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Author: Josef Donnerer
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805580045
Category : Medical
Languages : en
Pages : 226
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Book Description
Neurochemical transmission accounts for the majority of information transfer both in the central and peripheral nervous system. The initial findings centred around the experimental work of the two Nobel Prize winners Sir Henry H. Dale and Otto Loewi as well as Wilhelm Feldberg. Their historical findings opened the door to further investigations and extended the list of neurotransmitters to many others such as amino acids, peptides, purines and nitric oxide. In the first part, the publication provides fascinating insights into the life of the three scientists. Their personality and scientific approach are presented through autobiographical sketches and personal memories by authors. Various comments and details of the atmosphere in the laboratory complete the picture of the conditions at the time. The second part is dedicated to the history of the substances, such as neurotransmitters, their antagonists and analogues. The stories of these substances are presented to the reader in a succinct way, including many anecdotes and unusual events on the way to their therapeutic application. Contents Preface Introduction Otto Loewi Otto Loewi Introductory Remarks Autobiographic Sketch. By O. Loewi Otto Loewi 1873-1961. By H.H. Dale Otto Loewi. By F. Brucke Loewi's Time in Graz Comment on Loewi's Dream An Overlooked Parallel to Kekule's Dream: The Discovery of the Chemical Transmission of Nerve Impulses by Otto Loewi. By U. Weiss and R.A. Brown The Loewi Family's Way to the New World Comment on the Film Nobelpreistrager Otto Loewi Henry Hallett Dale Henry Hallett Dale Introductory Remarks Henry Hallett Dale 1875-1968. By W. Feldberg Fifty Years after the Nobel Prize Award to H.H. Dale and Otto Loewi. By G.B. Koelle Religious Reflections of Dale and Loewi Wilhelm Feldberg Wilhelm Feldberg Introductory Remarks The Early History of Synaptic and Neuromuscular Transmission by Acetylcholine: Reminiscences of an Eye Witness. By W. Feldberg From the History of Scientists to that of Neurotransmitters A Substance Isolated from Brain, Synthesized and Called Neurin: Acetylcholine Adrenaline, Noradrenaline and Dopamine: The Catecholamines Enteramine and Serotonin: Two Names and Three Functions of 5-Hydroxytryptamine Histamine: One Substance and Three Functions The Amino Acid Transmitter Family A Cloud of Peptides Substance P Calcitonin Gene-Related Peptide Neuropeptide, Galanine and Vasoactive Intephinal Polypeptide Opioid Peptides Nitric Oxide ATP and Adenosine Peripheral Neurogenic Stimulators Neurotransmission in the Central Nervous System From Transmitter to Receptor: Progress within 50 Years.
Author: Josef Donnerer
Publisher: Karger Medical and Scientific Publishers
ISBN: 3805580045
Category : Medical
Languages : en
Pages : 226
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Book Description
Neurochemical transmission accounts for the majority of information transfer both in the central and peripheral nervous system. The initial findings centred around the experimental work of the two Nobel Prize winners Sir Henry H. Dale and Otto Loewi as well as Wilhelm Feldberg. Their historical findings opened the door to further investigations and extended the list of neurotransmitters to many others such as amino acids, peptides, purines and nitric oxide. In the first part, the publication provides fascinating insights into the life of the three scientists. Their personality and scientific approach are presented through autobiographical sketches and personal memories by authors. Various comments and details of the atmosphere in the laboratory complete the picture of the conditions at the time. The second part is dedicated to the history of the substances, such as neurotransmitters, their antagonists and analogues. The stories of these substances are presented to the reader in a succinct way, including many anecdotes and unusual events on the way to their therapeutic application. Contents Preface Introduction Otto Loewi Otto Loewi Introductory Remarks Autobiographic Sketch. By O. Loewi Otto Loewi 1873-1961. By H.H. Dale Otto Loewi. By F. Brucke Loewi's Time in Graz Comment on Loewi's Dream An Overlooked Parallel to Kekule's Dream: The Discovery of the Chemical Transmission of Nerve Impulses by Otto Loewi. By U. Weiss and R.A. Brown The Loewi Family's Way to the New World Comment on the Film Nobelpreistrager Otto Loewi Henry Hallett Dale Henry Hallett Dale Introductory Remarks Henry Hallett Dale 1875-1968. By W. Feldberg Fifty Years after the Nobel Prize Award to H.H. Dale and Otto Loewi. By G.B. Koelle Religious Reflections of Dale and Loewi Wilhelm Feldberg Wilhelm Feldberg Introductory Remarks The Early History of Synaptic and Neuromuscular Transmission by Acetylcholine: Reminiscences of an Eye Witness. By W. Feldberg From the History of Scientists to that of Neurotransmitters A Substance Isolated from Brain, Synthesized and Called Neurin: Acetylcholine Adrenaline, Noradrenaline and Dopamine: The Catecholamines Enteramine and Serotonin: Two Names and Three Functions of 5-Hydroxytryptamine Histamine: One Substance and Three Functions The Amino Acid Transmitter Family A Cloud of Peptides Substance P Calcitonin Gene-Related Peptide Neuropeptide, Galanine and Vasoactive Intephinal Polypeptide Opioid Peptides Nitric Oxide ATP and Adenosine Peripheral Neurogenic Stimulators Neurotransmission in the Central Nervous System From Transmitter to Receptor: Progress within 50 Years.
