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Author: Kazuo Ishiguro
Publisher: Vintage
ISBN: 030776415X
Category : Fiction
Languages : en
Pages : 546
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Book Description
From the universally acclaimed author of The Remains of the Day comes a mesmerizing novel of completely unexpected mood and matter--a seamless, fictional universe, both wholly unrecognizable and familiar. When the public, day-to-day reality of a renowned pianist takes on a life of its own, he finds himself traversing landscapes that are by turns eerie, comical, and strangely malleable.
Author: Kazuo Ishiguro
Publisher: Vintage
ISBN: 030776415X
Category : Fiction
Languages : en
Pages : 546
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Book Description
From the universally acclaimed author of The Remains of the Day comes a mesmerizing novel of completely unexpected mood and matter--a seamless, fictional universe, both wholly unrecognizable and familiar. When the public, day-to-day reality of a renowned pianist takes on a life of its own, he finds himself traversing landscapes that are by turns eerie, comical, and strangely malleable.
Author: Jong Hoon Park
Publisher: Springer
ISBN: 9811020418
Category : Medical
Languages : en
Pages : 128
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Book Description
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.
Author: Adam Savage
Publisher: Atria Books
ISBN: 1982113480
Category : Science
Languages : en
Pages : 320
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Book Description
In this New York Times bestselling “imperative how-to for creativity” (Nick Offerman), Adam Savage—star of Discovery Channel’s Mythbusters—shares his golden rules of creativity, from finding inspiration to following through and successfully making your idea a reality. Every Tool’s a Hammer is a chronicle of my life as a maker. It’s an exploration of making, but it’s also a permission slip of sorts from me to you. Permission to grab hold of the things you’re interested in, that fascinate you, and to dive deeper into them to see where they lead you. Through stories from forty-plus years of making and molding, building and breaking, along with the lessons I learned along the way, this book is meant to be a toolbox of problem solving, complete with a shop’s worth of notes on the tools, techniques, and materials that I use most often. Things like: In Every Tool There Is a Hammer—don’t wait until everything is perfect to begin a project, and if you don’t have the exact right tool for a task, just use whatever’s handy; Increase Your Loose Tolerance—making is messy and filled with screwups, but that’s okay, as creativity is a path with twists and turns and not a straight line to be found; Use More Cooling Fluid—it prolongs the life of blades and bits, and it prevents tool failure, but beyond that it’s a reminder to slow down and reduce the friction in your work and relationships; Screw Before You Glue—mechanical fasteners allow you to change and modify a project while glue is forever but sometimes you just need the right glue, so I dig into which ones will do the job with the least harm and best effects. This toolbox also includes lessons from many other incredible makers and creators, including: Jamie Hyneman, Nick Offerman, Pixar director Andrew Stanton, Oscar-winner Guillermo del Toro, artist Tom Sachs, and chef Traci Des Jardins. And if everything goes well, we will hopefully save you a few mistakes (and maybe fingers) as well as help you turn your curiosities into creations. I hope this book serves as “creative rocket fuel” (Ed Helms) to build, make, invent, explore, and—most of all—enjoy the thrills of being a creator.
Author: Tiago Forte
Publisher: Simon and Schuster
ISBN: 1982167386
Category : Business & Economics
Languages : en
Pages : 272
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Book Description
"Building a second brain is getting things done for the digital age. It's a ... productivity method for consuming, synthesizing, and remembering the vast amount of information we take in, allowing us to become more effective and creative and harness the unprecedented amount of technology we have at our disposal"--
Author: Philip K. Dick
Publisher: Houghton Mifflin Harcourt
ISBN: 0547572298
Category : Fiction
Languages : en
Pages : 241
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Book Description
A mind-bending, classic Philip K. Dick novel about the perception of reality. Named as one of Time's 100 best books.
Author: Alan Branch
Publisher: Routledge
ISBN: 1134742673
Category : Business & Economics
Languages : en
Pages : 597
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Book Description
Now in its second edition Maritime Economics provides a valuable introduction to the organisation and workings of the global shipping industry. The author outlines the economic theory as well as many of the operational practicalities involved. Extensively revised for the new edition, the book has many clear illustrations and tables. Topics covered include: * an overview of international trade * Maritime Law * economic organisation and principles * financing ships and shipping companies * market research and forecasting.
