Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Studies on DNA Repair in Escherichia Coli
Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Recombinational Repair of DNA Damage
Author: Andrei Kuzminov
Publisher: Landes Bioscience
ISBN:
Category : Medical
Languages : en
Pages : 234
Book Description
Publisher: Landes Bioscience
ISBN:
Category : Medical
Languages : en
Pages : 234
Book Description
DNA Damage and Repair
Author: Jac A. Nickoloff
Publisher: Springer Science & Business Media
ISBN: 1592594557
Category : Science
Languages : en
Pages : 1050
Book Description
Cutting edge reviews by leading researchers illuminate key aspects of DNA repair in mammalian systems and its relationship to human genetic disease and cancer. Major topics include UV and X-Ray repair, repair of chemical damage, recombinational repair, mismatch repair, transcription-repair coupling, and the role of DNA repair in disease prevention. Extensive up-to-date references and rigorous peer-review of each chapter make this volume definitive and bring it to the active frontiers of research.
Publisher: Springer Science & Business Media
ISBN: 1592594557
Category : Science
Languages : en
Pages : 1050
Book Description
Cutting edge reviews by leading researchers illuminate key aspects of DNA repair in mammalian systems and its relationship to human genetic disease and cancer. Major topics include UV and X-Ray repair, repair of chemical damage, recombinational repair, mismatch repair, transcription-repair coupling, and the role of DNA repair in disease prevention. Extensive up-to-date references and rigorous peer-review of each chapter make this volume definitive and bring it to the active frontiers of research.
Studies of DNA Repair and Mutagenesis in Escherichia Coli and Bacillus Subtilis
Author: Bradley Theodore Smith
Publisher:
ISBN:
Category : Press
Languages : en
Pages : 316
Book Description
All organisms face constant challenges to the integrity of their genomes, from environmental agents such as ultraviolet light (UV) to errors generated by their own DNA polymerases. To deal with these challenges, all organisms possess a range of DNA repair and damage tolerance systems. In bacteria, there exists an inducible response to DNA damage termed the SOS response, in which damage induces the expression of greater than forty genes involved in repair. Mismatch repair (MMR) is a system by which the cell is able to avoid mutations by correcting DNA replication errors. Working with living Bacillus subtilis cells, the studies described here have found that MutS and MutL, the key proteins of MMR, form discrete foci in response to mismatches. These MMR foci are the active sites of repair, and appear to assemble near the DNA polymerase at mismatched base-pairs. This is consistent with a model in which the newly-synthesized DNA strand containing the error is discriminated from the parental strand via interactions between MMR proteins and the replisome.
Publisher:
ISBN:
Category : Press
Languages : en
Pages : 316
Book Description
All organisms face constant challenges to the integrity of their genomes, from environmental agents such as ultraviolet light (UV) to errors generated by their own DNA polymerases. To deal with these challenges, all organisms possess a range of DNA repair and damage tolerance systems. In bacteria, there exists an inducible response to DNA damage termed the SOS response, in which damage induces the expression of greater than forty genes involved in repair. Mismatch repair (MMR) is a system by which the cell is able to avoid mutations by correcting DNA replication errors. Working with living Bacillus subtilis cells, the studies described here have found that MutS and MutL, the key proteins of MMR, form discrete foci in response to mismatches. These MMR foci are the active sites of repair, and appear to assemble near the DNA polymerase at mismatched base-pairs. This is consistent with a model in which the newly-synthesized DNA strand containing the error is discriminated from the parental strand via interactions between MMR proteins and the replisome.