Author: J. Gordon Betts
Publisher:
ISBN: 9781947172807
Category :
Languages : en
Pages : 0
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Book Description
Author: Firas H. Kobeissy
Publisher: CRC Press
ISBN: 1466565993
Category : Medical
Languages : en
Pages : 718
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Book Description
With the contribution from more than one hundred CNS neurotrauma experts, this book provides a comprehensive and up-to-date account on the latest developments in the area of neurotrauma including biomarker studies, experimental models, diagnostic methods, and neurotherapeutic intervention strategies in brain injury research. It discusses neurotrauma mechanisms, biomarker discovery, and neurocognitive and neurobehavioral deficits. Also included are medical interventions and recent neurotherapeutics used in the area of brain injury that have been translated to the area of rehabilitation research. In addition, a section is devoted to models of milder CNS injury, including sports injuries.
Author: David R Soderquist
Publisher: SAGE
ISBN: 9780761923336
Category : Medical
Languages : en
Pages : 404
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Book Description
This core text emphasizes the underlying neural structures and functions of sensory systems (pain, olfaction, gustation, audition, vision, etc.) and presents this complex material at a level comprehensible to undergraduates as well as beginning graduate students. The text begins with a review of the central nervous system and its sensory components and includes discussions of methodological techniques and procedures used to study sensory processes.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309040477
Category : Science
Languages : en
Pages : 449
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Book Description
Exposure to toxic chemicalsâ€"in the workplace and at homeâ€"is increasing every day. Human behavior can be affected by such exposure and can give important clues that a person or population is in danger. If we can understand the mechanisms of these changes, we can develop better ways of testing for toxic chemical exposure and, most important, better prevention programs. This volume explores the emerging field of neurobehavioral toxicology and the potential of behavior studies as a noninvasive and economical means for risk assessment and monitoring. Pioneers in this field explore its promise for detecting environmental toxins, protecting us from exposure, and treating those who are exposed.
Author: and Director NIBS Neuroscience Program University of Southern California Larry W. Swanson Milo Don and Lucille Appleman Professor of Biological Sciences
Publisher: Oxford University Press, USA
ISBN: 0198026463
Category : Medical
Languages : en
Pages : 283
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Book Description
Depending on your point of view the brain is an organ, a machine, a biological computer, or simply the most important component of the nervous system. How does it work as a whole? What are its major parts and how are they interconnected to generate thinking, feelings, and behavior? This book surveys 2,500 years of scientific thinking about these profoundly important questions from the perspective of fundamental architectural principles, and then proposes a new model for the basic plan of neural systems organization based on an explosion of structural data emerging from the neuroanatomy revolution of the 1970's. The importance of a balance between theoretical and experimental morphology is stressed throughout the book. Great advances in understanding the brain's basic plan have come especially from two traditional lines of biological thought-- evolution and embryology, because each begins with the simple and progresses to the more complex. Understanding the organization of brain circuits, which contain thousands of links or pathways, is much more difficult. It is argued here that a four-system network model can explain the structure-function organization of the brain. Possible relationships between neural networks and gene networks revealed by the human genome project are explored in the final chapter. The book is written in clear and sparkling prose, and it is profusely illustrated. It is designed to be read by anyone with an interest in the basic organization of the brain, from neuroscience to philosophy to computer science to molecular biology. It is suitable for use in neuroscience core courses because it presents basic principles of the structure of the nervous system in a systematic way.
Author: Elliot S. Valenstein
Publisher: Columbia University Press
ISBN: 0231135882
Category : Computers
Languages : en
Pages : 257
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Book Description
The question of how nerves communicate with one another was the subject of a heated & protracted dispute between pharmacologists & neurophysiologists. This book recalls the debate & how the theory of chemical transmission was eventually confirmed by the discovery of neurotransmitters.
