Ultrashort Pulse Laser Effects in the Primate Eye PDF Download
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Category :
Languages : en
Pages : 121
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Book Description
Minimum visible lesion (MVL) threshold measurements at the retina for rhesus monkey eyes are reported for femtosecond, picosecond, and nanosecond single laser pulses using visible wavelengths. Estimates of the dose causing 50% probability for damage (ED50) are calculated for 1-hour and 24-hours postexposure as well as the 95% fiducial intervals for ED. The ED values are found to be dependent on both wavelength and pulsewidth, and for a single wavelength are, in general, lower for short pulsewidths, with the exception of values at the shortest pulsewidth of 90 fs at 580 nm. At 90 fs the ED(50) dosages were noted to increase slightly when compared with the 3-ps and 600-fs values, all three delivered at 580-nm wavelength. The 4-ns ED(50) value was more than double the value at 60 ps delivered at 532-nm wavelength. Fluorescein angiography was accomplished at 1-hour and 24-hours postexposure and did not demonstrate lower threshold for damage, which has been the case for MVLs created with longer pulse duration (greater than 1 ns) or for rabbit eyes at the same pulse-widths as measured in our laboratory.
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 121
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Book Description
Minimum visible lesion (MVL) threshold measurements at the retina for rhesus monkey eyes are reported for femtosecond, picosecond, and nanosecond single laser pulses using visible wavelengths. Estimates of the dose causing 50% probability for damage (ED50) are calculated for 1-hour and 24-hours postexposure as well as the 95% fiducial intervals for ED. The ED values are found to be dependent on both wavelength and pulsewidth, and for a single wavelength are, in general, lower for short pulsewidths, with the exception of values at the shortest pulsewidth of 90 fs at 580 nm. At 90 fs the ED(50) dosages were noted to increase slightly when compared with the 3-ps and 600-fs values, all three delivered at 580-nm wavelength. The 4-ns ED(50) value was more than double the value at 60 ps delivered at 532-nm wavelength. Fluorescein angiography was accomplished at 1-hour and 24-hours postexposure and did not demonstrate lower threshold for damage, which has been the case for MVLs created with longer pulse duration (greater than 1 ns) or for rabbit eyes at the same pulse-widths as measured in our laboratory.
Author: Paul M. Pellegrino
Publisher: CRC Press
ISBN: 1482233290
Category : Technology & Engineering
Languages : en
Pages : 402
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Book Description
Laser-Based Optical Detection of Explosives offers a comprehensive review of past, present, and emerging laser-based methods for the detection of a variety of explosives. This book: Considers laser propagation safety and explains standard test material preparation for standoff optical-based detection system evaluation Explores explosives detection using deep ultraviolet native fluorescence, Raman spectroscopy, laser-induced breakdown spectroscopy, reflectometry, and hyperspectral imaging Examines photodissociation followed by laser-induced fluorescence, photothermal methods, cavity-enhanced absorption spectrometry, and short-pulse laser-based techniques Describes the detection and recognition of explosives using terahertz-frequency spectroscopic techniques Each chapter is authored by a leading expert on the respective technology, and is structured to supply historical perspective, address current advantages and challenges, and discuss novel research and applications. Readers are left with an in-depth understanding and appreciation of each technology’s capabilities and potential for standoff hazard detection.
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Category : Aeronautics
Languages : en
Pages : 542
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Book Description
Author: Cynthia Toth
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ISBN:
Category :
Languages : en
Pages : 12
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Book Description
Toth et al. identified the acute pathologic retinal events which determined the extent of tissue damage from minimal laser energy and suprathreshold energy. She identified the acute pathology of primate maculas with minimal visible retinal lesions generated by 90 femtosecond and 5 picosecond pulses of 580 nm laser energy. Dr. Toth's study included light microscopic evaluation of macular damage and electron microscopic ultrastructural analysis of melanosome ruptures within the retinal pigment epithelium. The pathology was reported at AFOSR with a CDROM summary of lesion data provided to armstrong Laboratory for reference. Dr. Toth scored the area and extent of tissue damage and compiled a list for Dr. Rockwell and Dr. Clarence Cain at Armstrong Laboratory, Brooks, AFB for analysis and comparison to the ED50 MVL data. A paper summarizing this work has been published as the lead article in October, 1997 in Investigative Ophthalmology and Visual Science (I0VS). Dr. Toth's Laboratory group gathered significant tissue data on ultrashort pulses of other laser wavelengths. They collaborated with Armstrong Laboratory (Dr. Cain et al.) in analyzing near-infrared ultrashort laser pulse injury MVL data which was published at Society of Photo-Optical Instrumentation Engineers (SPIE), 1997 (Cain, Toth, et al.).
