The Total Synthesis of the Proposed Structure of Mycosporulone and the Enantiospecific Formal Total Synthesis of (+)-fawcettimine PDF Download
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Author: Jonah James Chang
Publisher:
ISBN:
Category :
Languages : en
Pages : 346
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Book Description
Author: Jonah James Chang
Publisher:
ISBN:
Category :
Languages : en
Pages : 346
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Book Description
Author: Haichen Ma
Publisher:
ISBN:
Category :
Languages : en
Pages : 228
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Author: Hon Wai Lam
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
![Part 1, Difluorocyclopentenone Synthesis [microform] : Part 2, Formal Total Synthesis of Racemic Roseophilin; Part 3, Enantioselective Total Synthesis of Roseophilin PDF](https://books.google.com/books/content/images/frontcover/1p1PuQAACAAJ?fife=w80-h100)
Author: Harrington, Paul E. (Paul Edward)
Publisher: Ann Arbor, Mich. : University Microfilms International
ISBN:
Category : Carbonyl compounds
Languages : en
Pages : 468
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Author: William D. Shipe
Publisher:
ISBN:
Category : Cyclobutane
Languages : en
Pages : 340
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The evolution of a convergent strategy that led to efficient, enantioselective syntheses of guanacastepene E and guanacastepene A (formal) is described. The first chapter of this thesis provides background information on (1) the isolation and biology of the guanacastepene family of secondary metabolites, (2) the substantial synthetic work carried out by other research groups toward their synthesis, and (3) the basis of our ultimate approach to the natural product. The synthesis of a fully functionalized C ring and two major model studies that provided critical information about the system are described in the second chapter. The final chapter describes (1) the enantiospecific synthesis of an A ring fragment from R-(-)-carvone, including a novel ring-contracting reaction, (2) the classical resolution of the C ring, and (3) the union of the two enantiopure fragments and further elaboration, culminating in the enantioselective total synthesis of both the natural (+)- and unnatural (-)-guanacastepene E and a formal total synthesis of (+)-guanacastepene A. The foundation of our convergent approach is the following sequence of three reactions: (1) the union of two functionalized building blocks through a [pi]-allyl Stille cross-coupling reaction, (2) the stereoselective construction of the C-11 quaternary carbon center with a [2+2] photocycloaddition, and (3) the stereoselective, reductive fragmentation of a cyclobutyl bond to form the seven-membered central B ring of the guanacastepenes.
Author: Paul Edward Harrington
Publisher:
ISBN:
Category : Carbonyl compounds
Languages : en
Pages : 468
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Author: Fabrice Gallou
Publisher:
ISBN:
Category :
Languages : en
Pages : 532
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Author: Ganfeng Cao
Publisher:
ISBN:
Category :
Languages : en
Pages : 366
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Author: R. Jeffrey Neitz
Publisher:
ISBN:
Category :
Languages : en
Pages : 344
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Book Description
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Total synthesis of natural products with diverse architecture and varying degree of complexity is an area that has not only inspired and attracted several generations of organic chemists but also continues to enrich and refresh the foundations of organic chemistry itself, by offering new ideas and directions. Synthetic organic chemistry is perhaps the most formative and expressive enterprise of science in terms of its creative power and unlimited scope. Its impact on present day life and prosperity gets manifested when we see this science as the bedrock behind the production of pharmaceuticals, pesticides, fertilizers, nutritional products, high tech materials, polymers, cosmetics, plastics and clothing. Science of synthesis is also going to play an important role in the evolution of future societies based on the principles of the sustainable development. Being a precise science and a fine art, the endeavor of total synthesis is in a constant state of effervescence. Most significantly, the discipline is being continually challenged by new structures unraveled from the Nature bosom. The practice of total synthesis is being enriched constantly by new tools such as new reagents and catalysts as well as by analytical techniques. In fact, there has been a dramatic advancement in the recent past in the development of new synthetic protocols with high regio-, streo-, and enantiocontrol, which makes it possible to target natural product of any complexity. The demand for enantiomerically pure drugs, agrochemicals and food additives is growing, since pure enantiomers are often more target-specific and have fewer side effects than the recemic mixtures. As a result, synthesis of natural products in an enantioselective manner has been receiving increasing attention from synthetic chemists in recent years. Nature synthesizes a vast array of novel molecular structures in enantioselective fashion through several well-established biosynthetic pathways utilizing a few key building.
