Search for the Tourette Syndrome and Human Behavior Genes PDF Download
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Author: David E. Comings
Publisher: Hope Press
ISBN: 9781878267368
Category : Behavior genetics
Languages : en
Pages : 330
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Book Description
Presents the story of the development of the concept of Tourette Syndrome as a polygenic (multiple gene), behavioral spectrum disorder involving many different behavioral problems, plus an update on new medications. A classic story of how new ideas are often resisted before they are accepted.
Author: David E. Comings
Publisher: Hope Press
ISBN: 9781878267368
Category : Behavior genetics
Languages : en
Pages : 330
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Book Description
Presents the story of the development of the concept of Tourette Syndrome as a polygenic (multiple gene), behavioral spectrum disorder involving many different behavioral problems, plus an update on new medications. A classic story of how new ideas are often resisted before they are accepted.
Author: Ingrid Simonic
Publisher:
ISBN:
Category : Tourette syndrome
Languages : en
Pages : 350
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Book Description
Author: David E. Comings
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 886
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Book Description
"Tourette syndrome is a common, hereditary disorder that provides insight into how we and our children behave and misbehave and why some of us can't read, learn, or pay attention; compulsively do things including eating and abusing drugs or alcohol, spouses or children and are angry, short-tempered, anxious afraid, depressed or feel different and all alone. This book is written for both the lay reader and the health or education professional as a guide to the exciting story of how a common gene may control a wide range of human behaviors."--Page [i]
Author: Thomas Newell Chase
Publisher: Lippincott Williams & Wilkins
ISBN:
Category : Medical
Languages : en
Pages : 410
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Book Description
This volume presents an encyclopedic account of the past decade's achievements in the study and treatment of Tourette Syndrome (TS) and associated behavioral and psychiatric disorders. More than 90 of the foremost authorities from all relevant basic science, clinical, and behavioral science disciplines highlight the major recent developments worldwide - from groundbreaking genetic and neurochemical research and studies using state-of-the-art neuroimaging technologies, to new concepts on the clinical spectrum and natural history of TS, increasing recognition of comorbid conditions, and improved strategies for pharmacotherapy and psychosocial management. The contributors assess the practical utility of current diagnostic criteria for TS and present extensive data on its natural history, its range of clinical manifestations, and its associated disorders. The findings indicate that the severity of TS varies widely among patients, that tics tend to diminish during adolescence and adulthood, and that comorbid conditions - such as obsessive-compulsive disorder and attention deficit hyperactivity disorder - are often the chief source of impairment. Much evidence suggests that these disturbances and the tics are manifestations of the same underlying diathesis. Noted investigators document significant findings on the mode of inheritance for TS, define the key methodological issues in genetic linkage studies, and describe molecular approaches to the search for the genetic locus for the syndrome. The book also includes new data implicating specific monoamine neurotransmitters and endogenous opioid peptides in the pathogenesis of TS. Other contributors present neuroimaging studies using MRI, PET, and SPECT to delineate brain mechanisms involved in TS. The book offers definitive guidelines on pharmacotherapy for tics and, particularly, for associated obsessive-compulsive disorder (OCD) and attention deficit hyperactivity disorder (ADHD). Of special note are the discussions on treatment of OCD with serotonin reuptake inhibitors and on use of clonidine and stimulants for ADHD with comorbid tics. Additional chapters explore the potential of novel drugs and of nutritional interventions such as megavitamin therapy. Full consideration is also given to the role of behavioral and psychosocial therapies and the educational management of children with TS. This volume is an indispensable resource for all clinicians and investigators involved in the treatment or study of neuropsychiatric disorders. It exemplifies the creative application of the full range of current neuroscience and behavioral methodologies to a complex and important syndrome.
Author: Davide Martino
Publisher: Oxford University Press
ISBN: 0197543219
Category : Medical
Languages : en
Pages : 577
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Book Description
Tourette syndrome (TS) has become increasingly recognised within society and has gained scientific interest worldwide. Knowledge of its clinical presentation, mechanisms of disease, and available treatment approaches has increased remarkably over the last two decades. Likewise, the way clinicians, teachers, social care workers, and families face the problems manifested by patients with TS is rapidly evolving. Tourette Syndrome, edited by Davide Martino and James F. Leckman, offers a unique opportunity to capture this knowledge advance through a comprehensive and up-to-date overview. Tourette Syndrome covers all the main aspects related to TS, analyzing its complex clinical presentation, the novel viewpoints of causes and mechanisms, state-of-the-art assessment techniques, and the diversity of treatment options. Multidisciplinarity is the main asset of this volume, which represents a source of consultation for a wide audience of professionals, integrated with video tutorials related to particularly complex areas of patient management. Medical and PhD students, as well as post-doctoral scientists, will be able to use the volume as a valuable learning source.
Author: Samar Reghunandanan
Publisher: OUP Oxford
ISBN: 019101687X
Category : Medical
Languages : en
Pages : 167
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Book Description
Providing clinicians and patients with the latest developments in research, this new edition is a succinct and practical introduction to the diagnosis, evaluation and management of OCD and other related disorders. Part of the Oxford Psychiatry Library series, this pocketbook includes individual chapters on the phenomenology, pathogenesis, pharmacotherapy and psychotherapy of OCD and other related disorders, and features fully updated content and research. The book also includes a helpful resources chapter, and an Appendix with summaries of the major rating scales used to assess patients with OCD, which will be of use to both clinicians and patients. Obsessive-compulsive disorder (OCD) and Obsessive-compulsive-related disorders (OCRDs) are anxiety disorders characterized by obsessions and compulsions, and varying degrees of anxiety and depression. OCRDs are considered to be one of the most disabling of psychiatric disorders and they present a tremendous economic and social burden, both for the affected individual, their family, and for society at large. In contrast to other psychiatric conditions of a comparable or lesser prevalence and patient burden, relatively little is understood about the aetiology, and cognitive effects of OCRDs.
