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Author: Laurence O. Trussell
Publisher: Springer Science & Business Media
ISBN: 144199517X
Category : Science
Languages : en
Pages : 242
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Book Description
Synaptic Mechanisms in the Auditory System will provide a basic reference for students, clinicians, and researchers on how synapses in the auditory system function to encode acoustic signals. These mechanisms are the groundwork for all auditory processing, and understanding them requires knowledge of the microphysiology of synapses, cellular biophysics, receptor pharmacology, and an appreciation for what these synapses must do for a living, what unique jobs they carry out.
Author: Laurence O. Trussell
Publisher: Springer Science & Business Media
ISBN: 144199517X
Category : Science
Languages : en
Pages : 242
Get Book Here
Book Description
Synaptic Mechanisms in the Auditory System will provide a basic reference for students, clinicians, and researchers on how synapses in the auditory system function to encode acoustic signals. These mechanisms are the groundwork for all auditory processing, and understanding them requires knowledge of the microphysiology of synapses, cellular biophysics, receptor pharmacology, and an appreciation for what these synapses must do for a living, what unique jobs they carry out.
Author: Laurence O. Trussell
Publisher: Springer
ISBN: 9781441995186
Category : Science
Languages : en
Pages : 234
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Book Description
Synaptic Mechanisms in the Auditory System will provide a basic reference for students, clinicians, and researchers on how synapses in the auditory system function to encode acoustic signals. These mechanisms are the groundwork for all auditory processing, and understanding them requires knowledge of the microphysiology of synapses, cellular biophysics, receptor pharmacology, and an appreciation for what these synapses must do for a living, what unique jobs they carry out.
Author: Aage Moller
Publisher: Elsevier
ISBN: 0323141935
Category : Science
Languages : en
Pages : 956
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Book Description
Basic Mechanisms in Hearing is a collection of papers that discusses the function of the auditory system covering its ultrastructure, physiology, and the mechanism's connection with experimental psychology. Papers review the mechanics, morphology, and physiology of the cochlear, including the physiology of individual hair cells and their synapses. One paper examines the combined physiological and anatomical studies of stimulus coding in the mammalian auditory nervous system. The results of these studies pertain to the latency, frequency selectivity, and time pattern of responses to short tone bursts. Other research compare the cochlear nerve, behavioral, and psychophysical frequency selectivity which show that frequency selectivity of the auditory system occurs at the level of the cochlear nerve, becoming downgraded in end-organ deafness. Other papers discuss neural coding at higher levels such as the feature extraction in the auditory system of bats. Some papers also analyze the specialized hearing mechanisms in animals, for example, the echolocation of bats and in some insects, the function of the swimbladder in fish hearing, as well as the "invertebrate frequency analyzer" in the locust ear. Physiologists, neurophysiologists, neurobiologists, general medical practioners, and EENT specialists will find this collection valuable.
Author: Douglas L. Oliver
Publisher: Springer
ISBN: 3319717987
Category : Medical
Languages : en
Pages : 276
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Book Description
The auditory system is a complex neural system composed of many types of neurons connected into networks. One feature that sets the auditory system apart from other sensory systems, such as somatosensory or visual systems, is the many stages of neural processing that occur between the ear in the periphery and the cerebral cortex. Each stage is composed of specialized types of neurons connected in specific microcircuits that perform computations on the information about sound. To understand this processing, all the tools of neuroscience must be employed. The proposed text integrates cell biology, synaptic physiology, and electrophysiology to fully develop the topic, presenting an overview of the functional anatomy of the central auditory system. It is organized based on the neuronal connectivity of the central auditory system, which emphasizes the neurons, their synaptic organization, and their formation of functional pathways and microcircuits. The goal of the book is to stimulate research into the cell biology of the central auditory system and the characteristics of the specific neurons and connections that are necessary for normal hearing. Future research on the development of the central auditory including that employing stem cells will require such information in order to engineer appropriate therapeutic approaches.
