The Predictive Value of Short-term Screening Tests in Carcinogenicity Evaluation PDF Download
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Author:
Publisher: Elsevier-North-Holland Biomedical Press
ISBN:
Category : Medical
Languages : en
Pages : 366
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Book Description
Author:
Publisher: Elsevier-North-Holland Biomedical Press
ISBN:
Category : Medical
Languages : en
Pages : 366
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Book Description
Author: Council of Europe
Publisher: Council of Europe
ISBN: 928718478X
Category : Medical
Languages : en
Pages : 272
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Book Description
As the third volume of a trilogy on Plants in cosmetics, this study concerns potentially harmful components which occur naturally in some plants the ingredients of which could likely be used in cosmetic products. Its aim is to raise awareness on the implication on consumer health by use of such ingredients and to trigger preventive measures. The 24 data sheets of components, selected by the authors because they are not regulated specifically in cosmetic legislation, give useful information particularly for the competent authorities and the manufacturers of raw materials and cosmetic products, mainly based on currently available pharmaco-toxicological data. Each monograph includes a bibliography and conclusions / recommendations.
Author: Heath J. Carney
Publisher:
ISBN:
Category : Carcinogenicity testing
Languages : en
Pages : 78
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Book Description
Author: Michael Williams
Publisher: Springer Science & Business Media
ISBN: 1461248280
Category : Medical
Languages : en
Pages : 453
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Book Description
The conceptual process of drug discovery is one that is often the result of an identified need in a defined disease area. This need represents a mandate from the marketing department of a phar maceutical company or a breakthrough at the research level that has agreed applicability in response to a valid therapeutic demand. Although the intelligent design and development of new thera peutic entities, as evidenced by Sir James Black's H -receptor an 2 tagonist cimetidine (Tagamet), is intellectually satisfying, many novel drugs arise from serendipity, from the chance observation of the research scientist or the clinician, that a compound has unex pected actions of use for the treatment of human disease states. Drugs that have been identified by this route include the antipsy chotic chlorpromazine and the putative anxiolytic buspirone. The events surrounding the process of drug discovery and de velopment are the theme of the present volume, which attempts to present, in a logical and lucid manner, the complexity of a process that is often naively assumed to represent nothing more than the identification of a new compound and its rapid introduction into humans, free of such complications as efficacy, selectivity, safety, bioavailability, toxicity, and need.
Author: United States-Japan Cooperative Medical Science Program
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 304
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Book Description
Author: Council of Europe
Publisher: Council of Europe
ISBN: 9287195544
Category : Medical
Languages : en
Pages : 441
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Book Description
Ingredients are used in cosmetics to give them specific properties. Certain ingredients, so called active ingredients, may produce pharmacological or toxic effects under certain conditions. Cosmetic products containing such ingredients may pose a health risk both because of their potential toxicity and because they may mask underlying serious diseases and consequently cause a dangerous delay in diagnosis and treatment. The objective of this study is to give safety information on certain active ingredients which give raise to toxicological concerns and for which restrictions of use in cosmetics should be considered. Monographs were prepared for 45 active ingredients for which no specific regulations exist including, inter alia, information about uses, properties, a risk evaluation of the use in cosmetic products considering as toxicological endpoints both systemic and local effects. Each monograph includes a bibliography, conclusions and recommendations. The study complements a series of three volumes containing monographs about the safety of certain natural ingredients used in cosmetics and will serve as a useful reference in the field, for health authorities, manufacturers and health professionals in particular.
Author: G. Gordon Gibson
Publisher: CRC Press
ISBN: 9780203481516
Category : Medical
Languages : en
Pages : 756
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Book Description
Provides an update on several new aspects of peroxisome biology, including the role of the peroxisome proliferator activated receptor. The book covers morphilogical, biochemical and molecular biological aspects of peroxisomes.
Author: K.H. Norpoth
Publisher: Springer Science & Business Media
ISBN: 3642672027
Category : Medical
Languages : en
Pages : 424
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Book Description
The varying cancer incidence from country to country and region to region suggests that en vironmental factors play a considerable role in the aetiology of cancer. Whether these factors in the environment moderate the effect of car cinogenic chemicals or whether they might them selves be carcinogenic is not known at the present time. What is known is that there are various chemicals, both naturally occurring and man-made, which can induce cancer in man. In the Western world estimates vary as to how much cancer is occupational in origin; the figures range from 1% to 40%. It is our feeling that probably about 10% of cancer has a direct oc cupational origin. Nevertheless this number is considerable and it behoves us therefore to identify those chemicals which are carcinogenic and to reduce human exposure. Recent work on the mode of action of carcinogenic chemicals suggests that the majority exert their effect through an activation step to give elec trophilic metabolites. Such metabolites have as a common feature the ability to react with cel lular nucleophiles to give covalently bound products. Such reaction will occur after carcino gen treatment of animals with nucleic acids par ticularly in target organs. It is reaction with nucleic acids that provides the basis of a num ber of short-term tests for carcinogens, since the basic composition of DNA is similar in micro-organisms and in human cells.
Author: James Devillers
Publisher: Springer Science & Business Media
ISBN: 1441901973
Category : Science
Languages : en
Pages : 400
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Book Description
Ecotoxicology Modeling is a comprehensive and well-documented text providing a collection of computational methods to the ecotoxicologists primarily interested in the study of the adverse effects of chemicals, their mechanisms of action and/or their environmental fate and behavior. Avoiding mathematical jargon, the book presents numerous case studies to enable the reader to understand the interest but also the limitations of linear and nonlinear models in ecotoxicology. Written by an international team of scientists, Ecotoxicology Modeling is of primary interest to those whose research or professional activity is directly concerned with the development and application of models in ecotoxicology. It is also intended to provide the graduate and post-graduate students with a clear and accessible text covering the main types of modeling approaches used in environmental sciences.
Author:
Publisher:
ISBN:
Category : Environmental health
Languages : en
Pages : 1724
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Book Description
