Systemic Lupus Erythematosus - Predisposition Factors, Pathogenesis, Diagnosis, Treatment and Disease Models PDF Download
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Author: Kutty Selva Nandakumar
Publisher: Frontiers Media SA
ISBN: 2832511996
Category : Medical
Languages : en
Pages : 264
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Book Description
Author: Kutty Selva Nandakumar
Publisher: Frontiers Media SA
ISBN: 2832511996
Category : Medical
Languages : en
Pages : 264
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Book Description
Author: Sophia Lionaki
Publisher: BoD – Books on Demand
ISBN: 1838801693
Category : Medical
Languages : en
Pages : 140
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Book Description
Systemic lupus erythematosus, the prototype of an autoimmune disorder, may affect several organs and may run a chronic course between relapse and remission. This book covers important aspects of the disease, including epidemiology, pathophysiology, and neuropsychiatric manifestations, including basic science and clinical features and management. In affected patients, the fundamental problem of fertility is reassessed including the risk of the disease, the possibility of fetal loss, the safety of drugs during pregnancy, and the current diagnostic and suggested therapeutic strategies of reproductive medicine. Finally, the issue of pathogenesis is revisited with a thorough description of animal models in relation to physiology and potential novel therapies.
Author: Peter H. Schur
Publisher: Springer Science & Business Media
ISBN: 1461411890
Category : Medical
Languages : en
Pages : 266
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Book Description
Often considered the prototypic autoimmune disease, Lupus is characterized by protean manifestations and affects a wide range of organ systems. Despite widespread availability of anti nuclear antibody testing and other technological diagnostic advances, the diagnosis of lupus can be elusive, difficult, and inexact. Treatment of the disease can also be challenging. Advances in immunology and biotechnology have led to a burgeoning world of new therapies in development that offer patients the real possibility of new therapies and physicians and scientists novel insights into the pathogenesis of this complicated immunological disease. Lupus Erythematosus: Clinical Evaluation and Treatment summarizes the clinical aspects of lupus facing the general clinician in the 21st century. In this invaluable, practical book, the reader will find introductory chapters regarding general diagnostic and treatment principles, followed by chapters addressing the lupus-specific organ manifestations. Special topics regarding pregnancy and comorbidities are also presented. Written by highly experienced physicians with special expertise in lupus, Lupus Erythematosus: Clinical Evaluation and Treatment is an indispensable reference for the common and not so common problems affecting patients with lupus.
Author: Irvine Turner
Publisher: Nova Science Publishers
ISBN: 9781536106701
Category : Systemic lupus erythematosus
Languages : en
Pages : 0
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Book Description
Being diagnosed with Systemic Lupus Erythematosus (SLE) can be a severe disappointment, and life after diagnosis can be defined as an existence filled with uncertainty as to the short-and long-term impact of the disease. SLE is a chronic multi-system autoimmune disease that is persistent and recurrent and has the potential of becoming life threatening. The manifestations and severity of the disease varies between individuals. SLE can potentially influence nearly all of the bodys organ systems. In this book, Chapter One reviews, Raynauds phenomenon (RP), one of the nonspecific skin changes that occur in SLE. Chapter Two presents the debate on the causes of fatigue in SLE and factors that increase fatigue. Chapter Three reviews and illustrates the important findings of musculoskeletal diseases in SLE. Chapter Four examines SLE in young adults and reviews information about the pain, social impact, and interventions to improve functioning of these young adults.
Author: Hani Almoallim
Publisher: BoD – Books on Demand
ISBN: 9535102664
Category : Medical
Languages : en
Pages : 568
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Book Description
This book provides a comprehensive overview of the basic and clinical sciences of Systemic Lupus Erythematosus. It is suitable for basic scientists looking for detailed coverage of their areas of interest. It describes how advances in molecular biology have increased our understanding of this disease. It is a valuable clinical resource for practicing clinicians from different disciplines including rheumatologists, rheumatology fellows and residents. This book provides convenient access to information you need about cytokines, genetics, Fas pathway, toll like receptors and atherogenesis in SLE. Animal models have been reviewed as well. How to avoid delay in SLE diagnosis and management, in addition to various clinical manifestations including pregnancy and SLE have all been explained thoroughly in this book.
Author: Syuichi Koarada
Publisher:
ISBN: 9781629480411
Category : Medical
Languages : en
Pages : 198
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Book Description
Systemic lupus erythematosus (SLE) is one of the prototypical systemic autoimmune diseases characterized by inflammation, immune complex deposition, and vasculitis.?Patients with SLE show various symptoms and clinical images, both constitutional and specific organ symptoms. They include the skin, joints, muscles, kidneys, lungs, nervous system, and blood vessels. Although the etiology of the disease is still unclear, genetic, hormonal, immunologic abnormalities and environmental factors complicatedly play important roles in the pathophysiology in SLE. It is evident that multiple genes show genetic susceptibility to SLE. Environmental factors of SLE and immunologic abnormalities, especially the production of a number of auto-antibody, are important features of the disease. In this book, we present recent knowledge about the prevalence, pathophysiology and prognosis of SLE. The book includes various interesting chapters: Chapter One - an illustrated overview of the prevalence and clinical symptoms of systemic lupus erythematosus; Chapter Two - the pathophysiology of systemic lupus erythematosus; Chapter Three - MBL and MBL genotypes in SLE; Chapter Four - novel biological activities of autoantibodies as the potential markers of systematic lupus erythematosus; Chapter Five - cytokines in systemic lupus erythematosus (sle) with clinical aspects and prognostics; Chapter Six - prognosis in systemic lupus erythematosus; and Chapter Seven - autoantibody-producing RP105-negative B cells in humans and a murine model of lupus erythematosus.