Author: National Academy of Sciences
Publisher: National Academies Press
ISBN: 0309045290
Category : Medical
Languages : en
Pages : 195
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Book Description
The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."
Author: P. Michael Conn
Publisher: Academic Press
ISBN: 0128025964
Category : Medical
Languages : en
Pages : 778
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Book Description
Conn's Translational Neuroscience provides a comprehensive overview reflecting the depth and breadth of the field of translational neuroscience, with input from a distinguished panel of basic and clinical investigators. Progress has continued in understanding the brain at the molecular, anatomic, and physiological levels in the years following the 'Decade of the Brain,' with the results providing insight into the underlying basis of many neurological disease processes. This book alternates scientific and clinical chapters that explain the basic science underlying neurological processes and then relates that science to the understanding of neurological disorders and their treatment. Chapters cover disorders of the spinal cord, neuronal migration, the autonomic nervous system, the limbic system, ocular motility, and the basal ganglia, as well as demyelinating disorders, stroke, dementia and abnormalities of cognition, congenital chromosomal and genetic abnormalities, Parkinson's disease, nerve trauma, peripheral neuropathy, aphasias, sleep disorders, and myasthenia gravis. In addition to concise summaries of the most recent biochemical, physiological, anatomical, and behavioral advances, the chapters summarize current findings on neuronal gene expression and protein synthesis at the molecular level. Authoritative and comprehensive, Conn's Translational Neuroscience provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, as well as a clear demonstration of their emerging diagnostic and therapeutic importance. - Provides a fully up-to-date and readily accessible guide to brain functions at the cellular and molecular level, while also clearly demonstrating their emerging diagnostic and therapeutic importance - Features contributions from leading global basic and clinical investigators in the field - Provides a great resource for researchers and practitioners interested in the basic science underlying neurological processes - Relates and translates the current science to the understanding of neurological disorders and their treatment
Author: Richard D. Andreatta
Publisher: Plural Publishing
ISBN: 1635502705
Category : Medical
Languages : en
Pages : 729
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Book Description
Neuroscience Fundamentals for Communication Sciences and Disorders is a comprehensive textbook designed for undergraduate neural bases or graduate neuroscience courses in communication sciences and disorders programs (CSD). Written with a fresh user-friendly conversational style and complemented by more than 350 visually rich and beautifully drawn full-color illustrations, this book emphasizes brain and behavior relationships while also ensuring coverage of essential neuroanatomy in an integrative fashion. With a comprehensive background in neuroscience fundamentals, students will be able to better understand and apply brain-behavior relationships to make appropriate clinical assessments and treatment decisions. Neuroscience Fundamentals for Communication Sciences and Disorders is designed to provide CSD students with a broad overview of the principles, processes, and structures underlying the workings of the human nervous system. Extending well beyond traditional neuroanatomy-based textbooks, this publication is designed to satisfy three major goals: Provide neuroanatomical and neurophysiological detail that meets the real-world needs of the contemporary CSD student, as they move forward toward clinical practice, and into the future where advancements in the field of health and brain sciences are accelerating and contributing more and more to rehabilitation.Provide clear, understandable explanations and intuitive material that explains how and why neuroanatomical systems, processes, and mechanisms of the nervous system operate as they do during human behavior.Provide a depth and scope of material that will allow students to read, better understand, and appreciate a wide range of evidence-based literature related to behavior, cognition, emotion, language, and sensory perception--areas that directly impact treatment decisions. Key Features: An emphasis on fundamental information on neuroanatomy, neurophysiology, and functional processes using an analogy-driven and relaxed conversational writing style.More than 350 new and beautifully illustrated full-color neuroanatomical and neurophysiological figures that work to bring the written material to life.Content is divided into four major sections that build upon each other to foster a comprehensive understanding of the nervous system from the cellular to systems.Three summary chapters on the neural bases of speech, language, and hearing that help integrate the basic information from earlier chapters with content specific to CSD.Each chapter begins with an introduction and learning objectives and ends with a top ten summary list of key take-home concepts and study review questions.Bolded key terms throughout with a comprehensive glossary of definitions.Clinical Importance boxes highlight clinically relevant disorders and syndromes that compliment topic coverage.Further Interest boxes highlight interesting and exciting facts about the nervous system's structure, physiology, and functionality.Disclaimer: Please note that ancillary content (such as documents, audio, and video, etc.) may not be included as published in the original print version of this book.
