Author: Bahgat Hussein
Publisher: LAP Lambert Academic Publishing
ISBN: 9783659385285
Category :
Languages : en
Pages : 176
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Book Description
Various 1,2,4-triazoles found extensive investigations due to their useful application in different areas of biological activity and as industrial intermediates such as antiasthmatic, antiviral, antifungal, antimicrobial, antibacterial, insecticidal, amoebicidal, hypnotic, cytotoxic and hypotensive activities. This moiety was also found in potent agonist and antagonist receptor ligands, in HIV-1 protease inhibitors and in thrombin inhibitors. Along with these significant pharmaceutical uses, 1,2,4-triazole derivatives are effectively used in polymers, dyestuff, photographic chemicals and agricultural chemicals. In view of these findings and in continuation of our work in the same field we provide in this book, the synthesis of some new s-triazole derivatives and tested for antibacterial activity.
Author: Wim Dehaen
Publisher: Springer
ISBN: 331907962X
Category : Science
Languages : en
Pages : 389
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Book Description
The series Topics in Heterocyclic Chemistry presents critical reviews on present and future trends in the research of heterocyclic compounds. Overall the scope is to cover topics dealing with all areas within heterocyclic chemistry, both experimental and theoretical, of interest to the general heterocyclic chemistry community. The series consists of topic related volumes edited by renowned editors with contributions of experts in the field.
Author: John M. Collier
Publisher:
ISBN:
Category : Heterocyclic compounds
Languages : en
Pages : 126
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Book Description
Author: Achim Stolle
Publisher: Royal Society of Chemistry
ISBN: 1782621989
Category : Science
Languages : en
Pages : 321
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Book Description
Ball milling has emerged as a powerful tool over the past few years for effecting chemical reactions by mechanical energy. Allowing a variety of reactions to occur at ambient temperatures and in solvent-free conditions, ball milling presents a greener route for many chemical processes. Compared to the use of microwave and ultrasound as energy sources for chemical reactions, ball milling is not as familiar to chemists and yet it holds great potential. This book will introduce practicing chemists to the technique and will highlight its importance for green transformations. Current applications of ball milling will be covered in detail as well as its origin, recent developments and future scope, challenges and prospects. Chemical transformations covered include carbon-carbon and carbon-heteroatom bond formation, oxidation by solid oxidants, asymmetric organo-catalytic reactions, dehydrogenative coupling, peptide syntheses and polymeric material syntheses. The book will provide a valuable guide for organic, inorganic and organometallic chemists, material scientists, polymer scientists, reaction engineers and postgraduate students in chemistry.
Author: Nathan Brown
Publisher: John Wiley & Sons
ISBN: 3527654321
Category : Medical
Languages : en
Pages : 249
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Book Description
Written with the practicing medicinal chemist in mind, this is the first modern handbook to systematically address the topic of bioisosterism. As such, it provides a ready reference on the principles and methods of bioisosteric replacement as a key tool in preclinical drug development. The first part provides an overview of bioisosterism, classical bioisosteres and typical molecular interactions that need to be considered, while the second part describes a number of molecular databases as sources of bioisosteric identification and rationalization. The third part covers the four key methodologies for bioisostere identification and replacement: physicochemical properties, topology, shape, and overlays of protein-ligand crystal structures. In the final part, several real-world examples of bioisosterism in drug discovery projects are discussed. With its detailed descriptions of databases, methods and real-life case studies, this is tailor-made for busy industrial researchers with little time for reading, while remaining easily accessible to novice drug developers due to its systematic structure and introductory section.
Author: Goutam Brahmachari
Publisher: Elsevier
ISBN: 0128011386
Category : Science
Languages : en
Pages : 388
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Book Description
Filling a gap in the scientific literature, Room Temperature Organic Synthesis is unique in its authoritative, thorough, and applied coverage of a wide variety of "green" organic synthetic methodologies. The book describes practical, feasible protocols for room temperature reactions to produce carbon-carbon and carbon-heteroatom bond formations including aliphatic, aromatic, alicyclic, heterocycles, and more. Consistently organized for easy access, each selected reaction is discussed in a very compact and structured manner including: reaction type, reaction condition, reaction strategy, catalyst, keywords, general reaction scheme, mechanism (in selected cases), representative entries, experimental procedure, characterization data of representative entries, and references. This book will be a valuable resource for synthetic organic, natural products, medicinal, and biochemists as well as those working in the pharmaceutical and agrochemical industry. - Includes more than 300 protocols for a green approach to organic synthesis - Provides specific detail about experimental conditions - Increases efficiency in the laboratory by eliminating time-consuming literature searches
Author:
Publisher:
ISBN:
Category : Medicine
Languages : en
Pages : 584
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Book Description
Author: Aleksey Kuznetsov
Publisher: BoD – Books on Demand
ISBN: 1839681799
Category : Science
Languages : en
Pages : 148
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Book Description
Azoles are a broad and promising class of five-membered heterocyclic compounds containing from one up to five nitrogen atom(s) that can also contain sulfur or oxygen atoms. Widely used as potent antifungal agents, various azole derivatives have also demonstrated many other promising biological properties. This book covers studies of several types of thiazole-based heterocyclic scaffolds, the development of 4-thiazolidinone and thiazole derivatives with heterocyclic fragments as potential candidates for new drugs against trypanosomiasis, numerous synthetic approaches for the synthesis of 1,2,3-triazoles, the application of N-azole, N,S-azole, and N,O-azole as well as their derivatives as retarders of metallic corrosion, and the integration of azoles in materials used for renewable energy processing and applications and wood treatment.
Author: Loutfy H. Madkour
Publisher: Academic Press
ISBN: 0128197781
Category : Science
Languages : en
Pages : 652
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Book Description
Nucleic Acids as Gene Anticancer Drug Delivery Therapy highlights the most recent developments in cancer treatment using nucleic acids, nanoparticles and polymer nanoparticles for genomic nanocarriers as drug delivery, including promising opportunities for targeted and combination therapy. The development of a wide spectrum of nanoscale technologies is beginning to change the scientific landscape in terms of disease diagnosis, treatment, and prevention. This book presents the use of nanotechnology for medical applications, focusing on its use for anticancer drug delivery. Various intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery are discussed. The use of smart drug delivery systems seems to be a promising approach for developing intelligent therapeutic systems for cancer immunotherapies and is discussed in detail along with nucleic acid-targeted drug delivery combination therapy for cancer. Nucleic Acids as Gene Anticancer Drug Delivery Therapy will be a useful reference for pharmaceutical scientists, pharmacologiests, and those involved in nanotechnology and cancer research. - Discusses intelligent drug delivery systems such as inorganic nanoparticles and polymer-based drug delivery - Contains a comprehensive comparison of various delivery systems, listing their advantages and limitations - Presents combination therapy as a new hope for enhancing current gene-based treatment efficacy
Author: Hélène Pellissier
Publisher: Royal Society of Chemistry
ISBN: 1849736510
Category : Science
Languages : en
Pages : 519
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Book Description
Accessible references for researchers and industrialists in this exciting field, covering both developments and applications of catalysis.
