The Role of Dendritic Cells During Immunity Generated in the Spleen PDF Download
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Author: Christina Tzung-Ying Lu
Publisher:
ISBN:
Category :
Languages : en
Pages : 156
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Book Description
Author: Christina Tzung-Ying Lu
Publisher:
ISBN:
Category :
Languages : en
Pages : 156
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Book Description
Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :
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Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0
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Book Description
Author: Paola Ricciardi-Castagnoli
Publisher: Springer Science & Business Media
ISBN: 1475799667
Category : Medical
Languages : en
Pages : 566
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Book Description
These proceedings contain selected contributions from the participants to the Fourth International Symposium on Dendritic cells that was held in Venice (Lido) Italy, from Oc tober 5 to 10, 1996. The symposium was attended by more than 500 scientists coming from 24 different countries. Studies on dendritic cells (DC) have been greatly hampered by the difficulties in preparing sufficient cell numbers and in a reasonable pure form. At this meeting it has been shown that large quantities of DC can be generated from precursors in both mice and humans, and this possibility has enormously encouraged studies aimed to characterize DC physiology and DC-specific genes, and to employ DC therapeutically as adjuvants for im munization. The possibility of generating large numbers of autologous DC that can be used in the manipulation of the immune response against cancer and infectious diseases has tremendously boosted dendritic cell research and the role of DC in a number of medi cal areas has been heatedly discussed.
Author:
Publisher: Academic Press
ISBN: 0123947960
Category : Science
Languages : en
Pages : 2972
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Book Description
The Encyclopedia of Cell Biology, Four Volume Set offers a broad overview of cell biology, offering reputable, foundational content for researchers and students across the biological and medical sciences. This important work includes 285 articles from domain experts covering every aspect of cell biology, with fully annotated figures, abundant illustrations, videos, and references for further reading. Each entry is built with a layered approach to the content, providing basic information for those new to the area and more detailed material for the more experienced researcher. With authored contributions by experts in the field, the Encyclopedia of Cell Biology provides a fully cross-referenced, one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences. Fully annotated color images and videos for full comprehension of concepts, with layered content for readers from different levels of experience Includes information on cytokinesis, cell biology, cell mechanics, cytoskeleton dynamics, stem cells, prokaryotic cell biology, RNA biology, aging, cell growth, cell Injury, and more In-depth linking to Academic Press/Elsevier content and additional links to outside websites and resources for further reading A one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences
Author: Penelope Anne Morel
Publisher: Frontiers Media SA
ISBN: 2889198685
Category : Dendritic cells
Languages : en
Pages : 123
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Book Description
Dendritic cells (DC) are among the first cells to encounter pathogens and damage in peripheral tissues and, upon activation, DC migrate to lymph nodes where they activate and educate T cells to initiate and shape the immune response. DC present pathogen-derived antigen to T cells and drive T cell differentiation into particular effector cells through the expression and secretion of co-stimulatory molecules and cytokines respectively. The study of DC biology has included the identification of multiple DC subsets in tissues and lymphoid organs, the differentiation and plasticity of DC subsets, the functional consequences of DC interaction with pathogen, control of DC migratory properties and the impact of DC on T cell activation and differentiation. In recent years sophisticated systems biology approaches have been developed to deepen our understanding of DC function. These studies have identified differences between DC subsets located in various tissues and critical factors that drive the outcome of the interaction between DC and T cells. DC are currently being used in in various clinical therapeutic settings, including as vaccines for cancer and autoimmune disease. A clear understanding of DC factors that contribute to specific immune responses is vital to the success of DC based therapies. This research topic will give a comprehensive overview of current issues in DC biology and provides an update on the clinical uses of DC in the therapy of autoimmunity and cancer.