Author: Philip K. Dick
Publisher: Houghton Mifflin Harcourt
ISBN: 0547572255
Category : Fiction
Languages : en
Pages : 259
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Book Description
Altered reality, genetic enhancement and drugs combine to create one of the most popular and enduring science fiction novels from award-winning novelist Philip K. Dick.
Author: Keith Devlin
Publisher: Basic Books
ISBN: 0786725087
Category : Science
Languages : en
Pages : 348
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Book Description
If people are endowed with a "number instinct" similar to the "language instinct" -- as recent research suggests -- then why can't everyone do math? In The Math Gene, mathematician and popular writer Keith Devlin attacks both sides of this question. Devlin offers a breathtakingly new theory of language development that describes how language evolved in two stages and how its main purpose was not communication. Devlin goes on to show that the ability to think mathematically arose out of the same symbol-manipulating ability that was so crucial to the very first emergence of true language. Why, then, can't we do math as well as we speak? The answer, says Devlin, is that we can and do -- we just don't recognize when we're using mathematical reasoning.
Author: Gene F. Franklin
Publisher: Pearson Higher Ed
ISBN: 0133002276
Category : Technology & Engineering
Languages : en
Pages : 843
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Book Description
This is the eBook of the printed book and may not include any media, website access codes, or print supplements that may come packaged with the bound book. For senior-level or first-year graduate-level courses in control analysis and design, and related courses within engineering, science, and management. Feedback Control of Dynamic Systems, Sixth Edition is perfect for practicing control engineers who wish to maintain their skills. This revision of a top-selling textbook on feedback control with the associated web site, FPE6e.com, provides greater instructor flexibility and student readability. Chapter 4 on A First Analysis of Feedback has been substantially rewritten to present the material in a more logical and effective manner. A new case study on biological control introduces an important new area to the students, and each chapter now includes a historical perspective to illustrate the origins of the field. As in earlier editions, the book has been updated so that solutions are based on the latest versions of MATLAB and SIMULINK. Finally, some of the more exotic topics have been moved to the web site.
Author: Christopher Brown
Publisher: HarperCollins
ISBN: 0062563823
Category : Fiction
Languages : en
Pages : 450
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Book Description
“Timely, dark, and ultimately hopeful: it might not ‘make America great again,’ but then again, it just might.”—Cory Doctorow, New York Times bestselling and award winning author of Homeland Acclaimed short story writer and editor of the World Fantasy Award-nominee Three Messages and a Warning eerily envisions an American society unraveling and our borders closed off—from the other side—in this haunting and provocative novel that combines Max Barry’s Jennifer Government, Philip K. Dick’s classic Man in the High Castle, and China Mieville’s The City & the City The United States of America is no more. Broken into warring territories, its center has become a wasteland DMZ known as “the Tropic of Kansas.” Though this gaping geographic hole has no clear boundaries, everyone knows it's out there—that once-bountiful part of the heartland, broken by greed and exploitation, where neglect now breeds unrest. Two travelers appear in this arid American wilderness: Sig, the fugitive orphan of political dissidents, and his foster sister Tania, a government investigator whose search for Sig leads her into her own past—and towards an unexpected future. Sig promised those he loves that he would make it to the revolutionary redoubt of occupied New Orleans. But first he must survive the wild edgelands of a barren mid-America policed by citizen militias and autonomous drones, where one wrong move can mean capture . . . or death. One step behind, undercover in the underground, is Tania. Her infiltration of clandestine networks made of old technology and new politics soon transforms her into the hunted one, and gives her a shot at being the agent of real change—if she is willing to give up the explosive government secrets she has sworn to protect. As brother and sister traverse these vast and dangerous badlands, their paths will eventually intersect on the front lines of a revolution whose fuse they are about to light. “Futurist as provocateur! The world is sheer batshit genius . . . a truly hallucinatorily envisioned environment.”—William Gibson, New York Times bestselling and award-winning author
