Archaeal Ribosomes: Biogenesis, Structure and Function PDF Download
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Author: Paola Londei
Publisher: Frontiers Media SA
ISBN: 2889741419
Category : Science
Languages : en
Pages : 164
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Book Description
Author: Paola Londei
Publisher: Frontiers Media SA
ISBN: 2889741419
Category : Science
Languages : en
Pages : 164
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Book Description
Author: Vijay Kumar
Publisher: Academic Press
ISBN: 0128167343
Category : Science
Languages : en
Pages : 298
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Book Description
Ribosome biogenesis is the process of making ribosomes which are responsible for mRNA translation into proteins. It is a tightly regulated process closely linked to nearly all biochemical and cellular processes, including cell division, growth, and development. Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides a synthesized overview of all the parts engaged in this process. The book begins by providing an introduction to the ribosome factory, its origin, and its evolution of translation. It then goes on to describe ribosome structure including subunits, RNA, and protein components. Ribosome biogenesis and its emergence as a frontier research area for translational potential in cancer and other diseases are also discussed. In addition, the book explores current developments in ribosome research like the emergence of ribosomopathies, how deregulation of ribosome biogenesis can impact disease mechanisms and aging, and the discovery of specialized ribosomes that have specific functions that may translate differentially with consequences on normal and pathological processes. Emerging Concepts in Ribosome Structure, Biogenesis, and Function provides fundamental coverage and emerging research on ribosomes, biogenesis, and their structure and function and is a resourceful introduction for new researchers and those engaged in interdisciplinary ribosomal research. - Provides an overview of ribosome biogenesis and examines its involvement in cell transformation and cancerous growth - Covers disorders related to the ribosome (ribosomopathies) and explains the significance of ribosome dysfunction in human diseases - Includes commonly used methods to study ribosomes, such as polysome preparation, RNA profiling and proteomics, CryoEM, and Cell-free assays along with proper illustrations
Author: Heinz Bielka
Publisher: de Gruyter
ISBN: 9783112729748
Category : Science
Languages : en
Pages : 0
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Book Description
No detailed description available for "The Eukaryotic Ribosome".
Author: Béatrice Clouet-d'Orval
Publisher: Springer
ISBN: 331965795X
Category : Science
Languages : en
Pages : 276
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Book Description
This book focuses on the regulation of transcription and translation in Archaea and arising insights into the evolution of RNA processing pathways. From synthesis to degradation and the implications of gene expression, it presents the current state of knowledge on archaeal RNA biology in 13 chapters. Topics covered include the modification and maturation of RNAs, the function of small non-coding RNAs and the CRISPR-Cas defense system. While Archaea have long been considered exotic microbial extremophiles, they are now increasingly being recognized as important model microorganisms for the study of molecular mechanisms conserved across the three domains of life, and with regard to the relevance of similarities and differences to eukaryotes and bacteria. This unique book offers a valuable resource for all readers interested in the regulation of gene expression in Archaea and RNA metabolism in general.
Author: Marina V. Rodnina
Publisher: Springer Science & Business Media
ISBN: 3709102154
Category : Medical
Languages : en
Pages : 428
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Book Description
The ribosome is a macromolecular machine that synthesizes proteins with a high degree of speed and accuracy. Our present understanding of its structure, function and dynamics is the result of six decades of research. This book collects over 40 articles based on the talks presented at the 2010 Ribosome Meeting, held in Orvieto, Italy, covering all facets of the structure and function of the ribosome. New high-resolution crystal structures of functional ribosome complexes and cryo-EM structures of translating ribosomes are presented, while partial reactions of translation are examined in structural and mechanistic detail, featuring translocation as a most dynamic process. Mechanisms of initiation, both in bacterial and eukaryotic systems, translation termination, and novel details of the functions of the respective factors are described. Structure and interactions of the nascent peptide within, and emerging from, the ribosomal peptide exit tunnel are addressed in several articles. Structural and single-molecule studies reveal a picture of the ribosome exhibiting the energy landscape of a processive Brownian machine. The collection provides up-to-date reviews which will serve as a source of essential information for years to come.
