SITC’s Guide to Managing Immunotherapy Toxicity PDF Download
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Author: Marc S. Ernstoff, MD
Publisher: Springer Publishing Company
ISBN: 0826172156
Category : Medical
Languages : en
Pages : 275
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Book Description
The Society for Immunotherapy of Cancer's handbook,SITC’s Guide to Managing Immunotherapy Toxicity, is a practical reference to managing side effects associated with FDA-approved cancer immunotherapy drugs. Separated into two parts, Part I contains chapter-based overviews of immune checkpoint inhibitors in the clinic, starting with anti-CTLA4 agents, anti-PD1/PD-L1 agents, and approved immunotherapeutic combinations. These chapters cover relevant mechanisms of action, indications, and toxicities seen while combating early, advanced, and metastatic stages in cancer patients. Part II is structured by common and uncommon toxicities that affect major organ sites throughout the body. It begins with a general summary of principles and management options followed by chapters focusing on specific toxicities such as rash and mucosal irritation, muscle and joint toxicity, diarrhea and colitis, pneumonitis, endocrine toxicities, neurological toxicities, cardiac toxicity, renal toxicity, hematologic toxicity, and ocular toxicities. Each chapter provides guidance on how to assess and treat the toxicity and how to support the patient through acute and chronic effects with detailed summary tables for quick reference. Part II concludes with chapters covering management of special patient populations, including patients with autoimmune disease and geriatric patients, treatment and management of fatigue, and a final chapter dedicated to cost effectiveness and the toll of financial toxicity on patients and caregivers. With chapters written by world-recognized leaders in the immuno-oncology field, this text provides thorough coverage of the toxicity and management of adverse effects for immune checkpoint inhibitors. It is an indispensable resource for clinical oncologists, emergency physicians, hospitalists and other medical practitioners in both the hospital and community clinic settings, especially as the use of immune checkpoint inhibitors becomes a fixture in oncology care. Key Features: Outlines strategies for treating high-risk patients facing an acute or chronic side effect to immunotherapy Provides numerous tables that condense and highlight pertinent information for quick reference Describes the various clinical presentations and toxic reactions caused by immunotherapy Purchase includes access to the eBook for use on most mobile devices or computer
Author: Marc S. Ernstoff, MD
Publisher: Springer Publishing Company
ISBN: 0826172156
Category : Medical
Languages : en
Pages : 275
Get Book Here
Book Description
The Society for Immunotherapy of Cancer's handbook,SITC’s Guide to Managing Immunotherapy Toxicity, is a practical reference to managing side effects associated with FDA-approved cancer immunotherapy drugs. Separated into two parts, Part I contains chapter-based overviews of immune checkpoint inhibitors in the clinic, starting with anti-CTLA4 agents, anti-PD1/PD-L1 agents, and approved immunotherapeutic combinations. These chapters cover relevant mechanisms of action, indications, and toxicities seen while combating early, advanced, and metastatic stages in cancer patients. Part II is structured by common and uncommon toxicities that affect major organ sites throughout the body. It begins with a general summary of principles and management options followed by chapters focusing on specific toxicities such as rash and mucosal irritation, muscle and joint toxicity, diarrhea and colitis, pneumonitis, endocrine toxicities, neurological toxicities, cardiac toxicity, renal toxicity, hematologic toxicity, and ocular toxicities. Each chapter provides guidance on how to assess and treat the toxicity and how to support the patient through acute and chronic effects with detailed summary tables for quick reference. Part II concludes with chapters covering management of special patient populations, including patients with autoimmune disease and geriatric patients, treatment and management of fatigue, and a final chapter dedicated to cost effectiveness and the toll of financial toxicity on patients and caregivers. With chapters written by world-recognized leaders in the immuno-oncology field, this text provides thorough coverage of the toxicity and management of adverse effects for immune checkpoint inhibitors. It is an indispensable resource for clinical oncologists, emergency physicians, hospitalists and other medical practitioners in both the hospital and community clinic settings, especially as the use of immune checkpoint inhibitors becomes a fixture in oncology care. Key Features: Outlines strategies for treating high-risk patients facing an acute or chronic side effect to immunotherapy Provides numerous tables that condense and highlight pertinent information for quick reference Describes the various clinical presentations and toxic reactions caused by immunotherapy Purchase includes access to the eBook for use on most mobile devices or computer
