ferric iron-reducing and sulfate-reducing bacteria. The book will be of valued for students, researchers as well as for practitioners dealing with the subject.
Author: Byung Hong Kim
Publisher: Cambridge University Press
ISBN: 1107171733
Category : Medical
Languages : en
Pages : 509
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Book Description
Extensive and up-to-date review of key metabolic processes in bacteria and archaea and how metabolism is regulated under various conditions.