Author: Weidong Yang
Publisher: Springer
ISBN: 3319773097
Category : Science
Languages : en
Pages : 277
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Book Description
Dysfunction of nuclear-cytoplasmic transport systems has been associated with many human diseases. Thus, understanding of how functional this transport system maintains, or through dysfunction fails to maintain remains the core question in cell biology. In eukaryotic cells, the nuclear envelope (NE) separates the genetic transcription in the nucleus from the translational machinery in the cytoplasm. Thousands of nuclear pore complexes (NPCs) embedded on the NE selectively mediate the bidirectional trafficking of macromolecules such as RNAs and proteins between these two cellular compartments. In this book, the authors integrate recent progress on the structure of NPC and the mechanism of nuclear-cytoplasmic transport system in vitro and in vivo.
Author: Tessa Quax
Publisher:
ISBN: 9789461737830
Category :
Languages : en
Pages : 152
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Book Description
The work presented in this thesis provides novel insights in several aspects of the molecular biology of Archaea, Bacteria and their viruses. The archaeal virus Sulfolobus islandicus rod-shaped virus 2 (SIRV2), has a remarkable infection cycle. Infection with SIRV2 results in the formation of large virus associated pyramids (VAPs) on the host cell surface. The pyramids open during the final step of the infection cycle, to allow the release of virions. This virus release mechanism is unique. The VAPs are formed by self-assembly of one virus-encoded protein, PVAP. VAPs exist as discrete particles, and are baseless pyramids with heptagonal perimeter. The assembly process of the VAPs is described, based on cryo-electron tomography experiments and mutational analysis of PVAP. VAPs consists of two layers of which the outer one continuous with the cell membrane. PVAP expression in bacterial and eukaryotic cells resulted in VAP formation on nearly all membranes, demonstrating that PVAP serves as a universal membrane remodeling system, which might be exploited for biotechnological purposes. Whole transcriptome sequencing allowed determination of a global map of virus and host gene expression during the infection cycle. Host genes involved in anti-viral defence are activated (i.e. CRISPR-Cas and toxin anti-toxin systems). The multi-subunit protein complexes crucial for CRISPR anti-viral defence have an uneven stoichiometry and are encoded on operons. It is shown that differential translation is a key determinant of modulated expression of genes clustered in operons and that codon bias generally is the best in silico indicator of unequal protein production.
Author: Mark O. J. Olson
Publisher: Springer Science & Business Media
ISBN: 1461405149
Category : Science
Languages : en
Pages : 434
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Book Description
Within the past two decades, extraordinary new functions for the nucleolus have begun to appear, giving the field a new vitality and generating renewed excitement and interest. These new discoveries include both newly-discovered functions and aspects of its conventional role. The Nucleolus is divided into three parts: nucleolar structure and organization, the role of the nucleolus in ribosome biogenesis, and novel functions of the nucleolus.
Author: Jose Antonio Morales-Gonzalez
Publisher: BoD – Books on Demand
ISBN: 953511123X
Category : Science
Languages : en
Pages : 516
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Book Description
This work responds to the need to find, in a sole document, the affect of oxidative stress at different levels, as well as treatment with antioxidants to revert and diminish the damage. Oxidative Stress and Chronic Degenerative Diseases - a Role for Antioxidants is written for health professionals by researchers at diverse educative institutions (Mexico, Brazil, USA, Spain, Australia, and Slovenia). I would like to underscore that of the 19 chapters, 14 are by Mexican researchers, which demonstrates the commitment of Mexican institutions to academic life and to the prevention and treatment of chronic degenerative diseases.
Author: Anders Liljas
Publisher: World Scientific
ISBN: 9814531804
Category : Science
Languages : en
Pages : 494
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Book Description
This highly illustrated book provides an up-to-date description of the structure and function of the translation system including ribosomes, tRNAs, translation factors, antibiotics and aminoacyl-tRNA synthetases.Research on translation is undergoing rapid changes and is receiving significant attention as evidenced by the Nobel Prize in Chemistry 2009. The structural research by crystallography and cryo-EM forms part of an interactive framework that involves biochemistry and molecular computation. The book provides a comprehensive overview of translation in light of the structural results. It is a valuable resource for scientists in this and related fields, as well as for students taking courses with a focus on translation.There is no other book in this field currently except the previous edition of this book. The authors have for a long time worked in the field of structure and function of the translation system.