Author: R. Michael Burger
Publisher: Frontiers Media SA
ISBN: 2889196674
Category : Auditory perception
Languages : en
Pages : 233
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Book Description
There seems little doubt that from the earliest evolutionary beginnings, inhibition has been a fundamental feature of neuronal circuits - even the simplest life forms sense and interact with their environment, orienting or approaching positive stimuli while avoiding aversive stimuli. This requires internal signals that both drive and suppress behavior. Traditional descriptions of inhibition sometimes limit its role to the suppression of action potential generation. This view fails to capture the vast breadth of inhibitory function now known to exist in neural circuits. A modern perspective on inhibitory signaling comprises a multitude of mechanisms. For example, inhibition can act via a shunting mechanism to speed the membrane time constant and reduce synaptic integration time. It can act via G-protein coupled receptors to initiate second messenger cascades that influence synaptic strength. Inhibition contributes to rhythm generation and can even activate ion channels that mediate inward currents to drive action potential generation. Inhibition also appears to play a role in shaping the properties of neural circuitry over longer time scales. Experience-dependent synaptic plasticity in developing and mature neural circuits underlies behavioral memory and has been intensively studied over the past decade. At excitatory synapses, adjustments of synaptic efficacy are regulated predominantly by changes in the number and function of postsynaptic glutamate receptors. There is, however, increasing evidence for inhibitory modulation of target neuron excitability playing key roles in experience-dependent plasticity. One reason for our limited knowledge about plasticity at inhibitory synapses is that in most circuits, neurons receive convergent inputs from disparate sources. This problem can be overcome by investigating inhibitory circuits in a system with well-defined inhibitory nuclei and projections, each with a known computational function. Compared to other sensory systems, the auditory system has evolved a large number of subthalamic nuclei each devoted to processing distinct features of sound stimuli. This information once extracted is then re-assembled to form the percept the acoustic world around us. The well-understood function of many of these auditory nuclei has enhanced our understanding of inhibition's role in shaping their responses from easily distinguished inhibitory inputs. In particular, neurons devoted to processing the location of sound sources receive a complement of discrete inputs for which in vivo activity and function are well understood. Investigation of these areas has led to significant advances in understanding the development, physiology, and mechanistic underpinnings of inhibition that apply broadly to neuroscience. In this series of papers, we provide an authoritative resource for those interested in exploring the variety of inhibitory circuits and their function in auditory processing. We present original research and focused reviews touching on development, plasticity, anatomy, and evolution of inhibitory circuitry. We hope our readers will find these papers valuable and inspirational to their own research endeavors.
Author: Philippe Jean
Publisher:
ISBN:
Category :
Languages : en
Pages : 0
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Book Description
Cochlear inner hair cells (IHCs) are the genuine sensory receptors that translate sound-borne cochlear vibrations into neuronal signals via ribbon synapses with the spiral ganglion neurons (SGNs). The precise mechanisms of these ribbon synapses, the first relay of the auditory pathway, are still not fully resolved. Sound intensity coding over a wide dynamic range is thought to be fractionated through the SGNs presenting distinct firing characteristics. One hypothesis is that much of this diversity reflects the presynaptic heterogeneity observed among the active zones (AZs) of IHCs. There, a...
Author: Federico Bermudez-Rattoni
Publisher: CRC Press
ISBN: 1420008412
Category : Psychology
Languages : en
Pages : 368
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Book Description
A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniq
Author: Lindsay Aitkin
Publisher: Springer Science & Business Media
ISBN: 1468439081
Category : Medical
Languages : en
Pages : 416
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Book Description
In contrast to the level of interest which is paid to the orga nization of meetings about the structure and function of the audi tory periphery, the central auditory system has received little attention in the last several years. However, much recent data accu mulated during this period has provided auditory physiologists with new ideas about the function of the central auditory system. The successful exploration of new anatomical tracing techniques (triti ated aminoacids, horseradish peroxidase, 2-deoxyglucose) together with the collection of electrophysiological data obtained with intra cellular and extracellular recordings from the receptors and neurones in the auditory pathway have considerably deepened our understanding of central auditory function. Particular interest was concentrated upon the development of the auditory system under normal conditions and in conditions ofaudi tory deprivation. Although, from the methodological point of view, the conditions of reversible auditory deprivation are complicated, promising new data appeared in this field. Similarly the specific ability of the auditory system to encode communication signals and speech sounds has been examined in many laboratories allover the world. A very fruitful method. based upon the results of electrical stimulation of cochlear nerve fibres in experimental animals, is the application of neuroprostheses in deaf patients. At the present time, the method still does not meet all requirements and many improvements will be necessary. Undoubtedly the exploration of the results of recent physiological experiments may help in the further improvement of neuroprostheses.
Author: Grant Lister Rasmussen
Publisher:
ISBN:
Category : Acoustic nerve
Languages : en
Pages : 470
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Book Description
Author: Paul H. Delano
Publisher: Frontiers Media SA
ISBN: 2889199355
Category : Neurosciences. Biological psychiatry. Neuropsychiatry
Languages : en
Pages : 122
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Book Description
The main function of the sensory systems is the transducing of external stimuli into bioelectrical signals, which are conducted through afferent pathways from sensory epithelia to the brain. However, it is known that descending projections are ubiquitous in the different sensory modalities, and in the case of auditory efferents connect the cerebral cortex with sensory receptor cells. Several functions have been attributed to the efferent system, including protection to acoustic trauma, unmasking of auditory stimuli in background noise, balance of interaural sensitivity and some cognitive functions like modulation of cochlear sensitivity during selective attention to auditory or visual stimuli. In addition there is evidence of a possible involvement of the efferent system in the etiology or treatment of some clinical pathologies like tinnitus. In this e-book, entitled “Auditory Efferent System: New Insights from Cortex to Cochlea”, we aimed to give an overview of the advances concerning the descending projections from the auditory cortex to subcortical nuclei and the olivocochlear system. In addition, different theoretical proposals of efferent functions are presented. We think that this e-book is an important contribution to the understanding of the efferent system in mammals, merging auditory-cortex literature with studies performed in the olivocochlear system.
