Synthesis and Complexation of Functionalized Mixes Thia-aza-macrocyclic and Medium Sized Ligands PDF Download
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Author: Wilhelm S. Malasi
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 210
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Book Description
"Six ligands of mixed thia-aza donor atoms 40, 90, 100, 107, 110 and 112 have been synthesized and characterized. The metal complexes of Copper 114, Rhodium 116, and Nickel 115 with 1,8-dithia-4,11-diazacyclotetradecane 40 have been made and crystal structures grown in appropriate solvents to give good crystals suitable for X-ray crystallographic analysis. Other molecules whose crystals have been made and analyzed by X-ray crystallography are the secondary amine 82, tosylated double ligand tertiary amine 91, the seven member ring ester 100 and the perchlorate salt of the double nine member ligand tertiary amine 110. All these crystals have their analysis data in the appendix D. The seventh ligand 113 has been adapted, and complexed with rhodium and its crystal structure 117 has been analyzed. The curative activity of the rhodium complex 116 was tested against ovarian cancer cells Nutu-19 at 1.54 mM concentrations. The results showed that the cells became detached with extreme morphological changes and extreme internal vesicle formation causing the cells to die. Ovarian normal cells, tested at the same concentration, showed that the cells remain attached, with no morphological changes and only slightly vesicle formation. Table 4 in chapter 2 shows 87% of the cancer cells died while only 30% of the normal ovarian cells died. If the toxicity of this complex can be further controlled and minimized, it may be very useful in the treatment of cancer in the future. The ligand 40 was functionalized through carboxylic acid derivatives to give rise to the new ligand 90. Also ligand 107 was functionalized in the same way to give the new ligand 110, while the liands 82 and 107 were successfully joined by a butane chain to form a new ligand 112. In an attempt to synthesize the carbon bridged functionalized fourteen membered ring, ligand 99, the functionalized seven membered ring molecule 100 was isolated instead."--Abstract.
Author: Wilhelm S. Malasi
Publisher:
ISBN:
Category : Cancer
Languages : en
Pages : 210
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Book Description
"Six ligands of mixed thia-aza donor atoms 40, 90, 100, 107, 110 and 112 have been synthesized and characterized. The metal complexes of Copper 114, Rhodium 116, and Nickel 115 with 1,8-dithia-4,11-diazacyclotetradecane 40 have been made and crystal structures grown in appropriate solvents to give good crystals suitable for X-ray crystallographic analysis. Other molecules whose crystals have been made and analyzed by X-ray crystallography are the secondary amine 82, tosylated double ligand tertiary amine 91, the seven member ring ester 100 and the perchlorate salt of the double nine member ligand tertiary amine 110. All these crystals have their analysis data in the appendix D. The seventh ligand 113 has been adapted, and complexed with rhodium and its crystal structure 117 has been analyzed. The curative activity of the rhodium complex 116 was tested against ovarian cancer cells Nutu-19 at 1.54 mM concentrations. The results showed that the cells became detached with extreme morphological changes and extreme internal vesicle formation causing the cells to die. Ovarian normal cells, tested at the same concentration, showed that the cells remain attached, with no morphological changes and only slightly vesicle formation. Table 4 in chapter 2 shows 87% of the cancer cells died while only 30% of the normal ovarian cells died. If the toxicity of this complex can be further controlled and minimized, it may be very useful in the treatment of cancer in the future. The ligand 40 was functionalized through carboxylic acid derivatives to give rise to the new ligand 90. Also ligand 107 was functionalized in the same way to give the new ligand 110, while the liands 82 and 107 were successfully joined by a butane chain to form a new ligand 112. In an attempt to synthesize the carbon bridged functionalized fourteen membered ring, ligand 99, the functionalized seven membered ring molecule 100 was isolated instead."--Abstract.
