Author: Harry Luman Russell
Publisher:
ISBN:
Category : Agriculture
Languages : en
Pages : 24

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Author: Great Britain: Parliament: House of Commons: Environment, Food and Rural Affairs Committee
Publisher: Stationery Office
ISBN: 9780215058829
Category : Technology & Engineering
Languages : en
Pages : 122

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The Environment, Food and Rural Affairs Committee warns that vaccination against bovine TB is expensive, offers no guarantee of protection and will provide little benefit in the immediate future. More than £58 million has been invested in vaccine research and development since 1994. Deployment of the injectable badger vaccine will cost an estimated £2,000-£4,000 per km2. The cattle vaccine is expected to cost £5-6 per dose and the DIVA test (which differentiates between infected and vaccinated cattle) costs £25. Small-scale studies to test the efficacy of the vaccine in cattle overseas have shown the protective effect to be between 56-68%, a level of protection that won't immediately solve the problems of bovine TB in the cattle industry. The UK needs more reliable skin tests than the current one that could miss one in four infected cows. An injectable BCG vaccine for badgers is now available but it does not confer complete protection and has no discernible effect on animals already infected with TB. An oral baited vaccine that can be laid at setts is likely to be cheaper and more practical, but development and deployment of it will take several years to resolve. A variety of ongoing research projects could make a real difference to the eradication of bovine TB in the United Kingdom. These include: PCR testing to determine infected badger setts, a new type of test to identify bovine TB in cattle after slaughter, and work on a vaccine that does not interfere with the skin test.

Author: John P. Bannantine
Publisher: Frontiers Media SA
ISBN: 2889194760
Category : Bacterial vaccines
Languages : en
Pages : 95

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The two most prominent mycobacterial diseases in animals include bovine tuberculosis, caused by Mycobacterium bovis and Johne’s disease, caused by Mycobacterium avium subspecies paratuberculosis. Erradication of both diseases has been hampered by a variety of factors. In many countries, the persistence of tuberculosis in cattle has been attributed to reservoirs of M. bovis in wildlife species. Brushtail possums, deer and badgers are notable examples of wildlife reservoirs for M. bovis. The difficulties in eliminating the wildlife reservoir for M. bovis further suggest the need for vaccination of farmed livestock. Vaccination of wildlife species has also been attempted with mixed results. Delivery of the vaccine to wildlife species appears to be a chief obstacle. Vaccination itself leads to complications for diagnostics. For example, when cattle are vaccinated with both BCG and a commercial Johne’s vaccine there is a biased toward the avian tuberculin skin test reaction. Despite these issues, BCG seems to be the clear standard for vaccination against M. bovis, yet many laboratories are investigating ways to improve on BCG. For Johne’s disease, the available commercial vaccines consist of whole-cell preparations in one form or another. But with the ability to generate directed knockouts of specific genes, a number of defined mutants have been constructed in a few laboratories. These should be tested and directly compared with each other and alongside commercial vaccine formulations to determine not only which vaccine is most protective, but which animal model is best for predicting protection in the target host. To this end, there has been a nation-wide, multi-institutional effort to test the best live, attenuated vaccine against Johne's disease in cattle, sheep and goats. This vaccine trial has spanned six years and was conducted in three phases. The first phase examined attenuation in bovine macrophages, the second phase was colonization of spleen and liver in mice and the third phase was protection from bacterial challenge in goats. Many new ideas and retrospective approaches have emerged from this unprecedented effort. These aspects will be captured in this Research Topic. In this Research Topic, we will seek articles on these above topics, but other issues surrounding vaccination of animals against mycobacteria will also be explored. These include immune parameters, correlates of protection, adjuvants and other vaccine formulations, etc.

Author:
Publisher:
ISBN: 9780908654710
Category : Tuberculosis in cattle
Languages : en
Pages : 119

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Author: Lin-Mari De Klerk-Lorist
Publisher:
ISBN:
Category :
Languages : en
Pages :

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To assist in the evaluation of BCG vaccination in African buffaloes (Syncerus caffer), an infection model for Mycobacterium bovis was established, using an intratonsilar route of inoculation. Two groups of 11 buffaloes each, aged approximately 18 months, were infected with either 3,2 x 102 cfu (low dose) or 3 x 104 (high dose) of virulent buffalo strain M. bovis. A control group of six buffaloes received saline via the same route. The infection status was monitored using the intradermal tuberculin test, an ELISA and a modified interferon-gamma assay. All buffaloes were euthanased 22 weeks post infection and the development of lesions in the left retropharyngeal lymph node was evaluated by macroscopic examination, mycobacterial culture and histopathology. It was found that the high dose caused macroscopic lesions in 9 out of 11 buffaloes that were comparable to that observed in buffaloes with natural disease. Mycobacterium bovis was isolated from all animals in the high dose and from 6 out of 11 buffaloes in the low dose group. The efficacy of a live BCG-Pasteur vaccine was tested in a group of buffalo calves captured in the northern districts of the Kruger National Park from herds with known negative tuberculosis status. Primary and booster vaccinations with BCG (1173P2) were administered to 15 calves, while another 15 were left unvaccinated as control animals. All the buffalo calves were challenged with the high dose of live M. bovis (as determined in the Infection Model) via intratonsilar inoculation. Laboratory tests were able to distinguish between infected and non-infected animals from an early stage. All buffaloes were euthanased 34 weeks after infection and the development of lesions in the lymph nodes of the head, thorax, carcass and abdomen was evaluated by macroscopic examination, mycobacterial culture and histopathology. The lungs were carefully palpated to detect the presence of tuberculous granulomas. Macroscopic lesions in the lymph nodes were found in 10 out of 14 control buffaloes and 7 out of 15 vaccinated animals. The lesions were comparable to that observed in buffaloes with natural infection. The lesion scores of individual animals were generally much higher in the BCG vaccine study than what was experienced with the Infection Model. Mycobacterium bovis was isolated from 12 out of 14 control animals and from 12 out of 15 vaccinated buffaloes. Although fewer vaccinated animals developed tuberculous lesions, the differences between the two groups were not statistically significant and it can be concluded that under the prevailing conditions the BCG vaccine was unable to protect buffalo calves against the establishment of M. bovis infection.

Author: Harry Luman Russell
Publisher:
ISBN:
Category : Tuberculosis in cattle
Languages : en
Pages : 13

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Author: Samuel Howard Gilliland
Publisher:
ISBN:
Category :
Languages : en
Pages : 162

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Author: S. H. Gilliland
Publisher:
ISBN:
Category : Cattle
Languages : en
Pages : 158

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Author: Giovanni Battista Migliori
Publisher: Springer Nature
ISBN: 3030667030
Category : Medical
Languages : en
Pages : 416

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This textbook covers the full spectrum of tuberculosis-related topics in a comprehensive yet easy-to-follow, readily accessible format. Filling a significant gap in tuberculosis literature, it addresses tuberculosis sensu latu, mirroring the content of the London Queen Mary University tuberculosis Diploma. Covering all aspects related to this condition, from prevention, diagnosis and treatment to public and global health, the book provides a broad overview of tuberculosis management. Further, it includes a wealth of case studies and exercises, making it an essential guide for all staff involved in tuberculosis management. Written by an international and interdisciplinary panel of experts, the book appeals to a broad readership including students, postdoctoral fellows, clinicians, researchers, and nurses, as well as public health officers working in tuberculosis control programs.

Author: Babita Agrawal
Publisher: Frontiers Media SA
ISBN: 2889639657
Category :
Languages : en
Pages : 168

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