Author:
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ISBN:
Category : Eye
Languages : en
Pages : 238
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Book Description
Author: T. F. Deutsch
Publisher:
ISBN:
Category :
Languages : en
Pages : 8
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Book Description
The goals of this project are: (1) To develop assays for functional damage to retinal cells by pressure waves (stress transients); (2) To determine the acoustic properties of the aqueous and vitreous humors of the eye; and (3) To examine the effect of pressure waves to the retinal pigment epithelium in vitro. During this first year our efforts have been directed primarily at the first goal, with some initial efforts on the second. During this period we developed the capability of growing human retinal pigment epithelium (RPE) cells in culture, incorporating them intest capillaries, recovering them after exposure to stress transients and assessing cell damage.
Author:
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ISBN:
Category : Government publications
Languages : en
Pages : 936
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Book Description
Author: Zoltan Nagy
Publisher: CRC Press
ISBN: 1040143423
Category : Medical
Languages : en
Pages : 191
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Book Description
Dr. Zoltan Z. Nagy performed the first femtosecond laser-assisted cataract surgery in a human eye in 2008. As one of the most authoritative sources on the topic, Femtosecond Laser-Assisted Cataract Surgery: Facts and Results presents the history of the development and use of femtosecond laser-assisted cataract surgery summarizes the results of five years of pioneering techniques by Dr. Nagy and his team, including personal reflections and thoughts, as well as a series of classic papers. Femtosecond Laser-Assisted Cataract Surgery consists of two main sections. The first section discusses and reviews the new results for the reader from the research. The second section comprises original articles on the topic of femtosecond laser cataract surgery that is essential to ophthalmologists. Additional features include: • A review of the current state-of-the-art usages of femtosecond laser-assisted cataract surgery • Examine existing technologies that compete with femtosecond laser-assisted cataract surgery and compare outcomes • Discuss key secrets to successful surgical techniques using femtosecond laser-assisted cataract surgery • How to address and manage common complications associated with femtosecond laser-assisted cataract surgery Femtosecond Laser-Assisted Cataract Surgery presents these clinical results with cataract and corneal application, and highlights basic research with the strength of the anterior capsule and will assist ophthalmologists and residents alike gain a better understanding of the femtosecond laser cataract surgery process.
Author:
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ISBN:
Category : Medicine
Languages : en
Pages : 928
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Book Description
Author: Ken Barat
Publisher: CRC Press
ISBN: 1351831798
Category : Science
Languages : en
Pages : 438
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Book Description
New chapters and updates highlight the second edition of Laser Safety: Tools and Training. This text provides background information relating to lasers and laser safety, and examines the components of laser work and laser safety from a different perspective. Written by a working laser safety officer, the book considers ways to keep users, as well as those around them, safe. The author encourages readers to think beyond protective eyewear. As it relates to safety, he determines that if eyewear is required, then the laser system is not ideal. This book factors in optics, the vibration elements of the optical table, the power meter, and user training, elements that are not commonly considered in the context of laser safety. It presents ways for users to evaluate the hazards of any laser procedure and ensure that they are following documented laser safety standards. The material serves as a fundamental means or road map for laser users seeking to utilize the safest system possible. What’s New in the Second Edition: The second edition provides an inclusion of the Z136.8 Research Laser Standard, and offers updates and an explanation of eye exposure limits (MPE), presents new cases studies, and presents practical example images. It includes coverage of, laser lab design lessons, addresses user facility challenges and laser disposal. Presents case studies of real accidents, preventive measures, and templates for documenting potential laser risks and attendant safety measures Reviews factors often overlooked when one is setting up a laser lab Demonstrates how to investigate a laser incident This text which includes fundamental laser and laser safety information, as well as critical laser use information, is appropriate for both the novice and the seasoned professional.