Studies of Methyl-directed DNA Repair in Escherichia Coli
Author: Brian Amos Learn
Publisher:
ISBN:
Category :
Languages : en
Pages : 232
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 232
Book Description
Molecular Biology of the Cell
Author:
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0
Book Description
Publisher:
ISBN: 9780815332183
Category : Cells
Languages : en
Pages : 0
Book Description
The Response of Escherichia Coli to DNA Damage
Author: A. J. Von Wright
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages :
Book Description
Study of DNA Repair Endonucleases from Escherichia Coli
Author: Frederick Taylor Gates
Publisher:
ISBN:
Category :
Languages : en
Pages : 232
Book Description
Publisher:
ISBN:
Category :
Languages : en
Pages : 232
Book Description
DNA Damage and Repair
Author: Jac A. Nickoloff
Publisher: Springer Science & Business Media
ISBN: 1592590950
Category : Science
Languages : en
Pages : 417
Book Description
Jac A. Nickoloff and Merl F. Hoekstra update and expand their two earlier acclaimed volumes (Vol. I: DNA Repair in Prokaryotes and Lower Eukaryotes and Vol. II: DNA Repair in Higher Eurkaryotes) with cutting-edge reviews by leading authorities of primary experimental findings about DNA repair processes in cancer biology. The reviews cover a wide range of topics from viruses and prokaryotes to higher eukaryotes, and include several new topics, among them the role of recombination in replication of damaged DNA, X-ray crystallographic analysis of DNA repair protein structures, DNA repair proteins and teleomere function, and the roles of BRCA1 and BRCA2 in DNA repair. Authoritative and up-to-date, DNA Damage and Repair, Vol. III: Advances from Phage to Humans surveys the rapidly moving research in DNA damage and repair, and explains the important functional relationships among different DNA repair pathways and the relationship between DNA repair pathways, cancer etiology, and cancer therapies.
Publisher: Springer Science & Business Media
ISBN: 1592590950
Category : Science
Languages : en
Pages : 417
Book Description
Jac A. Nickoloff and Merl F. Hoekstra update and expand their two earlier acclaimed volumes (Vol. I: DNA Repair in Prokaryotes and Lower Eukaryotes and Vol. II: DNA Repair in Higher Eurkaryotes) with cutting-edge reviews by leading authorities of primary experimental findings about DNA repair processes in cancer biology. The reviews cover a wide range of topics from viruses and prokaryotes to higher eukaryotes, and include several new topics, among them the role of recombination in replication of damaged DNA, X-ray crystallographic analysis of DNA repair protein structures, DNA repair proteins and teleomere function, and the roles of BRCA1 and BRCA2 in DNA repair. Authoritative and up-to-date, DNA Damage and Repair, Vol. III: Advances from Phage to Humans surveys the rapidly moving research in DNA damage and repair, and explains the important functional relationships among different DNA repair pathways and the relationship between DNA repair pathways, cancer etiology, and cancer therapies.
DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells
Author: M. Lambert
Publisher: Springer Science & Business Media
ISBN: 1468413279
Category : Science
Languages : en
Pages : 654
Book Description
This volume contains edited contributions from the speakers at the NATO Advanced Research Workshop on "DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells" held October 1-6, 1988, at the Abbaye Royale de Fontevraud, Fontevraud France. The meeting was dedicated to Paul Howard-Flanders (Yale University, New Haven, CT. , 1919-1988), whose seminal con tributions to the DNA repair field include the cO-discovery of the excision repair pathway, the elucidation of post-repli cation repair in E. coli, the isolation of the lexA and recC mutants, and his extensive work on the enzymology of RecA. A plethora of recent developments in DNA repair mechan isms and related processes in mammalian cells have advanced our understanding of this field in a number of different areas and have given new emphasis to the ways these systems both resemble DNA repair processes in other groups of organisms in some respects yet are strikingly different from them in others. Within the past decade there have been a number of international conferences on DNA damage and repair mechanisms but none has been focused on these processes in mammalian cells.
Publisher: Springer Science & Business Media
ISBN: 1468413279
Category : Science
Languages : en
Pages : 654
Book Description
This volume contains edited contributions from the speakers at the NATO Advanced Research Workshop on "DNA Repair Mechanisms and Their Biological Implications in Mammalian Cells" held October 1-6, 1988, at the Abbaye Royale de Fontevraud, Fontevraud France. The meeting was dedicated to Paul Howard-Flanders (Yale University, New Haven, CT. , 1919-1988), whose seminal con tributions to the DNA repair field include the cO-discovery of the excision repair pathway, the elucidation of post-repli cation repair in E. coli, the isolation of the lexA and recC mutants, and his extensive work on the enzymology of RecA. A plethora of recent developments in DNA repair mechan isms and related processes in mammalian cells have advanced our understanding of this field in a number of different areas and have given new emphasis to the ways these systems both resemble DNA repair processes in other groups of organisms in some respects yet are strikingly different from them in others. Within the past decade there have been a number of international conferences on DNA damage and repair mechanisms but none has been focused on these processes in mammalian cells.