Towards the Next Generation of Deep Brain Stimulation Therapies: Technological Advancements, Computational Methods, and New Targets PDF Download
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Author: George C. McConnell
Publisher: Frontiers Media SA
ISBN: 2889714640
Category : Science
Languages : en
Pages : 152
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Book Description
Author: George C. McConnell
Publisher: Frontiers Media SA
ISBN: 2889714640
Category : Science
Languages : en
Pages : 152
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Book Description
Author: Timothée Levi
Publisher: Frontiers Media SA
ISBN: 2889454665
Category :
Languages : en
Pages : 326
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Book Description
Millions of people worldwide are affected by neurological disorders which disrupt the connections within the brain and between brain and body causing impairments of primary functions and paralysis. Such a number is likely to increase in the next years and current assistive technology is yet limited. A possible response to such disabilities, offered by the neuroscience community, is given by Brain-Machine Interfaces (BMIs) and neuroprostheses. The latter field of research is highly multidisciplinary, since it involves very different and disperse scientific communities, making it fundamental to create connections and to join research efforts. Indeed, the design and development of neuroprosthetic devices span/involve different research topics such as: interfacing of neural systems at different levels of architectural complexity (from in vitro neuronal ensembles to human brain), bio-artificial interfaces for stimulation (e.g. micro-stimulation, DBS: Deep Brain Stimulation) and recording (e.g. EMG: Electromyography, EEG: Electroencephalography, LFP: Local Field Potential), innovative signal processing tools for coding and decoding of neural activity, biomimetic artificial Spiking Neural Networks (SNN) and neural network modeling. In order to develop functional communication with the nervous system and to create a new generation of neuroprostheses, the study of closed-loop systems is mandatory. It has been widely recognized that closed-loop neuroprosthetic systems achieve more favorable outcomes for users then equivalent open-loop devices. Improvements in task performance, usability, and embodiment have all been reported in systems utilizing some form of feedback. The bi-directional communication between living neurons and artificial devices is the main final goal of those studies. However, closed-loop systems are still uncommon in the literature, mostly due to requirement of multidisciplinary effort. Therefore, through eBook on closed-loop systems for next-generation neuroprostheses, we encourage an active discussion among neurobiologists, electrophysiologists, bioengineers, computational neuroscientists and neuromorphic engineers. This eBook aims to facilitate this process by ordering the 25 contributions of this research in which we highlighted in three different parts: (A) Optimization of different blocks composing the closed-loop system, (B) Systems for neuromodulation based on DBS, EMG and SNN and (C) Closed-loop BMIs for rehabilitation.
Author: Gordon H. Baltuch
Publisher: CRC Press
ISBN: 1420019759
Category : Medical
Languages : en
Pages : 374
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Book Description
Considered the largest breakthrough in the treatment of Parkinson's disease in the past 40 years, Deep Brain Stimulation (DBS) is a pioneering procedure of neurology and functional neurosurgery, forging enormous change and growth within the field. The first comprehensive text devoted to this surgical therapy, Deep Brain Stimulation for Parkinson's
Author: Adolfo Ramirez-Zamora
Publisher: Frontiers Media SA
ISBN: 2832551440
Category : Science
Languages : en
Pages : 195
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Book Description
In recent years, numerous developments have taken place in the field of neuromodulation. The introduction of newer technologies, software and increasing understanding of brain physiology in neurological and psychiatric conditions have shaped this rapidly growing field. To create a space where all stakeholders could freely interact to discuss challenges, advancements and opportunities in the field, the first Deep Brain Stimulation (DBS) Think Tank took place in 2012 in Gainesville Florida at the University of Florida. Since then, the meeting has grown to a hybrid virtual and in person meeting expanding the number of participants to over 200 world experts in the field. The most recent DBS think tank took place in Orlando Florida on August 25th to 27th, 2021. The meeting addressed new research, technologies, and neuroethical issues in the field of neuromodulation.
Author: Doris D. Wang
Publisher: Frontiers Media SA
ISBN: 2889762459
Category : Science
Languages : en
Pages : 165
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Book Description
Author: Alfredo Quinones-Hinojosa
Publisher: Elsevier Health Sciences
ISBN: 0323415199
Category : Medical
Languages : en
Pages : 2913
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Book Description
Schmidek and Sweet has been an indispensable reference for neurosurgery training and practice for nearly 50 years, and the 7th Edition of Operative Neurosurgical Techniques continues this tradition of excellence. A new editorial board led by editor-in-chief Dr. Alfredo Quinones-Hinojosa, along with more than 330 internationally acclaimed contributors, ensures that readers stay fully up to date with rapid changes in the field. New chapters, surgical videos, and quick-reference features throughout make this edition a must-have resource for expert procedural guidance for today's practitioners. - Discusses indications, operative techniques, complications, and results for nearly every routine and specialized procedure for brain, spinal, and peripheral nerve problems in adult patients. - Covers the latest techniques and knowledge in deep brain stimulation for epilepsy, movement disorders, dystonia, and psychiatric disorders; surgical management of blast injuries; invasive electrophysiology in functional neurosurgery; and interventional management of cerebral aneurysms and arterio-venous malformations. - Includes new chapters on bypass techniques in vascular disease, previously coiled aneurysms, CSF diversion procedures, surgical management of posterior fossa cystic and membranous obstruction, laser-ablation techniques, and brain stem tumors. - Explores hot topics such as wide-awake surgery and ventriculo-peritoneal, ventriculoatrial and ventriculo-pleural shunts. - Provides detailed visual guidance with more than 1,600 full-color illustrations and 50 procedural videos. - Contains quick-reference boxes with surgical pearls and complications. - Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.