Author: Syuichi Koarada
Publisher: Nova Science Publishers
ISBN: 9781628089905
Category : Systemic lupus erythematosus
Languages : en
Pages : 0
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Book Description
Systemic lupus erythematosus (SLE) is one of the prototypical systemic autoimmune diseases characterised by inflammation, immune complex deposition, and vasculitis. Patients with SLE show various symptoms and clinical images, both constitutional and specific organ symptoms. They include the skin, joints, muscles, kidneys, lungs, nervous system, and blood vessels. Although the aetiology of the disease is still unclear, genetic, hormonal, immunologic abnormalities and environmental factors complicatedly play important roles in the pathophysiology in SLE. It is evident that multiple genes show genetic susceptibility to SLE. Environmental factors of SLE and immunologic abnormalities, especially the production of a number of auto-antibody, are important features of the disease. In this book, we present recent knowledge about the prevalence, pathophysiology and prognosis of SLE. The book includes various interesting chapters: Chapter One: An illustrated overview of the prevalence and clinical symptoms of systemic lupus erythematosus; Chapter Two: Pathophysiology of systemic lupus erythematosus; Chapter Three: MBL and MBL genotypes in SLE; Chapter Four: Novel biological activities of autoantibodies as the potential markers of systematic lupus erythematosus; Chapter Five: Cytokines in systemic lupus erythematosus (sle) with clinical aspects and prognostics; Chapter Six: Prognosis in systemic lupus erythematosus; Chapter Seven: Auto-antibody-producing RP105-negative B cells in humans and a murine model of lupus erythematosus.
Author: Caroline Gordon
Publisher: Oxford University Press
ISBN: 0198739184
Category : Medical
Languages : en
Pages : 161
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Book Description
Systemic Lupus Erythematosus provides a practical approach to the assessment and management of patients with this complex, multisystem autoimmune disease to improve the diagnosis and treatment of the disease and its complications.
Author: Udi Nussinovitch
Publisher: Academic Press
ISBN: 0128032685
Category : Medical
Languages : en
Pages : 768
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Book Description
The prevalence of autoimmune diseases and rheumatic conditions is constantly increasing. Autoimmune diseases affect approximately 7-10% of the population of the United States, while more than 50,000,000 American adults suffer from some type of arthritis. The Heart in Rheumatic, Autoimmune and Inflammatory Diseases examines the complex mechanisms relating to cardiac diseases from a pathophysiological and clinical point of view. Autoimmune rheumatic diseases can affect the coronary vessels, myocardium, pericardium, heart valves and the conduction system. The diagnosis of these unique cardiac complications necessitates medical awareness and a high index of suspicion. Increased risk of advanced atherosclerosis plays a pivotal role in the development of cardiac diseases in systemic, rheumatic and autoimmune illnesses. Yet, other complex immune medicated mechanisms may contribute to the pathogenesis. Patients' optimal care requires coordination between the primary caregiver, the rheumatologist, immunologist and cardiologist. Screening for cardiovascular risk factors, recognition of high-risk patients and identification of subclinical cardiac conditions are of great importance. Moreover, regulation of inflammation, as well as abnormal immune responses and the initiation of early treatments should be the focus of patient management. A continuous attempt to identify novel therapeutic targets and change the natural history of the underlying disease and its cardiac manifestations is in progress. The book aims at providing the readers with a state of the art collection of up to date information regarding clinically important topics based on experts' perspectives. This book was a result of an extended coordinated collaboration of one-hundred and fifty-four distinguished scientists from thirty-one countries around the globe. A review of common, as well as unusual (yet clinically significant) medical cardiac complications of prevalent rheumatic, autoimmune and inflammatory diseases. Focuses on aspects of pathophysiological processes, clinical presentations, screening tests, prognostic implications and novel therapeutic approaches. Presents an up-to-date “level of evidence” and “strengths of recommendations” for suggested therapies and reviews all randomized clinical trials, meta-analyses and other supporting published clinical findings.
Author: Philip Conaghan
Publisher: Oxford University Press
ISBN: 0199642486
Category : Medical
Languages : en
Pages : 1553
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Book Description
A strong clinical emphasis is present throughout this volume from the first section of commonly presenting problems through to the section addressing problems shared with a range of other clinical sub-specialties.