Author: Suzanne L. Walker
Publisher:
ISBN: 9781635930184
Category :
Languages : en
Pages :
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Book Description
Author: Daniel W. Lee
Publisher: Elsevier Health Sciences
ISBN: 0323755976
Category : Medical
Languages : en
Pages : 246
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Book Description
From patient referral to post-therapy management, Chimeric Antigen Receptor (CAR) T-Cell Therapies for Cancer: A Practical Guide presents a comprehensive view of CAR modified T-cells in a concise and practical format. Providing authoritative guidance on the implementation and management of CAR T-cell therapy from Drs. Daniel W. Lee and Nirali N. Shah, this clinical resource keeps you up to date on the latest developments in this rapidly evolving area. - Covers all clinical aspects, including patient referral, toxicities management, comorbidities, bridging therapy, post-CAR monitoring, and multidisciplinary approaches to supportive care. - Includes key topics on associated toxicities such as predictive biomarkers, infections, and multidisciplinary approaches to supportive care. - Presents current knowledge on FDA approved CAR T-cell products as well as developments on the horizon. - Editors and authors represent leading investigators in academia and worldwide pioneers of CAR therapy.
Author: Vamsidhar Velcheti
Publisher: Elsevier Health Sciences
ISBN: 032367299X
Category : Medical
Languages : en
Pages : 355
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Book Description
Early recognition and management of adverse effects of cancer treatments are essential for optimal care of patients with cancer, and drastically different approaches are required for different physiologic reactions. Handbook of Cancer Treatment-Related Symptoms and Toxicities is a focused, one-stop resource that enables clinicians to quickly find up-to-date, reliable information needed at the point of care. The high-yield approach prioritizes the most common toxicities associated with cancer treatment, and concise, templated chapters offer fast access to information needed in day-to-day practice. - Presents a user-friendly overview of cancer treatment-related symptoms and toxicities management in a practical, easy-to-use format, allowing you to quickly find information in one convenient, concise resource. - Covers systemic and radiation therapies, including chemotherapy, immunotherapy, targeted therapies, and radiation therapy, detailing symptoms of each toxicity to confirm your diagnosis. - Overviews pharmacologic and non-pharmacologic approaches to symptom management. - Offers recommendations for mitigating toxicities in high-risk patients. - Discusses key topics such as management of infusion reactions, when the need for biopsy is warranted, and the unique challenges posed by novel immunotherapies.
Author: Tim F. Greten
Publisher: Springer
ISBN: 9783319879116
Category : Medical
Languages : en
Pages : 0
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Book Description
In this book we provide insights into liver – cancer and immunology. Experts in the field provide an overview over fundamental immunological questions in liver cancer and tumorimmunology, which form the base for immune based approaches in HCC, which gain increasing interest in the community due to first promising results obtained in early clinical trials. Hepatocellular carcinoma (HCC) is the third most common cause of cancer related death in the United States. Treatment options are limited. Viral hepatitis is one of the major risk factors for HCC, which represents a typical “inflammation-induced” cancer. Immune-based treatment approaches have revolutionized oncology in recent years. Various treatment strategies have received FDA approval including dendritic cell vaccination, for prostate cancer as well as immune checkpoint inhibition targeting the CTLA4 or the PD1/PDL1 axis in melanoma, lung, and kidney cancer. Additionally, cell based therapies (adoptive T cell therapy, CAR T cells and TCR transduced T cells) have demonstrated significant efficacy in patients with B cell malignancies and melanoma. Immune checkpoint inhibitors in particular have generated enormous excitement across the entire field of oncology, providing a significant benefit to a minority of patients.
