Special Issue: Second European Symposium on Calcium Binding Proteins in Normal and Transformed Cells PDF Download
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Author:
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Category :
Languages : en
Pages : 144
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Author:
Publisher:
ISBN:
Category :
Languages : en
Pages : 144
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Author: Joseph R. Lacowicz
Publisher: Springer Science & Business Media
ISBN: 0306471027
Category : Science
Languages : en
Pages : 320
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Book Description
The intrinsic or natural fluorescence of proteins is perhaps the most complex area of biochemical fluorescence. Fortunately the fluorescent amino acids, phenylalanine, tyrosine and tryptophan are relatively rare in proteins. Tr- tophan is the dominant intrinsic fluorophore and is present at about one mole % in protein. As a result most proteins contain several tryptophan residues and even more tyrosine residues. The emission of each residue is affected by several excited state processes including spectral relaxation, proton loss for tyrosine, rotational motions and the presence of nearby quenching groups on the protein. Additionally, the tyrosine and tryptophan residues can interact with each other by resonance energy transfer (RET) decreasing the tyrosine emission. In this sense a protein is similar to a three-particle or mul- particle problem in quantum mechanics where the interaction between particles precludes an exact description of the system. In comparison, it has been easier to interpret the fluorescence data from labeled proteins because the fluorophore density and locations could be controlled so the probes did not interact with each other. From the origins of biochemical fluorescence in the 1950s with Prof- sor G. Weber until the mid-1980s, intrinsic protein fluorescence was more qualitative than quantitative. An early report in 1976 by A. Grindvald and I. Z. Steinberg described protein intensity decays to be multi-exponential. Attempts to resolve these decays into the contributions of individual tryp- phan residues were mostly unsuccessful due to the difficulties in resolving closely spaced lifetimes.
Author: National Library of Medicine (U.S.)
Publisher:
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Category : Medicine
Languages : en
Pages : 524
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First multi-year cumulation covers six years: 1965-70.
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Category : Calcium
Languages : en
Pages : 586
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Author: British Library. Document Supply Centre
Publisher:
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Category : Conference proceedings
Languages : en
Pages : 870
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Author:
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Category : Medicine
Languages : en
Pages : 1340
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Author: United States. Public Health Service. Office of the Surgeon General
Publisher:
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Category : Government publications
Languages : en
Pages : 728
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This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Author:
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Category : Science
Languages : en
Pages : 2910
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Vols. for 1964- have guides and journal lists.
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Category : United States
Languages : en
Pages : 1464
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Author: Fabrizio d'Adda di Fagagna
Publisher: Springer Science & Business Media
ISBN: 0387691162
Category : Medical
Languages : en
Pages : 274
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Proceedings of the 2nd Annual IFOM-IEO Meeting on Cancer. This is a new meeting, it has about 200 attendees from Australia, Austria, Belgium, Brazil, Canada, England, France, Germany, Greece, Ireland, Italy, Japan, Netherlands, Spain, Sweden, Switzerland, and the USA. The 2nd IFOM-IEO international meeting on cancer will provide a forum in which the world’s leading cancer researchers and young scientists will discuss the latest advances in molecular oncology. The impact of recent breakthroughs in basic research and of emerging technologies on molecular medicine in cancer will be highlighted.