Author: Peristera Paschou
Publisher: Frontiers Media SA
ISBN: 2889453235
Category :
Languages : en
Pages : 324
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Book Description
Gilles de la Tourette Syndrome (TS) is a common, albeit severely under-diagnosed, neuropsychiatric disorder that is caused by a complex genetic basis, interacting with environmental factors. High comorbidity rates with other neurodevelopmental disorders such as attention deficit/hyperactivity disorder and obsessive compulsive disorder raise the intriguing hypothesis of a shared etiological background. Abnormalities of corticostriatal-thalamic-cortical circuits (CSTC) and dysfunction of both dopamine and serotonin neurotransmitter systems are assumed to be associated with TS. Recently, multiple lines of evidence also point towards an important role of additional neurotransmitters such as histamine and glutamate. For a very long time, efforts to elucidate the etiology and pathophysiology of TS have been fragmented and hampered by low statistical power. Finally, after more than two decades of active research aiming to identify the etiology and pathophysiology of TS, we are on the verge of a new era, promising exciting and rapid discoveries in the field. Investigators from around the world, representing multiple disciplines and scientific approaches, are joining their efforts in large-scale initiatives supported both by European Union and US National funding agencies, such as the European-funded EMTICS, TACTICS, and TSGeneSEE consortia, the Marie Curie Initial Training Network TS-EUROTRAIN and the European Society for the Study of TS joining forces with the NIH-funded TSAICG, GGRI, and Tic Genetics consortia. Importantly, all these initiatives are supported by TS patient support and advocacy groups. Multiple resources are being consolidated and coming together to serve the study of TS, including large well-characterized patient cohorts, and specialized epidemiological databases, such as the unique resource of the Netherlands Twin Register. This research topic showcases current large-scale collaborative efforts aiming to elucidate the genetic and neurobiological background of TS, through diverse approaches; from genomewide association studies aiming to identify common variants associated to the disorder to neuroimaging studies and animal models. Furthermore, current approaches on the clinical assessment and management of the disorder are presented. Propelled by the gradual availability of large scale TS cohorts, novel methodologies, and importantly, sheer enthusiasm by multiple researchers working together across different countries, the new era of the neurobiology of TS holds the promise to identify novel targets for improved therapies.
Author: Douglas W. Woods
Publisher: Oxford University Press
ISBN: 019971228X
Category : Psychology
Languages : en
Pages : 81
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Book Description
If you suffer from Tourette Syndrome (TS), or any other chronic motor or vocal tic disorder, you know how difficult it can be to manage your symptoms. You may be taking medication or working with a medical doctor to control your tics. If you are seeking an alternative or adjunctive treatment, you may wish to try the scientifically proven behavior therapy program described in this workbook. Behavior therapy can teach you skills for effectively managing your tics. Designed to be used in conjunction with visits to a qualified mental health professional, this workbook outlines an 11-session treatment package for adults and children with tic disorders. Behavior therapy can teach you skills for effectively managing your tics. Designed to be used in conjunction with visits to a qualified mental health professional, this workbook outlines an 11-session treatment package for adults and children with tic disorders. The goal of this program is not to cure your disorder, but to teach you the best ways to manage it so that you can improve your quality of life and look to the future with optimism. TreatmentsThatWorkTM represents the gold standard of behavioral healthcare interventions! · All programs have been rigorously tested in clinical trials and are backed by years of research · A prestigious scientific advisory board, led by series Editor-In-Chief David H. Barlow, reviews and evaluates each intervention to ensure that it meets the highest standard of evidence so you can be confident that you are using the most effective treatment available to date · Our books are reliable and effective and make it easy for you to provide your clients with the best care available · Our corresponding workbooks contain psychoeducational information, forms and worksheets, and homework assignments to keep clients engaged and motivated · A companion website (www.oup.com/us/ttw) offers downloadable clinical tools and helpful resources · Continuing Education (CE) Credits are now available on select titles in collaboration with PsychoEducational Resources, Inc. (PER)
Author: Uttom Chowdhury
Publisher: Jessica Kingsley Publishers
ISBN: 1843103958
Category : Education
Languages : en
Pages : 96
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Book Description
Discusses what tourette syndrome is, how it is treated, how to cope, and what the future will be with this condition.
Author: Adriana Díaz Anzaldúa
Publisher:
ISBN:
Category : French-Canadians
Languages : en
Pages : 212
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Book Description
Tourette syndrome (TS) is a childhood-onset neuropsychiatric disorder characterized by multiple motor and one or more phonic tics. TS affects all races and ethnic groups and its prevalence is estimated to be 1% of school children who are 6 to 17 years old. The etiology of this disorder is unknown, but there is strong evidence that supports the involvement of genetic factors. No specific gene unequivocally increasing the risk for TS has been identified. However, positive linkage and association studies, as well as chromosomal anomalies have been reported in the past. The aim of this study was to search for genetic variants associated with TS as a step towards the elucidation of the causes of the disorder. This study represents the first population-based genetic analysis of TS in the French Canadian population, a genetically homogenous group with respect to typical outbred human populations. We found associations between TS and variants in two dopaminergic genes, the dopamine D4 receptor and the Monoamine oxidase genes. Furthermore, we identified a new locus on chromosome 7, flanked by Dock 4 and FoxP2 genes, within a larger region previously suggested as candidate for TS by cytogenetic studies. Our results illustrate the multifactorial etiology of TS in the French Canadian population. It is probable that there is locus heterogeneity for TS even in homogenous populations such as the French Canadians in Quebec, which adds to the complexity of the involvement of non-genetic factors.
