Structural Studies of Terminal Protein-primed DNA Replication by Phi29 DNA Polymerase PDF Download

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Structural Studies of Terminal Protein-primed DNA Replication by Phi29 DNA Polymerase

Structural Studies of Terminal Protein-primed DNA Replication by Phi29 DNA Polymerase PDF Author: Andrea Jeanne Berman
Publisher:
ISBN: 9780549064886
Category :
Languages : en
Pages : 166

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Book Description
Sequence-independent DNA binding and the mechanism of translocation in B-family polymerases were examined in DNA substrate complexes of phi29 DNA polymerase. These complexes included the translocated binary complex and the post-insertion pre-translocation ternary complex. Comparison of these structures revealed a mechanism of translocation, different from the mechanism for A-family polymerases, based on the coordinated movement of two conserved tyrosine residues.