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Author: Giuseppe A. Ramirez
Publisher: Frontiers Media SA
ISBN: 2889450902
Category :
Languages : en
Pages : 150
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Book Description
Plasticity and dynamism characterize the immune system as a tissue-integrating network with defensive functions. Blood and lymphatic vessel trees constitute the most evident and intuitive physical platform for the development of the net of interactions between immune cells, body tissues and foreign agents. Moreover vessel repair and immune patrolling are intimately linked physiological functions with common evolutionary roots. Not surprisingly variable degrees of vascular inflammation are often detectable in the setting of systemic inflammation and autoimmunity, whereas research in the field of cardiovascular pathology is progressively converging towards the identification of a common inflammatory background. The definition of the role of vascular inflammation in causing, sustaining and/or predicting the development of systemic autoimmunity constitute a challenging, unexplored frontier towards the development of a new generation of treatments and a better patient care.
Author: Giuseppe A. Ramirez
Publisher: Frontiers Media SA
ISBN: 2889450902
Category :
Languages : en
Pages : 150
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Book Description
Plasticity and dynamism characterize the immune system as a tissue-integrating network with defensive functions. Blood and lymphatic vessel trees constitute the most evident and intuitive physical platform for the development of the net of interactions between immune cells, body tissues and foreign agents. Moreover vessel repair and immune patrolling are intimately linked physiological functions with common evolutionary roots. Not surprisingly variable degrees of vascular inflammation are often detectable in the setting of systemic inflammation and autoimmunity, whereas research in the field of cardiovascular pathology is progressively converging towards the identification of a common inflammatory background. The definition of the role of vascular inflammation in causing, sustaining and/or predicting the development of systemic autoimmunity constitute a challenging, unexplored frontier towards the development of a new generation of treatments and a better patient care.
Author: Ronald A. Asherson
Publisher: CRC Press
ISBN: 1420040391
Category : Medical
Languages : en
Pages : 624
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Book Description
Not too long ago, it was thought that inflammation of blood vessels was the sole manifestation of systemic autoimmune diseases. Today, however, we know that disorders of coagulation, injuries to both neutrophils and endothelial cells, and certain lipids and amino acids are all intricately involved in the development of vascular disease. How are all
Author: Renato Alberto Sinico
Publisher: Springer Nature
ISBN: 3030022390
Category : Medical
Languages : en
Pages : 336
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Book Description
This volume, written by well-known experts in the field, covers all aspects of Anti-Neutrophil Cytoplasmic Antibody (ANCA) Associated Vasculitis (AAV). The expression refers to a group of diseases, characterized by destruction and inflammation of small vessels. The clinical signs vary and affect several organs, such as the kidney, lung, skin, nervous system and others. The opening chapters give some historical hints, explain the genetic basis of the disease and provide insights into the pathogenesis derived from recent experimental studies and guides the reader through classification and nomenclature. A large part of the book is then devoted to a detailed description of the specific related diseases and their clinical presentations, the disease course, and potential complications. The advice regarding treatment is based on the best currently available evidence in this constantly evolving area. The book is part of Springer’s series Rare Diseases of the Immune System, which presents recently acquired knowledge on pathogenesis, diagnosis, and therapy with the aim of promoting a more holistic approach to these conditions. AAVs are systemic autoimmune diseases of unknown cause that affect small (to medium) sized blood vessels. They include granulomatosis with polyangiitis (formerly Wegener's granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (formerly Churg–Strauss syndrome). This volume will be an invaluable source of up-to-date information for all practitioners involved in the care of patients with these diseases.
Author: Gary S. Hoffman
Publisher: John Wiley & Sons
ISBN: 111835527X
Category : Medical
Languages : en
Pages : 597
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Book Description
Inflammatory Diseases of Blood Vessels“/b> Inflammatory Diseases of Blood Vessels Second Edition Inflammatory Diseases of Blood Vessels provides a comprehensive overview of the science and clinical consequences of vascular inflammation in health and disease. In recent years, considerable progress has been made in understanding different forms of vasculitis. Investigation of pathogenesis of vascular inflammation has led to improved treatments and outcomes. Surgical and transplant procedures have improved in parallel with medical therapies. These areas are extensively examined in this new edition. Inflammatory Diseases of Blood Vessels is an excellent resource for a broad readership, including clinicians, investigators and their support teams in numerous specialties e.g. rheumatology, immunology, cardiology, cardiovascular surgery, pulmonary medicine, nephrology, pathology, vascular biology, embryology and imaging.
