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Author: Pauline M. H. Mazumdar
Publisher: Cambridge University Press
ISBN: 9780521525237
Category : Science
Languages : en
Pages : 480
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Book Description
An account of scientific disputes over the core problems of research and practice in immunology.
Author: Pauline M. H. Mazumdar
Publisher: Cambridge University Press
ISBN: 9780521525237
Category : Science
Languages : en
Pages : 480
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Book Description
An account of scientific disputes over the core problems of research and practice in immunology.
Author: Pauline Margaret Hodgson Mazumdar
Publisher:
ISBN:
Category : Immunology
Languages : en
Pages : 457
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Book Description
Their science was designed only in part to wrest an answer from nature: it was at least as important to wring an admission of defeat from their opponents. One of the key figures in the debate was the Austrian immunochemist Karl Landsteiner, whose career provides the central focus for Mazumdar's account. His unitarian views excluded him from promotion within European institutions, where the specificity and pluralism espoused by Robert Koch and Paul Ehrlich were entrenched. Landsteiner himself was forced into a kind of exile at Rockefeller University in New York. Though Landsteiner won a Nobel prize for his work, his inability to gain more widespread acceptance of his views caused him to view his life as a failure.
Author: Kenneth Murphy
Publisher: Garland Science
ISBN: 9780815344575
Category : Medical
Languages : en
Pages :
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Book Description
The Janeway's Immunobiology CD-ROM, Immunobiology Interactive, is included with each book, and can be purchased separately. It contains animations and videos with voiceover narration, as well as the figures from the text for presentation purposes.
Author: Karl Landsteiner
Publisher: Courier Corporation
ISBN: 0486151441
Category : Science
Languages : en
Pages : 348
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Book Description
Nobel prizewinner's account of experiments he and colleagues carried out on antigens and serological reactions with simple compounds. Exceptionally broad coverage of basic immunology. Extensive bibliography.
Author: Hervé Tettelin
Publisher: Springer Nature
ISBN: 3030382818
Category : Science
Languages : en
Pages : 311
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Book Description
This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The book’s respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.
Author: Robert Langenbach
Publisher: Springer Science & Business Media
ISBN: 146844400X
Category : Medical
Languages : en
Pages : 680
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Book Description
The Symposium on Organ and Species Specificity in Chemical Carcinogenesis was held March 1981 in Raleigh, North Carolina. Dr. James Miller concluded this Symposium with these remarks: "Without a doubt all of us would agree this has been a very successful symposium in illustrating a very wide range of chemical, stereochemical, biochemical, metabolic, molecular, and biological factors in chemical carcinogenesis. I think it is noteworthy that many of the discussions have dealt with pharmacodynamic, or toxicodynamic, factors that can influence the biological activities of the extremely wide range of structures that we choose to call chemical carcinogens. I sincerely hope that after this symposium everyone here will realize the very great need we have for further information on these agents in the species we profess to be working for, the human species. We badly need an adequate data base on human organs, human tissues, human cells, human subcellular preparations, and human body fluids. I don't think we can rely on extrapolations of data on chemical carcinogenesis from experimental animals to humans, no matter how sophisticated or plausible these extrapolations may seem, until we know far more about chemical carcinogenesis in humans. Now, I'd like to add a somewhat personal note. As many of you know, my wife and I have shared a joint career of some 40 years in this field, and I'd like to emphasize in these closing remarks the factor of youth.
Author: Steven A. Frank
Publisher: Princeton University Press
ISBN: 9780691095950
Category : Medical
Languages : en
Pages : 364
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Book Description
Publisher Description
Author: Otso Ovaskainen
Publisher: Cambridge University Press
ISBN: 1108492460
Category : Nature
Languages : en
Pages : 389
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Book Description
A comprehensive account of joint species distribution modelling, covering statistical analyses in light of modern community ecology theory.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309220424
Category : Science
Languages : en
Pages : 200
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Book Description
For many years, experiments using chimpanzees have been instrumental in advancing scientific knowledge and have led to new medicines to prevent life-threatening and debilitating diseases. However, recent advances in alternate research tools have rendered chimpanzees largely unnecessary as research subjects. The Institute of Medicine, in collaboration with the National Research Council, conducted an in-depth analysis of the scientific necessity for chimpanzees in NIH-funded biomedical and behavioral research. The committee concludes that while the chimpanzee has been a valuable animal model in the past, most current biomedical research use of chimpanzees is not necessary, though noted that it is impossible to predict whether research on emerging or new diseases may necessitate chimpanzees in the future.
Author: National Research Council
Publisher: National Academies Press
ISBN: 0309070864
Category : Nature
Languages : en
Pages : 348
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Book Description
Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.