Author: Tia Louise Walker
Publisher:
ISBN:
Category : Chemistry
Languages : en
Pages : 287
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Book Description
Following the structural characterization and analysis of Blue Copper Proteins (BCP's), macrocyclic ligands have attracted much interest as simple models for naturally occurring metal-macrocycle centers. Presented in this dissertation are the syntheses and characterization of small, simple organic analogs of BCP's. Chapter I of this work gives a brief literature review of Blue Copper Proteins, including their unique spectral characteristics. The synthesis and characterization of several linear and cyclic molecular analogs will be discussed including polythiaethers,3 polyazacycloalkanes,4 thia-aza5 and trithiaethers. The macrocyclic effect will be explained and why cyclic molecular analogs are of current interest. Presented in the second chapter are the syntheses of two 14-membered rings with a 2,3,2,3 altering carbon chain arrangement for 1,8-dithia-4,11-diazacyclotetradecane and 1,11-dithia-4,8-diazacyclotetradecane. The 1,8-dithia-4,11-diazacyclotetradecane is complexed to both Cu2+ and Cu+ and fully characterized using UV-Vis, EPR and CV. The 1,11-dithia-4,8-diazacyclotetradecane was synthesized for structural X-ray comparison of the Cu2+ metal ion. The 1,8-dithia-4,11-diazacyclotetradecane having two nitrogen atoms also makes it attractive for functionalization. Presented in the third chapter of this dissertation is the expansion of these ligands for use as cryptands. The syntheses of two cryptands are fully described and include crystallographic data. One of the cryptand ligands, 1,8-dithia-4,11,18,21-tetraazatricyclo[10.6.6]pentacosane-25-one was successfully complexed to Cu2+ and those results are also discussed. To further conclude this research is a pendant arm derivative and its synthesis. Each nitrogen atom of 1,8-dithia-4,11-diazacyclotetradecane is functionalized with a four carbon chain connecting to 1,4-diaza-7-thiacyclononane.
Author: Paul M. Griffiths
Publisher:
ISBN:
Category :
Languages : en
Pages : 608
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Book Description
Author: Vinny R. Sastri
Publisher: Elsevier
ISBN: 0080536689
Category : Science
Languages : en
Pages : 1005
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Book Description
In order to use rare earths successfully in various applications, a good understanding of the chemistry of these elements is of paramount importance. Nearly three to four decades have passed since titles such as The Rare Earths edited by F.H. Spedding and A.H. Daane, The chemistry of the Rare Earth Elements by N.E. Topp and Complexes of the Rare Earths by S.P. Sinha were published. There have been many international conferences and symposia on rare earths, as well as the series of volumes entitled Handbook of Physics and Chemistry of Rare Earths edited by K.A. Gschneidner and L. Eyring. Thus, there is a need for a new title covering modern aspects of rare earth complexes along with the applications. The present title consists of twelve chapters. 1. Introduction2. General aspects3. Stability of complexes4. Lanthanide complexes5. Structural chemistry of lanthanide compounds6. Organometallic complexes7. Kinetics and mechanisms of rare earths complexation8. Spectroscopy of lanthanide complexes9. Photoelectron spectroscopy of rare earths10. Lanthanide NMR shift reagents11. Environmental ecological biological aspects12. Applications The authors studied in schools headed by pioneers in rare earth chemistry, have a combined experience of one hundred and fifty years in inorganic chemistry, rare earth complex chemistry, nuclear and radiochemistry of rare earths and supramolecular chemistry. The present monograph is a product of this rich experience.
Author: Tsutomu Ishikawa
Publisher: John Wiley & Sons
ISBN: 9780470740866
Category : Science
Languages : en
Pages : 336
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Book Description
Guanidines, amidines and phosphazenes have been attracting attention in organic synthesis due to their potential functionality resulting from their extremely strong basicity. They are also promising catalysts because of their potential for easy molecular modification, possible recyclability, and reduced or zero toxicity. Importantly, these molecules can be derived as natural products – valuable as scientists move towards “sustainable chemistry”, where reagents and catalysts are derived from biomaterial sources. Superbases for Organic Synthesis is an essential guide to these important molecules for preparative organic synthesis. Topics covered include the following aspects: an introduction to organosuperbases physicochemical properties of organic superbases amidines and guanidines in organic synthesis phosphazene: preparation, reaction and catalytic role polymer-supported organosuperbases application of organosuperbases to total synthesis related organocatalysts: proton sponges and urea derivatives amidines and guanidines in natural products and medicines Superbases for Organic Synthesis is a comprehensive, authoritative and up-to-date guide to these important reagents for organic chemists, drug discovery researchers and those interested in the chemistry of natural products.