Author: Kulmira Nurgali
Publisher: Frontiers Media SA
ISBN: 2889454827
Category :
Languages : en
Pages : 245
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Book Description
Advances in anti-cancer chemotherapy over recent years have led to improved efficacy in curing or controlling many cancers. Some chemotherapy-related side-effects are well recognized and include: nausea, vomiting, bone marrow suppression, peripheral neuropathy, cardiac and skeletal muscle dysfunction and renal impairment. However, it is becoming clearer that some chemotherapy-related adverse effects may persist even in long term cancer survivors. Problems such as cognitive, cardiovascular and gastrointestinal dysfunction, and neuropathy may lead to substantial long term morbidity. Despite improvements in treatments to counteract acute chemotherapy-induced adverse effects, they are often incompletely effective. Furthermore, counter-measures for some acute side-effects and many potential longer term sequelae of anti-cancer chemotherapy have not been developed. Thus, new insights into prevalence and mechanisms of cancer chemotherapy-related side effects are needed and new approaches to improving tolerance and reduce sequelae of cancer chemotherapy are urgently needed. The present Research Topic focuses on adverse effects and sequelae of chemotherapy and strategies to counteract them.
Author: Lisa H. Butterfield
Publisher:
ISBN: 9781620700976
Category : Cancer
Languages : en
Pages : 0
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Book Description
Part 1: Intratumoral Signatures Associated With Immune Responsiveness
Author: Florian Falter
Publisher: Springer Science & Business Media
ISBN: 1447122593
Category : Medical
Languages : en
Pages : 208
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Book Description
This handbook is a guide to best practice in interventions commonly encountered in the ICU. It is clinically orientated providing :step-by-step explanations and illustrations of most invasive procedures, check lists to make sure the indication is right, check lists to ensure appropriate assessment once the procedure has been carried out. The information is easily accessible providing practical advice and essential background for every member of the multi-disciplinary team caring for critically ill patients. It will serve the senior consultant who has not performed a procedure for some time as well as the junior doctor in need of an aide memoire.
Author: Jennifer Yu, MD, PhD
Publisher: Springer Publishing Company
ISBN: 1617052914
Category : Medical
Languages : en
Pages : 520
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Book Description
Radiobiology Self-Assessment Guide--a companion to the Radiation Oncology Self-Assessment Guide and Physics in Radiation Oncology Self-Assessment Guide--is a comprehensive review for practitioners of radiation oncology looking to enhance their knowledge of radiobiology. It covers in depth the principles of radiobiology as applied to radiation oncology along with their clinical applications. To foster retention of key concepts and data, the resource utilizes a user-friendly "flash card" question and answer format with over 700 questions. The questions are supported by detailed answers and rationales along with reference citations for source information. The guide is comprised of 29 chapters and cover topics commonly found on the radiation and cancer biology portion of the radiation oncology board examination. Aspects of basic radiobiology covered include fundamentals such as cell cycle, cell survival curves and interactions of radiation with matter, and acute and long-term sequelae of radiation. Modern concepts such as immunotherapy, radiogenomics, and normal and cancer stem cells are also included. Focused and authoritative, this must-have review provides the expertise of faculty from the Department of Radiation Oncology at the Cleveland Clinic Taussig Cancer Institute and Lerner Research Institute. Key Features: Provides a comprehensive study guide for the Radiation and Cancer Biology portion to the Radiation Oncology Board Exam Includes more than 700 questions with detailed answers and rationales on flip pages for easy, flash card-like review Includes essential review of cancer biology concepts such as immunotherapy, stem cells, gene therapy, chemotherapy and targeted agents Content provided by a vast array of contributors, including attending radiation oncology physicians, physicists, and radiation oncology residents
Author: Per-Ulf Tunn
Publisher: Springer Science & Business Media
ISBN: 3540779604
Category : Medical
Languages : en
Pages : 372
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Book Description
Bone and soft tissue sarcomas represent only about 2% of all malignancies; however, their treatment – with the goal of curing the patient while preserving the functionality of the affected body part – can, unlike other malignancies, only be successful with therapy concepts devised by interdisciplinary teams. This volume provides an extensive up-to-date overview of the specific diagnostics and current treatment standards of these rare entities, presenting the various limb-sparing modalities for patients with bone and soft tissue sarcomas with special regard to innovative reconstructive options. The evaluation of quality of life based on validated scores and the individual methods of coping with the illness through creative artistic projects are also acknowledged and integrated in the whole concept.