Author: Franco Franceschini
Publisher: Frontiers Media SA
ISBN: 283254682X
Category : Medical
Languages : en
Pages : 119
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Book Description
Systemic autoimmune diseases are a heterogeneous group of disorders characterized by humoral and cell-mediated immune responses against various self-constituents. In specific cases, the heart and cardiovascular (CV) system are the primary organs targeted by the disease. On the other hand, several systemic autoimmune conditions are linked to enhanced atherosclerosis, with a consequently high CV morbidity and mortality rates. Persistent low-grade inflammation in the vascular wall is described to be important in the physiopathology of CV events. At first, inflammation is linked to endothelial dysfunction supporting the proliferation of vascular smooth muscle cells with subsequent vascular remodeling. Furthermore, the infiltration of innate and adaptive immune cells promotes a milieu of molecules that contributes to the perpetuation of inflammation itself. Although CV risk assessment should be part of routine care in patients with autoimmune diseases, no disease-specific models are currently available for this purpose. The main pillars of CV risk reduction are pharmacological and nonpharmacological management of cardiovascular CV risk factors, as well as tight control of disease activity.
Author: Piercarlo Sarzi-Puttini
Publisher: Elsevier
ISBN: 0080461921
Category : Medical
Languages : en
Pages : 359
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Book Description
This book represents the state-of-the-art in the field of skin and autoimmune rheumatic diseases. It covers systematically a growing and multifaceted topic which is of great importance in the clinical practice. It also serves as a sharp educational tool as each chapter provides summaries and specific highlights to key references cited into the text. The pathophysiological link between skin involvement and autoimmunity has been explained in detail, as well as diagnostic and therapeutic aspects. This book yields an impressive body of well ordered information which summarizes the experience of a selected panel of distinguished physicians and scientists actively involved in the field of skin immunology and systemic autoimmunity. * Written by a respected panel of distinguished physician-scientists actively involved in the field of skin immunology and systemic autoimmunity * Box summaries at the end of each chapter highlight important topics * Up-to-date basic knowledge as well as modern approach to diagnosis and therapy
Author: Arnold von Eckardstein
Publisher: Springer
ISBN: 9783319096643
Category : Medical
Languages : en
Pages : 0
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Book Description
In this Handbook of Experimental Pharmacology on “High Density Lipoproteins – from biological understanding to clinical exploitation” contributing authors (members of COST Action BM0904/HDLnet) summarize in more than 20 chapters our current knowledge on the structure, function, metabolism and regulation of HDL in health and several diseases as well as the status of past and ongoing attempts of therapeutic exploitation. The book is of interest to researchers in academia and industry focusing on lipoprotein metabolism, cardiovascular diseases and immunology as well as clinical pharmacologists, cardiologists, diabetologists, nephrologists and other clinicians interested in metabolic or inflammatory diseases.
Author: Andrea Dorea
Publisher: Elsevier
ISBN: 0080507964
Category : Medical
Languages : en
Pages : 276
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Book Description
This first volume represents the state-of-the-art in the field of cardiovascular disease and autoimmune rheumatic diseases. Systemic autoimmune diseases comprise a family of conditions that share common pathogenetic mechanisms as well as a multi-organ involvement including the heart. This volume has been subdivided into three parts. In the first part, the immune mechanisms involved in cardiac damage have been considered. The role of proinflammatory and regulatory cytokines in driving an autoimmune response to cardiac self-tissues has been analysed. Moreover, the prevalence, the clinical meaning and the hypothetical pathogenicity of a broad spectrum of organ and non-organ specific autoantibodies have been discussed in detail. In the second part of the volume, the role of humoral and innate immunity in promoting the development of atherosclerotic plaque has been extensively reviewed, along with the newly discovered anti-inflammatory properties of statins. These two parts of the volume deal with exciting aspects of this topic, suggesting a very close connection between heart diseases and immunology. Finally, in the third part, the cardiac manifestations observed in the major systemic autoimmune conditions have been comprehensively examined. This book yields an impressive body of well ordered information, highlighting key references and summarising the experience of a selected panel of distinguished physician-scientists actively involved in the field of cardiovascular disease and systemic autoimmunity.
Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :
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Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author: Marta Catalfamo
Publisher: Frontiers Media SA
ISBN: 288971232X
Category : Medical
Languages : en
Pages : 167
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Book Description