Author: Ying Ying Hey
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Dendritic cells (DC) are specialised antigen presenting cells, which induce and control the adaptive immune response. DC mediate a wide range of immune responses including generation of T helper cells, development of cytotoxic T cell responses and induction of tolerance. In this lab, a splenic longterm culture (LTC) was established that produces distinct dendritic-like cells (LTC-DC) continuously in the absence of added growth factors or cytokines. Previous studies have identified an in vivo equivalent of LTC-DC in murine spleen. This thesis further characterises this novel dendritic-like subset (L-DC). The relationship between L-DC and other known dendritic and myeloid subsets has also been investigated through phenotypic, morphological and functional studies, by comparing gene expression, and by analysis of cell development in mutant mouse models. In order to identify L-DC, it was necessary to redefine splenic dendritic and myeloid subsets. L-DC have now been characterised with the CD11bhiCD11cloMHCII-Ly6C-Ly6G-CD43+CX3CR1+Siglec-F- phenotype. CD43 expression, lack of MHCII expression, and a low level of CD11c expression best differentiate L-DC from conventional DC (cDC). Like CD8+ cDC, L-DC have high capacity for receptor-medicated endocytosis and induce activation and proliferation of CD8+ T cells, although not CD4+ T cells. L-DC also show capacity to induce an in vivo cytotoxic T lymphocyte response equivalent to that induced by CD8+ cDC. L-DC are distinguishable from neutrophils by the absence of Ly6G and 7/4 expression, and from eosinophils by lack of Siglec-F expression. L-DC can be distinguished from monocytes by their lack Ly6C expression. Morphological studies revealed L-DC to be mononuclear cells with vacuoles in the cytoplasm, and distinct from other myeloid cell types. All of these findings have identified L-DC as a novel antigen presenting cell subset, distinct from other known dendritic and myeloid subsets in murine spleen. Attempts have been made to understand the lineage relationship between L-DC and the other splenic dendritic and myeloid subsets, and to identify new markers for easier delineation of L-DC. Transcriptome analysis (Affymetrix) was performed on L-DC, dendritic and myeloid subsets. The L-DC gene expression profile was found to be distinct from that of cDC. However, the L-DC gene expression profile was also found to be distinct from that of monocytes subsets. L-DC specifically expressed genes like Siglec-e, Igsf2, CD300ld, CD300e and CD9. Overall, gene expression analysis showed that L-DC resembled a myeloid lineage cell having dendritic-like characteristics and function in antigen presentation. Mouse strains carrying mutations which affect the development of dendritic and myeloid cell types were investigated for changes in L-DC development in spleen. However L-DC numbers were not altered in any of the mutant mice studied, suggesting that L-DC is a distinct lineage of cells that arise from endogenous splenic progenitors, separate from the dendritic and monocyte. This study has revealed a novel dendritic-like cell type distinct from known dendritic and myeloid subsets in spleen, and having specialised function in cross-priming CD8+ T cells. The findings presented here predict an important role for L-DC in the immune response against blood-borne antigens which enter the splenic microenvironment.
Author: Michael T. Lotze
Publisher:
ISBN:
Category : Medical
Languages : en
Pages : 808
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Book Description
Dendritic Cells is the first definitive book on this subject, and brings together the most current information in the field for scientists and clinicians. It outlines research studies, the first reports of therapeutic applications of dendritic cells, and the enormous potential of these unique cells. Contributors are from the key research groups around the world who are working on the immunobiology of dendritic cells and in applied areas, striving to develop their therapeutic potential.
Author: Eduard W. A. Kamperdijk
Publisher: Springer Science & Business Media
ISBN: 1461529301
Category : Medical
Languages : en
Pages : 631
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Book Description
These Proceedings contain the contributions of the participants of the Second International Symposium on Dendritic Cells that was held from the 1st to 25th of June 1992 in Amsterdam, the Netherlands. The First International Symposium on Dendritic Cells was organized as a Satellite symposium at the occasion of the 30th anniversary of the Japanese Reticuloendothelial Society by Dr. Y. Imai in Yamagata (Japan), in 1990. It was entitled "Dendritic Cells in Lymphoid Tissues," and focused primarily on the Interdigitating Cells (IDC), Epidermal Langerhans cells (LC) and Follicular Dendritic Cells (FDC) , from the point of view of human pathology. However, the concept of Dendritic Cell System, comprising the bone marrow derived IDC and LC but not the FDC, was based on animal experiments and mainly on in vitro experiments on isolated cells. In a report from the Reticuloendothelial Society Committee on Nomenclature in 1982, Tew, Thorbecke and Steinman had already characterized these different types of DC, but the gap between in vivo and in vitro function remained. In Amsterdam, the Symposium focused on the Role of Dendritic Cells in Fundamental and Clinical Immunology. First, recent developments in molecular biology of antigen presentation and cell biological aspects of signal transduction were discussed, in relation to the potential of DC to stimulate lymphocytes and to trigger their in vitro differentiation.
Author: Samantha Fowler
Publisher:
ISBN: 9781739015503
Category :
Languages : en
Pages : 0
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Book Description
Black & white print. Concepts of Biology is designed for the typical introductory biology course for nonmajors, covering standard scope and sequence requirements. The text includes interesting applications and conveys the major themes of biology, with content that is meaningful and easy to understand. The book is designed to demonstrate biology concepts and to promote scientific literacy.
