The Quantitative Assessment of Human Myocardial Perfusion in Vivo Using Dynamic Magnetic Resonance Imaging PDF Download
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Author: Asvina Jivan
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
Author: Asvina Jivan
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Cian Scannell
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Author: Rui Liu
Publisher:
ISBN:
Category : Magnetic resonance imaging
Languages : en
Pages : 230
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Author: John David Biglands
Publisher:
ISBN:
Category :
Languages : en
Pages :
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Book Description
The assessment of myocardial perfusion using dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) is a powerful tool for diagnosing myocardial ischaemia due to coronary heart disease, which affects nearly 2.7 million people in the UK and for which there is an effective treatment. Although visual analysis of DCE-MRI data performs well diagnostically, a quantitative estimate of myocardial blood flow (MBF) makes the diagnosis objective and could increase diagnostic performance. Obtaining MBF estimates from DCE-MRI data is a multi-step process requiring: - the localisation of the myocardium and arterial input function (AIF) to generate signal intensity vs. time curves; - the conversion of signal intensity data to contrast agent concentration values; - the application of a perfusion model to generate a quantitative MBF estimate; - the interpretation of MBF estimates to make a diagnostic assessment of myocardial ischaemia. There are a range of approaches for solving each of these problems. The aim of the work presented in this thesis has been to provide clinically relevant evidence for choosing between these approaches. Myocardial localisation contour error tolerance levels are suggested based on simulations using a volunteer dataset. A non-linear signal intensity to contrast agent concentration conversion method is presented and tested using simulations and phantom data. An investigation into the best way to interpret quantitative MBF estimates is then presented. Finally a comparison of four, widely applied, perfusion models is conducted. Where possible, methods have been compared on a sizeable patient dataset in terms of diagnostic performance rather than MBF estimate accuracy. This provides evidence suitable for informing clinical decisions on the best methodology for quantitative perfusion. Such evidence could contribute to a standard methodology for quantitative cardiac MR perfusion. This is necessary for large clinical trials, which are essential before quantitative MBF estimates can be accepted into routine clinical practice.
Author: E. Nagel
Publisher: Springer Science & Business Media
ISBN: 9783798514027
Category : Medical
Languages : en
Pages : 324
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Book Description
"The accompanying CD-ROM contains additional figures and numerous videos." -- p. [4] of cover.
Author: Sudhakar K. Venkatesh
Publisher: Springer
ISBN: 1493915754
Category : Medical
Languages : en
Pages : 143
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Book Description
The first book to cover the groundbreaking development and clinical applications of Magnetic Resonance Elastography, this book is essential for all practitioners interested in this revolutionary diagnostic modality. The book is divided into three sections. The first covers the history of MRE. The second covers technique and clinical applications of MRE in the liver with respect to fibrosis, liver masses, and other diseases. Case descriptions are presented to give the reader a hands-on approach. The final section presents the techniques, sequence and preliminary results of applications in other areas of the body including muscle, brain, lung, heart, and breast.
Author: Vasken Dilsizian
Publisher: John Wiley & Sons
ISBN: 1444347969
Category : Medical
Languages : en
Pages : 525
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Book Description
This careful revision keeps pace with developments in the field, with new chapters on PET Metabolism, CT and MRI in the Emergency Department, Image-Guided Electrophysiology Mapping and Ablation, and Identification of Vulnerable Atherosclerotic Plaque by Radionuclide and CT techniques, plus the introduction of new contributors Udo Hoffman and Stephan Achenbach. Praised in its previous edition as a concise source of essential information, this new edition presents the most recent information in an accessible format and serves as an excellent reference source for all cardiologists, radiologists and nuclear medicine physicians.
Author: J. P. Schadé
Publisher:
ISBN: 9780444409522
Category : Brain
Languages : en
Pages : 438
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Book Description
Author: Michael E. Phelps
Publisher: Springer Science & Business Media
ISBN: 0387225293
Category : Medical
Languages : en
Pages : 650
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Book Description
This book is written as both a text and a reference book. It contains numerous images from the biological sciences and clinical practice, tables, graphs, and fig ures, as well as exercises that are worked out to aid the reader in understanding principles or solving problems. In some cases, derivations are placed in appen dices so as not to break up the flow of the subject matter in the text. The book is intended for a broad audience interested in molecular imaging with positron emission tomography (PET). It is expected that the readers will range from undergraduate, graduate, and medical students to residents, physi cians, and scientists with backgrounds from various physical, biological, and medical specialty areas. Each chapter presents material in a straightforward man ner that is well illustrated and explained. Because of the diverse audience for the book, certain chapters or sections of chapters will be of more interest than oth ers to certain segments of the readership. Chapter 1 introduces the fundamental physics upon which PET imaging sys tems is based and discusses in detail the technologies and methods used to pro duce PET images. The chapter starts out by reviewing the physics of positron emission and annihilation and explains how positron range and photon non colinearity in coincidence detection place certain limits on spatial resolution.
Author: Sven Plein
Publisher: Springer
ISBN: 331920940X
Category : Medical
Languages : en
Pages : 475
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Book Description
The book provides an introduction to CMR imaging that is understandable and focused on the relevant information needed to using CMR imaging in clinical practice. Cardiovascular magnetic resonance (CMR) imaging has become an established imaging modality with an expanding range of clinical indications. While in the past the availability of CMR imaging was limited to a few specialist centres the method is becoming more widely available. Most clinicians therefore need to have a general understanding of the diagnostic information that can be obtained from CMR imaging, the indications for referral as well as contraindications and limitations of the method. For cardiologists and radiologists in particular, CMR imaging will become a routine diagnostic tool and training curricula in Cardiology or Radiology reflect this trend by increasingly demanding training in CMR imaging.