Author: Michael B. Smith
Publisher: John Wiley & Sons
ISBN: 0470084944
Category : Science
Languages : en
Pages : 2379
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Book Description
The Sixth Edition of a classic in organic chemistry continues its tradition of excellence Now in its sixth edition, March's Advanced Organic Chemistry remains the gold standard in organic chemistry. Throughout its six editions, students and chemists from around the world have relied on it as an essential resource for planning and executing synthetic reactions. The Sixth Edition brings the text completely current with the most recent organic reactions. In addition, the references have been updated to enable readers to find the latest primary and review literature with ease. New features include: More than 25,000 references to the literature to facilitate further research Revised mechanisms, where required, that explain concepts in clear modern terms Revisions and updates to each chapter to bring them all fully up to date with the latest reactions and discoveries A revised Appendix B to facilitate correlating chapter sections with synthetic transformations
Author: Xiaoqi Yu
Publisher: John Wiley & Sons
ISBN: 3527341870
Category : Science
Languages : en
Pages : 226
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Book Description
The first comprehensive book focusing on synthesis and applications of macrocyclic polyamines and their derivatives Macrocyclic polyamines are a class of widely used important compounds. This is the first book that systematically summarizes the synthesis and applications of macrocyclic polyamines and their analogues, including the properties and synthetic methods of macrocyclic polyamines, chemical nucleases based on macrocyclic polyamines, the derivatives of macrocyclic polyamines as nano-vector materials, macrocyclic polyamines derivatives for bio-imaging, chemical sensors based on macrocyclic polyamines, and other applications of macrocyclic polyamines. Macrocyclic Polyamines: Synthesis and Applications includes most of the studies involving macrocyclic polyamines and their derivatives, and may be used as a reference for the researchers in related fields. It offers in-depth coverage of cyclization modes; special procedures for tetraza macrocyclic compounds; diacids-diamines condensation; oxidative DNA cleaving by macrocyclic polyamines; lipids with cationic MPA headgroups; the derivatives of DOTA, DO3A, and PCTA; receptors for anions; sensors for bioactive molecules; macrocyclic polyamines for solvent extraction and membrane transport of amino acids and their derivatives, electrophoretic separation, and open-tubular CEC; and much more. ?The first book that systematically summarizes the chemistry of macrocyclic polyamines and their derivatives in terms of synthetic methods for their preparation, functionalization, and application in the main fields of chemical sensors, chemical nucleases, drug-delivery, bio-imaging and vector materials ?Provides a comprehensive reference for the researchers working on macrocyclic polyamines ?Offers train of thought in related research fields such as organic chemistry, coordination chemistry, analytical chemistry, supramolecular chemistry, biomaterials, etc. Macrocyclic Polyamines: Synthesis and Applications will not only provide a reference for the researchers working on macrocyclic polyamines, but also offer opportunities for researchers in related research fields to understand the benefits of these key compounds.
Author: Luigi Mandolini
Publisher: World Scientific
ISBN: 1783261897
Category : Science
Languages : en
Pages : 283
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Book Description
Calixarenes in Action is unique among books devoted to this interesting class of synthetic macrocycles. Rather than emphasizing the molecular properties of calixarenes, it covers in depth their supramolecular functions, enlightening the reader as to the peculiar features of calixarenes as hosts and as platforms for the synthesis of more complex receptors and catalysts. Topics covered in detail include the use of calixarenes in:molecular modeling of calixarenesnon-covalent interactionscrystal engineeringcation recognitionanion recognitionsupramolecular devicesnew materialsself-assembly processessupramolecular catalysisThe interest in calixarenes has grown tremendously in the last few years and this book reports, for each topic, the most recent literature critically evaluated by active researchers in the field. Calixarenes in Action is a valuable reference book for researchers in organic, inorganic, analytical and environmental chemistry and can serve as a graduate-level text for students of supramolecular science and technology.
Author: Ananya Srivastava
Publisher: Elsevier
ISBN: 012821547X
Category : Science
Languages : en
Pages : 506
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Book Description
Copper in N-Heterocyclic Chemistry provides an overview of copper-catalyzed synthesis and functionalization of N-heterocyclic compounds, covering all recent developments in a way that is ideal for researchers and students working in the area of synthetic organic chemistry and medicinal chemistry. The book explores N-heterocyclic compounds as unique structural units in the development of natural products and pharmaceuticals, along with the remarkable progress made in the area of high atom economic strategies, and more recently, copper-catalyzed C-H activation and its applications in organic synthesis. Readers will find troubleshooting protocols, as well as the advantages and limitations of each method discussed. As copper catalysts show versatile chemical reactivity in many aspects, including their oxidation states 0–3 are accessible and their ability to facilitate bond formations due to their ability to serve as Lewis acids, oxidizing agents and catalysts, this book is an ideal resource on the topics explored. - Discusses novel synthetic methods developed over the past decade for copper-catalyzed synthesis of N-heterocyclic compounds - Covers the most recent methodologies adapted in synthetic chemistry for applications in natural products and pharmaceuticals - Includes troubleshooting protocols, as well as the advantages and limitations of each method discussed in detail
Author:
Publisher:
ISBN:
Category : Chemistry
Languages : en
Pages : 2726
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Book Description