Author: Mihail C. Roco
Publisher: Springer Science & Business Media
ISBN: 9401703590
Category : Technology & Engineering
Languages : en
Pages : 477
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Book Description
M. C. Roco and W.S. Bainbridge In the early decades of the 21st century, concentrated efforts can unify science based on the unity of nature, thereby advancing the combination of nanotechnology, biotechnology, information technology, and new technologies based in cognitive science. With proper attention to ethical issues and societal needs, converging in human abilities, societal technologies could achieve a tremendous improvement outcomes, the nation's productivity, and the quality of life. This is a broad, cross cutting, emerging and timely opportunity of interest to individuals, society and humanity in the long term. The phrase "convergent technologies" refers to the synergistic combination of four major "NBIC" (nano-bio-info-cogno) provinces of science and technology, each of which is currently progressing at a rapid rate: (a) nanoscience and nanotechnology; (b) biotechnology and biomedicine, including genetic engineering; (c) information technology, including advanced computing and communications; (d) cognitive science, including cognitive neuroscience. Timely and Broad Opportunity. Convergence of diverse technologies is based on material unity at the nanoscale and on technology integration from that scale.
Author: Andreas Horn
Publisher: Academic Press
ISBN: 0128218622
Category : Medical
Languages : en
Pages : 602
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Book Description
Connectomic Deep Brain Stimulation (DBS) covers this highly efficacious treatment option for movement disorders such as Parkinson's Disease, Essential Tremor and Dystonia. The book examines its impact on distributed brain networks that span across the human brain in parallel with modern-day neuroimaging concepts and the connectomics of the brain. It asks several questions, including which cortical areas should DBS electrodes be connected in order to generate the highest possible clinical improvement? Which connections should be avoided? Could these connectomic insights be used to better understand the mechanism of action of DBS? How can they be transferred to individual patients, and more. This book is suitable for neuroscientists, neurologists and functional surgeons studying DBS. It provides practical advice on processing strategies and theoretical background, highlighting and reviewing the current state-of-the-art in connectomic surgery. - Written to provide a "hands-on" approach for neuroscience graduate students, as well as medical personnel from the fields of neurology and neurosurgery - Includes preprocessing strategies (such as co-registration, normalization, lead localization, VTA estimation and fiber-tracking approaches) - Presents references (key articles, books and protocols) for additional detailed study - Provides data analysis boxes in each chapter to help with data interpretation
Author: Steve M Potter
Publisher: Frontiers Media SA
ISBN: 288919356X
Category : Neurophysiology
Languages : en
Pages : 424
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Book Description
Closed-loop neurophysiology has been accelerated by recent software and hardware developments and by the emergence of novel tools to control neuronal activity with spatial and temporal precision, in which stimuli are delivered in real time based on recordings or behavior. Real-time stimulation feedback enables a wide range of innovative studies of information processing and plasticity in neuronal networks. This Research Topic e-Book comprises 16 Original Research Articles, seven Methods Articles, and seven Reviews, Mini- Reviews, and Perspectives, all peer-reviewed and published in Frontiers in Neural Circuits. The contributions deal with closed loop neurophysiology experiments at a variety of levels of neural circuit complexity. Some include modeling and theoretical analyses. New enabling technologies and techniques are described. Novel work is presented from experiments in vitro, in vivo, and in humans, along with their clinical and technological implications for improving the human condition.
Author: Ignacio Obeso
Publisher: Frontiers Media SA
ISBN: 2889451348
Category :
Languages : en
Pages : 209
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Book Description
The potential efficacy of non-invasive brain stimulation procedures for the management of specific symptoms in diverse neurological and psychiatric conditions has been tested in the past decade or so. For example, repetitive transcranial magnetic stimulation (rTMS) over prefrontal areas has been extensively investigated as a treatment for patients with medication-resistant depression and has been shown to be associated with improvement of mood. Similarly, non-invasive stimulation techniques have been applied to various symptoms of Parkinson's disease such as bradykinesia and dyskinesias, with variables degrees of success reported. However, attempts to expand previously observed clinical improvements to other neurological disorders (e.g. Tourette's syndrome, autism, epilepsy) has been controversial. In trying to bypass potential confounding elements, researchers aim to target neural populations altered in disease to either increase or decrease their corrupted baseline activity. In addition, a complementary approach is to extend stimulation protocols that results enhanced behavior in healthy participants. This Frontiers Research Topic on non-invasive brain stimulation and enhancement of function tries to combine a series of articles from researchers who used non-invasive brain stimulation to aim improvement of either a motoric, cognitive or behavioral nature investigated behaviorally, physiologically or using brain imaging techniques in clinical populations. Investigation of the relation between enhancement of function in healthy populations and clinical improvement in patients with neurological or psychiatric disorders needs further consideration.
